Detailed information for compound 155212

Basic information

Technical information
  • TDR Targets ID: 155212
  • Name: 2-(2,5-dioxopyrrolidin-1-yl)-4-pyridin-3-yl-4 H-benzo[h]chromene-3-carbonitrile
  • MW: 381.384 | Formula: C23H15N3O3
  • H donors: 0 H acceptors: 4 LogP: 2.39 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(Oc2c(C1c1cccnc1)ccc1c2cccc1)N1C(=O)CCC1=O
  • InChi: 1S/C23H15N3O3/c24-12-18-21(15-5-3-11-25-13-15)17-8-7-14-4-1-2-6-16(14)22(17)29-23(18)26-19(27)9-10-20(26)28/h1-8,11,13,21H,9-10H2
  • InChiKey: DYZCISMGJIGFDY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2,5-dioxopyrrolidin-1-yl)-4-(3-pyridyl)-4H-benzo[h]chromene-3-carbonitrile
  • 2-(2,5-dioxo-1-pyrrolidinyl)-4-(3-pyridyl)-4H-benzo[h][1]benzopyran-3-carbonitrile
  • 4-(3-pyridyl)-2-succinimido-4H-benzo[h]chromene-3-carbonitrile
  • 2-(2,5-dioxo-1-pyrrolidinyl)-4-(3-pyridyl)-4H-benzo[h]chromene-3-carbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tar DNA binding protein 0.0469 0.3626 0.3626
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 24 0.0022 0.0029 0.0029
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0029 0.0029
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0022 0.0029 0.0029
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 12 0.0022 0.0029 0.0029
Loa Loa (eye worm) nuclear factor I 0.0023 0.0036 0.0036
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0001 0.0001
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0022 0.0029 0.0029
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0054 0.0285 0.0285
Schistosoma mansoni smad1 5 8 and 0.0042 0.0187 0.0187
Schistosoma mansoni hypothetical protein 0.0022 0.0029 0.0029
Brugia malayi RNA recognition motif domain containing protein 0.0469 0.3626 0.3626
Schistosoma mansoni smad1 5 8 and 0.0042 0.0187 0.0187
Schistosoma mansoni tar DNA-binding protein 0.0469 0.3626 0.3626
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 14 0.0022 0.0029 0.0029
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0019 0.0001 0.0003
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0054 0.0285 0.0285
Leishmania major hypothetical protein, conserved 0.0161 0.1147 1
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0001 0.0001
Brugia malayi hypothetical protein 0.0019 0.0001 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.1261 1 1
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0054 0.0285 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0029 0.0029
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0029 0.0029
Entamoeba histolytica G protein alpha subunit, putative 0.0054 0.0285 1
Schistosoma mansoni hypothetical protein 0.0033 0.0115 0.0115
Brugia malayi ubiquitin carboxyl-terminal hydrolase 46 0.0022 0.0029 0.0029
Toxoplasma gondii hypothetical protein 0.0022 0.0029 0.0242
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0054 0.0285 0.0285
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0689 0.0689
Echinococcus multilocularis tar DNA binding protein 0.0469 0.3626 0.3626
Echinococcus granulosus ubiquitin specific peptidase c family 0.0022 0.0029 0.0029
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0054 0.0285 0.0285
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0001 0.0001
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0054 0.0285 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0029 0.0029
Echinococcus granulosus smad 0.0042 0.0187 0.0187
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0054 0.0285 0.0285
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 20 0.0022 0.0029 0.0029
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0001 0.0001
Echinococcus multilocularis GPCR, family 2 0.0033 0.0115 0.0115
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 5 0.0022 0.0029 0.0029
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0054 0.0285 0.0285
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0054 0.0285 1
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0029 0.0029
Onchocerca volvulus 0.0054 0.0285 0.0971
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0022 0.0029 0.0029
Brugia malayi MH1 domain containing protein 0.0042 0.0187 0.0187
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0022 0.0029 0.0242
Echinococcus multilocularis expressed protein 0.0054 0.0285 0.0285
Schistosoma mansoni hypothetical protein 0.0072 0.0431 0.0431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0029 0.0029
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0054 0.0285 0.0285
Plasmodium falciparum ataxin-2 like protein, putative 0.0161 0.1147 1
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0054 0.0285 0.0285
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0054 0.0285 0.0285
Onchocerca volvulus 0.0022 0.0029 0.0098
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0022 0.0029 0.5
Schistosoma mansoni ubiquitin-specific peptidase 24 (C19 family) 0.0022 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0029
Brugia malayi hypothetical protein 0.0161 0.1147 0.1147
Loa Loa (eye worm) MH2 domain-containing protein 0.0616 0.4809 0.4809
Brugia malayi MH1 domain containing protein 0.0023 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.1261 1 1
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0054 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0029 0.0029
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0022 0.0029 0.0029
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0022 0.0029 0.0029
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0001 0.0001
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0022 0.0029 0.0242
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0022 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0033 0.0115 0.0115
Onchocerca volvulus 0.0022 0.0029 0.0098
Brugia malayi MH2 domain containing protein 0.0616 0.4809 0.4809
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0022 0.0029 0.0242
