Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | spcc417.12 protein, putative | 0.1524 | 0.1662 | 0.5 |
Onchocerca volvulus | 0.1524 | 0.1662 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.9022 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1524 | 0.1662 | 0.1662 |
Loa Loa (eye worm) | hypothetical protein | 0.9022 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.9022 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1524 | 0.1662 | 0.1662 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.9022 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.9022 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.9022 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1524 | 0.1662 | 0.1662 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.1524 | 0.1662 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.9022 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.1524 | 0.1662 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1524 | 0.1662 | 0.1662 |
Echinococcus multilocularis | acetylcholinesterase | 0.9022 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.1524 | 0.1662 | 0.1662 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Onchocerca volvulus | 0.1524 | 0.1662 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.1524 | 0.1662 | 0.1662 |
Loa Loa (eye worm) | hypothetical protein | 0.9022 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1524 | 0.1662 | 0.1662 |
Brugia malayi | Carboxylesterase family protein | 0.1524 | 0.1662 | 0.1662 |
Loa Loa (eye worm) | hypothetical protein | 0.1524 | 0.1662 | 0.1662 |
Onchocerca volvulus | 0.1524 | 0.1662 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.9022 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1524 | 0.1662 | 0.1662 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.1524 | 0.1662 | 0.5 |
Onchocerca volvulus | 0.1524 | 0.1662 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.1524 | 0.1662 | 0.1662 |
Loa Loa (eye worm) | hypothetical protein | 0.1524 | 0.1662 | 0.1662 |
Brugia malayi | Carboxylesterase family protein | 0.1524 | 0.1662 | 0.1662 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.1524 | 0.1662 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.9022 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1524 | 0.1662 | 0.1662 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.9022 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.1524 | 0.1662 | 0.5 |
Onchocerca volvulus | 0.1524 | 0.1662 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0084 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.