TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 408.331 | Formula: C14H18BrNO4S2
H donors: 1 H acceptors: 3 LogP: 3.01 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C1CSCC[S+](=O)(N1Cc1ccccc1Br)[O-]
InChi: 1S/C14H18BrNO4S2/c1-2-20-14(17)13-10-21-7-8-22(18,19)16(13)9-11-5-3-4-6-12(11)15/h3-6,13H,2,7-10H2,1H3
InChiKey: DYFQNZCRHOVVKV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	phd:f box containing protein	0.0029	0.0008	0.0008
Onchocerca volvulus		0.0039	0.0022	0.0135
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0022	1
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0022	0.4448
Echinococcus multilocularis	muscleblind protein	0.0166	0.0204	0.0204
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0022	0.0135
Echinococcus multilocularis	carboxylesterase 5A	0.7022	1	1
Onchocerca volvulus		0.0051	0.0041	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0204	0.0204
Echinococcus granulosus	microtubule associated protein 2	0.0782	0.1084	0.1084
Leishmania major	4-coumarate:coa ligase-like protein	0.0078	0.0079	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0079	0.0079
Brugia malayi	beta-lactamase family protein	0.0039	0.0022	0.0022
Onchocerca volvulus		0.0039	0.0022	0.0135
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0022	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.0022	0.0135
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1186	0.1663	0.1663
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0022	0.0135
Loa Loa (eye worm)	hypothetical protein	0.1186	0.1663	0.1663
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1186	0.1663	0.1663
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0058	0.005	0.005
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0055	0.0046	0.0276
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0055	0.0046	0.0276
Echinococcus multilocularis	geminin	0.0388	0.0521	0.0521
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0055	0.0046	0.0276
Brugia malayi	jmjC domain containing protein	0.0107	0.0121	0.0121
Echinococcus granulosus	tumor protein p63	0.0352	0.047	0.047
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0107	0.0121	0.0121
Echinococcus multilocularis	lysine specific demethylase 5A	0.0107	0.0121	0.0121
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0029	0.0008	0.3677
Loa Loa (eye worm)	hypothetical protein	0.1186	0.1663	0.1663
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.7022	1	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.1186	0.1663	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0017	0.0017
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0022	0.0135
Echinococcus granulosus	para nitrobenzyl esterase	0.1186	0.1663	0.1663
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.1186	0.1663	1
Brugia malayi	Carboxylesterase family protein	0.7022	1	1
Brugia malayi	PHD-finger family protein	0.0034	0.0015	0.0015
Echinococcus granulosus	JmjC domain containing protein 4	0.0029	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0008	0.0008
Loa Loa (eye worm)	jmjC domain-containing protein	0.007	0.0067	0.0067
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.1186	0.1663	0.1663
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0022	0.0022
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0022	0.0135
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0022	0.0022
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0022	0.0135
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0078	0.0079	1
Brugia malayi	DnaJ domain containing protein	0.0066	0.0061	0.0061
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0078	0.0079	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0022	0.0022
Schistosoma mansoni	cellular tumor antigen P53	0.0051	0.0041	0.0041
Onchocerca volvulus		0.0078	0.0079	0.0473
Echinococcus granulosus	carboxylesterase 5A	0.7022	1	1
Schistosoma mansoni	jumonji domain containing protein	0.0154	0.0188	0.0188
Echinococcus multilocularis	jumonji domain containing 1A	0.0029	0.0008	0.0008
Schistosoma mansoni	microtubule-associated protein tau	0.0782	0.1084	0.1084
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0015	0.6879
Mycobacterium ulcerans	carboxylesterase, LipT	0.1186	0.1663	1
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0029	0.0008	0.3677
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0022	0.0022
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.1186	0.1663	0.1663
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0022	0.0135
Loa Loa (eye worm)	transcription factor SMAD2	0.0135	0.0161	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0022	0.0022
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0029	0.0008	0.3677
Mycobacterium ulcerans	lipase LipD	0.0039	0.0022	0.0135
Brugia malayi	AMP-binding enzyme family protein	0.0078	0.0079	0.0079
Echinococcus multilocularis	acetylcholinesterase	0.7022	1	1
Brugia malayi	Carboxylesterase family protein	0.1186	0.1663	0.1663
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0022	0.0135
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1186	0.1663	0.1663
Loa Loa (eye worm)	jmjC domain-containing protein	0.0029	0.0008	0.0008
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.1186	0.1663	0.1663
Brugia malayi	Carboxylesterase family protein	0.1186	0.1663	0.1663
Schistosoma mansoni	jumonji domain containing protein	0.0029	0.0008	0.0008
