Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/FER protein kinase | 0.002 | 0.3185 | 0.355 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.002 | 0.3185 | 0.355 |
Schistosoma mansoni | tyrosine kinase | 0.002 | 0.3185 | 0.3185 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0012 | 0.1028 | 0.1145 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.002 | 0.3185 | 0.355 |
Echinococcus multilocularis | suppressor of cytokine signaling 7 | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2002 | 0.2231 |
Echinococcus granulosus | SH2 domain containing adapter protein F | 0.0015 | 0.2002 | 0.2231 |
Echinococcus granulosus | c src tyrosine kinase | 0.002 | 0.3185 | 0.355 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.002 | 0.3185 | 0.355 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0015 | 0.2002 | 0.2002 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0015 | 0.2002 | 0.2231 |
Schistosoma mansoni | vav2 | 0.0015 | 0.2002 | 0.2002 |
Brugia malayi | Variant SH3 domain containing protein | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0015 | 0.2002 | 0.2231 |
Schistosoma mansoni | suppressor of cytokine signaling | 0.0015 | 0.2002 | 0.2002 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0012 | 0.1028 | 0.1145 |
Schistosoma mansoni | tyrosine kinase | 0.002 | 0.3185 | 0.3185 |
Echinococcus granulosus | suppressor of cytokine signaling 6 | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.3185 | 0.355 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0015 | 0.2002 | 0.2231 |
Brugia malayi | Tensin | 0.0015 | 0.2002 | 0.2231 |
Brugia malayi | STAT protein, DNA binding domain containing protein | 0.0015 | 0.2002 | 0.2231 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.002 | 0.3185 | 0.355 |
Echinococcus granulosus | NCK adaptor protein | 0.0015 | 0.2002 | 0.2231 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0015 | 0.2002 | 0.2002 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.002 | 0.3185 | 0.355 |
Brugia malayi | RhoGAP domain containing protein | 0.0015 | 0.2002 | 0.2231 |
Onchocerca volvulus | 0.002 | 0.3185 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.002 | 0.3185 | 0.355 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0015 | 0.2002 | 0.2231 |
Echinococcus multilocularis | SH2 motif | 0.0015 | 0.2002 | 0.2231 |
Schistosoma mansoni | adapter molecule crk | 0.0015 | 0.2002 | 0.2002 |
Echinococcus granulosus | expressed conserved protein | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2002 | 0.2231 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.002 | 0.3185 | 0.355 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.002 | 0.3185 | 0.355 |
Echinococcus multilocularis | signal transduction protein lnk realted | 0.0015 | 0.2002 | 0.2231 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0015 | 0.2002 | 0.2002 |
Echinococcus multilocularis | SH2 motif | 0.0015 | 0.2002 | 0.2231 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0041 | 0.8972 | 1 |
Schistosoma mansoni | GTPase activating protein | 0.0015 | 0.2002 | 0.2002 |
Echinococcus multilocularis | tyrosine kinase | 0.002 | 0.3185 | 0.355 |
Loa Loa (eye worm) | STAT protein | 0.0015 | 0.2002 | 0.2231 |
Onchocerca volvulus | 0.002 | 0.3185 | 1 | |
Schistosoma mansoni | tyrosine kinase | 0.002 | 0.3185 | 0.3185 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.2002 | 0.2002 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0015 | 0.2002 | 0.2231 |
Echinococcus multilocularis | guanine nucleotide exchange factor VAV2 | 0.0015 | 0.2002 | 0.2231 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.002 | 0.3185 | 0.355 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.002 | 0.3185 | 0.355 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.002 | 0.3185 | 0.3185 |
Brugia malayi | SH2 domain containing protein | 0.002 | 0.3185 | 0.355 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.002 | 0.3185 | 0.355 |
Echinococcus granulosus | signal transduction protein lnk realted | 0.0015 | 0.2002 | 0.2231 |
Brugia malayi | Protein kinase domain containing protein | 0.002 | 0.3185 | 0.355 |
Echinococcus granulosus | hypothetical protein | 0.0015 | 0.2002 | 0.2231 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 1 | 1 |
Onchocerca volvulus | 0.002 | 0.3185 | 1 | |
Echinococcus granulosus | tensin C1 domain containing phosphatase | 0.0015 | 0.2002 | 0.2231 |
Schistosoma mansoni | tensin | 0.0015 | 0.2002 | 0.2002 |
Brugia malayi | Protein kinase domain containing protein | 0.002 | 0.3185 | 0.355 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.002 | 0.3185 | 0.355 |
Brugia malayi | SH2 domain containing protein | 0.0015 | 0.2002 | 0.2231 |
Schistosoma mansoni | nck2/grb4 | 0.0015 | 0.2002 | 0.2002 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.002 | 0.3185 | 0.355 |
