Detailed information for compound 1552405

Basic information

Technical information
  • TDR Targets ID: 1552405
  • Name: oxetan-3-yl 2-[(4,6-dimethylpyrimidin-2-yl)ca rbamoylsulfamoyl]benzoate
  • MW: 406.413 | Formula: C17H18N4O6S
  • H donors: 2 H acceptors: 6 LogP: 1.57 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NS(=O)(=O)c1ccccc1C(=O)OC1COC1)Nc1nc(C)cc(n1)C
  • InChi: 1S/C17H18N4O6S/c1-10-7-11(2)19-16(18-10)20-17(23)21-28(24,25)14-6-4-3-5-13(14)15(22)27-12-8-26-9-12/h3-7,12H,8-9H2,1-2H3,(H2,18,19,20,21,23)
  • InChiKey: IOXAXYHXMLCCJJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[[(4,6-dimethyl-2-pyrimidinyl)amino]-oxomethyl]sulfamoyl]benzoic acid 3-oxetanyl ester
  • 2-[(4,6-dimethylpyrimidin-2-yl)carbamoylsulfamoyl]benzoic acid oxetan-3-yl ester
  • 144651-06-9
  • Benzoic acid, 2-(((((4,6-dimethyl-2-pyrimidinyl)amino)carbonyl)amino)sulfonyl)-, 3-oxetanyl ester
  • CGA-277476
  • CGA-277476 Herbicide
  • EP-A 0496701
  • Expert
  • Oxasulfuron
  • oxetan-3-yl 2-({[(4,6-dimethylpyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate
  • 46416_RIEDEL

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens estrogen receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0007 0.0135 0.0154
Loa Loa (eye worm) TAR-binding protein 0.0068 0.3331 0.3791
Loa Loa (eye worm) hypothetical protein 0.0173 0.8786 1
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.1528 0.2281
Loa Loa (eye worm) hypothetical protein 0.0123 0.6167 0.702
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.089 0.0585
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.089 0.1254
Schistosoma mansoni hypothetical protein 0.0017 0.0621 0.0492
Brugia malayi steroid hormone receptor 0.0007 0.0135 0.0154
Brugia malayi Cytochrome P450 family protein 0.0057 0.2708 0.3082
Leishmania major ATP-dependent phosphofructokinase 0.0126 0.6326 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0126 0.6326 1
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.3095 0.3
Onchocerca volvulus 0.003 0.1333 0.1986
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.6326 1
Schistosoma mansoni hypothetical protein 0.0015 0.0552 0.0423
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.3331 0.3791
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.1528 0.1175
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0866 0.0986
Brugia malayi cytochrome P450 0.0015 0.0552 0.0628
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.1528 0.2281
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0.0135 0.0154
Brugia malayi MH2 domain containing protein 0.0126 0.6324 0.7198
Brugia malayi CXXC zinc finger family protein 0.003 0.1333 0.1517
Echinococcus multilocularis 6 phosphofructokinase 0.0126 0.6326 0.6276
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0621 0.0492
Schistosoma mansoni rab6-interacting 0.0021 0.0866 0.0741
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.6326 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.089 0.0585
Echinococcus granulosus Smad4 0.0009 0.02 0.0066
Brugia malayi Cytochrome P450 family protein 0.0025 0.1047 0.1192
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.089 0.0585
Leishmania major cytochrome p450-like protein 0.0025 0.1047 0.0857
Loa Loa (eye worm) RNA binding protein 0.0068 0.3331 0.3791
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.1528 0.3839
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0866 0.0741
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0007 0.0135 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0007 0.0135 0.0154
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.1528 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0145 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0007 0.0135 0.0154
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0621 0.0492
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.089 0.0765
Onchocerca volvulus Huntingtin homolog 0.0123 0.6167 1
Echinococcus multilocularis tar DNA binding protein 0.0068 0.3331 0.324
Echinococcus multilocularis smad 0.0009 0.02 0.0066
Loa Loa (eye worm) hypothetical protein 0.0007 0.0135 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0007 0.0135 0.0154
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0866 0.0741
Loa Loa (eye worm) hypothetical protein 0.0173 0.8786 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0.0135 0.0154
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.1528 0.2281
Loa Loa (eye worm) hypothetical protein 0.0017 0.0621 0.0706
Loa Loa (eye worm) hypothetical protein 0.0007 0.0135 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0007 0.0135 0.0154
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.02 0.0066
Onchocerca volvulus 0.0021 0.0866 0.1212
Schistosoma mansoni loxhd1 0.0021 0.0866 0.0741
Trypanosoma brucei cytochrome P450, putative 0.0025 0.1047 0.0857
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.3331 0.3791
Loa Loa (eye worm) phosphofructokinase 0.0126 0.6326 0.72
Schistosoma mansoni cpg binding protein 0.003 0.1333 0.1214
Schistosoma mansoni ap endonuclease 0.0022 0.089 0.0765
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.6326 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.1528 0.5
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.006 0.2871 0.2774
Loa Loa (eye worm) hypothetical protein 0.0021 0.0866 0.0986
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.1528 1
Schistosoma mansoni ap endonuclease 0.0022 0.089 0.0765
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.1528 0.2281