Echinococcus granulosus	jumonji domain containing 1A	0.0029	0.0008	0.0008
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.1186	0.1663	1
Loa Loa (eye worm)	acetylcholinesterase 1	0.7022	1	1
Plasmodium falciparum	acyl-CoA synthetase	0.0058	0.005	1
Echinococcus granulosus	peregrin	0.0034	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0058	0.005	0.005
Brugia malayi	jmjC domain containing protein	0.0029	0.0008	0.0008
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.004	0.004
Echinococcus granulosus	lysine specific demethylase 6a	0.0029	0.0008	0.0008
Echinococcus granulosus	dnaJ subfamily C 6	0.0066	0.0061	0.0061
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0029	0.0008	0.1635
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0022	0.0022
Mycobacterium ulcerans	acyl-CoA synthetase	0.0078	0.0079	0.0473
Brugia malayi	Carboxylesterase family protein	0.1186	0.1663	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0051	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0058	0.005	0.005
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0015	0.6879
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0029	0.0008	0.0008
Loa Loa (eye worm)	carboxylesterase	0.1186	0.1663	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0075	0.0075
Echinococcus multilocularis	JmjC domain containing protein 4	0.0029	0.0008	0.0008
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0058	0.005	0.0303
Onchocerca volvulus		0.1186	0.1663	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0022	0.0135
Onchocerca volvulus		0.1186	0.1663	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.004	0.004
Toxoplasma gondii	ABC1 family protein	0.0039	0.0022	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0177	0.022	0.022
Plasmodium falciparum	phd finger protein, putative	0.0034	0.0015	0.306
Echinococcus multilocularis	muscleblind protein 1	0.0166	0.0204	0.0204
Echinococcus multilocularis	tumor protein p63	0.0352	0.047	0.047
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0041	0.0041
Echinococcus multilocularis	phd:f box containing protein	0.0029	0.0008	0.0008
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.004	0.004
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.004	0.004
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0022	0.0135
Echinococcus multilocularis	jumonji domain containing protein	0.0047	0.0034	0.0034
Echinococcus multilocularis	dnaJ subfamily C 6	0.0066	0.0061	0.0061
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0022	0.0135
Trichomonas vaginalis	protein kinase inhibitor, putative	0.0066	0.0061	0.0367
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0029	0.0008	0.0008
Leishmania major	hypothetical protein, conserved	0.0039	0.0022	0.2856
Onchocerca volvulus		0.1186	0.1663	1
Loa Loa (eye worm)	DnaJ domain-containing protein	0.0066	0.0061	0.0061
Loa Loa (eye worm)	jmjC domain-containing protein	0.0029	0.0008	0.0008
Brugia malayi	beta-lactamase	0.0039	0.0022	0.0022
Mycobacterium ulcerans	hypothetical protein	0.0078	0.0079	0.0473
Loa Loa (eye worm)	hypothetical protein	0.1186	0.1663	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0079	0.0079
Brugia malayi	Muscleblind-like protein	0.0166	0.0204	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0022	0.0022
Echinococcus granulosus	acetylcholinesterase	0.7022	1	1
Brugia malayi	MH2 domain containing protein	0.0135	0.0161	0.0161
Echinococcus granulosus	geminin	0.0388	0.0521	0.0521
Onchocerca volvulus		0.1186	0.1663	1
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0034	0.0015	0.0015
Echinococcus granulosus	muscleblind protein	0.0166	0.0204	0.0204
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.004	0.004
Schistosoma mansoni	acetylcholinesterase	0.1186	0.1663	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0015
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0022	0.2856
Loa Loa (eye worm)	hypothetical protein	0.0058	0.005	0.005
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0078	0.0079	0.0473
Schistosoma mansoni	neuroligin 3 (S09 family)	0.1186	0.1663	0.1663
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0078	0.0079	0.0473
Schistosoma mansoni	phosphatidylserine receptor	0.0029	0.0008	0.0008
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0058	0.005	0.0303
Brugia malayi	Carboxylesterase family protein	0.1186	0.1663	0.1663
Echinococcus granulosus	PHD finger protein rhinoceros	0.0034	0.0015	0.0015
Schistosoma mansoni	hypothetical protein	0.0034	0.0015	0.0015
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0029	0.0008	0.3677
Leishmania major	hypothetical protein, conserved	0.0029	0.0008	0.105
Echinococcus granulosus	BC026374 protein S09 family	0.1186	0.1663	0.1663
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0022	0.2856
Schistosoma mansoni	phd/f-box containing protein	0.0029	0.0008	0.0008
Schistosoma mansoni	BC026374 protein (S09 family)	0.1186	0.1663	0.1663
Echinococcus multilocularis	para nitrobenzyl esterase	0.1186	0.1663	0.1663
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.0022	0.0135
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0078	0.0079	0.0473
Loa Loa (eye worm)	jmjC domain-containing protein	0.0107	0.0121	0.0121
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0029	0.0008	0.0008
Plasmodium vivax	hypothetical protein, conserved	0.0034	0.0015	0.306
Brugia malayi	hypothetical protein	0.1186	0.1663	0.1663
