Detailed information for compound 1552889

Basic information

Technical information
  • TDR Targets ID: 1552889
  • Name: 4-methoxy-3-nitro-N-[4-(tetrazol-1-yl)phenyl] benzenesulfonamide
  • MW: 376.347 | Formula: C14H12N6O5S
  • H donors: 1 H acceptors: 7 LogP: 1.55 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1[N+](=O)[O-])S(=O)(=O)Nc1ccc(cc1)n1cnnn1
  • InChi: 1S/C14H12N6O5S/c1-25-14-7-6-12(8-13(14)20(21)22)26(23,24)16-10-2-4-11(5-3-10)19-9-15-17-18-19/h2-9,16H,1H3
  • InChiKey: HBBVCYZXJUSUAO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-methoxy-3-nitro-N-[4-(1-tetrazolyl)phenyl]benzenesulfonamide
  • 4-methoxy-3-nitro-N-[4-(1,2,3,4-tetrazol-1-yl)phenyl]benzenesulfonamide
  • T5356839

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.011 0.1194 0.1394
Echinococcus granulosus acetylcholinesterase 0.0648 0.8103 0.9557
Onchocerca volvulus Chorion peroxidase homolog 0.0054 0.0484 0.1026
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0484 0.0583
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0031 0.0189 0.0207
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0321 0.0308
Loa Loa (eye worm) hypothetical protein 0.0054 0.0484 0.0583
Brugia malayi hypothetical protein 0.0035 0.0242 0.0283
Loa Loa (eye worm) hypothetical protein 0.011 0.1194 0.1461
Onchocerca volvulus 0.011 0.1194 0.2575
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1561 0.1549
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0088 0.5
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.019 0.2225 0.916
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0093
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Echinococcus granulosus carboxylesterase 5A 0.0648 0.8103 0.9557
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.019 0.2225 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0484 0.0583
Onchocerca volvulus 0.011 0.1194 0.2575
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0169 0.1957 0.2296
Onchocerca volvulus Matrilysin homolog 0.0169 0.1957 0.424
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0396 0.0473
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0498 0.0572
Brugia malayi Protein kinase domain containing protein 0.0031 0.0187 0.0215
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.011 0.1194 0.1394
Loa Loa (eye worm) hypothetical protein 0.0054 0.0484 0.0583
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0088 0.0361
Echinococcus multilocularis para nitrobenzyl esterase 0.011 0.1194 0.1182
Loa Loa (eye worm) hypothetical protein 0.0097 0.1029 0.1256
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Brugia malayi Carboxylesterase family protein 0.011 0.1194 0.1459
Plasmodium falciparum enoyl-acyl carrier reductase 0.019 0.2225 1
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1561 0.1828
Schistosoma mansoni hypothetical protein 0.004 0.0302 0.0341
Loa Loa (eye worm) hypothetical protein 0.0054 0.0484 0.0583
Brugia malayi Uncoordinated protein 44 0.0031 0.0187 0.0215
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0088 0.0092
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0615 0.767 0.7667
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.011 0.1194 0.4915
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0088 0.5
Brugia malayi Matrixin family protein 0.0169 0.1957 0.2402
Echinococcus granulosus microtubule associated protein 2 0.0678 0.8479 1
Schistosoma mansoni BC026374 protein (S09 family) 0.011 0.1194 0.1394
Echinococcus multilocularis netrin receptor unc 5 0.0031 0.0187 0.0174
Onchocerca volvulus Matrilysin homolog 0.0375 0.4597 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0498 0.0572
Loa Loa (eye worm) carboxylesterase 0.011 0.1194 0.1461
Brugia malayi Carboxylesterase family protein 0.0648 0.8103 1
Echinococcus multilocularis Ankyrin 0.0031 0.0189 0.0176
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0484 0.0583
Mycobacterium ulcerans hydrolase 0.0206 0.2429 1
Loa Loa (eye worm) hypothetical protein 0.011 0.1194 0.1461
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0088 0.0312
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0304 0.3684 0.3675
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0012 0.005
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0484 0.0583
