Detailed information for compound 1553053

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 329.225 | Formula: C12H6Cl2N2OS2
  • H donors: 1 H acceptors: 2 LogP: 4.82 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)sc(n2)NC(=O)c1sccc1Cl
  • InChi: 1S/C12H6Cl2N2OS2/c13-6-1-2-8-9(5-6)19-12(15-8)16-11(17)10-7(14)3-4-18-10/h1-5H,(H,15,16,17)
  • InChiKey: JIFQARCSCBNIIB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SUMO1/sentrin specific peptidase 7 Starlite/ChEMBL No references
Homo sapiens SUMO/sentrin specific peptidase family member 8 Starlite/ChEMBL No references
Homo sapiens SUMO1/sentrin specific peptidase 6 Starlite/ChEMBL No references
Homo sapiens caspase 3, apoptosis-related cysteine peptidase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
Candida albicans one of three potential ubiquitin-like protein-specific protease genes Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_131076 All targets in OG5_131076
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma mansoni family C48 unassigned peptidase (C48 family) Get druggable targets OG5_131076 All targets in OG5_131076
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus sentrin specific protease 8 Get druggable targets OG5_129942 All targets in OG5_129942
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase Get druggable targets OG5_129942 All targets in OG5_129942
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis sentrin specific protease 8 Get druggable targets OG5_129942 All targets in OG5_129942
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_129942 All targets in OG5_129942
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus granulosus sentrin specific protease 7 Get druggable targets OG5_131076 All targets in OG5_131076
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_131076 All targets in OG5_131076
Trichomonas vaginalis Sentrin-specific protease, putative Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Loa Loa (eye worm) Ulp1 protease Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase Get druggable targets OG5_129942 All targets in OG5_129942
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma mansoni family C48 unassigned peptidase (C48 family) Get druggable targets OG5_129942 All targets in OG5_129942
Schistosoma japonicum ko:K08596 sentrin-specific protease 7, putative Get druggable targets OG5_131076 All targets in OG5_131076
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_129942 All targets in OG5_129942
Neospora caninum hypothetical protein Get druggable targets OG5_129942 All targets in OG5_129942
Candida albicans one of three potential ubiquitin-like protein-specific protease genes Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum ko:K08597 sentrin-specific protease 8, putative Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus multilocularis sentrin specific protease 7 Get druggable targets OG5_131076 All targets in OG5_131076
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_131076 All targets in OG5_131076
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cell death protein 3 precursor caspase 3, apoptosis-related cysteine peptidase 277 aa 253 aa 38.7 %
Plasmodium falciparum sentrin-specific protease 1 SUMO/sentrin specific peptidase family member 8 212 aa 197 aa 23.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0173 0.088 1
Echinococcus granulosus delta-like protein 1 0.0076 0.0327 0.0814
Schistosoma mansoni microtubule-associated protein tau 0.072 0.4015 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0063 0.0255 0.2894
Brugia malayi steroid hormone receptor 0.0032 0.0074 0.0228
Echinococcus multilocularis neurogenic locus notch protein 0.0076 0.0327 0.0327
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0133 0.0331
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0069 0.0244
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0266 0.0662
Echinococcus multilocularis neurogenic locus notch protein 4 0.0076 0.0327 0.0327
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.0489 0.1219
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0275 0.0846
Brugia malayi EGF-like domain containing protein 0.0076 0.0327 0.1003
Schistosoma mansoni jumonji/arid domain-containing protein 0.0123 0.0598 0.149
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Brugia malayi EGF-like domain containing protein 0.0076 0.0327 0.1003
Echinococcus multilocularis protein jagged 2 0.0076 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0053 0.0194 0.0597
Leishmania major phosphoglycerate kinase B, cytosolic 0.0173 0.088 1
Trypanosoma brucei phosphoglycerate kinase 0.0173 0.088 1
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0074 0.0185
Echinococcus multilocularis JmjC domain containing protein 4 0.0033 0.008 0.008
Loa Loa (eye worm) animal heme peroxidase 0.0588 0.3257 1
Schistosoma mansoni notch 0.0076 0.0327 0.0814
Schistosoma mansoni jumonji/arid domain-containing protein 0.0123 0.0598 0.149
Giardia lamblia Sentrin specific protease, putative 0.0047 0.0159 0.0965
Onchocerca volvulus Huntingtin homolog 0.0257 0.1363 0.4053
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0144 0.0443
