Detailed information for compound 1552878

Basic information

Technical information
  • TDR Targets ID: 1552878
  • Name: 2-[3-oxo-1-[(E)-3-phenylprop-2-enyl]piperazin -2-yl]-N-(2-pyrazin-2-ylethyl)acetamide
  • MW: 379.456 | Formula: C21H25N5O2
  • H donors: 2 H acceptors: 4 LogP: 0.66 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CC1N(CCNC1=O)C/C=C/c1ccccc1)NCCc1cnccn1
  • InChi: 1S/C21H25N5O2/c27-20(24-9-8-18-16-22-10-11-23-18)15-19-21(28)25-12-14-26(19)13-4-7-17-5-2-1-3-6-17/h1-7,10-11,16,19H,8-9,12-15H2,(H,24,27)(H,25,28)/b7-4+
  • InChiKey: XFAPPMRUPNRXOW-QPJJXVBHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[3-oxo-1-[(E)-3-phenylprop-2-enyl]-2-piperazinyl]-N-[2-(2-pyrazinyl)ethyl]acetamide
  • 2-[3-keto-1-[(E)-3-phenylprop-2-enyl]piperazin-2-yl]-N-(2-pyrazin-2-ylethyl)acetamide
  • 2-[3-oxo-1-[(E)-3-phenylprop-2-enyl]piperazin-2-yl]-N-(2-pyrazin-2-ylethyl)ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus hyperpolarization activated cyclic 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Echinococcus granulosus voltage gated potassium channel 0.001 0.0057 0.0064
Brugia malayi olfactory channel protein osm-9 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Echinococcus multilocularis transient receptor potential cation channel 0.001 0.0057 0.0057
Brugia malayi Transient-receptor-potential like protein 0.001 0.0057 0.0064
Brugia malayi Patched family protein 0.0006 0.0008 0.0009
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.001 0.0057 0.0057
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0013 0.0096 0.0665
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0059 0.0345
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0057 0.0064
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.001 0.0057 0.0064
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.02 0.2498 0.2813
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Schistosoma mansoni hypothetical protein 0.0047 0.0532 0.0599
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0154 0.043
Echinococcus granulosus neuroligin 0.0118 0.1446 0.1628
Echinococcus multilocularis hyperpolarization activated cyclic 0.001 0.0057 0.0057
Schistosoma mansoni voltage-gated ion channel 0.001 0.0057 0.0064
Brugia malayi cation channel family protein 0.001 0.0057 0.0064
Echinococcus multilocularis transient receptor potential cation channel 0.001 0.0057 0.0057
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.001 0.0056 0.0063
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0059 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0059 0.0067
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0057 0.0064
Brugia malayi Myosin head containing protein 0.0006 0.0008 0.0009
Toxoplasma gondii transporter, cation channel family protein 0.001 0.0057 0.021
Loa Loa (eye worm) acetylcholinesterase 1 0.0698 0.8882 1
Brugia malayi Hemopexin family protein 0.0078 0.0934 0.1051
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0013 0.0096 0.0108
Brugia malayi topoisomerase 0.001 0.0056 0.0063
Schistosoma mansoni gliotactin 0.0118 0.1446 0.1628
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Onchocerca volvulus 0.0118 0.1446 0.9648
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.001 0.0057 0.0064
Brugia malayi AMP-binding enzyme family protein 0.0007 0.002 0.0023
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.2869 0.323
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.002 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1175 0.1323
Schistosoma mansoni dihydropteridine reductase 0.0013 0.0096 0.0108
Treponema pallidum DNA ligase (lig) 0.001 0.0056 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0642 0.0642
Echinococcus multilocularis protein dispatched 1 0.0047 0.0532 0.0532
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0059 0.0067
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0013 0.0096 1
Echinococcus granulosus transient receptor potential cation channel 0.001 0.0057 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0642 0.0723
Brugia malayi Patched family protein 0.0006 0.0008 0.0009
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.008 0.0965 0.1086
Brugia malayi Patched family protein 0.0006 0.0008 0.0009
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0059 0.0059
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.001 0.0057 0.021
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.001 0.0057 0.0064
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0118 0.1446 0.6203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0059 0.0067
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.001 0.0057 0.0064
Brugia malayi voltage-dependent calcium channel 0.001 0.0057 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0458 0.192
Loa Loa (eye worm) hypothetical protein 0.0023 0.0228 0.0257
Loa Loa (eye worm) oxidoreductase 0.0007 0.002 0.0023
Loa Loa (eye worm) hypothetical protein 0.0118 0.1446 0.1628
Echinococcus granulosus BC026374 protein S09 family 0.0118 0.1446 0.1628
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.001 0.0057 0.0057
Echinococcus granulosus short transient receptor potential channel 6 0.001 0.0057 0.0064
Echinococcus multilocularis short transient receptor potential channel 6 0.001 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Echinococcus granulosus FTZ F1 alpha 0.001 0.0059 0.0067
Loa Loa (eye worm) hypothetical protein 0.0698 0.8882 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0022 0.0022
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.001 0.0057 0.0064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0142 0.0576
