Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | jumonji domain containing protein | 0.0075 | 0.2828 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0012 | 0.0008 | 0.0008 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0748 | 0.2645 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0029 | 0.0748 | 0.0749 |
Brugia malayi | Bromodomain containing protein | 0.0074 | 0.279 | 0.2795 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.2109 | 0.2112 |
Onchocerca volvulus | 0.0029 | 0.0779 | 0.0137 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1264 | 0.1266 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.2131 | 0.2135 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.105 | 0.1052 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.1155 | 0.1157 |
Brugia malayi | hypothetical protein | 0.0233 | 0.9982 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0651 | 0.0652 |
Schistosoma mansoni | lamin | 0.0027 | 0.0651 | 0.23 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1676 | 0.1679 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0046 | 0.1539 | 0.544 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.0748 | 0.9601 |
Trypanosoma cruzi | ISWI complex protein | 0.0015 | 0.0131 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0029 | 0.0029 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0454 | 0.1604 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0321 | 0.1136 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0321 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0007 | 0.0007 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0093 | 0.0093 |
Echinococcus granulosus | lamin | 0.0027 | 0.0651 | 0.0652 |
Leishmania major | hypothetical protein, conserved | 0.0015 | 0.0131 | 0.5 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0017 | 0.0209 | 0.0209 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.2268 | 0.8019 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0029 | 0.0029 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.1257 | 0.1259 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0651 | 0.0652 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0029 | 0.0029 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0321 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0748 | 0.0749 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0147 | 0.6103 | 0.6114 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0205 | 0.8719 | 0.8735 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.6103 | 0.6114 |
Brugia malayi | Pre-SET motif family protein | 0.0205 | 0.8719 | 0.8735 |
Trichomonas vaginalis | set domain proteins, putative | 0.0233 | 1 | 0.5 |
Schistosoma mansoni | lamin | 0.0027 | 0.0651 | 0.23 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0454 | 0.0454 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0007 | 0.0007 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0046 | 0.1539 | 0.1541 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0368 | 0.1303 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.0093 | 0.0093 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0779 | 0.2754 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0779 | 0.078 |
Echinococcus granulosus | muscleblind protein | 0.0147 | 0.6103 | 0.6114 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.1021 | 0.1023 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0651 | 0.0652 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0651 | 0.0652 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.0559 | 0.056 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0236 | 0.0237 |
Schistosoma mansoni | zinc finger protein | 0.0015 | 0.0131 | 0.0463 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0029 | 0.0748 | 0.2645 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.1598 | 0.5649 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0209 | 0.0739 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0651 | 0.23 |
Echinococcus multilocularis | peregrin | 0.0031 | 0.0853 | 0.0855 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.073 | 0.0731 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0029 | 0.0748 | 0.0749 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0651 | 0.0652 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0029 | 0.0748 | 0.0749 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2599 | 0.2604 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.1257 | 0.1259 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0046 | 0.1539 | 0.544 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.0748 | 0.9601 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0779 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.1598 | 0.1601 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0037 | 0.1106 | 0.1108 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0454 | 0.0454 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0094 | 0.3702 | 0.3709 |
Plasmodium falciparum | phd finger protein, putative | 0.0029 | 0.0748 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0147 | 0.6103 | 0.6114 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1349 | 0.1351 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1539 | 0.1541 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0368 | 0.0369 |
Echinococcus granulosus | peregrin | 0.0031 | 0.0853 | 0.0855 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.1106 | 0.3911 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0651 | 0.0652 |
Brugia malayi | Bromodomain containing protein | 0.0031 | 0.0853 | 0.0855 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.2109 | 0.2112 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0037 | 0.1106 | 0.1108 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0131 | 0.0463 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0029 | 0.0748 | 0.9601 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.9982 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0779 | 0.2754 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0651 | 0.0652 |
Giardia lamblia | PHD finger protein 15 | 0.0029 | 0.0748 | 0.5 |
Trypanosoma cruzi | ISWI complex protein | 0.0015 | 0.0131 | 1 |
Onchocerca volvulus | Alhambra homolog | 0.0029 | 0.0748 | 0.0104 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.105 | 0.1052 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0233 | 0.9982 | 1 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0209 | 0.0739 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0779 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1158 | 0.1161 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0651 | 0.0652 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1598 | 0.5649 |
Brugia malayi | jmjC domain containing protein | 0.0094 | 0.3702 | 0.3709 |
Echinococcus multilocularis | muscleblind protein | 0.0147 | 0.6103 | 0.6114 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0094 | 0.3702 | 0.3709 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0779 | 0.078 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0651 | 0.0652 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.0748 | 0.0749 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.1106 | 0.3911 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0046 | 0.1539 | 0.1541 |
Trypanosoma brucei | ISWI complex protein | 0.0015 | 0.0131 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0651 | 0.0652 |
Brugia malayi | jmjC domain containing protein | 0.0037 | 0.1106 | 0.1108 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0629 | 0.063 |
Onchocerca volvulus | 0.0047 | 0.1598 | 0.1013 | |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0233 | 0.9982 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.6103 | 0.6114 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0017 | 0.0209 | 0.0209 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.