Brugia malayi | hypothetical protein | 0.0015 | 0.2002 | 0.2231 |
Echinococcus multilocularis | SHC transforming protein 3 | 0.0015 | 0.2002 | 0.2231 |
Brugia malayi | Variant SH3 domain containing protein | 0.0015 | 0.2002 | 0.2231 |
Echinococcus multilocularis | phosphatidylinositol 3 kinase regulatory subunit | 0.0015 | 0.2002 | 0.2231 |
Echinococcus multilocularis | suppressor of cytokine signaling 6 | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2002 | 0.2231 |
Echinococcus multilocularis | 0.0015 | 0.2002 | 0.2231 | |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2002 | 0.2231 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0015 | 0.2002 | 0.2002 |
Brugia malayi | SH2 domain containing protein | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | RhoGAP domain-containing protein | 0.0015 | 0.2002 | 0.2231 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0012 | 0.1028 | 0.1145 |
Echinococcus granulosus | SH2 motif | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | TK protein kinase | 0.002 | 0.3185 | 0.355 |
Schistosoma mansoni | tensin | 0.0015 | 0.2002 | 0.2002 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.7495 | 0.8354 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0015 | 0.2002 | 0.2231 |
Echinococcus multilocularis | SH2 domain containing protein 7 | 0.0015 | 0.2002 | 0.2231 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.002 | 0.3185 | 0.355 |
Echinococcus multilocularis | SH2 motif | 0.0015 | 0.2002 | 0.2231 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.002 | 0.3185 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2002 | 0.2231 |
Echinococcus multilocularis | tensin | 0.0015 | 0.2002 | 0.2231 |
Schistosoma mansoni | signal transduction protein lnk-related | 0.0015 | 0.2002 | 0.2002 |
Schistosoma mansoni | tyrosine-protein kinase zap-70 | 0.0015 | 0.2002 | 0.2002 |
Echinococcus multilocularis | NCK adaptor protein | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0015 | 0.2002 | 0.2231 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2002 | 0.2231 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.1028 | 0.1028 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.002 | 0.3185 | 0.355 |
Brugia malayi | SH2 domain containing protein | 0.0015 | 0.2002 | 0.2231 |
Echinococcus granulosus | tyrosine kinase | 0.002 | 0.3185 | 0.355 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.002 | 0.3185 | 0.355 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.002 | 0.3185 | 0.355 |
Schistosoma mansoni | shc transforming protein | 0.0015 | 0.2002 | 0.2002 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.002 | 0.3185 | 0.355 |
Echinococcus multilocularis | N chimaerin | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.002 | 0.3185 | 0.355 |
Echinococcus granulosus | SH2 motif | 0.0015 | 0.2002 | 0.2231 |
Onchocerca volvulus | 0.002 | 0.3185 | 1 | |
Brugia malayi | hypothetical protein | 0.002 | 0.3185 | 0.355 |
Onchocerca volvulus | 0.002 | 0.3185 | 1 | |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.002 | 0.3185 | 0.355 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2002 | 0.2231 |
Brugia malayi | Protein kinase domain containing protein | 0.002 | 0.3185 | 0.355 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0012 | 0.1028 | 0.1145 |
Brugia malayi | SH2 domain containing protein | 0.0015 | 0.2002 | 0.2231 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.002 | 0.3185 | 0.355 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.002 | 0.3185 | 0.355 |
Brugia malayi | SH2 domain containing protein | 0.0015 | 0.2002 | 0.2231 |
Brugia malayi | Variant SH3 domain containing protein | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.002 | 0.3185 | 0.355 |
Echinococcus granulosus | tensin | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0015 | 0.2002 | 0.2231 |
Brugia malayi | Protein kinase domain containing protein | 0.002 | 0.3185 | 0.355 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.2002 | 0.2002 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.002 | 0.3185 | 0.355 |
Brugia malayi | cytokine inducible SH2-containing protein 5 | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.002 | 0.3185 | 0.355 |
Echinococcus granulosus | phosphatidylinositol 3 kinase regulatory subunit | 0.0015 | 0.2002 | 0.2231 |
Echinococcus granulosus | guanine nucleotide exchange factor VAV2 | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0041 | 0.8972 | 1 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.002 | 0.3185 | 0.355 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2002 | 0.2231 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.002 | 0.3185 | 0.355 |
Brugia malayi | SH2 domain containing protein | 0.002 | 0.3185 | 0.355 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.002 | 0.3185 | 0.355 |
Onchocerca volvulus | 0.002 | 0.3185 | 1 | |