Loa Loa (eye worm) voltage-dependent calcium channel 0.001 0.0057 0.0064
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.002 0.002
Brugia malayi Patched family protein 0.0006 0.0008 0.0009
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0228 1
Echinococcus multilocularis sodium channel protein 0.001 0.0057 0.0057
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0013 0.0096 0.0175
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.2869 0.2869
Echinococcus granulosus potassium voltage gated channel protein 0.001 0.0057 0.0064
Loa Loa (eye worm) carboxylesterase 0.0698 0.8882 1
Schistosoma mansoni topbp1 0.001 0.0056 0.0063
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.001 0.0057 0.0057
Loa Loa (eye worm) patched family protein 0.0006 0.0008 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0007 0.002 0.0023
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0437 0.0492
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.001 0.0057 0.0064
Mycobacterium tuberculosis Carboxylesterase LipT 0.0118 0.1446 0.6203
Entamoeba histolytica hypothetical protein 0.001 0.0056 0.0315
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Echinococcus granulosus dnaJ subfamily B 0.0396 0.5011 0.5642
Brugia malayi Patched family protein 0.0006 0.0008 0.0009
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0228 0.0902
Onchocerca volvulus 0.0007 0.002 0.0083
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0642 0.0723
Schistosoma mansoni vesicular amine transporter 0.001 0.0057 0.0064
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.001 0.0057 0.0064
Brugia malayi steroid hormone receptor 0.001 0.0059 0.0067
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.002 0.0023
Loa Loa (eye worm) hypothetical protein 0.0118 0.1446 0.1628
Entamoeba histolytica hypothetical protein 0.0035 0.038 0.3171
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0013 0.0096 0.0328
Echinococcus granulosus potassium voltage gated channel protein 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0096 0.0328
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0056 0.0179
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Echinococcus multilocularis TRP (transient receptor potential) channel 0.001 0.0057 0.0057
Echinococcus granulosus expressed conserved protein 0.009 0.1082 0.1218
Echinococcus multilocularis transient receptor potential cation channel 0.001 0.0057 0.0057
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0096 0.0328
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.002 0.0052
Loa Loa (eye worm) hypothetical protein 0.0007 0.002 0.0023
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0013 0.0096 0.0108
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0013 0.0096 0.0379
Echinococcus granulosus sodium leak channel non selective protein 0.001 0.0057 0.0064
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.001 0.0057 0.0064
Echinococcus granulosus potassium voltage gated channel subfamily D 0.001 0.0057 0.0064
Echinococcus multilocularis voltage gated hydrogen channel 1 0.001 0.0057 0.0057
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0228 0.0257
Loa Loa (eye worm) hypothetical protein 0.0118 0.1446 0.1628
Chlamydia trachomatis oxoacy-ACP reductase 0.0013 0.0096 0.0175
Echinococcus granulosus hypothetical protein 0.001 0.0057 0.0064
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0059 0.0059
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0056 0.4737
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0059 0.0067
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.005 0.0576 0.0649
Brugia malayi Patched related family protein 4 0.0006 0.0008 0.0009
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0056 0.0179
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0056 0.0179
Loa Loa (eye worm) matrixin family protein 0.0122 0.1498 0.1687
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0059 0.0059
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0059 0.0059
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0056 0.4737
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0059 0.0067
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0118 0.1446 0.6192
Schistosoma mansoni hypothetical protein 0.0078 0.0934 0.1051
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.001 0.0057 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0059 0.0067
Echinococcus multilocularis potassium large conductance calcium activated 0.001 0.0057 0.0057
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0059 0.0067
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Loa Loa (eye worm) calcium channel 0.001 0.0057 0.0064
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0056 0.0063
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0642 0.0723
Schistosoma mansoni hypothetical protein 0.0035 0.038 0.0428
Loa Loa (eye worm) hypothetical protein 0.0017 0.0154 0.0173
Schistosoma mansoni voltage-gated cation channel 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0067
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0013 0.0096 0.0379
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.001 0.0057 0.0064
Echinococcus granulosus para nitrobenzyl esterase 0.0118 0.1446 0.1628
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0096 0.0328
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.001 0.0057 0.0182
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0022 0.0025
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Echinococcus multilocularis short transient receptor potential channel 6 0.001 0.0057 0.0057
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0022 0.0022
