Detailed information for compound 1552515

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 438.335 | Formula: C19H20BrNO4S
  • H donors: 0 H acceptors: 3 LogP: 4.71 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc2c(c1)OC[C@@H](N(S2(=O)=O)C(=O)c1cccc(c1)C)C(C)C
  • InChi: 1S/C19H20BrNO4S/c1-12(2)16-11-25-17-10-15(20)7-8-18(17)26(23,24)21(16)19(22)14-6-4-5-13(3)9-14/h4-10,12,16H,11H2,1-3H3/t16-/m1/s1
  • InChiKey: JNOMWYFBUIBRLE-MRXNPFEDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0621 1
Brugia malayi hypothetical protein 0.0036 0.0524 0.1078
Brugia malayi hypothetical protein 0.0071 0.1297 0.2833
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0019 0.016 0.0217
Brugia malayi Cyclic-nucleotide gated cation channel 0.0019 0.016 0.0252
Leishmania major hypothetical protein, conserved 0.0073 0.1341 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.075 0.1004
Brugia malayi Nuclear hormone receptor-like 1 0.0071 0.1297 0.2833
Mycobacterium leprae Probable lipase LipE 0.0073 0.1341 1
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1341 0.2555
Brugia malayi Pre-SET motif family protein 0.0031 0.0411 0.0822
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0134 0.2693 0.6001
Schistosoma mansoni hypothetical protein 0.0329 0.703 0.9526
Loa Loa (eye worm) hypothetical protein 0.0026 0.0315 0.038
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0507 0.732
Schistosoma mansoni hypothetical protein 0.0015 0.007 0.0095
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0089 0.0054
Schistosoma mansoni hypothetical protein 0.0067 0.122 0.1653
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0859 0.6266
Brugia malayi Cytochrome P450 family protein 0.002 0.0167 0.0267
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0859 1
Trichomonas vaginalis set domain proteins, putative 0.0243 0.5106 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0134 0.2693 0.6001
Loa Loa (eye worm) hypothetical protein 0.0063 0.113 0.1548
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0134 0.2693 0.6001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0134 0.2693 0.3606
Schistosoma mansoni zinc finger protein 0.0023 0.0244 0.0331
Schistosoma mansoni ran 0.0023 0.0237 0.0322
Onchocerca volvulus 0.0134 0.2693 0.5228
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0134 0.2693 0.3649
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.1124 0.1466
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0199 0.1846
Brugia malayi nuclear receptor RXR 0.0063 0.113 0.2454
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0014 0.0049 0.0067
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0134 0.2693 0.3606
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0019 0.016 0.0151
Brugia malayi beta-lactamase 0.0073 0.1341 0.2933
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0134 0.2693 0.3787
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0753 0.5447
Schistosoma mansoni steroid hormone receptor ad4bp 0.0134 0.2693 0.3649
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0109 0.0147
Loa Loa (eye worm) hypothetical protein 0.0019 0.016 0.0159
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0075 0.14 0.2671
Echinococcus multilocularis nuclear receptor nhr 48 0.0063 0.113 0.1474
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0019 0.016 0.0151
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1765 0.2392
Echinococcus multilocularis thyroid hormone receptor alpha 0.0134 0.2693 0.3606
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0237 0.027
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0785 0.1004
Echinococcus granulosus hyperpolarization activated cyclic 0.0019 0.016 0.0151
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0063 0.113 0.1474
Echinococcus multilocularis zinc finger protein 0.0023 0.0244 0.0266
Onchocerca volvulus Bile acid receptor homolog 0.0134 0.2693 0.5228
Echinococcus granulosus potassium voltage gated channel subfamily H 0.008 0.1511 0.1994
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0411 0.0494
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0134 0.2693 0.3787
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0063 0.113 0.1474
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.1341 0.1298
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0237 0.1457
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0203 0.4235 0.8278
Brugia malayi tailless protein 0.0063 0.113 0.2454
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0026 0.0315 0.0362
Brugia malayi nuclear receptor NHR-88 0.0134 0.2693 0.6001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0524 0.0648
Loa Loa (eye worm) hypothetical protein 0.0071 0.1297 0.1788
Onchocerca volvulus 0.0073 0.1341 0.2555
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.122 0.1597
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0167 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0134 0.2693 0.6001
Echinococcus granulosus ecdysone induced protein 78C 0.0134 0.2693 0.3606
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0237 0.2325
Loa Loa (eye worm) hypothetical protein 0.0063 0.113 0.1548
Echinococcus multilocularis geminin 0.0345 0.738 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0134 0.2693 0.3649
