Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | vitamin D (1,25- dihydroxyvitamin D3) receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | steroid hormone receptor | vitamin D (1,25- dihydroxyvitamin D3) receptor | 427 aa | 416 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0047 | 0.0047 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.1471 | 0.1671 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.1471 | 0.1671 | 0.1671 |
Loa Loa (eye worm) | carboxylesterase | 0.1471 | 0.1671 | 0.1671 |
Echinococcus granulosus | acetylcholinesterase | 0.8706 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.1471 | 0.1671 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.8706 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.1471 | 0.1671 | 0.1671 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.8706 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.1471 | 0.1671 | 0.1671 |
Echinococcus multilocularis | neuroligin | 0.1471 | 0.1671 | 0.1671 |
Loa Loa (eye worm) | hypothetical protein | 0.8706 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1471 | 0.1671 | 0.1671 |
Loa Loa (eye worm) | hypothetical protein | 0.1471 | 0.1671 | 0.1671 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0047 | 0.0047 |
Echinococcus granulosus | BC026374 protein S09 family | 0.1471 | 0.1671 | 0.1671 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0047 | 0.0047 |
Echinococcus granulosus | acetylcholinesterase | 0.8706 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.8706 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0047 | 0.0047 |
Echinococcus multilocularis | acetylcholinesterase | 0.8706 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.1471 | 0.1671 | 0.1671 |
Echinococcus granulosus | carboxylesterase 5A | 0.8706 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.8706 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.8706 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1471 | 0.1671 | 0.1671 |
Brugia malayi | Carboxylesterase family protein | 0.1471 | 0.1671 | 0.1671 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.1471 | 0.1671 | 0.1671 |
Loa Loa (eye worm) | hypothetical protein | 0.1471 | 0.1671 | 0.1671 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.8706 | 1 | 1 |
Onchocerca volvulus | 0.1471 | 0.1671 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.1471 | 0.1671 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.1471 | 0.1671 | 0.1671 |
Onchocerca volvulus | 0.1471 | 0.1671 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.1471 | 0.1671 | 0.1671 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.1471 | 0.1671 | 0.5 |
Onchocerca volvulus | 0.1471 | 0.1671 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.1471 | 0.1671 | 0.1671 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.1471 | 0.1671 | 0.1671 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.1471 | 0.1671 | 0.1671 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1471 | 0.1671 | 0.1671 |
Brugia malayi | Carboxylesterase family protein | 0.1471 | 0.1671 | 0.1671 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0025 | 0.0025 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1471 | 0.1671 | 0.1671 |
Onchocerca volvulus | 0.1471 | 0.1671 | 0.5 | |
Brugia malayi | hypothetical protein | 0.1471 | 0.1671 | 0.1671 |
Loa Loa (eye worm) | hypothetical protein | 0.8706 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1471 | 0.1671 | 0.1671 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.1471 | 0.1671 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1471 | 0.1671 | 0.1671 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1471 | 0.1671 | 0.1671 |
Loa Loa (eye worm) | hypothetical protein | 0.1471 | 0.1671 | 0.1671 |
Loa Loa (eye worm) | hypothetical protein | 0.1471 | 0.1671 | 0.1671 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0025 | 0.0025 |
Onchocerca volvulus | 0.1471 | 0.1671 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.1471 | 0.1671 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.1471 | 0.1671 | 0.1671 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0025 | 0.0025 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.1471 | 0.1671 | 0.1671 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.