Detailed information for compound 1551973

Basic information

Technical information
  • TDR Targets ID: 1551973
  • Name: 2-[2-methoxy-4-[(E)-prop-1-enyl]phenoxy]-N-[2 -morpholin-4-yl-5-(trifluoromethyl)phenyl]ace tamide
  • MW: 450.451 | Formula: C23H25F3N2O4
  • H donors: 1 H acceptors: 1 LogP: 4.41 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C=C/c1ccc(c(c1)OC)OCC(=O)Nc1cc(ccc1N1CCOCC1)C(F)(F)F
  • InChi: 1S/C23H25F3N2O4/c1-3-4-16-5-8-20(21(13-16)30-2)32-15-22(29)27-18-14-17(23(24,25)26)6-7-19(18)28-9-11-31-12-10-28/h3-8,13-14H,9-12,15H2,1-2H3,(H,27,29)/b4-3+
  • InChiKey: LXRLZRSTVVNDBJ-ONEGZZNKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-methoxy-4-[(E)-prop-1-enyl]phenoxy]-N-[2-morpholino-5-(trifluoromethyl)phenyl]acetamide
  • 2-[2-methoxy-4-[(E)-prop-1-enyl]phenoxy]-N-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi EGF-like domain containing protein 0.0072 0.1061 0.1035
Echinococcus granulosus neurogenic locus notch protein 4 0.0072 0.1061 0.1061
Echinococcus multilocularis protein jagged 1 0.0072 0.1061 0.1061
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0469 0.0442
Loa Loa (eye worm) tubulin beta-1 chain 0.0016 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0166 0.2823 0.2823
Loa Loa (eye worm) animal heme peroxidase 0.0553 1 1
Echinococcus granulosus lamin 0.003 0.0285 0.0285
Echinococcus multilocularis tubulin subunit beta 0.0016 0.0028 0.0028
Echinococcus multilocularis beta tubulin 0.0016 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Echinococcus granulosus tubulin alpha chain 0.0016 0.0028 0.0028
Echinococcus granulosus protein jagged 1 0.0072 0.1061 0.1061
Brugia malayi EGF-like domain containing protein 0.0072 0.1061 0.1035
Echinococcus multilocularis Tubulin beta 2C chain 0.0016 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0553 1 1
Loa Loa (eye worm) hypothetical protein 0.0553 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0285 0.0285
Brugia malayi hypothetical protein 0.0166 0.2823 0.2803
Trichomonas vaginalis tubulin beta chain, putative 0.0016 0.0028 0.5
Loa Loa (eye worm) hypothetical protein 0.0553 1 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0016 0.0028 0.0028
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0212 0.5
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0212 1
Onchocerca volvulus 0.0553 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0016 0.0028 0.5
Echinococcus multilocularis tubulin alpha 3 chain 0.0016 0.0028 0.0028
Loa Loa (eye worm) tubulin gamma chain 0.0016 0.0028 0.0028
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0285 0.0258
Brugia malayi hypothetical protein 0.004 0.0469 0.0442
Echinococcus multilocularis tubulin alpha 0.0016 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Echinococcus multilocularis protein jagged 2 0.0072 0.1061 0.1061
Echinococcus granulosus Tubulin alpha 1 chain 0.0016 0.0028 0.0028
Trichomonas vaginalis tubulin alpha chain, putative 0.0016 0.0028 0.5
Brugia malayi Animal haem peroxidase family protein 0.0553 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0016 0.0028 0.5
Schistosoma mansoni hypothetical protein 0.0072 0.1061 0.1035
Toxoplasma gondii EGF family domain-containing protein 0.0072 0.1061 1
Brugia malayi Peroxidasin 0.0553 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0016 0.0028 0.5
Echinococcus granulosus protein jagged 1 0.0072 0.1061 0.1061
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0092 0.1434 0.1409
Trichomonas vaginalis tubulin beta chain, putative 0.0016 0.0028 0.5
Brugia malayi notch-like transmembrane receptor 0.0072 0.1061 0.1035