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0134 0.2693 0.6001
Schistosoma mansoni bromodomain containing protein 0.0066 0.1203 0.163
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0049 0.0067
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0239 0.0259
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0199 0.1157
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0089 0.0057
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0237 0.3295
Trypanosoma cruzi ISWI complex protein 0.0015 0.007 0.0161
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0019 0.016 0.0217
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0019 0.016 0.0151
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0134 0.2693 0.3606
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0418 0.0503
Schistosoma mansoni coup transcription factor 0.0134 0.2693 0.3649
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0089 0.0308
Entamoeba histolytica hypothetical protein 0.0036 0.0524 0.7717
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0167 0.0168
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0526 0.0683
Brugia malayi MH2 domain containing protein 0.0121 0.2414 0.5368
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0089 0.0308
Echinococcus granulosus muscleblind protein 0.0155 0.3174 0.4262
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0014 0.0049 0.0067
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.008 0.1511 0.3318
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0621 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.122 0.2657
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0212 0.4429 0.9942
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1341 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.016 0.0217
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0199 0.015
Loa Loa (eye worm) hypothetical protein 0.0073 0.1341 0.1851
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0859 1
Leishmania major cytochrome p450-like protein 0.002 0.0167 0.091
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0063 0.113 0.2137
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0063 0.113 0.1474
Plasmodium vivax importin-beta 2, putative 0.0031 0.0418 0.2853
Entamoeba histolytica hypothetical protein 0.0036 0.0524 0.7717
Echinococcus granulosus Nuclear hormone receptor HR96 0.0063 0.113 0.1474
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0397 0.0498
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0229 0.0245
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0199 0.0204
Echinococcus multilocularis muscleblind protein 1 0.0155 0.3174 0.4262
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0289 0.0473
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0063 0.113 0.1474
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0089 0.004
Mycobacterium tuberculosis Conserved protein 0.0073 0.1341 0.1298
Mycobacterium tuberculosis Conserved protein 0.0073 0.1341 0.1298
Entamoeba histolytica Ran family GTPase 0.0023 0.0237 0.0919
Echinococcus multilocularis hyperpolarization activated cyclic 0.0019 0.016 0.0151
Brugia malayi nuclear receptor NHR-67 0.0063 0.113 0.2454
Schistosoma mansoni nuclear hormone receptor 0.0134 0.2693 0.3649
Loa Loa (eye worm) nuclear receptor NHR-67 0.0063 0.113 0.1548
Schistosoma mansoni ran 0.0023 0.0237 0.0322
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0063 0.113 0.1474
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0229 0.0245
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0507 0.3547
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1765 0.2341
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.1341 1
Schistosoma mansoni hypothetical protein 0.0067 0.122 0.1653
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0411 0.0558
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0289 0.0473
Leishmania major hypothetical protein, conserved 0.0015 0.007 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0526 0.0943
Brugia malayi Steroid receptor seven-up type 2 0.0134 0.2693 0.6001
Trichomonas vaginalis rotamase, putative 0.0036 0.0526 0.0943
Loa Loa (eye worm) hypothetical protein 0.0134 0.2693 0.3787
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0418 0.2853
Brugia malayi Bromodomain containing protein 0.0042 0.0655 0.1375
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0134 0.2693 0.5228
Loa Loa (eye worm) DR-78 0.0063 0.113 0.1548
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0526 0.1083
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.008 0.1511 0.2094
Brugia malayi steroid hormone receptor 0.0134 0.2693 0.6001
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0063 0.113 0.1474
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0237 0.1457
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0026 0.0315 0.0362
Schistosoma mansoni voltage-gated potassium channel 0.0087 0.1665 0.2257
Schistosoma mansoni retinoic acid receptor RXR 0.0134 0.2693 0.3649
Brugia malayi Nuclear hormone receptor E75 0.0063 0.113 0.2454
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1765 0.2392
Schistosoma mansoni ap endonuclease 0.0021 0.0199 0.0269
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0418 0.2853
Loa Loa (eye worm) CYP4Cod1 0.002 0.0167 0.0168