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0088 0.0312
Echinococcus granulosus netrin receptor unc 5 0.0031 0.0187 0.0205
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0088 0.0312
Entamoeba histolytica hypothetical protein 0.0035 0.0242 0.1641
Echinococcus multilocularis expressed conserved protein 0.0091 0.0954 0.0941
Onchocerca volvulus Peroxidasin homolog 0.0054 0.0484 0.1026
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0484 0.0581
Loa Loa (eye worm) hypothetical protein 0.0054 0.0484 0.0583
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0187 0.0215
Echinococcus granulosus geminin 0.0166 0.1923 0.2255
Brugia malayi Carboxylesterase family protein 0.011 0.1194 0.1459
Brugia malayi Carboxylesterase family protein 0.011 0.1194 0.1459
Loa Loa (eye worm) hypothetical protein 0.011 0.1194 0.1461
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0088 0.0312
Brugia malayi Matrixin family protein 0.0169 0.1957 0.2402
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0088 0.0312
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0498 0.06
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.1029 0.1199
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0498 0.0572
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0093
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0206 0.2429 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0088 0.0092
Echinococcus granulosus peroxidasin 0.0054 0.0484 0.0556
Trichomonas vaginalis hypothetical protein 0.019 0.2225 1
Schistosoma mansoni patched 1 0.0041 0.0321 0.0363
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0417 0.05
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0242 0.027
Entamoeba histolytica hypothetical protein 0.0035 0.0242 0.1641
Loa Loa (eye worm) hypothetical protein 0.0232 0.2767 0.3404
Schistosoma mansoni hypothetical protein 0.0033 0.0218 0.0242
Echinococcus granulosus nuclear factor of activated T cells 5 0.0304 0.3684 0.4336
Mycobacterium ulcerans hypothetical protein 0.0023 0.0088 0.0312
Brugia malayi hypothetical protein 0.011 0.1194 0.1459
Onchocerca volvulus Peroxidase homolog 0.0054 0.0484 0.1026
Echinococcus granulosus neuroligin 0.011 0.1194 0.1394
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Onchocerca volvulus Netrin receptor homolog 0.0031 0.0187 0.0379
Onchocerca volvulus 0.0169 0.1957 0.424
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.019 0.2225 0.9156
Echinococcus granulosus acetylcholinesterase 0.0648 0.8103 0.9557
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0417 0.0498
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.011 0.1194 0.1394
Brugia malayi Matrixin family protein 0.0169 0.1957 0.2402
Onchocerca volvulus 0.0054 0.0484 0.1026
Onchocerca volvulus Neurogenic locus notch homolog 0.0018 0.0015 0.0003
Schistosoma mansoni acetylcholinesterase 0.011 0.1194 0.1394
Loa Loa (eye worm) carboxylesterase 0.0648 0.8103 1
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0615 0.767 0.9045
Loa Loa (eye worm) hypothetical protein 0.0033 0.0218 0.0255
Onchocerca volvulus Peroxidase homolog 0.0054 0.0484 0.1026
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0648 0.8103 0.9557
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.019 0.2225 1
Brugia malayi Death domain containing protein 0.0031 0.0187 0.0215
Echinococcus granulosus Ankyrin 0.0031 0.0189 0.0207
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Schistosoma mansoni hypothetical protein 0.0166 0.1923 0.2255
Brugia malayi Peroxidasin 0.0054 0.0484 0.0581
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0484 0.0581
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0498 0.0598
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.2767 0.3252
Loa Loa (eye worm) matrix metalloproteinase 0.0169 0.1957 0.2403
Brugia malayi notch-like transmembrane receptor 0.0018 0.0014 0.000000079988
Echinococcus multilocularis neurogenic locus notch protein 0.0018 0.0014 0.000000064797
Onchocerca volvulus 0.011 0.1194 0.2575
Loa Loa (eye worm) hypothetical protein 0.011 0.1194 0.1461
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.019 0.2225 0.9128
Brugia malayi hypothetical protein 0.0148 0.1692 0.2075
Echinococcus granulosus death domain containing protein 0.0031 0.0187 0.0205
