Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.0901 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.266 | 0.1934 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 0.8487 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.4524 | 0.4775 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.0901 | 0.0901 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.266 | 0.2319 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.0901 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5303 | 0.4837 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.266 | 0.2319 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.5303 | 0.5303 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 0.8487 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.266 | 0.2319 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.0901 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.0901 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.0901 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.5303 | 0.5802 |
Brugia malayi | hypothetical protein | 0.003 | 0.266 | 0.266 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.0901 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.266 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 0.8487 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.266 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0054 | 0.8487 | 0.8487 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 0.8487 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0901 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.266 | 0.2319 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0901 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.8487 | 0.8338 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.4524 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 0.8487 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.266 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.4524 | 0.4775 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 0.8487 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.8876 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.