Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0111 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0111 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0111 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0111 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0111 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0111 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0111 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0111 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0111 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0111 | 0.5 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0111 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0111 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0111 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0111 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0111 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0111 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0111 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK protein kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0111 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0111 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0111 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0111 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0111 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0111 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0111 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0111 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0111 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0111 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0111 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0111 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0111 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.