Echinococcus multilocularis phosphoglycerate kinase 1 0.0173 0.088 0.088
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0069 0.0417
Brugia malayi ecdysteroid receptor 0.0032 0.0074 0.0228
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0173 0.088 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0074 0.0228
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0111 0.0529 0.1625
Onchocerca volvulus Peroxidase homolog 0.0588 0.3257 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0074 0.0074
Schistosoma mansoni septate junction protein 0.0076 0.0327 0.0814
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0111 0.0529 0.1667
Onchocerca volvulus 0.0076 0.0327 0.0798
Loa Loa (eye worm) hypothetical protein 0.0044 0.0144 0.0443
Brugia malayi Animal haem peroxidase family protein 0.0588 0.3257 1
Onchocerca volvulus Cell death protein 3 homolog 0.0032 0.0075 0.0009
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0074 0.0185
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0133 0.0331
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.004 0.0458
Loa Loa (eye worm) hypothetical protein 0.0177 0.0904 0.2777
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0547 0.1362
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0074 0.0185
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0074 0.0005
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.0547 0.1594
Echinococcus granulosus microtubule associated protein 2 0.072 0.4015 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0074 0.0074
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0063 0.0255 0.2894
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0074 0.0228
Echinococcus multilocularis sentrin specific protease 8 0.0111 0.0529 0.0529
Brugia malayi Cadherin domain containing protein 0.0076 0.0327 0.1003
Schistosoma mansoni hypothetical protein 0.0043 0.0135 0.0337
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.0733 0.0733
Echinococcus multilocularis sentrin specific protease 7 0.021 0.1091 0.1091
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1653 0.5207
Brugia malayi Calcium binding EGF domain containing protein 0.0076 0.0327 0.1003
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.021 0.1091 0.6601
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0075 0.0238
Brugia malayi jmjC domain containing protein 0.0033 0.008 0.0246
Onchocerca volvulus Putative cubilin 0.0076 0.0327 0.0798
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0049 0.0552
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0074 0.0228
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0547 0.3308
Giardia lamblia Phosphoglycerate kinase 0.0173 0.088 0.5326
Loa Loa (eye worm) hypothetical protein 0.0033 0.008 0.0246
Loa Loa (eye worm) hypothetical protein 0.0588 0.3257 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.048 0.048
Onchocerca volvulus 0.0097 0.0449 0.1182
Loa Loa (eye worm) blistered cuticle protein 3 0.0588 0.3257 1
Loa Loa (eye worm) hypothetical protein 0.0257 0.1363 0.4185
Echinococcus granulosus geminin 0.0527 0.2911 0.725
Trypanosoma cruzi metacaspase, putative 0.0032 0.0075 0.0856
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.0547 0.0547
Loa Loa (eye worm) animal heme peroxidase 0.0588 0.3257 1
Plasmodium falciparum metacaspase 1 0.0032 0.0075 0.0322
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0212 0.1104 0.3389
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0547 0.1362
Loa Loa (eye worm) hypothetical protein 0.0032 0.0074 0.0228
Loa Loa (eye worm) hypothetical protein 0.0588 0.3257 1
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0547 0.1723
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0205 0.1065 0.3269
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0097 0.0449 0.1379
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0 0.0002
Brugia malayi notch-like transmembrane receptor 0.0076 0.0327 0.1003
Plasmodium vivax phosphoglycerate kinase, putative 0.0173 0.088 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0074 0.0185
Loa Loa (eye worm) hypothetical protein 0.0033 0.008 0.0246
Onchocerca volvulus 0.0076 0.0327 0.0798
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0074 0.0074
Schistosoma mansoni notch 0.0076 0.0327 0.0814
Treponema pallidum fructose-bisphosphate aldolase 0.0308 0.1653 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0266 0.0662
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0074 0.0185
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0159 0.049
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0075 0.0238
Brugia malayi Calcitonin receptor-like protein seb-1 0.0212 0.1104 0.3389
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0074 0.0228
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0069 0.0244
Plasmodium vivax JmjC domain containing protein 0.0033 0.008 0.0381
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0255 0.2894
Loa Loa (eye worm) Ulp1 protease 0.0047 0.0159 0.049
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.0752 0.8459
Echinococcus granulosus serine protein kinase ATM 0.0026 0.004 0.0101