Loa Loa (eye worm) hypothetical protein 0.0161 0.1147 0.1147
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0029 0.0029
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.1261 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0469 0.3626 0.3626
Echinococcus multilocularis ubiquitin specific protease 41 0.0022 0.0029 0.0029
Schistosoma mansoni dishevelled 0.0019 0.0001 0.0001
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0022 0.0029 0.0029
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0054 0.0285 1
Schistosoma mansoni hypothetical protein 0.0033 0.0115 0.0115
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0187 0.0187
Trypanosoma cruzi PAB1-binding protein , putative 0.0161 0.1147 1
Schistosoma mansoni peptidase 0.0022 0.0029 0.0029
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0022 0.0029 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0469 0.3626 0.3626
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0071 0.0423 0.0423
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0054 0.0285 0.0285
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0054 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Schistosoma mansoni family C19 unassigned peptidase (C19 family) 0.0022 0.0029 0.0029
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0022 0.0029 0.0242
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 16 0.0022 0.0029 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0469 0.3626 0.3626
Loa Loa (eye worm) hypothetical protein 0.0054 0.0285 0.0285
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 20 0.0022 0.0029 0.0029
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0001 0.0001
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0071 0.0423 0.0423
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 47 0.0022 0.0029 0.0029
Brugia malayi hypothetical protein 0.0054 0.0285 0.0285
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0022 0.0029 0.0029
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0022 0.0029 0.0029
Schistosoma mansoni ubiquitin-specific peptidase 48 (C19 family) 0.0022 0.0029 0.0029
Echinococcus granulosus Ubiquitin carboxyl terminal hydrolase 48 0.0022 0.0029 0.0029
Brugia malayi ubiquitin specific protease 14 0.0022 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0029
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 36 0.0022 0.0029 0.0029
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0383 0.2936 1
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0029 0.0029
Plasmodium falciparum ataxin-2 like protein, putative 0.0161 0.1147 1
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0022 0.0029 0.0242
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0001 0.0001
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0029 0.0029
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0029 0.0029
Schistosoma mansoni dep domain containing protein 0.0019 0.0001 0.0001
Schistosoma mansoni Smad4 0.0042 0.0187 0.0187
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0022 0.0029 0.0029
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0689 0.0689
Brugia malayi G-protein alpha subunit 0.0054 0.0285 0.0285
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0019 0.0001 0.0001
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0187 0.0187
Trypanosoma brucei PAB1-binding protein , putative 0.0161 0.1147 1
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0022 0.0029 0.0242
Schistosoma mansoni GTP-binding protein alpha subunit 0.0054 0.0285 0.0285
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0054 0.0285 0.0285
Schistosoma mansoni dishevelled 0.0019 0.0001 0.0001
Schistosoma mansoni ubiquitin-specific peptidase 42 (C19 family) 0.0022 0.0029 0.0029
Echinococcus granulosus ubiquitin specific peptidase 30 (C19 family) 0.0022 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0054 0.0285 0.0285
Onchocerca volvulus 0.0019 0.0001 0.0003
Schistosoma mansoni ubiquitin-specific peptidase 45 (C19 family) 0.0022 0.0029 0.0029
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0001 0.0001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0115 0.0115
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0187 0.0187
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0022 0.0029 0.0029
Echinococcus multilocularis smad 0.0042 0.0187 0.0187
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 23 0.0022 0.0029 0.0029
Schistosoma mansoni smad 0.0042 0.0187 0.0187
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0054 0.0285 0.0285
Brugia malayi hypothetical protein 0.0022 0.0029 0.0029
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0029
Echinococcus granulosus neuropeptide receptor A26 0.0418 0.3214 0.3214
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0072 0.0431 0.0431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0022 0.0029 0.0029
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0104 0.0689 0.0689
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0187 0.0187
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 47 0.0022 0.0029 0.0029
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0022 0.0029 0.5
Onchocerca volvulus 0.0054 0.0285 0.0971
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0022 0.0029 0.0242
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0022 0.0029 0.0029
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0054 0.0285 0.0285
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0733 0.575 0.575
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0054 0.0285 1
Schistosoma mansoni ubiquitin-specific peptidase 10 (C19 family) 0.0022 0.0029 0.0029
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0423 0.0423
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0029 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1261 1 1
Brugia malayi TAR-binding protein 0.0469 0.3626 0.3626
Onchocerca volvulus 0.0022 0.0029 0.0098
Schistosoma mansoni ubiquitin-specific peptidase 4 (C19 family) 0.0022 0.0029 0.0029