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.089 0.1013
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0007 0.0135 0.0154
Loa Loa (eye worm) hypothetical protein 0.0123 0.6167 0.702
Schistosoma mansoni tar DNA-binding protein 0.0068 0.3331 0.324
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.3095 0.4404
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.02 0.0228
Schistosoma mansoni tar DNA-binding protein 0.0068 0.3331 0.324
Schistosoma mansoni cpg binding protein 0.0032 0.1423 0.1306
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.6326 1
Loa Loa (eye worm) Smad1 0.0009 0.02 0.0228
Echinococcus multilocularis cpg binding protein 0.0032 0.1423 0.1306
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0.0135 0.0154
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.3095 0.3
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.3095 0.4404
Echinococcus multilocularis RUN 0.0021 0.0866 0.0741
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.6324 0.7198
Brugia malayi MH1 domain containing protein 0.0009 0.02 0.0228
Schistosoma mansoni polycystin 1-related 0.0021 0.0866 0.0741
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0126 0.6326 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.089 0.0765
Schistosoma mansoni cpg binding protein 0.0032 0.1423 0.1306
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0621 0.0706
Schistosoma mansoni tar DNA-binding protein 0.0068 0.3331 0.324
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0007 0.0135 0.0154
Schistosoma mansoni smad 0.0009 0.02 0.0066
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0621 0.0706
Schistosoma mansoni lipoxygenase 0.006 0.2871 0.2774
Schistosoma mansoni tar DNA-binding protein 0.0068 0.3331 0.324
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0866 0.0741
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.02 0.0066
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0866 0.0741
Brugia malayi photoreceptor-specific nuclear receptor 0.0007 0.0135 0.0154
Brugia malayi MH2 domain containing protein 0.0009 0.02 0.0228
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0241 0.0108
Echinococcus granulosus muscleblind protein 0.0173 0.8786 0.877
Loa Loa (eye worm) hypothetical protein 0.0052 0.2497 0.2841
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.2497 0.2841
Schistosoma mansoni hypothetical protein 0.0017 0.0621 0.0492
Echinococcus multilocularis muscleblind protein 0.0173 0.8786 0.877
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.6326 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.089 0.0354
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.2497 0.2841
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0126 0.6326 1
Echinococcus multilocularis 0.0015 0.0552 0.0423
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.2497 0.2841
Loa Loa (eye worm) hypothetical protein 0.0009 0.0247 0.0282
Brugia malayi hypothetical protein 0.0123 0.6167 0.702
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.1528 0.2281
Schistosoma mansoni lipoxygenase 0.0021 0.0866 0.0741
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.6324 0.7198
Brugia malayi Cytochrome P450 family protein 0.0015 0.0552 0.0628
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.3095 0.3
Echinococcus multilocularis geminin 0.0196 1 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.02 0.0228
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.1528 1
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.1047 0.0857
Echinococcus granulosus cpg binding protein 0.0032 0.1423 0.1306
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.02 0.0066
Schistosoma mansoni hypothetical protein 0.0017 0.0621 0.0492
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0.0135 0.0154
Brugia malayi 6-phosphofructokinase 0.0126 0.6326 0.72
Loa Loa (eye worm) hypothetical protein 0.0021 0.0866 0.0986
Brugia malayi Steroid receptor seven-up type 2 0.0007 0.0135 0.0154
Loa Loa (eye worm) steroid hormone receptor 0.0007 0.0135 0.0154
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.1333 0.1517
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0866 0.0741
Loa Loa (eye worm) hypothetical protein 0.0007 0.0135 0.0154
Brugia malayi Nuclear hormone receptor-like 1 0.0007 0.0135 0.0154
Schistosoma mansoni smad1 5 8 and 0.0009 0.02 0.0066
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0145 0.001
Brugia malayi nuclear hormone receptor 0.0007 0.0135 0.0154
Onchocerca volvulus 0.0021 0.0866 0.1212
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0007 0.0135 0.0154
Echinococcus multilocularis GPCR, family 2 0.0017 0.0621 0.0492
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.3095 0.4404
Echinococcus granulosus 6 phosphofructokinase 0.0126 0.6326 0.6276
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.6326 0.6276
Schistosoma mansoni rab6-interacting 0.0021 0.0866 0.0741
Schistosoma mansoni tar DNA-binding protein 0.0068 0.3331 0.324
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0235 0.0268
Schistosoma mansoni Smad4 0.0009 0.02 0.0066
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.6326 0.72
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0241 0.0275
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.1047 0.0857
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.02 0.0066
Toxoplasma gondii exonuclease III APE 0.0022 0.089 0.1328
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0007 0.0135 0.0154
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0621 0.0706