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0507 0.3547
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0859 0.6266
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0014 0.0049 0.5
Onchocerca volvulus 0.0073 0.1341 0.2555
Brugia malayi nuclear receptor RXR 0.0071 0.1297 0.2833
Brugia malayi Nuclear hormone receptor-like 1 0.0134 0.2693 0.6001
Brugia malayi nuclear receptor NHR-88 0.0063 0.113 0.2454
Trichomonas vaginalis rotamase, putative 0.0035 0.0507 0.0906
Loa Loa (eye worm) hypothetical protein 0.007 0.1285 0.1771
Schistosoma mansoni hypothetical protein 0.0067 0.122 0.1653
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0289 0.1853
Schistosoma mansoni hypothetical protein 0.0145 0.2943 0.3988
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0063 0.113 0.1531
Brugia malayi PHD-finger family protein 0.0028 0.0361 0.0709
Loa Loa (eye worm) hypothetical protein 0.0063 0.113 0.1548
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0859 0.6266
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0089 0.0308
Plasmodium vivax hypothetical protein, conserved 0.0073 0.1341 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0523 0.0646
Echinococcus multilocularis voltage gated potassium channel 0.0026 0.0315 0.0362
Mycobacterium ulcerans lipase LipD 0.0073 0.1341 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.113 0.1548
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0134 0.2693 0.3606
Leishmania major importin beta-1 subunit, putative 0.0025 0.0289 0.1853
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0063 0.113 0.2454
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0199 0.0214
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0134 0.2693 0.3606
Loa Loa (eye worm) hypothetical protein 0.0155 0.3174 0.4476
Echinococcus multilocularis GPCR, family 2 0.0067 0.122 0.1597
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.016 0.0217
Entamoeba histolytica hypothetical protein 0.0025 0.0289 0.2132
Loa Loa (eye worm) hypothetical protein 0.0063 0.113 0.1548
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.2414 0.3387
Loa Loa (eye worm) hypothetical protein 0.0031 0.0418 0.0528
Brugia malayi nuclear hormone receptor 0.0134 0.2693 0.6001
Echinococcus multilocularis ecdysone induced protein 78C 0.0134 0.2693 0.3606
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0237 0.0427
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.016 0.0217
Loa Loa (eye worm) hypothetical protein 0.0134 0.2693 0.3787
Brugia malayi beta-lactamase family protein 0.0073 0.1341 0.2933
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0523 0.0646
Brugia malayi ecdysone receptor 0.0063 0.113 0.2454
Loa Loa (eye worm) hypothetical protein 0.0134 0.2693 0.3787
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0199 0.1157
Brugia malayi Calcitonin receptor-like protein seb-1 0.0212 0.4429 0.9942
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0785 0.1064
Mycobacterium ulcerans hypothetical protein 0.0073 0.1341 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0785 0.1055
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0134 0.2693 0.3649
Schistosoma mansoni nuclear receptor 0.0063 0.113 0.1531
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.1341 0.1298
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.1341 0.1762
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0089 0.0054
Echinococcus granulosus GPCR family 2 0.0067 0.122 0.1597
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0329 0.703 1
Loa Loa (eye worm) hypothetical protein 0.0203 0.4235 0.5997
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.1341 0.2933
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0134 0.2693 0.6001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.4454 0.631
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.122 0.1597
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0199 0.0296
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0019 0.016 0.0159
Onchocerca volvulus 0.0063 0.113 0.2137
Schistosoma mansoni hypothetical protein 0.0036 0.0524 0.071
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0315 0.0426
Echinococcus granulosus hyperpolarization activated cyclic 0.0019 0.016 0.0151
Onchocerca volvulus 0.0063 0.113 0.2137
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0199 0.0296
Brugia malayi Bromodomain containing protein 0.0078 0.146 0.3202
Loa Loa (eye worm) hypothetical protein 0.0145 0.2943 0.4146
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0411 0.0558
Schistosoma mansoni hypothetical protein 0.0023 0.0239 0.0324
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0016 0.01 0.0135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0134 0.2693 0.3787
Brugia malayi hypothetical protein 0.0033 0.046 0.0933
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0167 0.091
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0753 0.096
Schistosoma mansoni hypothetical protein 0.002 0.0187 0.0253
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0019 0.016 0.0151
Schistosoma mansoni nuclear hormone receptor 0.0063 0.113 0.1531
Loa Loa (eye worm) hypothetical protein 0.0134 0.2693 0.3787
Trichomonas vaginalis ran, putative 0.0023 0.0237 0.0372
Schistosoma mansoni rotamase 0.0036 0.0526 0.0713
