Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0329 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0329 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0329 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 1 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.03 | 0.8601 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 1 | 1 |
Onchocerca volvulus | 0.0329 | 1 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0329 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0329 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0329 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0329 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0329 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0329 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0329 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.03 | 0.8601 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.03 | 0.8601 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0329 | 1 | 1 |
Onchocerca volvulus | 0.0329 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 1 | 1 |
Onchocerca volvulus | 0.0329 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0158 | 0.1752 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0329 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0329 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0158 | 0.1752 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0329 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0329 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0329 | 1 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.03 | 0.8601 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0329 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0329 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0329 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0329 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0329 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0329 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.