Loa Loa (eye worm) | cytokine inducible SH2-containing protein 5 | 0.0015 | 0.2002 | 0.2231 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0015 | 0.2002 | 0.2231 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.002 | 0.3185 | 0.355 |
Brugia malayi | SRC-1 | 0.002 | 0.3185 | 0.355 |
Schistosoma mansoni | tensin | 0.0015 | 0.2002 | 0.2002 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.002 | 0.3185 | 0.355 |
Schistosoma mansoni | suppressor of cytokine signaling | 0.0015 | 0.2002 | 0.2002 |
Loa Loa (eye worm) | SH2 domain-containing protein | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.002 | 0.3185 | 0.355 |
Brugia malayi | SH2 domain containing protein | 0.0015 | 0.2002 | 0.2231 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0041 | 0.8972 | 1 |
Loa Loa (eye worm) | SH2 domain-containing protein | 0.0015 | 0.2002 | 0.2231 |
Echinococcus granulosus | tyrosine kinase | 0.002 | 0.3185 | 0.355 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.002 | 0.3185 | 0.355 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.002 | 0.3185 | 0.355 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.002 | 0.3185 | 0.355 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2002 | 0.2231 |
Echinococcus multilocularis | c src tyrosine kinase | 0.002 | 0.3185 | 0.355 |
Brugia malayi | Protein kinase domain containing protein | 0.002 | 0.3185 | 0.355 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2002 | 0.2231 |
Schistosoma mansoni | SH2A | 0.0015 | 0.2002 | 0.2002 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0015 | 0.2002 | 0.2231 |
Echinococcus multilocularis | SH2 domain containing adapter protein F | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.002 | 0.3185 | 0.355 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.002 | 0.3185 | 0.355 |
Brugia malayi | Variant SH3 domain containing protein | 0.0015 | 0.2002 | 0.2231 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.002 | 0.3185 | 0.355 |
Echinococcus granulosus | N chimaerin | 0.0015 | 0.2002 | 0.2231 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0015 | 0.2002 | 0.2002 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.002 | 0.3185 | 0.355 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0015 | 0.2002 | 0.2231 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.002 | 0.3185 | 0.355 |
Schistosoma mansoni | tyrosine kinase | 0.002 | 0.3185 | 0.3185 |
Echinococcus granulosus | SH2 domain containing protein 7 | 0.0015 | 0.2002 | 0.2231 |
Brugia malayi | SH2 domain containing protein | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2002 | 0.2231 |
Echinococcus multilocularis | tensin | 0.0015 | 0.2002 | 0.2231 |
Schistosoma mansoni | tyrosine kinase | 0.002 | 0.3185 | 0.3185 |
Echinococcus multilocularis | suppressor of cytokine signaling 7 | 0.0015 | 0.2002 | 0.2231 |
Echinococcus granulosus | voltage gated potassium channel | 0.0012 | 0.1028 | 0.1145 |
Schistosoma mansoni | tensin-related | 0.0015 | 0.2002 | 0.2002 |
Echinococcus granulosus | SHC transforming protein 3 | 0.0015 | 0.2002 | 0.2231 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0015 | 0.2002 | 0.2002 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.002 | 0.3185 | 0.355 |
Loa Loa (eye worm) | SH2 domain-containing protein | 0.0015 | 0.2002 | 0.2231 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.002 | 0.3185 | 0.355 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0041 | 0.8972 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0038 | 0.8236 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0038 | 0.8236 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1028 | 0.1145 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.1028 | 0.1028 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2002 | 0.2231 |
Schistosoma mansoni | tensin-related | 0.0015 | 0.2002 | 0.2002 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2002 | 0.2231 |
Schistosoma mansoni | tyrosine kinase | 0.002 | 0.3185 | 0.3185 |
Brugia malayi | protein-tyrosine kinase | 0.002 | 0.3185 | 0.355 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.002 | 0.3185 | 0.355 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0015 | 0.2002 | 0.2231 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.002 | 0.3185 | 0.355 |
Echinococcus granulosus | suppressor of cytokine signaling 7 | 0.0015 | 0.2002 | 0.2231 |
Brugia malayi | tRNA modification GTPase TrmE family protein | 0.0015 | 0.2002 | 0.2231 |
Loa Loa (eye worm) | SRC-1 | 0.002 | 0.3185 | 0.355 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | = 131.2 uM | PUBCHEM_BIOASSAY: Antifungal Drug Resistance - Mammalian Cell Toxicity Measured in Cell-Based System Using Plate Reader - 2037-04_Inhibitor_Dose_DryPowder_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2007] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.