Loa Loa (eye worm) hypothetical protein 0.0063 0.113 0.1548
Echinococcus granulosus geminin 0.0345 0.738 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.113 0.1548
Loa Loa (eye worm) steroid hormone receptor 0.0134 0.2693 0.3787
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0134 0.2693 0.3649
Echinococcus granulosus zinc finger protein 0.0023 0.0244 0.0266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0134 0.2693 0.3787
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0134 0.2693 0.6001
Schistosoma mansoni nuclear receptor nhr-48 0.0063 0.113 0.1531
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0411 0.2803
Echinococcus multilocularis FTZ F1 alpha 0.0134 0.2693 0.3606
Loa Loa (eye worm) hypothetical protein 0.0134 0.2693 0.3787
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.1341 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0019 0.016 0.0219
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0014 0.0049 0.0067
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.122 0.1597
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0019 0.016 0.0151
Schistosoma mansoni nuclear hormone receptor 0.0063 0.113 0.1531
Leishmania major GTP-binding protein, putative 0.0023 0.0237 0.1457
Brugia malayi Nuclear hormone receptor E75 0.0063 0.113 0.2454
Trichomonas vaginalis esterase, putative 0.0073 0.1341 0.2555
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0134 0.2693 0.6001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0134 0.2693 0.3606
Echinococcus granulosus Nuclear hormone receptor HR96 0.0063 0.113 0.1474
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0167 0.091
Echinococcus granulosus expressed protein 0.0036 0.0526 0.0651
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0134 0.2693 0.6001
Loa Loa (eye worm) hypothetical protein 0.0063 0.113 0.1548
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0199 0.2616
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1341 0.2555
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0014 0.0049 0.0067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0785 0.1064
Trypanosoma cruzi ISWI complex protein 0.0015 0.007 0.0161
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0089 0.0054
Loa Loa (eye worm) hypothetical protein 0.0073 0.1341 0.1851
Brugia malayi Importin beta-1 subunit 0.0031 0.0418 0.0837
Echinococcus granulosus FTZ F1 alpha 0.0134 0.2693 0.3606
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0071 0.1297 0.1702
Schistosoma mansoni RAR-like nuclear receptor 0.0134 0.2693 0.3649
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1341 0.1817
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0229 0.031
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0202 0.0219
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.1341 0.1298
Echinococcus granulosus nuclear receptor nhr 48 0.0063 0.113 0.1474
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0134 0.2693 0.3606
Trypanosoma brucei cytochrome P450, putative 0.002 0.0167 0.091
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0859 0.6266
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0109 0.0081
Brugia malayi orphan nuclear receptor NR2E1 0.0063 0.113 0.2454
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0237 0.1457
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.1341 0.1762
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0237 0.0257
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0014 0.0049 0.0067
Mycobacterium tuberculosis Conserved protein 0.0073 0.1341 0.1298
Brugia malayi Nuclear hormone receptor-like 1 0.0071 0.1297 0.2833
Brugia malayi photoreceptor-specific nuclear receptor 0.0134 0.2693 0.6001
Loa Loa (eye worm) hypothetical protein 0.0212 0.4429 0.6273
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0089 0.0054
Loa Loa (eye worm) hypothetical protein 0.0066 0.1196 0.1643
Plasmodium falciparum importin beta, putative 0.0031 0.0418 0.4553
Loa Loa (eye worm) beta-lactamase 0.0073 0.1341 0.1851
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0753 0.1392
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0134 0.2693 0.6001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1341 0.1817
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0014 0.0049 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0134 0.2693 0.6001
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0014 0.0049 0.0067
Loa Loa (eye worm) hypothetical protein 0.0051 0.0859 0.116
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0199 0.1157
Loa Loa (eye worm) hypothetical protein 0.0155 0.3174 0.4476
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0019 0.016 0.0159
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0014 0.0049 0.0067
Echinococcus granulosus snurportin 1 0.0329 0.703 0.9522
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0019 0.016 0.0151
Echinococcus granulosus thyroid hormone receptor alpha 0.0063 0.113 0.1474
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0199 0.1157
Loa Loa (eye worm) hypothetical protein 0.0134 0.2693 0.3787
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0134 0.2693 0.3787
Onchocerca volvulus 0.0243 0.5106 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0071 0.1297 0.1788
Plasmodium vivax SET domain protein, putative 0.0031 0.0411 0.2803