Loa Loa (eye worm) patched family protein 0.0006 0.0008 0.0009
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0187 0.2326 1
Echinococcus granulosus potassium voltage gated channel subfamily C 0.001 0.0057 0.0064
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0096 0.0108
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0096 0.0328
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0057 0.0064
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0013 0.0096 0.0379
Brugia malayi Carboxylesterase family protein 0.0118 0.1446 0.1628
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0609 0.2594
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.001 0.0057 0.0057
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.002 0.0053
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.1156 1
Echinococcus granulosus potassium voltage gated channel subfamily A 0.001 0.0057 0.0064
Brugia malayi hypothetical protein 0.0035 0.038 0.0428
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0013 0.0096 0.0328
Echinococcus multilocularis ryanodine receptor 44f 0.001 0.0057 0.0057
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0059 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0059 0.0067
Loa Loa (eye worm) hypothetical protein 0.0118 0.1446 0.1628
Echinococcus granulosus calcium activated potassium channel 0.001 0.0057 0.0064
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0228 0.0257
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.002 0.0052
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.002 0.0024
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0013 0.0096 0.0328
Toxoplasma gondii hypothetical protein 0.001 0.0057 0.021
Brugia malayi Carboxylesterase family protein 0.0698 0.8882 1
Loa Loa (eye worm) retinol dehydrogenase 12 0.0013 0.0096 0.0108
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.002 0.0052
Brugia malayi CXXC zinc finger family protein 0.0028 0.029 0.0327
Echinococcus multilocularis potassium voltage gated channel protein 0.001 0.0057 0.0057
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0118 0.1446 0.1446
Brugia malayi hypothetical protein 0.0035 0.0388 0.0437
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.001 0.0057 0.0064
Onchocerca volvulus 0.0007 0.002 0.0083
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0022 0.0025
Schistosoma mansoni hypothetical protein 0.0039 0.0439 0.0495
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.001 0.0057 0.0064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0642 0.0642
Schistosoma mansoni hypothetical protein 0.0396 0.5011 0.5642
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0096 0.0328
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0059 0.0067
Loa Loa (eye worm) hypothetical protein 0.0067 0.0793 0.0893
Schistosoma mansoni 60S ribosomal protein L21 0.001 0.0057 0.0064
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0096 0.0328
Onchocerca volvulus 0.0118 0.1446 0.9648
Echinococcus granulosus potassium voltage gated channel subfamily D 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0059 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0059 0.0067
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.001 0.0057 0.0057
Onchocerca volvulus 0.0118 0.1446 0.9648
Echinococcus granulosus ryanodine receptor 44f 0.001 0.0057 0.0064
Brugia malayi DKFZp564C0469 protein 0.001 0.0056 0.0063
Mycobacterium tuberculosis Possible oxidoreductase 0.0013 0.0096 0.0378
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0057 0.0064
Mycobacterium ulcerans hydrolase 0.0067 0.0793 0.3351
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0056 0.4737
Echinococcus multilocularis expressed conserved protein 0.009 0.1082 0.1082
Entamoeba histolytica hypothetical protein 0.0035 0.038 0.3171
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0154 0.0579
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0096 0.0328
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.1156 0.1156
Echinococcus multilocularis voltage gated potassium channel 0.001 0.0057 0.0057
Brugia malayi Carboxylesterase family protein 0.0118 0.1446 0.1628
Loa Loa (eye worm) hypothetical protein 0.0118 0.1446 0.1628
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.069 0.0777
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0096 0.0328
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0057 0.0064
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.001 0.0057 0.0064
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0013 0.0096 0.3635
Echinococcus granulosus voltage dependent calcium channel 0.001 0.0057 0.0064
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0059 0.0345
Onchocerca volvulus 0.0078 0.0934 0.6214
Loa Loa (eye worm) oxidoreductase 0.0013 0.0096 0.0108
Schistosoma mansoni DNA ligase IV 0.001 0.0056 0.0063
Schistosoma mansoni patched 1 0.0041 0.0458 0.0516
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0044 0.0044
Loa Loa (eye worm) voltage-gated potassium channel 0.001 0.0057 0.0064
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0067
Loa Loa (eye worm) ryanodine receptor 0.001 0.0057 0.0064
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0057 0.0064
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.001 0.0057 0.0064
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0096 0.0108
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0056 0.0063
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0013 0.0096 1
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.001 0.0057 0.0064
Echinococcus granulosus shaker cognate 0.001 0.0057 0.0064
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0056 0.0063
