Detailed information for compound 1551665

Basic information

Technical information
  • TDR Targets ID: 1551665
  • Name: N-methyl-N-(3-methyl-1,1-dioxothiolan-3-yl)th iophene-2-carboxamide
  • MW: 273.372 | Formula: C11H15NO3S2
  • H donors: 0 H acceptors: 3 LogP: 1.15 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C1(C)CCS(=O)(=O)C1)C(=O)c1cccs1
  • InChi: 1S/C11H15NO3S2/c1-11(5-7-17(14,15)8-11)12(2)10(13)9-4-3-6-16-9/h3-4,6H,5,7-8H2,1-2H3
  • InChiKey: PHHCUJPKGOSLCU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-methyl-N-(3-methyl-1,1-dioxo-thiolan-3-yl)thiophene-2-carboxamide
  • N-methyl-N-(3-methyl-1,1-dioxo-3-thiolanyl)-2-thiophenecarboxamide
  • N-(1,1-diketo-3-methyl-thiolan-3-yl)-N-methyl-thiophene-2-carboxamide
  • T5225948

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0091 0.0094
Loa Loa (eye worm) hypothetical protein 0.0209 0.8977 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.6318 0.7039
Echinococcus granulosus ecdysone induced protein 78C 0.0209 0.8977 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0209 0.8977 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.1136 0.1265
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0871 0.0971
Brugia malayi conserved hypotetical protein 0.0099 0.3287 0.3662
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0209 0.8977 1
Brugia malayi hypothetical protein 0.0038 0.0171 0.019
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.9659 1
Onchocerca volvulus Huntingtin homolog 0.0118 0.4307 0.4307
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0889 0.099
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0209 0.8977 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0209 0.8977 1
Brugia malayi Nuclear hormone receptor-like 1 0.0209 0.8977 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.3287 0.3662
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0099 0.3287 0.3662
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0889 0.099
Brugia malayi Steroid receptor seven-up type 2 0.0209 0.8977 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0099 0.3287 0.3662
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0049 0.0054
Schistosoma mansoni nuclear receptor 0.0099 0.3287 0.3662
Trypanosoma brucei glucosidase, putative 0.0035 0.0007 0.0814
Loa Loa (eye worm) hypothetical protein 0.0038 0.0171 0.019
Brugia malayi hypothetical protein 0.0038 0.0171 0.019
Schistosoma mansoni hypothetical protein 0.0038 0.0171 0.019
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0209 0.8977 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.1136 0.1265
Brugia malayi ecdysone receptor 0.0099 0.3287 0.3662
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0007 0.0007
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.1063 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.011 0.3897 0.4341
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0209 0.8977 1
Schistosoma mansoni nuclear receptor 0.0099 0.3287 0.3662
Brugia malayi hypothetical protein 0.0099 0.3287 0.3662
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0889 0.099
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0007 0.0814
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0007 0.0007
Loa Loa (eye worm) steroid hormone receptor 0.0209 0.8977 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0209 0.8977 1
Loa Loa (eye worm) hypothetical protein 0.011 0.3897 0.4341
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0167 0.6827 0.7606
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0209 0.8977 1
Onchocerca volvulus 0.0038 0.0171 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0209 0.8977 1
Brugia malayi glutathione reductase 0.0037 0.0091 0.0101
Loa Loa (eye worm) hypothetical protein 0.0038 0.0171 0.019
Brugia malayi photoreceptor-specific nuclear receptor 0.0209 0.8977 1
Brugia malayi ecdysteroid receptor 0.0209 0.8977 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0083 0.2503 0.2592
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0099 0.3287 0.3662
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0167 0.6827 0.7606
Onchocerca volvulus 0.0099 0.3287 0.3287
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0049 0.0054
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0007 0.0007
Onchocerca volvulus Huntingtin homolog 0.0118 0.4307 0.4307
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0099 0.3287 0.3287
Schistosoma mansoni polycystin 1-related 0.0038 0.0171 0.019
Brugia malayi hypothetical protein 0.011 0.3897 0.4341
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0099 0.3287 0.3662
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.011 0.3897 0.4341
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.0171 0.019
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.1063 0.1185
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0055 0.1063 0.1101
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0209 0.8977 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0049 0.535
Onchocerca volvulus 0.0091 0.2899 0.2899
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0007 0.0008
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0049 0.0054
Brugia malayi hypothetical protein 0.0099 0.3287 0.3662
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0049 0.0049
Brugia malayi hypothetical protein 0.0118 0.4307 0.4798
Schistosoma mansoni rab6-interacting 0.0038 0.0171 0.019
Echinococcus multilocularis thyroid hormone receptor alpha 0.0209 0.8977 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.1063 0.1185
Loa Loa (eye worm) hypothetical protein 0.0209 0.8977 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.011 0.3897 0.4341
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0091 1
Loa Loa (eye worm) hypothetical protein 0.011 0.3897 0.4341
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0209 0.8977 1
Schistosoma mansoni nuclear hormone receptor 0.0099 0.3287 0.3662
Brugia malayi Thioredoxin reductase 0.0037 0.0091 0.0101
Onchocerca volvulus Protein ultraspiracle homolog 0.0209 0.8977 0.8977
Loa Loa (eye worm) hypothetical protein 0.0209 0.8977 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0007 0.0814