Entamoeba histolytica hypothetical protein 0.0042 0.0133 0.0805
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0266 0.0662
Echinococcus granulosus jumonji domain containing 1A 0.0033 0.008 0.02
Schistosoma mansoni jumonji domain containing protein 0.0033 0.008 0.02
Echinococcus granulosus notch 0.0076 0.0327 0.0814
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0205 0.1065 0.2652
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0275 0.0686
Echinococcus multilocularis fibropellin Ia 0.0076 0.0327 0.0327
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.002 0.0222
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0205 0.1065 0.1065
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Schistosoma mansoni notch 0.0076 0.0327 0.0814
Treponema pallidum phosphoglycerate kinase 0.0173 0.088 0.5185
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1653 0.5207
Echinococcus granulosus sentrin specific protease 1 0.0047 0.0159 0.0397
Onchocerca volvulus Dual oxidase homolog 0.0588 0.3257 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0069 0.0217
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0144 0.036
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Loa Loa (eye worm) hypothetical protein 0.0032 0.0074 0.0228
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0111 0.0529 0.1667
Onchocerca volvulus Huntingtin homolog 0.0257 0.1363 0.4053
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0232
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0205 0.1065 0.2652
Loa Loa (eye worm) hypothetical protein 0.0054 0.0201 0.0618
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0547 0.1723
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0032 0.0075 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0074 0.0228
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Loa Loa (eye worm) glutaminase 0.0573 0.3174 0.9748
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0173 0.088 1
Echinococcus multilocularis neurogenic locus notch protein 0.0076 0.0327 0.0327
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0074 0.0228
Loa Loa (eye worm) Notch2 0.0076 0.0327 0.1003
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0194 0.2208
Loa Loa (eye worm) hypothetical protein 0.0588 0.3257 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0033 0.008 0.0912
Schistosoma mansoni cell polarity protein 0.0076 0.0327 0.0814
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0205 0.1065 0.2652
Brugia malayi jmjC domain containing protein 0.0033 0.008 0.0246
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0159 0.0965
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0074 0.0185
Schistosoma mansoni phosphoglycerate kinase 0.0173 0.088 0.2193
Echinococcus granulosus caspase 2 0.0032 0.0075 0.0188
Echinococcus multilocularis peroxidasin 0.0588 0.3257 0.3257
Brugia malayi jmjC domain containing protein 0.0123 0.0598 0.1837
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Echinococcus granulosus caspase 0.012 0.0578 0.144
Trichomonas vaginalis glutaminase, putative 0.0573 0.3174 1
Schistosoma mansoni notch 0.0076 0.0327 0.0814
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0547 0.1723
Brugia malayi Cadherin domain containing protein 0.0076 0.0327 0.1003
Loa Loa (eye worm) hypothetical protein 0.0588 0.3257 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0033 0.008 0.02
Echinococcus multilocularis GPCR, family 2 0.0067 0.0275 0.0275
Echinococcus granulosus lamin 0.0032 0.0073 0.0181
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0047 0.0159 0.1811
Trypanosoma brucei SUMO1/Ulp2, putative 0.0047 0.0159 0.1811
Onchocerca volvulus Peroxidase homolog 0.0588 0.3257 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0074 0.0228
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0173 0.088 1
Trypanosoma brucei phosphoglycerate kinase, putative 0.0063 0.0255 0.2894
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0159 0.0965
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0266 0.0662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.004 0.0127
Onchocerca volvulus 0.0032 0.0074 0.0005
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0074 0.0185
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0069 0.0244
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Loa Loa (eye worm) Ulp1 protease 0.0111 0.0529 0.1625
Onchocerca volvulus Peroxidasin homolog 0.0588 0.3257 1
Echinococcus multilocularis neurogenic locus protein delta 0.0076 0.0327 0.0327
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0159 0.049
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0075 0.0856
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0075 0.0238
Echinococcus granulosus protein jagged 2 0.0076 0.0327 0.0814
Loa Loa (eye worm) hypothetical protein 0.0032 0.0074 0.0228
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1653 0.5207
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0074 0.0185
Loa Loa (eye worm) hypothetical protein 0.0097 0.0449 0.1379
Schistosoma mansoni caspase-7 (C14 family) 0.012 0.0578 0.144
Leishmania major phosphoglycerate kinase C, glycosomal 0.0173 0.088 1