Brugia malayi nuclear hormone receptor 0.0063 0.113 0.2454
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0134 0.2693 0.3606
Mycobacterium leprae conserved hypothetical protein 0.0073 0.1341 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0199 0.5
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0237 0.0257
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0134 0.2693 0.6001
Loa Loa (eye worm) nuclear hormone receptor 0.0063 0.113 0.1548
Schistosoma mansoni zinc finger protein 0.0063 0.113 0.1531
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0089 0.009
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0026 0.0315 0.0603
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0063 0.113 0.1531
Schistosoma mansoni thyroid hormone receptor 0.0134 0.2693 0.3649
Brugia malayi RNA, U transporter 1 0.0088 0.1678 0.3697
Mycobacterium ulcerans beta-lactamase 0.0073 0.1341 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0387 0.046
Leishmania major hypothetical protein, conserved 0.0051 0.0859 0.6266
Loa Loa (eye worm) acetyltransferase 0.0151 0.3073 0.4332
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0289 0.0473
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1341 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0199 1
Schistosoma mansoni thyroid hormone receptor 0.0134 0.2693 0.3649
Loa Loa (eye worm) hypothetical protein 0.0038 0.0576 0.0755
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0237 0.1457
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0134 0.2693 0.3606
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0089 0.0308
Loa Loa (eye worm) hypothetical protein 0.0063 0.113 0.1548
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1765 0.2341
Toxoplasma gondii ABC1 family protein 0.0073 0.1341 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0524 0.0648
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0089 0.0308
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0109 0.0147
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.1765 0.3896
Schistosoma mansoni zinc finger protein 0.0015 0.007 0.0095
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0134 0.2693 0.3606
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.1341 0.1298
Loa Loa (eye worm) hypothetical protein 0.0063 0.113 0.1548
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0063 0.113 0.1474
Entamoeba histolytica hypothetical protein 0.0036 0.0524 0.7717
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0049 0.0067
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0014 0.0049 0.0067
Loa Loa (eye worm) hypothetical protein 0.0071 0.1297 0.1788
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0063 0.113 0.2137
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.3073 0.6865
Toxoplasma gondii exonuclease III APE 0.0021 0.0199 0.1157
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0089 0.0308
Loa Loa (eye worm) hypothetical protein 0.0071 0.1297 0.1788
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0167 0.091
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0239 0.0259
Schistosoma mansoni importin beta-1 0.0031 0.0418 0.0566
Brugia malayi nuclear hormone receptor family member odr-7 0.0063 0.113 0.2454
Loa Loa (eye worm) hypothetical protein 0.0067 0.122 0.1677
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0063 0.113 0.1548
Schistosoma mansoni hypothetical protein 0.0345 0.738 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1765 0.2341
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0507 0.3547
Brugia malayi conserved hypotetical protein 0.0063 0.113 0.2454
Brugia malayi N-terminal motif family protein 0.0203 0.4235 0.9504
Loa Loa (eye worm) hypothetical protein 0.0044 0.0708 0.0944
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1341 0.2555
Brugia malayi isocitrate dehydrogenase 0.0016 0.0089 0.009
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.2414 0.3387
Entamoeba histolytica hypothetical protein 0.0036 0.0524 0.7717
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0071 0.1297 0.1758
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0621 0.7056
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0089 0.0121
Brugia malayi nuclear hormone receptor family member nhr-6 0.0063 0.113 0.2454
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.1341 0.1298
Schistosoma mansoni hypothetical protein 0.0014 0.0049 0.0067
Brugia malayi hypothetical protein 0.0063 0.113 0.2454
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.1124 0.1466
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0753 0.1392
Brugia malayi Cytochrome P450 family protein 0.003 0.0397 0.0789
Brugia malayi latrophilin 2 splice variant baaae 0.0145 0.2943 0.657
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1341 0.2555
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0019 0.016 0.0151
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0049 0.0067
Schistosoma mansoni voltage-gated potassium channel 0.0087 0.1665 0.2257
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1765 0.2341
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.122 0.1597
Echinococcus multilocularis muscleblind protein 0.0155 0.3174 0.4262
Brugia malayi Cytochrome P450 family protein 0.002 0.0167 0.0267
Trypanosoma brucei ISWI complex protein 0.0015 0.007 0.0161
