Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human herpesvirus 4 (strain B95-8) | Latent membrane protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | vitamin D (1,25- dihydroxyvitamin D3) receptor | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | steroid hormone receptor | vitamin D (1,25- dihydroxyvitamin D3) receptor | 427 aa | 416 aa | 24.5 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | carboxylesterase | 0.0982 | 0.163 | 0.163 |
Loa Loa (eye worm) | hypothetical protein | 0.0982 | 0.163 | 0.163 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0033 | 0.0033 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.0061 | 0.0057 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0982 | 0.163 | 0.1627 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0004 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.5814 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0982 | 0.163 | 0.163 |
Echinococcus granulosus | neuroligin | 0.0982 | 0.163 | 0.1627 |
Loa Loa (eye worm) | carboxylesterase | 0.0982 | 0.163 | 0.163 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0982 | 0.163 | 0.1627 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0033 | 0.0033 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0982 | 0.163 | 0.1627 |
Onchocerca volvulus | 0.0982 | 0.163 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0043 | 0.0004 | 0.0004 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0982 | 0.163 | 0.163 |
Loa Loa (eye worm) | hypothetical protein | 0.0982 | 0.163 | 0.163 |
Loa Loa (eye worm) | hypothetical protein | 0.5814 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.5814 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.5814 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.5814 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.5814 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.0061 | 0.0057 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0982 | 0.163 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0004 | 0.0004 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0982 | 0.163 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.5814 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.0061 | 0.0061 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0061 | 0.0061 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0982 | 0.163 | 0.1627 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0982 | 0.163 | 0.163 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0061 | 0.0061 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0982 | 0.163 | 0.1627 |
Onchocerca volvulus | 0.0982 | 0.163 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0004 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0982 | 0.163 | 0.5 |
Onchocerca volvulus | 0.0982 | 0.163 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0004 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0061 | 0.0061 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0982 | 0.163 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0982 | 0.163 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0982 | 0.163 | 0.163 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0061 | 0.0061 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0004 | 0.0004 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0982 | 0.163 | 0.163 |
Brugia malayi | Carboxylesterase family protein | 0.0982 | 0.163 | 0.163 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0982 | 0.163 | 0.1627 |
Loa Loa (eye worm) | hypothetical protein | 0.0982 | 0.163 | 0.163 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0982 | 0.163 | 0.5 |
Onchocerca volvulus | 0.0982 | 0.163 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0982 | 0.163 | 0.163 |
Loa Loa (eye worm) | hypothetical protein | 0.5814 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0033 | 0.0033 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0982 | 0.163 | 0.163 |
Schistosoma mansoni | acetylcholinesterase | 0.0982 | 0.163 | 0.163 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0982 | 0.163 | 0.163 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | carboxylesterase | 0.5814 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0982 | 0.163 | 0.163 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0061 | 0.0061 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0982 | 0.163 | 0.163 |
Echinococcus granulosus | acetylcholinesterase | 0.5814 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0982 | 0.163 | 0.163 |
Onchocerca volvulus | 0.0982 | 0.163 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0004 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.5814 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.5814 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0982 | 0.163 | 0.1627 |
Brugia malayi | hypothetical protein | 0.0982 | 0.163 | 0.163 |
Loa Loa (eye worm) | hypothetical protein | 0.0982 | 0.163 | 0.163 |
Brugia malayi | Carboxylesterase family protein | 0.0982 | 0.163 | 0.163 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0061 | 0.0061 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AbsAC1 (functional) | = 4.64 uM | PubChem BioAssay. Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy Measured in Biochemical System Using RT-PCR - 7012-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
AC50 (functional) | = 1.14 uM | PUBCHEM_BIOASSAY: TES1 - eGFP vs TES2 -dsRED Pathway Differentiation Measured in Cell-Based System Using Imaging - 2122-04_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504586] | ChEMBL. | No reference |
AC50 (functional) | = 2.86 uM | PUBCHEM_BIOASSAY: Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504586] | ChEMBL. | No reference |
AC50 (functional) | = 30.423 uM | PUBCHEM_BIOASSAY: Lymphoblastoid Cells (LCL) Cytotoxicity Secondary Assay Measured in Cell-Based System Using Plate Reader - 2122-03_Inhibitor_Dose_CherryPick_Activity_Set2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504586] | ChEMBL. | No reference |
Potency (functional) | 2.5119 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.