Toxoplasma gondii ubiquitin-specific protease USP4 0.0022 0.0029 0.0242
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0115 0.0115
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0689 0.0689
Schistosoma mansoni ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold 0.0022 0.0029 0.0029
Echinococcus granulosus GPCR family 2 0.0033 0.0115 0.0115
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0115 0.0115
Schistosoma mansoni ubiquitin-specific peptidase 7 (C19 family) 0.0022 0.0029 0.0029
Brugia malayi RNA binding protein 0.0469 0.3626 0.3626
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0054 0.0285 0.0285
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 12 0.0022 0.0029 0.0029
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0029
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0054 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0029
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0054 0.0285 0.0285
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0115 0.0115
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 16 0.0022 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0029
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0029 0.0029
Echinococcus multilocularis expressed protein 0.0022 0.0029 0.0029
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0054 0.0285 0.0285
Brugia malayi DIX domain containing protein 0.0019 0.0001 0.0001
Toxoplasma gondii LsmAD domain-containing protein 0.0161 0.1147 1
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0022 0.0029 0.0242
Schistosoma mansoni hypothetical protein 0.0033 0.0115 0.0115
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0022 0.0029 0.0029
Loa Loa (eye worm) pax transcription factor protein 2 0.0256 0.1908 0.1908
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0001 0.0001
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0054 0.0285 0.0285
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0054 0.0285 0.0285
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0054 0.0285 0.0285
Brugia malayi MH1 domain containing protein 0.0023 0.0036 0.0036
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 36 0.0022 0.0029 0.0029
Echinococcus multilocularis ubiquitin specific peptidase 42 (C19 family) 0.0022 0.0029 0.0029
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0054 0.0285 0.0285
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0022 0.0029 0.0029
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0054 0.0285 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0161 0.1147 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0022 0.0029 0.0029
Loa Loa (eye worm) G protein alpha subunit 3 0.0054 0.0285 0.0285
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0054 0.0285 0.0285
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0001 0.0001
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0022 0.0029 0.0029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.1261 1 1
Echinococcus multilocularis ubiquitin specific peptidase (c family) ubiquitin terminal hydrolase 0.0022 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0383 0.2936 0.2936
Echinococcus granulosus Smad4 0.0042 0.0187 0.0187
Brugia malayi hypothetical protein 0.0104 0.0687 0.0687
Brugia malayi hypothetical protein 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0029
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0022 0.0029 0.0029
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 0.0022 0.0029 0.0029
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0054 0.0285 0.0285
Echinococcus multilocularis Ubiquitin carboxyl terminal hydrolase 48 0.0022 0.0029 0.0029
Onchocerca volvulus 0.0256 0.1908 0.6499
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0187 0.0187
Plasmodium vivax ataxin-2 like protein, putative 0.0161 0.1147 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0029
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0054 0.0285 1
Onchocerca volvulus 0.0054 0.0285 0.0971
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0054 0.0285 0.0285
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0054 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0029
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0187 0.0187
Brugia malayi MH2 domain containing protein 0.0042 0.0187 0.0187
Brugia malayi MH2 domain containing protein 0.0042 0.0187 0.0187
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0001 0.0001
Echinococcus multilocularis neuropeptide s receptor 0.0418 0.3214 0.3214
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0022 0.0029 0.0242
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0029 0.0029
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0022 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0029
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0054 0.0285 0.0285
Brugia malayi Smad1 0.0042 0.0187 0.0187
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.1261 1 1
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0022 0.0029 0.0242
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0022 0.0029 0.0029
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0022 0.0029 0.0029
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0054 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0029
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0022 0.0029 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0469 0.3626 0.3626
Loa Loa (eye worm) transcription factor SMAD2 0.0616 0.4809 0.4809
Echinococcus multilocularis neuropeptide receptor A26 0.0418 0.3214 0.3214
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0029 0.0029
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0054 0.0285 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.0029
Echinococcus granulosus Pleckstrin G protein interacting region 0.0019 0.0001 0.0001
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase family 2 protein 0.0022 0.0029 0.0242