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0209 0.8977 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0083 0.2503 0.2592
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0007 0.0007
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0049 0.535
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0209 0.8977 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.3287 0.3662
Brugia malayi nuclear receptor NHR-88 0.0099 0.3287 0.3662
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0209 0.8977 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0209 0.8977 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0099 0.3287 0.3662
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0889 0.099
Loa Loa (eye worm) hypothetical protein 0.0209 0.8977 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0209 0.8977 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0889 0.099
Schistosoma mansoni loxhd1 0.0038 0.0171 0.019
Echinococcus granulosus Nuclear hormone receptor HR96 0.0099 0.3287 0.3662
Toxoplasma gondii thioredoxin reductase 0.0037 0.0091 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.3287 0.3662
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0205 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0209 0.8977 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0038 0.0171 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.1063 0.1185
Echinococcus granulosus Nuclear hormone receptor HR96 0.0099 0.3287 0.3662
Brugia malayi Nuclear hormone receptor E75 0.0099 0.3287 0.3662
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0209 0.8977 0.8977
Loa Loa (eye worm) hypothetical protein 0.0118 0.4307 0.4798
Schistosoma mansoni retinoid-x-receptor (RXR) 0.011 0.3897 0.4341
Leishmania major trypanothione reductase 0.0037 0.0091 0.0854
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0099 0.3287 0.3662
Echinococcus granulosus RUN 0.0038 0.0171 0.019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0209 0.8977 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0209 0.8977 1
Plasmodium falciparum LCCL domain-containing protein 0.0038 0.0171 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.3287 0.3662
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0099 0.3287 0.3662
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0007 0.0008
Loa Loa (eye worm) doublecortin family protein 0.0038 0.0171 0.019
Brugia malayi orphan nuclear receptor NR2E1 0.0099 0.3287 0.3662
Schistosoma mansoni thyroid hormone receptor 0.0209 0.8977 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.113 0.1259
Loa Loa (eye worm) hypothetical protein 0.0039 0.0205 0.0229
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.2983 0.3088
Brugia malayi hypothetical protein 0.011 0.3897 0.4341
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0007 0.0007
Brugia malayi nuclear hormone receptor family member odr-7 0.0099 0.3287 0.3662
Loa Loa (eye worm) glutathione reductase 0.0037 0.0091 0.0101
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0209 0.8977 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.113 0.1259
Brugia malayi Nuclear hormone receptor-like 1 0.011 0.3897 0.4341
Echinococcus granulosus thyroid hormone receptor alpha 0.0099 0.3287 0.3662
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0889 0.099
Echinococcus multilocularis FTZ F1 alpha 0.0209 0.8977 1
Brugia malayi nuclear hormone receptor 0.0099 0.3287 0.3662
Schistosoma mansoni nuclear receptor nhr-48 0.0099 0.3287 0.3662
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0007 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0209 0.8977 1
Loa Loa (eye worm) hypothetical protein 0.0209 0.8977 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0209 0.8977 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0209 0.8977 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0038 0.0171 0.019
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.1136 0.1265
Brugia malayi Pre-SET motif family protein 0.0201 0.8569 0.9545
Schistosoma mansoni steroid hormone receptor ad4bp 0.0209 0.8977 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.6318 0.7039
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0049 0.535
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0099 0.3287 0.3662
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0209 0.8977 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.0171 0.019
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0049 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0209 0.8977 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.3287 0.3662
Schistosoma mansoni hypothetical protein 0.0039 0.0205 0.0229
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.2983 0.3088
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0007 0.0008
Schistosoma mansoni RAR-like nuclear receptor 0.0209 0.8977 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0049 0.0049
Loa Loa (eye worm) nuclear receptor NHR-67 0.0099 0.3287 0.3662
Schistosoma mansoni coup transcription factor 0.0209 0.8977 1
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0007 0.0069
Brugia malayi nuclear receptor NHR-88 0.0209 0.8977 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.0171 0.019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0209 0.8977 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0116 0.0129
Loa Loa (eye worm) hypothetical protein 0.0118 0.4307 0.4798
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0049 0.0054
Schistosoma mansoni alpha-glucosidase 0.0135 0.5189 0.5781
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.011 0.3897 0.4341
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0049 0.0054
Loa Loa (eye worm) hypothetical protein 0.0209 0.8977 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0209 0.8977 1
Brugia malayi tailless protein 0.0099 0.3287 0.3662
Schistosoma mansoni alpha-glucosidase 0.0135 0.5189 0.5781
Loa Loa (eye worm) hypothetical protein 0.011 0.3897 0.4341
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0889 0.099
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0049 0.0054
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0049 0.0054
Loa Loa (eye worm) hypothetical protein 0.0209 0.8977 1
Brugia malayi nuclear receptor RXR 0.0099 0.3287 0.3662