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0096 0.0328
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.1156 0.1301
Loa Loa (eye worm) carboxylesterase 0.0118 0.1446 0.1628
Loa Loa (eye worm) hypothetical protein 0.0095 0.1156 0.1301
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0458 0.0516
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Echinococcus multilocularis two pore calcium channel protein 1 0.001 0.0057 0.0057
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0228 0.0902
Onchocerca volvulus 0.001 0.0057 0.0327
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.001 0.0057 0.0064
Mycobacterium leprae PROBABLE HYDROLASE 0.0067 0.0793 0.3351
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0059 0.0067
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Leishmania major hypothetical protein, unknown function 0.001 0.0057 0.1754
Loa Loa (eye worm) hypothetical protein 0.0698 0.8882 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0228 0.0902
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0059 0.0067
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0228 0.0902
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.001 0.0057 0.4825
Brugia malayi nuclear hormone receptor 0.001 0.0059 0.0067
Trichomonas vaginalis hypothetical protein 0.0187 0.2326 1
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.001 0.0057 0.4825
Schistosoma mansoni cpg binding protein 0.0029 0.0311 0.035
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0698 0.8882 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Schistosoma mansoni cpg binding protein 0.0029 0.0311 0.035
Onchocerca volvulus 0.0118 0.1446 0.9648
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0228 0.0949
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.5011 0.5011
Brugia malayi Patched family protein 0.0006 0.0008 0.0009
Brugia malayi hypothetical protein 0.0118 0.1446 0.1628
Trichomonas vaginalis spcc417.12 protein, putative 0.0118 0.1446 0.6192
Echinococcus granulosus acetylcholinesterase 0.0698 0.8882 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0154 0.0629
Loa Loa (eye worm) hypothetical protein 0.0007 0.002 0.0023
Onchocerca volvulus 0.0055 0.0639 0.4236
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Toxoplasma gondii transporter, cation channel family protein 0.001 0.0057 0.021
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.002 0.0052
Onchocerca volvulus 0.0028 0.029 0.1895
Schistosoma mansoni transient receptor potential channel 4 0.001 0.0057 0.0064
Plasmodium falciparum enoyl-acyl carrier reductase 0.0187 0.2326 1
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0056 0.0208
Brugia malayi ion channel NompC 0.001 0.0057 0.0064
Onchocerca volvulus 0.0047 0.0532 0.352
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0642 0.0723
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.002 0.0052
Onchocerca volvulus 0.0007 0.002 0.0083
Echinococcus multilocularis voltage dependent calcium channel 0.001 0.0057 0.0057
Leishmania major pteridine reductase 1 0.0013 0.0096 0.3635
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.002 0.0052
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Brugia malayi hypothetical protein 0.0006 0.0008 0.0009
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.001 0.0057 0.0057
Onchocerca volvulus 0.0023 0.0228 0.1478
Loa Loa (eye worm) voltage-gated calcium channel 0.001 0.0057 0.0064
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0096 0.0328
Brugia malayi Patched family protein 0.0006 0.0008 0.0009
Schistosoma mansoni hypothetical protein 0.0039 0.0439 0.0495
Echinococcus multilocularis conserved hypothetical protein 0.001 0.0057 0.0057
Echinococcus granulosus transient receptor potential cation channel 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0067
Trypanosoma brucei oxidoreductase-like protein 0.0013 0.0096 1
Loa Loa (eye worm) matrix metalloproteinase 0.0055 0.0639 0.0719
Echinococcus multilocularis acetylcholinesterase 0.0698 0.8882 0.8882
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0142 0.0576
Onchocerca volvulus 0.001 0.0056 0.0323
Mycobacterium ulcerans oxidoreductase 0.0013 0.0096 0.0328
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0059 0.0067
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0096 0.0378
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0096 0.0328
Brugia malayi nuclear receptor NHR-88 0.001 0.0059 0.0067
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0059 0.0067
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0187 0.2326 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0056 0.0063
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0013 0.0096 0.0328
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0228 0.0902
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0642 0.0723
Echinococcus granulosus transient receptor potential cation channel 0.001 0.0057 0.0064
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.002 0.0053
Loa Loa (eye worm) matrixin family protein 0.0133 0.1639 0.1845
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0059 0.0067
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0228 0.0902
Schistosoma mansoni thyroid hormone receptor 0.001 0.0059 0.0067
Brugia malayi Matrixin family protein 0.0055 0.0639 0.0719
Schistosoma mansoni topbp1 0.001 0.0056 0.0063
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0039 0.0437 0.1851
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.002 0.0053
Echinococcus multilocularis transient receptor potential gamma protein 0.001 0.0057 0.0057
Onchocerca volvulus 0.0118 0.1446 0.9648
Loa Loa (eye worm) hypothetical protein 0.001 0.0056 0.0063
