Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | aurora B kinase, putative | 0.011 | 1 | 1 |
Entamoeba histolytica | protein kinase , putative | 0.011 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6127 | 0.6127 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6127 | 0.6127 |
Echinococcus multilocularis | aurora kinase A | 0.011 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.011 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.011 | 1 | 1 |
Echinococcus granulosus | aurora kinase A | 0.011 | 1 | 1 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.011 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.011 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.011 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.6127 | 0.6127 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0 | 0.5 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.011 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6127 | 0.6127 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.6127 | 0.6127 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.011 | 1 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.011 | 1 | 1 |
Giardia lamblia | Aurora kinase | 0.011 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.6127 | 0.6127 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.6127 | 0.6127 |
Brugia malayi | serine/threonine kinase 12 | 0.011 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.011 | 1 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.011 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.011 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6127 | 0.6127 |
Trichomonas vaginalis | AGC family protein kinase | 0.011 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.011 | 1 | 1 |
Toxoplasma gondii | aurora kinase | 0.011 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.011 | 1 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.011 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.6127 | 0.6127 |
Trypanosoma brucei | aurora B kinase | 0.011 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.6127 | 0.6127 |
Trichomonas vaginalis | AGC family protein kinase | 0.011 | 1 | 1 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.011 | 1 | 1 |
Leishmania major | protein kinase, putative | 0.011 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.6127 | 0.6127 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.6127 | 0.6127 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.011 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.011 | 1 | 1 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.011 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.6127 | 0.6127 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1259 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 26.6795 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.