Loa Loa (eye worm) hypothetical protein 0.011 0.3897 0.4341
Echinococcus granulosus FTZ F1 alpha 0.0209 0.8977 1
Onchocerca volvulus 0.0038 0.0171 0.0171
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.2983 0.3088
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0049 0.0049
Echinococcus multilocularis ecdysone induced protein 78C 0.0209 0.8977 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0083 0.2503 0.2592
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.1136 0.1265
Brugia malayi nuclear receptor NHR-67 0.0099 0.3287 0.3662
Schistosoma mansoni lipoxygenase 0.0167 0.6827 0.7606
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0099 0.3287 0.3662
Schistosoma mansoni lipoxygenase 0.0099 0.3294 0.3669
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0049 0.0054
Brugia malayi nuclear receptor RXR 0.011 0.3897 0.4341
Brugia malayi Nuclear hormone receptor-like 1 0.011 0.3897 0.4341
Loa Loa (eye worm) hypothetical protein 0.0099 0.3287 0.3662
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0209 0.8977 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.1136 0.1265
Schistosoma mansoni nuclear hormone receptor 0.0209 0.8977 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.0171 0.019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0209 0.8977 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0099 0.3287 0.3662
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0055 0.1063 1
Brugia malayi nuclear hormone receptor 0.0209 0.8977 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0889 0.099
Echinococcus granulosus Polycystic kidney disease protein 0.0038 0.0171 0.019
Brugia malayi Nuclear hormone receptor E75 0.0099 0.3287 0.3662
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0209 0.8977 1
Schistosoma mansoni zinc finger protein 0.0099 0.3287 0.3662
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.8569 0.9545
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0055 0.1063 0.1185
Schistosoma mansoni thyroid hormone receptor 0.0209 0.8977 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0209 0.8977 1
Loa Loa (eye worm) hypothetical protein 0.011 0.3897 0.4341
Onchocerca volvulus Bile acid receptor homolog 0.0209 0.8977 0.8977
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.1136 0.1265
Mycobacterium tuberculosis Probable reductase 0.0083 0.2503 0.2592
Loa Loa (eye worm) hypothetical protein 0.0099 0.3287 0.3662
Loa Loa (eye worm) hypothetical protein 0.0209 0.8977 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0083 0.2503 0.2592
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.113 0.1259
Brugia malayi jmjC domain containing protein 0.0057 0.1136 0.1265
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.2983 1
Brugia malayi jmjC domain containing protein 0.0057 0.1136 0.1265
Loa Loa (eye worm) hypothetical protein 0.0099 0.3287 0.3662
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0007 0.0814
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.6318 0.7039
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0209 0.8977 1
Schistosoma mansoni alpha glucosidase 0.0035 0.0007 0.0008
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.6318 0.7039
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0209 0.8977 1
Loa Loa (eye worm) nuclear hormone receptor 0.0099 0.3287 0.3662
Loa Loa (eye worm) hypothetical protein 0.0099 0.3287 0.3662
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0209 0.8977 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.3287 0.3662
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0209 0.8977 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0099 0.3287 0.3287
Echinococcus multilocularis RUN 0.0038 0.0171 0.019
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0116 0.0129
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.6318 0.7039
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0099 0.3287 0.3662
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0209 0.8977 1
Onchocerca volvulus 0.0209 0.8977 0.8977
Echinococcus multilocularis nuclear receptor nhr 48 0.0099 0.3287 0.3662
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0049 0.0054
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0083 0.2503 0.2592
Loa Loa (eye worm) hypothetical protein 0.0099 0.3287 0.3662
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0209 0.8977 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0083 0.2503 0.8393
Schistosoma mansoni rab6-interacting 0.0038 0.0171 0.019
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0049 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.113 0.1259
Schistosoma mansoni jumonji domain containing protein 0.0057 0.1136 0.1265
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0209 0.8977 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0049 0.0457
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0091 0.0101
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0889 0.099
Onchocerca volvulus 0.0099 0.3287 0.3287
Loa Loa (eye worm) hypothetical protein 0.0036 0.0049 0.0054
Trichomonas vaginalis set domain proteins, putative 0.0229 1 1
Brugia malayi steroid hormone receptor 0.0209 0.8977 1
Plasmodium vivax glutathione reductase, putative 0.0037 0.0091 0.5318
Echinococcus granulosus nuclear receptor nhr 48 0.0099 0.3287 0.3662
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.1136 0.1265
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0099 0.3287 0.3662
Schistosoma mansoni nuclear hormone receptor 0.0099 0.3287 0.3662
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0091 0.5318
Trypanosoma brucei trypanothione reductase 0.0037 0.0091 1
Brugia malayi Doublecortin family protein 0.0038 0.0171 0.019
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0007 0.0007
Loa Loa (eye worm) DR-78 0.0099 0.3287 0.3662
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0099 0.3287 0.3662
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0209 0.8977 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.3287 0.3662
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.1063 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0209 0.8977 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

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