Echinococcus multilocularis acetylcholinesterase 0.0648 0.8103 0.8101
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0088 0.0312
Echinococcus multilocularis BC026374 protein (S09 family) 0.011 0.1194 0.1182
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Plasmodium vivax enoyl-acyl carrier protein reductase 0.019 0.2225 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0484 0.0583
Schistosoma mansoni neuroligin 3 (S09 family) 0.011 0.1194 0.1394
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0206 0.2429 0.2986
Onchocerca volvulus 0.0023 0.0088 0.0162
Loa Loa (eye worm) hypothetical protein 0.0054 0.0484 0.0583
Brugia malayi Carboxylesterase family protein 0.011 0.1194 0.1459
Onchocerca volvulus 0.011 0.1194 0.2575
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0218 0.0253
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Brugia malayi CHE-14 protein 0.0041 0.0321 0.038
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0484 0.0583
Echinococcus granulosus para nitrobenzyl esterase 0.011 0.1194 0.1394
Onchocerca volvulus 0.0054 0.0484 0.1026
Loa Loa (eye worm) Notch2 0.0018 0.0014 0.0002
Loa Loa (eye worm) hypothetical protein 0.0148 0.1692 0.2076
Schistosoma mansoni survival motor neuron protein 0.0047 0.0396 0.0452
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0484 0.0581
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Mycobacterium ulcerans carboxylesterase, LipT 0.011 0.1194 0.4889
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0321 0.0363
Echinococcus multilocularis acetylcholinesterase 0.0648 0.8103 0.8101
Loa Loa (eye worm) hypothetical protein 0.0054 0.0484 0.0583
Schistosoma mansoni ankyrin 23/unc44 0.0031 0.0187 0.0205
Loa Loa (eye worm) hypothetical protein 0.0049 0.0417 0.05
Loa Loa (eye worm) hypothetical protein 0.011 0.1194 0.1461
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Brugia malayi Matrixin family protein 0.0169 0.1957 0.2402
Onchocerca volvulus Matrix metalloproteinase homolog 0.0375 0.4597 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0648 0.8103 1
Schistosoma mansoni hypothetical protein 0.0031 0.0187 0.0205
Loa Loa (eye worm) hypothetical protein 0.0169 0.1957 0.2403
Loa Loa (eye worm) hypothetical protein 0.0054 0.0484 0.0583
Loa Loa (eye worm) hypothetical protein 0.0054 0.0484 0.0583
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.011 0.1194 0.4915
Schistosoma mansoni notch 0.0018 0.0015 0.0002
Onchocerca volvulus Peroxidasin homolog 0.0054 0.0484 0.1026
Schistosoma mansoni hypothetical protein 0.0166 0.1923 0.2255
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0187 0.0217
Schistosoma mansoni hypothetical protein 0.004 0.0302 0.0341
Onchocerca volvulus 0.011 0.1194 0.2575
Loa Loa (eye worm) hypothetical protein 0.0648 0.8103 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0441 0.053
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0247 0.2957 0.3477
Loa Loa (eye worm) hypothetical protein 0.0169 0.1957 0.2403
Loa Loa (eye worm) hypothetical protein 0.0031 0.0187 0.0217
Loa Loa (eye worm) notch protein 0.0018 0.0014 0.0002
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.019 0.2225 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0498 0.0572
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0031 0.0187 0.0174
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.1029 0.1017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Schistosoma mansoni hypothetical protein 0.0047 0.0396 0.0452
Loa Loa (eye worm) hypothetical protein 0.0054 0.0484 0.0583
Onchocerca volvulus 0.0148 0.1692 0.3662
Mycobacterium tuberculosis Carboxylesterase LipT 0.011 0.1194 0.4915
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0088 0.5
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0018 0.0014 0.00000014119
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0321 0.0382
Schistosoma mansoni hypothetical protein 0.024 0.2863 0.3366
Schistosoma mansoni hypothetical protein 0.004 0.0302 0.0341
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Echinococcus granulosus expressed conserved protein 0.0091 0.0954 0.1111
Loa Loa (eye worm) hypothetical protein 0.0206 0.2429 0.2987
Echinococcus multilocularis protein dispatched 1 0.0047 0.0396 0.0383
