Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0203 | 0.2825 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0203 | 0.2825 | 0.4229 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0336 | 0.5004 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0062 | 0.052 | 0.052 |
Loa Loa (eye worm) | TAR-binding protein | 0.0197 | 0.273 | 0.273 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.005 | 0.0327 | 0.1159 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 0.273 | 0.4088 |
Schistosoma mansoni | glutaminase | 0.0268 | 0.3893 | 0.5828 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0197 | 0.273 | 0.273 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.0867 | 0.1298 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 0.273 | 0.4088 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0364 | 0.129 |
Loa Loa (eye worm) | glutaminase | 0.0268 | 0.3893 | 0.3893 |
Brugia malayi | Isocitrate dehydrogenase | 0.005 | 0.0327 | 0.0327 |
Brugia malayi | jmjC domain containing protein | 0.0099 | 0.1116 | 0.1116 |
Schistosoma mansoni | hypothetical protein | 0.0203 | 0.2825 | 0.4229 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0186 | 0.2543 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0186 | 0.2543 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0203 | 0.2825 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.01 | 0.0149 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0336 | 0.5004 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0364 | 0.0364 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0197 | 0.273 | 0.273 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0032 | 0.0035 | 0.0137 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.005 | 0.0327 | 0.1159 |
Loa Loa (eye worm) | glutaminase 2 | 0.0268 | 0.3893 | 0.3893 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0203 | 0.2825 | 0.2825 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0186 | 0.2543 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0186 | 0.2543 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0336 | 0.5004 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0336 | 0.5004 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0336 | 0.5004 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0268 | 0.3893 | 0.3893 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0364 | 0.0545 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.01 | 0.0352 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0364 | 0.129 |
Brugia malayi | hypothetical protein | 0.012 | 0.1466 | 0.1466 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0336 | 0.5004 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0197 | 0.273 | 0.9666 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0348 | 0.0348 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0203 | 0.2825 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.005 | 0.0327 | 0.1287 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0186 | 0.2543 | 1 |
Brugia malayi | TAR-binding protein | 0.0197 | 0.273 | 0.273 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.005 | 0.0327 | 0.1166 |
Schistosoma mansoni | hypothetical protein | 0.0438 | 0.6679 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0641 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0203 | 0.2825 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.005 | 0.0327 | 0.0296 |
Loa Loa (eye worm) | RNA binding protein | 0.0197 | 0.273 | 0.273 |
Echinococcus granulosus | dna polymerase eta | 0.0046 | 0.026 | 0.0919 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0203 | 0.2825 | 0.2825 |
Brugia malayi | N-terminal motif family protein | 0.0616 | 0.9593 | 0.9593 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0364 | 0.129 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0164 | 0.2191 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.005 | 0.0327 | 0.1287 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0641 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0197 | 0.273 | 0.9666 |
Leishmania major | hypothetical protein, conserved | 0.0186 | 0.2543 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0046 | 0.026 | 0.0919 |
Brugia malayi | RNA binding protein | 0.0197 | 0.273 | 0.273 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.2825 | 0.2825 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.2543 | 0.2543 |
Schistosoma mansoni | hypothetical protein | 0.0203 | 0.2825 | 0.4229 |
Mycobacterium ulcerans | glutaminase | 0.0268 | 0.3893 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.026 | 0.026 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0099 | 0.1116 | 0.3952 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0046 | 0.026 | 0.026 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.01 | 0.0149 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.005 | 0.0327 | 0.1166 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.005 | 0.0327 | 0.1159 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0042 | 0.0189 | 0.0668 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.005 | 0.0327 | 0.1159 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.005 | 0.0327 | 0.1166 |
Schistosoma mansoni | DNA polymerase eta | 0.0046 | 0.026 | 0.0389 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0364 | 0.0545 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0099 | 0.1116 | 0.3952 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0186 | 0.2543 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0336 | 0.5004 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.01 | 0.0352 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0164 | 0.2191 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0336 | 0.5004 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0336 | 0.5004 | 0.5 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0336 | 0.5004 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 0.273 | 0.4088 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0203 | 0.2825 | 0.2825 |
Echinococcus multilocularis | GPCR, family 2 | 0.0203 | 0.2825 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0364 | 0.0545 |
Schistosoma mansoni | jumonji domain containing protein | 0.0078 | 0.0785 | 0.1175 |
Loa Loa (eye worm) | hypothetical protein | 0.0641 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0364 | 0.0364 |
Leishmania major | DNA polymerase eta, putative | 0.0046 | 0.026 | 0.0896 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.005 | 0.0327 | 0.049 |
Schistosoma mansoni | hypothetical protein | 0.0203 | 0.2825 | 0.4229 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.005 | 0.0327 | 0.1159 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.01 | 0.01 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 0.273 | 0.4088 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0336 | 0.5004 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0197 | 0.273 | 0.4088 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0186 | 0.2543 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.005 | 0.0327 | 0.0327 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.005 | 0.0327 | 0.0296 |
Brugia malayi | isocitrate dehydrogenase | 0.005 | 0.0327 | 0.0327 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0083 | 0.0867 | 0.3068 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0364 | 0.129 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0203 | 0.2825 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0336 | 0.5004 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0046 | 0.026 | 0.0896 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.005 | 0.0327 | 0.1159 |
Echinococcus granulosus | jumonji domain containing protein | 0.0042 | 0.0189 | 0.0668 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0083 | 0.0867 | 0.3068 |
Brugia malayi | hypothetical protein | 0.0186 | 0.2543 | 0.2543 |
Loa Loa (eye worm) | hypothetical protein | 0.0616 | 0.9593 | 0.9593 |
Brugia malayi | Serotonin receptor | 0.0567 | 0.8787 | 0.8787 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0616 | 0.9593 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0438 | 0.6679 | 0.6679 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.01 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.6679 | 0.6679 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 4 mg kg-1 | In vivo Antipsychotic activity was quantified by induction of catalepsy in mice | ChEMBL. | 10425088 |
ED50 (functional) | > 7 mg kg-1 | In vivo Antipsychotic activity was quantified by inhibition of apomorphine-induced climbing(CL 95%) by mice | ChEMBL. | 10425088 |
Log Ki (binding) | = 5.81 | In vitro ability to displace [3H]-SCH-23,390 binding from Dopamine receptor D1 in rat striatal membrane. | ChEMBL. | 10425088 |
Log Ki (binding) | = 5.96 | In vitro ability to displace [3H]-mesulergine binding from 5-hydroxytryptamine 2C receptor from bovine choroid plexus. | ChEMBL. | 10425088 |
Log Ki (binding) | = 5.98 | In vitro ability to displace [3H]-spiperone binding from dopamine receptor D2 in rat striatal membrane. | ChEMBL. | 10425088 |
Log Ki (binding) | = 7.58 | In vitro ability to displace [3H]-ketanserin binding from 5-hydroxytryptamine 2A receptor in rat striatal membrane. | ChEMBL. | 10425088 |
pA2 (functional) | = 8.13 | pA2 value was evaluated by measuring the inhibition of the 5-HT-induced contraction of rat aorta. | ChEMBL. | 10425088 |
Ratio (binding) | = 1.27 | Ratio of pKi of 5-HT2A to that of D2 receptor | ChEMBL. | 10425088 |
Ratio (binding) | = 1.27 | Ratio of pKi of 5-HT2A to that of 5-HT2C receptor | ChEMBL. | 10425088 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.