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.001 0.0057 0.0057
Echinococcus multilocularis transient receptor potential cation channel 0.001 0.0057 0.0057
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0187 0.2326 1
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.001 0.0057 0.4825
Trypanosoma brucei pteridine reductase 1 0.0013 0.0096 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.038 0.0428
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0013 0.0096 0.0096
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0096 0.0328
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0059 0.0067
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0013 0.0096 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0639 0.0719
Brugia malayi cation channel family protein 0.001 0.0057 0.0064
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0057 0.0064
Schistosoma mansoni inositol 145-trisphosphate receptor 0.001 0.0057 0.0064
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0056 0.0315
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0059 0.0067
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0022 0.0025
Echinococcus granulosus carboxylesterase 5A 0.0698 0.8882 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.001 0.0057 0.0064
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0437 0.1851
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.002 0.0023
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0067
Onchocerca volvulus Matrix metalloproteinase homolog 0.0122 0.1498 1
Schistosoma mansoni transient receptor potential channel 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0056 0.0179
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.001 0.0057 0.0327
Echinococcus multilocularis transfer RNA-Gly 0.001 0.0057 0.0057
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0057 0.0064
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0013 0.0096 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0118 0.1446 0.1628
Echinococcus granulosus potassium voltage gated channel subfamily H 0.001 0.0057 0.0064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0228 0.0949
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Echinococcus granulosus two pore calcium channel protein 1 0.001 0.0057 0.0064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0142 0.0576
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0056 0.4737
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0437 0.0492
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0059 0.0059
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0013 0.0096 0.3635
Loa Loa (eye worm) hypothetical protein 0.001 0.0056 0.0063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0059 0.0067
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0059 0.0345
Brugia malayi Matrixin family protein 0.0055 0.0639 0.0719
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.002 0.0023
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0437 0.0492
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0013 0.0096 0.0328
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.001 0.0057 0.021
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0067
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0057 0.0064
Schistosoma mansoni nuclear hormone receptor 0.001 0.0059 0.0067
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.001 0.0057 0.0064
Brugia malayi hypothetical protein 0.001 0.0056 0.0063
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.001 0.0057 0.0064
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0118 0.1446 0.1628
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.001 0.0057 0.0064
Mycobacterium tuberculosis Possible oxidoreductase 0.0013 0.0096 0.0378
Loa Loa (eye worm) hypothetical protein 0.0118 0.1446 0.1628
Echinococcus multilocularis voltage dependent calcium channel 0.001 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0055 0.0639 0.0719
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0118 0.1446 0.6203
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0013 0.0096 0.0378
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0096 0.0328
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0096 0.0328
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0096 0.0328
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.002 0.0023
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0118 0.1446 0.1628
Brugia malayi hypothetical protein 0.0035 0.0388 0.0437
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.038 0.038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0059 0.0067
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0067 0.0793 0.3386
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.002 0.0052
Echinococcus granulosus acetylcholinesterase 0.0698 0.8882 1
Echinococcus multilocularis potassium voltage gated channel protein 0.001 0.0057 0.0057
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0059 0.0067
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.001 0.0057 0.0182
Schistosoma mansoni voltage-dependent calcium channel 0.001 0.0057 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0059 0.0067
Echinococcus multilocularis nibrin 0.001 0.0056 0.0056
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0228 1
Schistosoma mansoni transient receptor potential channel 0.001 0.0057 0.0064
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0437 0.0437
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0059 0.0067
Echinococcus multilocularis carboxylesterase 5A 0.0698 0.8882 0.8882
Echinococcus multilocularis cpg binding protein 0.0029 0.0311 0.0311