Echinococcus multilocularis tubulin alpha chain 0.0016 0.0028 0.0028
Schistosoma mansoni lamin 0.003 0.0285 0.0258
Brugia malayi Cytochrome P450 family protein 0.0027 0.0242 0.0215
Brugia malayi Animal haem peroxidase family protein 0.0553 1 1
Echinococcus granulosus tubulin alpha 1C chain 0.0016 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0072 0.1061 0.1035
Schistosoma mansoni hypothetical protein 0.0072 0.1061 0.1035
Echinococcus granulosus tubulin subunit beta 0.0016 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Echinococcus multilocularis beta tubulin 0.0016 0.0028 0.0028
Trichomonas vaginalis tubulin gamma chain, putative 0.0016 0.0028 0.5
Brugia malayi EGF-like domain containing protein 0.0072 0.1061 0.1035
Brugia malayi EGF-like domain containing protein 0.0072 0.1061 0.1035
Echinococcus multilocularis peroxisome assembly protein 26 0.0016 0.0028 0.0028
Echinococcus multilocularis fibropellin Ia 0.0072 0.1061 0.1061
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Echinococcus multilocularis slit 2 protein 0.0072 0.1061 0.1061
Trichomonas vaginalis tubulin alpha chain, putative 0.0016 0.0028 0.5
Echinococcus multilocularis neural cadherin 0.0072 0.1061 0.1061
Onchocerca volvulus Peroxidasin homolog 0.0553 1 1
Brugia malayi Cadherin domain containing protein 0.0072 0.1061 0.1035
Loa Loa (eye worm) hypothetical protein 0.0553 1 1
Echinococcus granulosus neurogenic locus notch protein 0.0072 0.1061 0.1061
Trichomonas vaginalis tubulin beta chain, putative 0.0016 0.0028 0.5
Loa Loa (eye worm) hypothetical protein 0.0553 1 1
Schistosoma mansoni notch 0.0072 0.1061 0.1035
Trichomonas vaginalis tubulin gamma chain, putative 0.0016 0.0028 0.5
Loa Loa (eye worm) tubulin beta-4 chain 0.0016 0.0028 0.0028
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0469 0.0469
Echinococcus granulosus Tubulin alpha 1 chain 0.0016 0.0028 0.0028
Echinococcus multilocularis tubulin alpha chain 0.0016 0.0028 0.0028
Onchocerca volvulus 0.0553 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0016 0.0028 0.5
Schistosoma mansoni peroxidasin 0.0553 1 1
Echinococcus granulosus tubulin beta 1 chain 0.0016 0.0028 0.0028
Onchocerca volvulus 0.0072 0.1061 0.0798
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0212 0.8576
Echinococcus multilocularis tubulin alpha 1C chain 0.0016 0.0028 0.0028
Brugia malayi EGF-like domain containing protein 0.0072 0.1061 0.1035
Loa Loa (eye worm) hypothetical protein 0.0092 0.1434 0.1434
Echinococcus granulosus neural cadherin 0.0072 0.1061 0.1061
Loa Loa (eye worm) blistered cuticle protein 3 0.0553 1 1
Echinococcus granulosus tubulin alpha chain 0.0016 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Echinococcus multilocularis Tubulin beta 2C chain 0.0016 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Loa Loa (eye worm) Notch2 0.0072 0.1061 0.1061
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0242 1
Echinococcus granulosus fibropellin Ia 0.0072 0.1061 0.1061
Onchocerca volvulus Neurogenic locus notch homolog 0.0072 0.1061 0.0798
Echinococcus granulosus protein jagged 2 0.0072 0.1061 0.1061
Loa Loa (eye worm) alpha-tubulin 0.0016 0.0028 0.0028
Schistosoma mansoni notch 0.0072 0.1061 0.1035
Loa Loa (eye worm) notch protein 0.0072 0.1061 0.1061
Echinococcus multilocularis tubulin epsilon chain 0.0016 0.0028 0.0028
Echinococcus multilocularis Tubulin alpha 1 chain 0.0016 0.0028 0.0028
Schistosoma mansoni notch 0.0072 0.1061 0.1035
Echinococcus granulosus notch 0.0072 0.1061 0.1061
Echinococcus granulosus tubulin gamma 1 chain 0.0016 0.0028 0.0028
Echinococcus multilocularis protein jagged 1 0.0072 0.1061 0.1061