Schistosoma mansoni hypothetical protein 0.0067 0.0275 0.0686
Chlamydia trachomatis deubiquitinase/deneddylase Dub1 0.0047 0.0159 0.1332
Trypanosoma cruzi metacaspase, putative 0.0032 0.0075 0.0856
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0194 0.1753
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0205 0.1065 0.1065
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0075 0.0238
Loa Loa (eye worm) hypothetical protein 0.0257 0.1363 0.4185
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0074 0.0185
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0074 0.0074
Schistosoma mansoni phd/f-box containing protein 0.0033 0.008 0.02
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0049 0.0552
Echinococcus granulosus phosphoglycerate kinase 1 0.0173 0.088 0.2193
Giardia lamblia High cysteine protein 0.0076 0.0327 0.1977
Loa Loa (eye worm) hypothetical protein 0.0022 0.002 0.006
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0547 0.3308
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1653 0.5207
Brugia malayi hypothetical protein 0.0042 0.0133 0.0408
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0074 0.0228
Schistosoma mansoni peroxidasin 0.0588 0.3257 0.8111
Brugia malayi phosphofructokinase 0.0114 0.0547 0.1679
Loa Loa (eye worm) hypothetical protein 0.0588 0.3257 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0073 0.0223
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.012 0.0578 0.144
Loa Loa (eye worm) animal heme peroxidase 0.0588 0.3257 1
Brugia malayi Peroxidasin 0.0588 0.3257 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0075 0.0856
Loa Loa (eye worm) notch protein 0.0076 0.0327 0.1003
Echinococcus multilocularis protein dispatched 1 0.005 0.018 0.018
Brugia malayi jmjC domain containing protein 0.0033 0.008 0.0246
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0047 0.0159 0.1811
Brugia malayi intermediate filament protein 0.0032 0.0073 0.0223
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0075 0.0238
Echinococcus granulosus neural cadherin 0.0076 0.0327 0.0814
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0075 0.0238
Brugia malayi Delta serrate ligand family protein 0.0076 0.0327 0.1003
Loa Loa (eye worm) hypothetical protein 0.0047 0.0159 0.049
Echinococcus granulosus GPCR family 2 0.0067 0.0275 0.0686
Entamoeba histolytica hypothetical protein 0.0042 0.0133 0.0805
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0205 0.1065 0.2652
Echinococcus granulosus fibropellin Ia 0.0076 0.0327 0.0814
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0063 0.0255 0.2894
Echinococcus multilocularis fat cadherin tumor suppressor 0.0076 0.0327 0.0327
Schistosoma mansoni hypothetical protein 0.0527 0.2911 0.725
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.0547 0.599
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.0733 0.1825
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0073 0.0223
Schistosoma mansoni protein phosphatase 2C 0.0033 0.008 0.02
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0076 0.0327 0.1003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0212 0.1104 0.3389
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0075 0.0238
Brugia malayi Phosphoglycerate kinase 0.0173 0.088 0.2704
Schistosoma mansoni notch 0.0076 0.0327 0.0814
Echinococcus multilocularis lysine specific demethylase 6a 0.0033 0.008 0.008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0205 0.1065 0.2652
Toxoplasma gondii FATC domain-containing protein 0.0026 0.004 0.0458
Echinococcus multilocularis expressed conserved protein 0.0163 0.0824 0.0824
Entamoeba histolytica phosphoglycerate kinase, putative 0.0173 0.088 0.5326
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0032 0.0075 0.0232
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0069 0.0217
Echinococcus granulosus protein jagged 1 0.0076 0.0327 0.0814
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0033 0.008 0.0912
Brugia malayi Calcium binding EGF domain containing protein 0.0076 0.0327 0.1003
Schistosoma mansoni hypothetical protein 0.0076 0.0327 0.0814
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.048 0.1196
Echinococcus granulosus neurogenic locus protein delta 0.0076 0.0327 0.0814
Brugia malayi nuclear hormone receptor 0.0032 0.0074 0.0228
Brugia malayi hypothetical protein 0.0034 0.0087 0.0268
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0074 0.0228
Loa Loa (eye worm) hypothetical protein 0.0588 0.3257 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0074 0.0228
Plasmodium vivax sentrin-specific protease 2, putative 0.0047 0.0159 0.1332
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1653 0.5207
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0047 0.0159 0.0397
Brugia malayi hypothetical protein 0.0257 0.1363 0.4185
Echinococcus granulosus JmjC domain containing protein 4 0.0033 0.008 0.02
Schistosoma mansoni hypothetical protein 0.0076 0.0327 0.0814
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0173 0.088 1
Brugia malayi Animal haem peroxidase family protein 0.0588 0.3257 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0073 0.0223