Echinococcus multilocularis para nitrobenzyl esterase 0.0118 0.1446 0.1446
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0044 0.005
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0154 0.0628
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0096 0.0378
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0056 0.0179
Echinococcus granulosus potassium voltage gated channel protein 0.001 0.0057 0.0064
Brugia malayi Patched family protein 0.0006 0.0008 0.0009
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0096 0.0328
Schistosoma mansoni neuroligin 3 (S09 family) 0.0118 0.1446 0.1628
Echinococcus multilocularis protein patched 0.0041 0.0458 0.0458
Leishmania major hypothetical protein, conserved 0.001 0.0057 0.1754
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0056 0.0155
Loa Loa (eye worm) patched family protein 0.0006 0.0008 0.0009
Giardia lamblia Replication factor C, subunit 1 0.001 0.0056 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0059 0.0067
Schistosoma mansoni coup transcription factor 0.001 0.0059 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0059 0.0067
Echinococcus granulosus sodium channel protein 0.001 0.0057 0.0064
Echinococcus granulosus potassium large conductance calcium activated 0.001 0.0057 0.0064
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.001 0.0057 0.0057
Echinococcus multilocularis BC026374 protein (S09 family) 0.0118 0.1446 0.1446
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.001 0.0057 0.0057
Brugia malayi Patched family protein 0.0006 0.0008 0.0009
Brugia malayi Patched related family protein 10 0.0006 0.0008 0.0009
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.002 0.0023
Echinococcus multilocularis voltage gated potassium channel 0.001 0.0057 0.0057
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0187 0.2326 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0154 0.0173
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0056 0.0208
Echinococcus multilocularis hyperpolarization activated cyclic 0.001 0.0057 0.0057
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.0055 0.0639 0.0719
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.002 0.0052
Entamoeba histolytica hypothetical protein 0.0035 0.038 0.3171
Echinococcus granulosus potassium voltage gated channel protein 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.0013 0.0096 0.0108
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0059 0.0067
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Echinococcus multilocularis neuroligin 0.0118 0.1446 0.1446
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.001 0.0057 0.0057
Echinococcus multilocularis transient receptor potential cation channel 0.001 0.0057 0.0057
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0096 0.0328
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0228 0.183
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.001 0.0057 0.0064
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0154 0.0629
Loa Loa (eye worm) hypothetical protein 0.0017 0.0154 0.0173
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.002 0.0024
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.168 0.1892
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0057 0.0064
Schistosoma mansoni transient receptor potential channel 0.001 0.0057 0.0064
Echinococcus granulosus cpg binding protein 0.0029 0.0311 0.035
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0056 0.0056
Echinococcus granulosus voltage gated potassium channel 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Echinococcus granulosus voltage gated hydrogen channel 1 0.001 0.0057 0.0064
Echinococcus granulosus cyclic nucleotide gated cation channel 0.001 0.0057 0.0064
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0096 0.0328
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0059 0.0067
Mycobacterium ulcerans carboxylesterase, LipT 0.0118 0.1446 0.6183
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0013 0.0096 0.0378
Brugia malayi Matrixin family protein 0.0055 0.0639 0.0719
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.001 0.0057 0.0064
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0532 0.0599
Mycobacterium tuberculosis Probable oxidoreductase 0.0013 0.0096 0.0378
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.001 0.0057 0.0327
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.001 0.0057 0.0057
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.002 0.0052
Brugia malayi Matrixin family protein 0.0055 0.0639 0.0719
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0013 0.0096 0.0108
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0056 0.0063
Leishmania major oxidoreductase-like protein 0.0013 0.0096 0.3635
Echinococcus multilocularis calcium activated potassium channel 0.001 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Echinococcus granulosus transient receptor potential cation channel 0.001 0.0057 0.0064
Brugia malayi AMP-binding enzyme family protein 0.0007 0.002 0.0023
Echinococcus granulosus voltage dependent calcium channel 0.001 0.0057 0.0064
Schistosoma mansoni hypothetical protein 0.0039 0.0439 0.0495
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0057 0.0064
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0437 0.1851
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.001 0.0057 0.0064
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0059 0.0067
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0228 0.183
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0013 0.0096 0.0328
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0067
Loa Loa (eye worm) ion channel NompC 0.001 0.0057 0.0064