Schistosoma mansoni notch 0.0072 0.1061 0.1035
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0212 0.8576
Brugia malayi Calcium binding EGF domain containing protein 0.0072 0.1061 0.1035
Echinococcus multilocularis Tubulin alpha 1 chain 0.0016 0.0028 0.0028
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0212 0.5
Entamoeba histolytica hypothetical protein 0.004 0.0469 1
Entamoeba histolytica hypothetical protein 0.004 0.0469 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Loa Loa (eye worm) animal heme peroxidase 0.0553 1 1
Echinococcus multilocularis tubulin alpha chain 0.0016 0.0028 0.0028
Echinococcus multilocularis tubulin alpha chain 0.0016 0.0028 0.0028
Echinococcus granulosus tubulin alpha 0.0016 0.0028 0.0028
Echinococcus multilocularis peroxidasin 0.0553 1 1
Brugia malayi MH2 domain containing protein 0.0132 0.2174 0.2152
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.2174 0.2174
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Echinococcus granulosus tubulin alpha chain 0.0016 0.0028 0.0028
Onchocerca volvulus Putative cubilin 0.0072 0.1061 0.0798
Echinococcus multilocularis neurogenic locus notch protein 0.0072 0.1061 0.1061
Echinococcus granulosus Tubulin beta 2C chain 0.0016 0.0028 0.0028
Loa Loa (eye worm) beta-tubulin 0.0016 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Loa Loa (eye worm) hypothetical protein 0.0553 1 1
Schistosoma mansoni cell polarity protein 0.0072 0.1061 0.1035
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0242 1
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0242 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Loa Loa (eye worm) intermediate filament protein 0.003 0.0285 0.0285
Entamoeba histolytica hypothetical protein 0.0026 0.0212 0.4162
Brugia malayi Cytochrome P450 family protein 0.0027 0.0242 0.0215
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0242 0.0242
Echinococcus multilocularis lamin dm0 0.003 0.0285 0.0285
Trichomonas vaginalis tubulin beta chain, putative 0.0016 0.0028 0.5
Onchocerca volvulus 0.0072 0.1061 0.0798
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Onchocerca volvulus Slit protein homolog 0.0072 0.1061 0.0798
Schistosoma mansoni hypothetical protein 0.0072 0.1061 0.1035
Echinococcus granulosus Tubulin beta 2C chain 0.0016 0.0028 0.0028
Brugia malayi Delta serrate ligand family protein 0.0072 0.1061 0.1035
Schistosoma mansoni septate junction protein 0.0072 0.1061 0.1035
Onchocerca volvulus 0.0553 1 1
Echinococcus granulosus peroxisome assembly protein 26 0.0016 0.0028 0.0028
Brugia malayi EGF-like domain containing protein 0.0072 0.1061 0.1035
Echinococcus granulosus tubulin alpha chain 0.0016 0.0028 0.0028
Onchocerca volvulus Chorion peroxidase homolog 0.0553 1 1
Onchocerca volvulus Peroxidase homolog 0.0553 1 1
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0072 0.1061 0.1035
Echinococcus multilocularis Tubulin beta 2C chain 0.0016 0.0028 0.0028
Onchocerca volvulus 0.0072 0.1061 0.0798
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0469 0.0469
Schistosoma mansoni intermediate filament proteins 0.003 0.0285 0.0258
Echinococcus granulosus beta tubulin 0.0016 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Brugia malayi Cadherin domain containing protein 0.0072 0.1061 0.1035
Echinococcus multilocularis tubulin subunit TubB 0.0016 0.0028 0.0028
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0212 0.5
Loa Loa (eye worm) animal heme peroxidase 0.0553 1 1
Onchocerca volvulus 0.0092 0.1434 0.1182
Trichomonas vaginalis tubulin, putative 0.0016 0.0028 0.5
Echinococcus granulosus Tubulin beta 2C chain 0.0016 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0553 1 1