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0089 0.0054
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0199 0.0339
Echinococcus multilocularis expressed protein 0.0036 0.0526 0.0651
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.1341 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0089 0.0308
Onchocerca volvulus 0.0073 0.1341 0.2555
Schistosoma mansoni nuclear receptor 0.0063 0.113 0.1531
Onchocerca volvulus 0.0031 0.0411 0.0716
Onchocerca volvulus Protein ultraspiracle homolog 0.0134 0.2693 0.5228
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1765 0.2392
Brugia malayi ecdysteroid receptor 0.0134 0.2693 0.6001
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0753 0.5447
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.016 0.0217
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0089 0.0492
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0019 0.016 0.0219
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0071 0.1297 0.1702
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0199 0.1157
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0507 0.3547
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0507 0.3547
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0212 0.4429 0.6273
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0134 0.2693 0.3606
Schistosoma mansoni hypothetical protein 0.0067 0.122 0.1653
Loa Loa (eye worm) hypothetical protein 0.0063 0.113 0.1548
Echinococcus multilocularis snurportin 1 0.0329 0.703 0.9522
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0134 0.2693 0.3649
Brugia malayi Latrophilin receptor protein 2 0.0067 0.122 0.2657
Loa Loa (eye worm) hypothetical protein 0.0073 0.1341 0.1851
Schistosoma mansoni ap endonuclease 0.0021 0.0199 0.0269
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0049 0.0067
Loa Loa (eye worm) hypothetical protein 0.0063 0.113 0.1548
Brugia malayi Muscleblind-like protein 0.0155 0.3174 0.7094
Loa Loa (eye worm) hypothetical protein 0.0073 0.1341 0.1851
Echinococcus multilocularis hyperpolarization activated cyclic 0.0019 0.016 0.0151
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.3073 0.4164
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0089 0.0054
Brugia malayi Pre-SET motif family protein 0.0213 0.4454 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.1341 0.1851
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0134 0.2693 0.3606
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.122 0.1677
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0109 0.0081
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0134 0.2693 0.3606
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0089 0.0308
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0199 0.0204
Echinococcus granulosus importin subunit beta 1 0.0031 0.0418 0.0503
Loa Loa (eye worm) hypothetical protein 0.0073 0.1341 0.1851
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.1341 0.1298
Schistosoma mansoni hypothetical protein 0.0345 0.738 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0134 0.2693 0.3787
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0049 0.0067
Brugia malayi hypothetical protein 0.0071 0.1297 0.2833
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0237 0.1457
Brugia malayi beta-lactamase family protein 0.0073 0.1341 0.2933
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0071 0.1297 0.1758
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0199 0.1157
Loa Loa (eye worm) hypothetical protein 0.0071 0.1297 0.1788
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1341 0.2555
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0753 0.5447
Loa Loa (eye worm) hypothetical protein 0.0071 0.1297 0.1788
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0134 0.2693 0.3787
Loa Loa (eye worm) hypothetical protein 0.0134 0.2693 0.3787
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0859 0.6266
Loa Loa (eye worm) hypothetical protein 0.0134 0.2693 0.3787
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.1341 0.1298
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0785 0.1004
Loa Loa (eye worm) hypothetical protein 0.0073 0.1341 0.1851
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.008 0.1511 0.1994
Echinococcus granulosus voltage gated potassium channel 0.0026 0.0315 0.0362
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0524 0.071
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.3073 0.4125
Loa Loa (eye worm) hypothetical protein 0.0063 0.113 0.1548
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.1765 0.2458
Brugia malayi hypothetical protein 0.0063 0.113 0.2454
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0187 0.0197
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0134 0.2693 0.3649
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0075 0.14 0.2671
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.2929 0.3928
Brugia malayi hypothetical protein 0.0051 0.0859 0.1838
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0315 0.0426
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0134 0.2693 0.6001
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0418 0.2853

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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