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.0022	0.0135
Echinococcus multilocularis	BC026374 protein (S09 family)	0.1186	0.1663	0.1663
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0022	0.0022
Mycobacterium ulcerans	acyl-CoA synthetase	0.0078	0.0079	0.0473
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.004	0.004
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0177	0.022	0.022
Echinococcus granulosus	jumonji domain containing protein	0.0047	0.0034	0.0034
Echinococcus granulosus	neuroligin	0.1186	0.1663	0.1663
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.004	0.004
Brugia malayi	jmjC domain containing protein	0.0029	0.0008	0.0008
Giardia lamblia	PHD finger protein 15	0.0034	0.0015	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0022	0.0135
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0022	0.0022
Loa Loa (eye worm)	PHD-finger family protein	0.0034	0.0015	0.0015
Echinococcus multilocularis	neuroligin	0.1186	0.1663	0.1663
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0078	0.0079	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0022	0.0022
Echinococcus granulosus	acetylcholinesterase	0.7022	1	1
Schistosoma mansoni	hypothetical protein	0.0388	0.0521	0.0521
Schistosoma mansoni	protein phosphatase 2C	0.0029	0.0008	0.0008
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0034	0.0015	0.0015
Loa Loa (eye worm)	carboxylesterase	0.7022	1	1
Loa Loa (eye worm)	hypothetical protein	0.1186	0.1663	0.1663
Echinococcus multilocularis	microtubule associated protein 2	0.0782	0.1084	0.1084
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0844	0.1173	0.1173
Schistosoma mansoni	hypothetical protein	0.0035	0.0017	0.0017
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.0022	0.0135
Schistosoma mansoni	hypothetical protein	0.0388	0.0521	0.0521
Brugia malayi	beta-lactamase family protein	0.0039	0.0022	0.0022
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0078	0.0079	0.0473
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0078	0.0079	0.0473
Leishmania major	4-coumarate:coa ligase-like protein	0.0078	0.0079	1
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0029	0.0008	0.3677
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.1186	0.1663	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0055	0.0046	0.0276
Loa Loa (eye worm)	hypothetical protein	0.1186	0.1663	0.1663
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.004	0.004
Echinococcus granulosus	lysine specific demethylase 5A	0.0107	0.0121	0.0121
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0246	0.0319	0.1921
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0022	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0078	0.0079	0.0473
Schistosoma mansoni	hypothetical protein	0.0066	0.0061	0.0061
Onchocerca volvulus		0.0039	0.0022	0.0135
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.004	0.004
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.004	0.004
Mycobacterium ulcerans	acyl-CoA synthetase	0.0078	0.0079	0.0473
Loa Loa (eye worm)	jmjC domain-containing protein	0.0029	0.0008	0.0008
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0107	0.0121	0.0121
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.0022	0.0135
Plasmodium vivax	acyl-CoA synthetase, putative	0.0058	0.005	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0079	0.0079
Onchocerca volvulus	Alhambra homolog	0.0034	0.0015	0.0093
Trichomonas vaginalis	esterase, putative	0.0039	0.0022	0.0135
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.004	0.004
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.0022	0.0135
Brugia malayi	Bromodomain containing protein	0.0034	0.0015	0.0015
Mycobacterium tuberculosis	Carboxylesterase LipT	0.1186	0.1663	1
Echinococcus multilocularis	acetylcholinesterase	0.7022	1	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0078	0.0079	1
Schistosoma mansoni	gliotactin	0.1186	0.1663	0.1663
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.0022	0.0135
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0058	0.005	0.5
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0022	0.0135
Onchocerca volvulus		0.1186	0.1663	1
Loa Loa (eye worm)	hypothetical protein	0.7022	1	1
Loa Loa (eye worm)	hypothetical protein	0.7022	1	1
Echinococcus multilocularis	peregrin	0.0034	0.0015	0.0015
Entamoeba histolytica	acyl-coA synthetase, putative	0.0078	0.0079	1
Brugia malayi	jmjC domain containing protein	0.0029	0.0008	0.0008
Brugia malayi	jmjC domain containing protein	0.0029	0.0008	0.0008
Brugia malayi	AMP-binding enzyme family protein	0.0078	0.0079	0.0079
Brugia malayi	jmjC domain containing protein	0.0177	0.022	0.022
Plasmodium vivax	JmjC domain containing protein	0.0029	0.0008	0.1635
Trichomonas vaginalis	spcc417.12 protein, putative	0.1186	0.1663	1
Brugia malayi	AMP-binding enzyme family protein	0.0078	0.0079	0.0079
Loa Loa (eye worm)	MH2 domain-containing protein	0.0135	0.0161	0.0161
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0078	0.0079	1
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0204	0.0204
Echinococcus multilocularis	lysine specific demethylase 6a	0.0029	0.0008	0.0008
Loa Loa (eye worm)	carboxylesterase	0.1186	0.1663	0.1663

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.1117 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1901732

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1552319