Echinococcus multilocularis neurogenic locus notch protein 0.0072 0.1061 0.1061
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0212 0.5
Echinococcus granulosus delta-like protein 1 0.0072 0.1061 0.1061
Schistosoma mansoni lamin 0.003 0.0285 0.0258
Loa Loa (eye worm) hypothetical protein 0.0553 1 1
Echinococcus granulosus tubulin epsilon chain 0.0016 0.0028 0.0028
Brugia malayi Animal haem peroxidase family protein 0.0553 1 1
Onchocerca volvulus Dual oxidase homolog 0.0553 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0285 0.0285
Echinococcus multilocularis neurogenic locus notch protein 4 0.0072 0.1061 0.1061
Loa Loa (eye worm) hypothetical protein 0.002 0.0096 0.0096
Loa Loa (eye worm) BEN-1 protein 0.0016 0.0028 0.0028
Loa Loa (eye worm) tubulin alpha-2 chain 0.0016 0.0028 0.0028
Brugia malayi Calcium binding EGF domain containing protein 0.0072 0.1061 0.1035
Loa Loa (eye worm) hypothetical protein 0.0553 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0016 0.0028 0.0028
Echinococcus granulosus tubulin alpha chain 0.0016 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0553 1 1
Schistosoma mansoni hypothetical protein 0.0072 0.1061 0.1035
Brugia malayi EGF-like domain containing protein 0.0072 0.1061 0.1035
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0212 0.1778
Echinococcus granulosus alpha tubulin 0.0016 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0072 0.1061 0.1035
Loa Loa (eye worm) BEN-1 protein 0.0016 0.0028 0.0028
Echinococcus multilocularis tubulin gamma 1 chain 0.0016 0.0028 0.0028
Echinococcus granulosus tubulin alpha 3 chain 0.0016 0.0028 0.0028
Brugia malayi Blistered cuticle protein 3 0.0553 1 1
Schistosoma mansoni hypothetical protein 0.0072 0.1061 0.1035
Echinococcus granulosus slit 2 protein 0.0072 0.1061 0.1061
Brugia malayi Calcium binding EGF domain containing protein 0.0072 0.1061 0.1035
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0212 0.5
Loa Loa (eye worm) hypothetical protein 0.0553 1 1
Schistosoma mansoni laminin gamma-3 chain 0.0072 0.1061 0.1035
Echinococcus multilocularis fat cadherin tumor suppressor 0.0072 0.1061 0.1061
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Loa Loa (eye worm) tubulin beta chain 0.0016 0.0028 0.0028
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0072 0.1061 0.1035
Brugia malayi intermediate filament protein 0.003 0.0285 0.0258
Schistosoma mansoni notch 0.0072 0.1061 0.1035
Onchocerca volvulus Peroxidase homolog 0.0553 1 1
Leishmania major cytochrome p450-like protein 0.0027 0.0242 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0016 0.0028 0.0028
Echinococcus granulosus tubulin alpha 1C chain 0.0016 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0028
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0212 0.1778
Onchocerca volvulus Peroxidasin homolog 0.0553 1 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0242 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0016 0.0028 0.5
Giardia lamblia High cysteine protein 0.0072 0.1061 1
Echinococcus multilocularis neurogenic locus protein delta 0.0072 0.1061 0.1061
Loa Loa (eye worm) hypothetical protein 0.0553 1 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0212 1
Echinococcus granulosus Tubulin beta 2C chain 0.0016 0.0028 0.0028
Onchocerca volvulus 0.0072 0.1061 0.0798
Entamoeba histolytica hypothetical protein 0.004 0.0469 1
Echinococcus multilocularis tubulin beta 1 chain 0.0016 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Echinococcus multilocularis Tubulin beta 2C chain 0.0016 0.0028 0.0028