Echinococcus granulosus short transient receptor potential channel 6 0.001 0.0057 0.0064
Loa Loa (eye worm) patched family protein 0.0006 0.0008 0.0009
Schistosoma mansoni acetylcholinesterase 0.0118 0.1446 0.1628
Brugia malayi hypothetical protein 0.0006 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0056 0.0063
Echinococcus granulosus transient receptor potential gamma protein 0.001 0.0057 0.0064
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0096 0.0328
Brugia malayi Patched related family protein 12 0.0006 0.0008 0.0009
Leishmania major calcium channel protein, putative,ion transporter, putative 0.001 0.0057 0.1754
Echinococcus multilocularis potassium voltage gated channel protein 0.001 0.0057 0.0057
Schistosoma mansoni calcium-activated potassium channel 0.001 0.0057 0.0064
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0118 0.1446 0.1628
Brugia malayi Carboxylesterase family protein 0.0698 0.8882 1
Loa Loa (eye worm) patched family protein 0.0006 0.0008 0.0009
Brugia malayi hypothetical protein 0.001 0.0056 0.0063
Brugia malayi Carboxylesterase family protein 0.0118 0.1446 0.1628
Echinococcus granulosus two pore calcium channel protein 2 0.001 0.0057 0.0064
Brugia malayi hypothetical protein 0.001 0.0057 0.0064
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Echinococcus granulosus potassium voltage gated channel protein 0.001 0.0057 0.0064
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.02 0.2498 0.2498
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.001 0.0057 0.0064
Echinococcus multilocularis shaker cognate 0.001 0.0057 0.0057
Echinococcus multilocularis two pore calcium channel protein 2 0.001 0.0057 0.0057
Onchocerca volvulus 0.0013 0.0096 0.059
Entamoeba histolytica hypothetical protein 0.0035 0.038 0.3171
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.002 0.0053
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Echinococcus granulosus replication factor c subunit 1 0.001 0.0056 0.0063
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0228 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0228 0.0902
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0056 0.0179
Echinococcus granulosus transient receptor potential cation channel 0.001 0.0057 0.0064
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.0023 0.0228 0.0257
Brugia malayi ecdysteroid receptor 0.001 0.0059 0.0067
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.002 0.0052
Loa Loa (eye worm) hypothetical protein 0.0039 0.0437 0.0492
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0096 0.0328
Brugia malayi AMP-binding enzyme family protein 0.0007 0.002 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0059 0.0067
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.029 0.0327
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0059 0.0067
Brugia malayi Patched family protein 0.0006 0.0008 0.0009
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0057 0.0064
Schistosoma mansoni two-pore calcium channel 0.001 0.0057 0.0064
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0228 0.183
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Loa Loa (eye worm) carboxylesterase 0.0118 0.1446 0.1628
Schistosoma mansoni hypothetical protein 0.0039 0.0437 0.0492
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0096 0.0328
Brugia malayi Matrixin family protein 0.0133 0.1639 0.1845
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0067
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.002 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0059 0.0067
Onchocerca volvulus Matrilysin homolog 0.0055 0.0639 0.4236
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0059 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0059 0.0067
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0056 0.0208
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0096 0.0328
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.001 0.0057 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0059 0.0067
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0059 0.0067
Brugia malayi protein C24B5.3 0.0006 0.0008 0.0009
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.001 0.0057 0.0064
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0059 0.0059
Echinococcus multilocularis acetylcholinesterase 0.0698 0.8882 0.8882
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.001 0.0057 0.0064
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0187 0.2326 1
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Schistosoma mansoni BC026374 protein (S09 family) 0.0118 0.1446 0.1628
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Onchocerca volvulus 0.0007 0.002 0.0083
Brugia malayi Patched family protein 0.0006 0.0008 0.0009
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.001 0.0057 0.0064
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0642 0.0723
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0013 0.0096 0.3635
Onchocerca volvulus Matrilysin homolog 0.0122 0.1498 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0458 0.0516
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.168 0.168
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0096 0.0328
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0059 0.0067
Echinococcus multilocularis sodium leak channel non selective protein 0.001 0.0057 0.0057
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.1156 0.1301
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0013 0.0096 0.0379
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0458 0.0516
Schistosoma mansoni survival motor neuron protein 0.0047 0.0532 0.0599