Echinococcus granulosus caspase 3 0.0088 0.0395 0.0983
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Entamoeba histolytica hypothetical protein 0.0042 0.0133 0.0805
Entamoeba histolytica hypothetical protein 0.0042 0.0133 0.0805
Loa Loa (eye worm) hypothetical protein 0.0032 0.0074 0.0228
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0069 0.0217
Schistosoma mansoni hypothetical protein 0.0067 0.0275 0.0686
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0074 0.0185
Chlamydia trachomatis deubiquitinase/deneddylase Dub2 0.0047 0.0159 0.1332
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0074 0.0228
Schistosoma mansoni hypothetical protein 0.0043 0.0135 0.0337
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0074 0.0228
Plasmodium falciparum sentrin-specific protease 1 0.0047 0.0159 0.1332
Loa Loa (eye worm) hypothetical protein 0.0588 0.3257 1
Echinococcus granulosus sentrin specific protease 7 0.021 0.1091 0.2718
Onchocerca volvulus 0.0047 0.0159 0.0273
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0308 0.1653 1
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0159 0.0965
Loa Loa (eye worm) glutaminase 2 0.0573 0.3174 0.9748
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0073 0.0223
Echinococcus multilocularis microtubule associated protein 2 0.072 0.4015 0.4015
Trypanosoma brucei metacaspase MCA2 0.0032 0.0075 0.0856
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0205 0.1065 0.3269
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0074 0.0228
Echinococcus granulosus intermediate filament protein 0.0032 0.0073 0.0181
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0047 0.0159 0.1811
Schistosoma mansoni hypothetical protein 0.0043 0.0135 0.0337
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0049 0.0552
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0075 0.0322
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.008 0.0912
Plasmodium falciparum JmjC domain-containing protein, putative 0.0033 0.008 0.0381
Echinococcus multilocularis slit 2 protein 0.0076 0.0327 0.0327
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0074 0.0185
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0159 0.049
Brugia malayi Animal haem peroxidase family protein 0.0588 0.3257 1
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0173 0.088 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0074 0.0185
Brugia malayi MH2 domain containing protein 0.014 0.0692 0.2124
Trypanosoma brucei metacaspase 0.0032 0.0075 0.0856
Brugia malayi nuclear receptor NHR-88 0.0032 0.0074 0.0228
Echinococcus granulosus neurogenic locus notch protein 0.0076 0.0327 0.0814
Brugia malayi EGF-like domain containing protein 0.0076 0.0327 0.1003
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0074 0.0185
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0075 0.0238
Loa Loa (eye worm) hypothetical protein 0.0032 0.0074 0.0228
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.0692 0.2124
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0069 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0144 0.0455
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0075 0.0856
Echinococcus granulosus lysine specific demethylase 6a 0.0033 0.008 0.02
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0074 0.0005
Echinococcus granulosus L aminoadipate semialdehyde 0.0097 0.0449 0.1118
Loa Loa (eye worm) hypothetical protein 0.0588 0.3257 1
Plasmodium vivax metacaspase 1, putative 0.0032 0.0075 0.0322
Echinococcus multilocularis caspase 2 0.0032 0.0075 0.0075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1653 0.5207
Schistosoma mansoni hypothetical protein 0.0076 0.0327 0.0814
Echinococcus granulosus protein jagged 2 0.0076 0.0327 0.0814
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0074 0.0185
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0074 0.0074
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0275 0.0275
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.0547 0.3106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0074 0.0228
Schistosoma mansoni hypothetical protein 0.0067 0.0275 0.0686
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0074 0.0074
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0074 0.0185
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0111 0.0529 0.1667
Echinococcus multilocularis lamin 0.0032 0.0073 0.0073
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0033 0.008 0.02
Echinococcus multilocularis sentrin specific protease 1 0.0047 0.0159 0.0159
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0111 0.0529 0.3202
Giardia lamblia Fructose-bisphosphate aldolase 0.0308 0.1653 1
Schistosoma mansoni hypothetical protein 0.0145 0.072 0.1794
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.048 0.1474
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.0547 0.599
Trypanosoma cruzi hypothetical protein 0.0111 0.0529 0.6011
Schistosoma mansoni notch 0.0076 0.0327 0.0814
Loa Loa (eye worm) animal heme peroxidase 0.0588 0.3257 1
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0275 0.0846
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0194 0.1753