Echinococcus multilocularis neuroligin 0.011 0.1194 0.1182
Schistosoma mansoni hypothetical protein 0.004 0.0302 0.0341
Loa Loa (eye worm) blistered cuticle protein 3 0.0054 0.0484 0.0583
Schistosoma mansoni peroxidasin 0.0054 0.0484 0.0556
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Echinococcus granulosus neurogenic locus notch protein 0.0018 0.0014 0.000000076443
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0498 0.0485
Loa Loa (eye worm) hypothetical protein 0.0031 0.0189 0.0218
Giardia lamblia High cysteine protein 0.0018 0.0014 0.5
Schistosoma mansoni microtubule-associated protein tau 0.0678 0.8479 1
Brugia malayi Matrixin family protein 0.0409 0.503 0.6201
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0498 0.0485
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.1048 0.1222
Loa Loa (eye worm) hypothetical protein 0.0054 0.0484 0.0583
Brugia malayi hypothetical protein 0.0232 0.2767 0.3403
Entamoeba histolytica hypothetical protein 0.0035 0.0242 0.1641
Loa Loa (eye worm) matrixin family protein 0.0409 0.503 0.6202
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0031 0.0187 0.0205
Schistosoma mansoni gliotactin 0.011 0.1194 0.1394
Loa Loa (eye worm) hypothetical protein 0.011 0.1194 0.1461
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.1029 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0484 0.0583
Brugia malayi hypothetical protein 0.0054 0.0484 0.0581
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0002
Loa Loa (eye worm) matrixin family protein 0.0375 0.4597 0.5666
Onchocerca volvulus 0.0054 0.0484 0.1026
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0088 0.0092
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0484 0.0581
Entamoeba histolytica hypothetical protein 0.0035 0.0242 0.1641
Loa Loa (eye worm) carboxylesterase 0.011 0.1194 0.1461
Onchocerca volvulus 0.024 0.2863 0.6216
Loa Loa (eye worm) hypothetical protein 0.0648 0.8103 1
Echinococcus multilocularis carboxylesterase 5A 0.0648 0.8103 0.8101
Schistosoma mansoni hypothetical protein 0.0035 0.0242 0.027
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0088 0.0312
Loa Loa (eye worm) hypothetical protein 0.011 0.1194 0.1461
Brugia malayi Carboxylesterase family protein 0.0648 0.8103 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0484 0.0583
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0242 0.027
Loa Loa (eye worm) hypothetical protein 0.0169 0.1957 0.2403
Schistosoma mansoni netrin receptor unc5 0.0031 0.0187 0.0205
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0242 0.0229
Onchocerca volvulus Dual oxidase homolog 0.0054 0.0484 0.1026
Echinococcus multilocularis protein patched 0.0041 0.0321 0.0308
Loa Loa (eye worm) hypothetical protein 0.0041 0.0321 0.0382
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.011 0.1194 0.1182
Echinococcus granulosus family S9 non peptidase ue S09 family 0.011 0.1194 0.1394
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0321 0.0363
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0417 0.0498
Echinococcus multilocularis microtubule associated protein 2 0.0678 0.8479 0.8477
Brugia malayi Blistered cuticle protein 3 0.0054 0.0484 0.0581
Onchocerca volvulus 0.0047 0.0396 0.0835
Mycobacterium leprae PROBABLE HYDROLASE 0.0206 0.2429 1
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.2767 0.2757
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0484 0.0581
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.1029 0.1255
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0088 0.0361
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0093
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.011 0.1194 0.4584
Echinococcus multilocularis peroxidasin 0.0054 0.0484 0.0471
Echinococcus multilocularis geminin 0.0166 0.1923 0.1912
Brugia malayi EGF-like domain containing protein 0.0018 0.0014 0.000000079988
Trichomonas vaginalis spcc417.12 protein, putative 0.011 0.1194 0.4584
Echinococcus granulosus BC026374 protein S09 family 0.011 0.1194 0.1394
Brugia malayi Hemopexin family protein 0.024 0.2863 0.3522
Schistosoma mansoni peroxidasin 0.0054 0.0484 0.0556
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0498 0.0572

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.