Echinococcus granulosus TRP transient receptor potential channel 0.001 0.0057 0.0064
Toxoplasma gondii propionate-CoA ligase 0.0007 0.002 0.0053
Echinococcus multilocularis potassium voltage gated channel protein 0.001 0.0057 0.0057
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0187 0.2326 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0056 0.0179
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0228 0.0902
Loa Loa (eye worm) hypothetical protein 0.0023 0.0228 0.0257
Schistosoma mansoni cpg binding protein 0.0028 0.029 0.0327
Schistosoma mansoni ryanodine receptor related 0.001 0.0057 0.0064
Brugia malayi Patched family protein 0.0006 0.0008 0.0009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0059 0.0067
Brugia malayi CHE-14 protein 0.0041 0.0458 0.0516
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0228 0.0902
Brugia malayi Patched family protein 0.0006 0.0008 0.0009
Brugia malayi Carboxylesterase family protein 0.0118 0.1446 0.1628
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.001 0.0057 0.0057
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0056 0.0155
Brugia malayi hypothetical protein 0.0006 0.0008 0.0009
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0013 0.0096 0.0378
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0057 0.0064
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0187 0.2326 1
Echinococcus granulosus hyperpolarization activated cyclic 0.001 0.0057 0.0064
Echinococcus granulosus cyclic nucleotide gated cation channel 0.001 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.0017 0.0154 0.0173
Loa Loa (eye worm) hypothetical protein 0.001 0.0059 0.0067
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0056 0.0179
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.001 0.0057 0.0057
Toxoplasma gondii transporter, cation channel family protein 0.001 0.0057 0.021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0142 0.0576
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0096 0.0378
Schistosoma mansoni hypothetical protein 0.0039 0.0439 0.0495
Loa Loa (eye worm) hypothetical protein 0.001 0.0057 0.0064
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0067 0.0793 0.0893
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0055 0.0639 0.0719
Toxoplasma gondii hypothetical protein 0.001 0.0057 0.021
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.001 0.0057 0.0064
Schistosoma mansoni thyroid hormone receptor 0.001 0.0059 0.0067
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0059 0.0067
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.038 0.0428
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0096 0.0328
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0458 0.0516
Echinococcus granulosus potassium voltage gated channel subfamily H 0.001 0.0057 0.0064
Echinococcus granulosus nibrin 0.001 0.0056 0.0063
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0056 0.4737
Brugia malayi protein C24B5.3 0.0006 0.0008 0.0009
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0044 0.005
Brugia malayi hypothetical protein 0.0006 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0154 0.0173
Brugia malayi hypothetical protein 0.0229 0.2869 0.323
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0056 0.0208
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.001 0.0057 0.0064
Schistosoma mansoni hypothetical protein 0.001 0.0057 0.0064
Echinococcus multilocularis transient receptor potential cation channel 0.001 0.0057 0.0057
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0059 0.0067
Onchocerca volvulus 0.0013 0.0096 0.059
Brugia malayi Patched family protein 0.0006 0.0008 0.0009
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.001 0.0057 0.0057
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0458 0.0458
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0057 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0642 0.0723
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.001 0.0057 0.0064
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.001 0.0057 0.4825
Loa Loa (eye worm) voltage-gated potassium channel 0.001 0.0057 0.0064
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0013 0.0096 0.0379
Echinococcus granulosus potassium voltage gated channel subfamily D 0.001 0.0057 0.0064
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0043 0.0048
Loa Loa (eye worm) hypothetical protein 0.0229 0.2869 0.323
Brugia malayi Patched protein homolog 1 0.0006 0.0008 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0056 0.0179
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.001 0.0057 0.0064
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0228 0.0257
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.001 0.0057 0.0064
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0057 0.0064
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0096 0.0328
Brugia malayi Cyclic-nucleotide gated cation channel 0.001 0.0057 0.0064
Mycobacterium ulcerans hypothetical protein 0.0023 0.0228 0.0902
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0056 0.0179
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0057 0.0064
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.001 0.0057 0.0064
Echinococcus granulosus transient receptor potential cation channel 0.001 0.0057 0.0064
Brugia malayi Patched family protein 0.0006 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0009
Onchocerca volvulus 0.001 0.0059 0.0345
Loa Loa (eye worm) hypothetical protein 0.0118 0.1446 0.1628

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4654 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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