Echinococcus granulosus expressed conserved protein 0.0163 0.0824 0.2052
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0074 0.0228
Loa Loa (eye worm) hypothetical protein 0.0145 0.072 0.2212
Onchocerca volvulus 0.0588 0.3257 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.0752 0.8459
Onchocerca volvulus Chorion peroxidase homolog 0.0588 0.3257 1
Onchocerca volvulus 0.0076 0.0327 0.0798
Mycobacterium ulcerans phosphoglycerate kinase 0.0173 0.088 0.2661
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0255 0.2894
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.021 0.1091 0.2718
Leishmania major hypothetical protein, conserved 0.0053 0.0194 0.2208
Brugia malayi EGF-like domain containing protein 0.0076 0.0327 0.1003
Schistosoma mansoni hypothetical protein 0.0076 0.0327 0.0814
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.012 0.0578 0.0578
Brugia malayi hypothetical protein 0.0177 0.0904 0.2777
Plasmodium falciparum phosphoglycerate kinase 0.0173 0.088 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0266 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0074 0.0228
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.004 0.0458
Toxoplasma gondii EGF family domain-containing protein 0.0076 0.0327 0.3711
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.008 0.0246
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0069 0.0244
Loa Loa (eye worm) hypothetical protein 0.0065 0.0266 0.0816
Brugia malayi CHE-14 protein 0.0044 0.0144 0.0443
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0266 0.0662
Brugia malayi jmjC domain containing protein 0.0123 0.0598 0.1837
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Echinococcus multilocularis caspase 3 0.0088 0.0395 0.0395
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.008 0.0246
Echinococcus granulosus neurogenic locus notch protein 0.0076 0.0327 0.0814
Schistosoma mansoni hypothetical protein 0.0043 0.0135 0.0337
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0097 0.0449 0.1118
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0 0.0002
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0069 0.0417
Brugia malayi Blistered cuticle protein 3 0.0588 0.3257 1
Brugia malayi jmjC domain containing protein 0.0033 0.008 0.0246
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0173 0.088 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0074 0.0074
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0255 0.2894
Onchocerca volvulus Slit protein homolog 0.0076 0.0327 0.0798
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0033 0.008 0.0912
Trypanosoma brucei metacaspase 5, putative 0.0032 0.0075 0.0856
Onchocerca volvulus 0.0588 0.3257 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0123 0.0598 0.0598
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0047 0.0159 0.0397
Onchocerca volvulus 0.0588 0.3257 1
Brugia malayi 6-phosphofructokinase 0.0114 0.0547 0.1679
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0047 0.0159 0.1811
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0074 0.0185
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Loa Loa (eye worm) phosphofructokinase 0.0114 0.0547 0.1679
Schistosoma mansoni coup transcription factor 0.0032 0.0074 0.0185
Echinococcus granulosus lamin dm0 0.0032 0.0073 0.0181
Echinococcus granulosus sentrin specific protease 8 0.0111 0.0529 0.1318
Schistosoma mansoni caspase-3 (C14 family) 0.012 0.0578 0.144
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0074 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0075 0.0238
Brugia malayi Animal haem peroxidase family protein 0.0588 0.3257 1
Schistosoma mansoni patched 1 0.0044 0.0144 0.036
Brugia malayi EGF-like domain containing protein 0.0076 0.0327 0.1003
Schistosoma mansoni hypothetical protein 0.0527 0.2911 0.725
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0074 0.0074
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0028 0.0069
Loa Loa (eye worm) hypothetical protein 0.0588 0.3257 1
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0047 0.0159 0.0502
Schistosoma mansoni lamin 0.0032 0.0073 0.0181
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0074 0.0185
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0069 0.0217
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0308 0.1653 1
Echinococcus multilocularis jumonji domain containing 1A 0.0033 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0588 0.3257 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0133 0.0133
Echinococcus granulosus caspase 8 0.0032 0.0075 0.0188
Echinococcus multilocularis geminin 0.0527 0.2911 0.2911
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0159 0.0502
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0069 0.0782
Brugia malayi hypothetical protein 0.0053 0.0194 0.0597
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0069 0.0217
Brugia malayi 6-phosphofructokinase 0.0114 0.0547 0.1679
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0074 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0075 0.0238
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0159 0.0502