Loa Loa (eye worm) TAR-binding protein 0.0469 0.3626 0.3626
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0029 0.0029
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0072 0.0431 0.0431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 24 0.0022 0.0029 0.0029
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0115 0.0115
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0029 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1261 1 1
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0054 0.0285 0.0285
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0001 0.0001
Echinococcus granulosus expressed protein 0.0054 0.0285 0.0285
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0054 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0054 0.0285 0.0285
Schistosoma mansoni ubiquitin-specific peptidase 22 (C19 family) 0.0022 0.0029 0.0029
Echinococcus granulosus 5'partial|Ubiquitin carboxyl terminal hydrolase 48 0.0022 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0033 0.0115 0.0115
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 46 0.0022 0.0029 0.0029
Schistosoma mansoni smad1 5 8 and 0.0042 0.0187 0.0187
Brugia malayi N-terminal motif family protein 0.0383 0.2936 0.2936
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0054 0.0285 0.0285
Brugia malayi MH1 domain containing protein 0.0042 0.0187 0.0187
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 0.0022 0.0029 0.0029
Loa Loa (eye worm) RNA binding protein 0.0469 0.3626 0.3626
Giardia lamblia DUB-1 0.0022 0.0029 0.5
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0029 0.0029
Schistosoma mansoni ubiquitin-specific peptidase 16 (C19 family) 0.0022 0.0029 0.0029
Schistosoma mansoni ubiquitin-specific peptidase 30 (C19 family) 0.0022 0.0029 0.0029
Schistosoma mansoni ubiquitin-specific peptidase 14 (C19 family) 0.0022 0.0029 0.0029
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0187 0.0187
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0022 0.0029 0.0242
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0001 0.0001
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0054 0.0285 0.0285
Giardia lamblia Hypothetical protein 0.0022 0.0029 0.5
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0029 0.0029
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0115 0.0115
Echinococcus multilocularis Smad4 0.0042 0.0187 0.0187
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0029 0.0029
Echinococcus granulosus ubiquitin specific protease 41 0.0022 0.0029 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1261 1 1
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0022 0.0029 0.0029
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0019 0.0001 0.0001
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0022 0.0029 0.5
Schistosoma mansoni tar DNA-binding protein 0.0469 0.3626 0.3626
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0022 0.0029 0.5
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0022 0.0029 0.0029
Loa Loa (eye worm) DIX domain-containing protein 0.0019 0.0001 0.0001
Echinococcus granulosus neuropeptide s receptor 0.0418 0.3214 0.3214
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0022 0.0029 0.0242
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0022 0.0029 0.0029
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0054 0.0285 0.0285
Schistosoma mansoni ubiquitin-specific peptidase 46 (C19 family) 0.0022 0.0029 0.0029
Brugia malayi Pax transcription factor protein 2 0.0256 0.1908 0.1908
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 14 0.0022 0.0029 0.0029
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0054 0.0285 0.0285
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0001 0.0001
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0022 0.0029 0.0029
Loa Loa (eye worm) Smad1 0.0042 0.0187 0.0187
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0054 0.0285 0.0285
Schistosoma mansoni GTP-binding protein alpha subunit 0.0054 0.0285 0.0285
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0022 0.0029 0.0029

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 41 % Percent reduction in arthritis score was measured in CP20961 injected rats on day 16 ChEMBL. No reference
AUC (ADMET) = 0.34 mg ml-1 Area under curve (AUR) of the compound was determined ChEMBL. No reference
Cmax (ADMET) = 55 ng ml-1 Maximum concentration of the compound in plasma at Tmax ChEMBL. No reference
Inhibition (binding) = -17 % Tested for percent inhibition of Neutral metalloprotease in rabbit chondrocytes at 0.1 uM concentration ChEMBL. No reference
Inhibition (functional) = -6 % Percent inhibition of Concanavalin A stimulated cell proliferation of rat spleen lymphocytes at 0.01 microM ChEMBL. No reference
Inhibition (functional) = -5 % Percent inhibition of Concanavalin A stimulated cell proliferation of rat spleen lymphocytes at 0.1 microM ChEMBL. No reference
Inhibition (functional) = 7 % Percent inhibition of Concanavalin A stimulated cell proliferation of rat spleen lymphocytes at 0.001 microM ChEMBL. No reference
Inhibition (binding) = 17 % Tested for percent inhibition of Neutral metalloprotease in rabbit chondrocytes at 1 uM concentration ChEMBL. No reference
Inhibition (binding) = 25 % Tested for percent inhibition of Neutral metalloprotease in rabbit chondrocytes at 10 microM concentration ChEMBL. No reference
Inhibition (functional) = 85 % Percent inhibition of Concanavalin A stimulated cell proliferation of rat spleen lymphocytes at 1 microM ChEMBL. No reference
Inhibition (functional) = 87 % Percent inhibition of Concanavalin A stimulated cell proliferation of rat spleen lymphocytes at 10 microM ChEMBL. No reference
T max (ADMET) = 0.5 hr Time at which the maximum concentration of the compound is achieved ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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