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0029 0.0029
Echinococcus granulosus L aminoadipate semialdehyde 0.0092 0.1434 0.1434
Schistosoma mansoni notch 0.0072 0.1061 0.1035
Echinococcus granulosus lamin dm0 0.003 0.0285 0.0285
Brugia malayi Animal haem peroxidase family protein 0.0553 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0016 0.0028 0.0028
Echinococcus multilocularis tubulin alpha chain 0.0016 0.0028 0.0028
Echinococcus multilocularis lamin 0.003 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Echinococcus multilocularis Tubulin beta 2C chain 0.0016 0.0028 0.0028
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0029 0.0001
Echinococcus granulosus neurogenic locus protein delta 0.0072 0.1061 0.1061
Schistosoma mansoni slit 0.0072 0.1061 0.1035
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0242 0.0242
Schistosoma mansoni peroxidasin 0.0553 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0016 0.0028 0.5
Echinococcus multilocularis musashi 0.003 0.0285 0.0285
Echinococcus granulosus Tubulin beta 2C chain 0.0016 0.0028 0.0028
Echinococcus multilocularis L aminoadipate semialdehyde 0.0092 0.1434 0.1434
Schistosoma mansoni hypothetical protein 0.004 0.0469 0.0442
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Echinococcus multilocularis hypothetical protein 0.0016 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0553 1 1
Loa Loa (eye worm) animal heme peroxidase 0.0553 1 1
Onchocerca volvulus 0.0072 0.1061 0.0798
Echinococcus multilocularis neurogenic locus protein delta 0.0072 0.1061 0.1061
Entamoeba histolytica hypothetical protein 0.004 0.0469 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0016 0.0028 0.5
Echinococcus granulosus tubulin beta 4A class IVa 0.0016 0.0028 0.0028
Brugia malayi Muscle positioning protein 4 0.0072 0.1061 0.1035
Onchocerca volvulus 0.0166 0.2823 0.2612
Loa Loa (eye worm) tubulin beta-2A chain 0.0016 0.0028 0.0028
Brugia malayi Animal haem peroxidase family protein 0.0553 1 1
Echinococcus granulosus beta tubulin 0.0016 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Loa Loa (eye worm) alpha-tubulin 0.0016 0.0028 0.0028
Echinococcus granulosus intermediate filament protein 0.003 0.0285 0.0285
Echinococcus multilocularis tubulin alpha 1C chain 0.0016 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0029 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0242 0.0242
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0072 0.1061 0.0798
Brugia malayi GCC2 and GCC3 family protein 0.0072 0.1061 0.1035
Echinococcus granulosus tubulin subunit TubB 0.0016 0.0028 0.0028
Echinococcus granulosus neurogenic locus notch protein 0.0072 0.1061 0.1061
Echinococcus granulosus peroxidasin 0.0553 1 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0092 0.1434 0.1409
Loa Loa (eye worm) tubulin alpha chain 0.0016 0.0028 0.0028
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0016 0.0028 0.5
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Trichomonas vaginalis tubulin beta chain, putative 0.0016 0.0028 0.5
Loa Loa (eye worm) hypothetical protein 0.0553 1 1
Loa Loa (eye worm) tubulin alpha chain 0.0016 0.0028 0.0028
Echinococcus multilocularis notch 0.0072 0.1061 0.1061
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.2174 0.2174
Echinococcus granulosus protein jagged 2 0.0072 0.1061 0.1061
Loa Loa (eye worm) hypothetical protein 0.0072 0.1061 0.1061
Echinococcus granulosus tubulin alpha 3 chain 0.0016 0.0028 0.0028

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.6511 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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