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.3095 0.4404
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.1528 0.2281
Onchocerca volvulus Huntingtin homolog 0.0123 0.6167 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.1528 0.2281
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.6326 1
Echinococcus multilocularis muscleblind protein 1 0.0173 0.8786 0.877
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.1047 0.0857
Brugia malayi phosphofructokinase 0.0126 0.6326 0.72
Brugia malayi MH2 domain containing protein 0.0009 0.02 0.0228
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.089 0.0585
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0145 0.001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.3106 0.3011
Schistosoma mansoni hypothetical protein 0.0021 0.0866 0.0741
Loa Loa (eye worm) hypothetical protein 0.0007 0.0135 0.0154
Schistosoma mansoni hypothetical protein 0.0196 1 1
Schistosoma mansoni cytochrome P450 0.0015 0.0552 0.0423
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.1528 1
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.089 0.1254
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0007 0.0135 0.0154
Schistosoma mansoni hypothetical protein 0.0196 1 1
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.089 0.1013
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.3095 0.4404
Schistosoma mansoni smad1 5 8 and 0.0009 0.02 0.0066
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.1528 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.089 0.0585
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0007 0.0135 0.0154
Brugia malayi hypothetical protein 0.0021 0.0866 0.0986
Brugia malayi hypothetical protein 0.0021 0.0866 0.0986
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0621 0.0492
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.1628 0.1853
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.6326 0.6276
Brugia malayi nuclear receptor NHR-88 0.0007 0.0135 0.0154
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.3095 0.3
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.02 0.0066
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0866 0.0741
Loa Loa (eye worm) hypothetical protein 0.0007 0.0135 0.0154
Schistosoma mansoni smad1 5 8 and 0.0009 0.02 0.0066
Echinococcus multilocularis Smad4 0.0009 0.02 0.0066
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0621 0.0492
Mycobacterium ulcerans 6-phosphofructokinase 0.0126 0.6326 1
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.1528 0.3839
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0145 0.001
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.1047 0.1192
Loa Loa (eye worm) cytochrome P450 0.0015 0.0552 0.0628
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0007 0.0135 0.0154
Brugia malayi Muscleblind-like protein 0.0173 0.8786 1
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0552 0.0423
Loa Loa (eye worm) hypothetical protein 0.0007 0.0135 0.0154
Echinococcus granulosus tar DNA binding protein 0.0068 0.3331 0.324
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.089 0.0354
Loa Loa (eye worm) hypothetical protein 0.0007 0.0135 0.0154
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.089 0.0585
Brugia malayi 6-phosphofructokinase 0.0126 0.6326 0.72
Brugia malayi RNA binding protein 0.0068 0.3331 0.3791
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.1528 0.1175
Brugia malayi ecdysteroid receptor 0.0007 0.0135 0.0154
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0.0135 0.0154
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.089 0.5
Echinococcus granulosus smad 0.0009 0.02 0.0066
Schistosoma mansoni hypothetical protein 0.0017 0.0621 0.0492
Echinococcus granulosus arachidonate 5 lipoxygenase 0.006 0.2871 0.2774
Brugia malayi TAR-binding protein 0.0068 0.3331 0.3791
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.1528 0.3839
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.2748 0.8634
Loa Loa (eye worm) CYP4Cod1 0.0025 0.1047 0.1192
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.6326 1
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.6326 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.2708 0.3082
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0145 0.001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0241 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0.0135 0.0154
Loa Loa (eye worm) hypothetical protein 0.0007 0.0135 0.0154
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.6326 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0007 0.0135 0.0154
Brugia malayi MH1 domain containing protein 0.0009 0.02 0.0228
Echinococcus granulosus RUN 0.0021 0.0866 0.0741
Brugia malayi Doublecortin family protein 0.0021 0.0866 0.0986
Schistosoma mansoni hypothetical protein 0.0036 0.1628 0.1513
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.3095 1
Echinococcus granulosus GPCR family 2 0.0017 0.0621 0.0492
Brugia malayi Smad1 0.0009 0.02 0.0228
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.6326 0.72
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.1047 0.1192
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.1528 0.5
Brugia malayi Cytochrome P450 family protein 0.0025 0.1047 0.1192
Loa Loa (eye worm) hypothetical protein 0.0036 0.1628 0.1853

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of estrogen receptor alpha signaling. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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