Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 6-phosphogluconate dehydrogenase, decarboxylating | 0.011 | 0.1691 | 0.3213 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0397 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Trypanosoma brucei | 6-phosphogluconate dehydrogenase, decarboxylating | 0.0184 | 0.3846 | 0.5 |
Onchocerca volvulus | 0.0397 | 1 | 1 | |
Trichomonas vaginalis | 6-phosphogluconate dehydrogenase, putative | 0.0184 | 0.3846 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0397 | 1 | 1 |
Plasmodium falciparum | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0184 | 0.3846 | 0.5 |
Toxoplasma gondii | 6-phosphogluconate dehydrogenase | 0.0184 | 0.3846 | 1 |
Chlamydia trachomatis | 6-phosphogluconate dehydrogenase | 0.0184 | 0.3846 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0397 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0397 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0114 | 0.0114 |
Onchocerca volvulus | Peroxidasin homolog | 0.0397 | 1 | 1 |
Mycobacterium ulcerans | 6-phosphogluconate dehydrogenase | 0.0184 | 0.3846 | 0.5 |
Mycobacterium ulcerans | 6-phosphogluconate dehydrogenase | 0.0184 | 0.3846 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0114 | 0.0114 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0114 | 0.0114 |
Schistosoma mansoni | transcription initiation factor iia (tfiia) gamma chain | 0.0074 | 0.0671 | 0.0671 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0114 | 0.0114 |
Giardia lamblia | 6-phosphogluconate dehydrogenase, decarboxylating | 0.0184 | 0.3846 | 1 |
Brugia malayi | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0184 | 0.3846 | 0.3846 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0397 | 1 | 1 |
Plasmodium vivax | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0184 | 0.3846 | 0.5 |
Onchocerca volvulus | 0.0397 | 1 | 1 | |
Leishmania major | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0184 | 0.3846 | 0.5 |
Schistosoma mansoni | 6-phosphogluconate dehydrogenase | 0.0184 | 0.3846 | 0.3846 |
Echinococcus granulosus | 6 phosphogluconate dehydrogenase | 0.0184 | 0.3846 | 0.3846 |
Onchocerca volvulus | Peroxidase homolog | 0.0397 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0397 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Echinococcus multilocularis | 6 phosphogluconate dehydrogenase | 0.0184 | 0.3846 | 0.3846 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0397 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0397 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0114 | 0.0114 |
Echinococcus granulosus | peroxidasin | 0.0397 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0397 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0114 | 0.0114 |
Trichomonas vaginalis | 6-phosphogluconate dehydrogenase, putative | 0.0184 | 0.3846 | 0.5 |
Brugia malayi | Peroxidasin | 0.0397 | 1 | 1 |
Treponema pallidum | 6-phosphogluconate dehydrogenase | 0.0184 | 0.3846 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0114 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0397 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | pgd protein | 0.0184 | 0.3846 | 0.3846 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOGLUCONATE DEHYDROGENASE GND1 | 0.0184 | 0.3846 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0114 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Mycobacterium tuberculosis | Probable 6-phosphogluconate dehydrogenase, decarboxylating Gnd2 | 0.0184 | 0.3846 | 0.5 |
Trypanosoma cruzi | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0184 | 0.3846 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxyisobutyrate dehydrogenase, putative | 0.0184 | 0.3846 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0397 | 1 | 1 |
Onchocerca volvulus | 0.0397 | 1 | 1 | |
Echinococcus multilocularis | peroxidasin | 0.0397 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0397 | 1 | 1 |
Mycobacterium tuberculosis | Probable 6-phosphogluconate dehydrogenase Gnd1 | 0.0184 | 0.3846 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0397 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0114 | 0.0114 |
Toxoplasma gondii | 6-phosphogluconate dehydrogenase | 0.0184 | 0.3846 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.