Brugia malayi GCC2 and GCC3 family protein 0.0076 0.0327 0.1003
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0074 0.0228
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0547 0.1679
Echinococcus multilocularis protein patched 0.0044 0.0144 0.0144
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0075 0.0856
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0074 0.0228
Echinococcus multilocularis caspase 0.012 0.0578 0.0578
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0047 0.0159 0.0965
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0076 0.0327 0.0798
Trichomonas vaginalis Sentrin-specific protease, putative 0.0111 0.0529 0.1667
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.004 0.0101
Schistosoma mansoni hypothetical protein 0.0024 0.0028 0.0069
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0252 0.0628
Trypanosoma brucei metacaspase MCA3 0.0032 0.0075 0.0856
Trypanosoma cruzi metacaspase, putative 0.0032 0.0075 0.0856
Brugia malayi Cell death protein 3 precursor 0.0032 0.0075 0.0232
Trypanosoma brucei Metacaspase-4 0.0032 0.0075 0.0856
Onchocerca volvulus 0.0518 0.2859 0.875
Plasmodium falciparum metacaspase-like protein 0.0032 0.0075 0.0322
Brugia malayi Animal haem peroxidase family protein 0.0588 0.3257 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0075 0.0238
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0144 0.0144
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.0752 0.2251
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Brugia malayi glutaminase DH11.1 0.0573 0.3174 0.9748
Entamoeba histolytica hypothetical protein 0.0027 0.0049 0.0294
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.008 0.0246
Trypanosoma brucei phosphoglycerate kinase 0.0173 0.088 1
Schistosoma mansoni hypothetical protein 0.0076 0.0327 0.0814
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0075 0.0238
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0266 0.3019
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0049 0.0552
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0547 0.6212
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0069 0.0244
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0069 0.0782
Loa Loa (eye worm) hypothetical protein 0.0033 0.008 0.0246
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.0692 0.2124
Loa Loa (eye worm) jmjC domain-containing protein 0.0123 0.0598 0.1837
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0028 0.0028
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0069 0.0126
Brugia malayi Pre-SET motif family protein 0.0065 0.0266 0.0816
Echinococcus multilocularis protein jagged 1 0.0076 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0047 0.0159 0.049
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0159 0.0502
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0194 0.2208
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0275 0.0846
Echinococcus multilocularis neural cadherin 0.0076 0.0327 0.0327
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0173 0.088 0.2774
Brugia malayi EGF-like domain containing protein 0.0076 0.0327 0.1003
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0159 0.0502
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0455 0.2498 0.7672
Brugia malayi Calcium binding EGF domain containing protein 0.0076 0.0327 0.1003
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0232
Loa Loa (eye worm) hypothetical protein 0.0032 0.0074 0.0228
Schistosoma mansoni slit 0.0076 0.0327 0.0814
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0069 0.0782
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.004 0.0124
Schistosoma mansoni laminin gamma-3 chain 0.0076 0.0327 0.0814
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0075 0.0238
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1653 0.5207
Brugia malayi EGF-like domain containing protein 0.0076 0.0327 0.1003
Echinococcus multilocularis caspase 8 0.0032 0.0075 0.0075
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0069 0.0217
Brugia malayi latrophilin 2 splice variant baaae 0.0145 0.072 0.2212
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0547 0.6212
Echinococcus multilocularis expressed conserved protein 0.0097 0.0444 0.0444
Schistosoma mansoni peroxidasin 0.0588 0.3257 0.8111
Brugia malayi hypothetical protein 0.0588 0.3257 1
Echinococcus multilocularis musashi 0.0032 0.0073 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0074 0.0228
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0275 0.0686
Echinococcus granulosus slit 2 protein 0.0076 0.0327 0.0814
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0144 0.036
Echinococcus granulosus expressed conserved protein 0.0097 0.0444 0.1107
Loa Loa (eye worm) hypothetical protein 0.0103 0.048 0.1474
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.004 0.004
Onchocerca volvulus Peroxidasin homolog 0.0588 0.3257 1
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0194 0.2208
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0074 0.0228
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0547 0.1679
Schistosoma mansoni hypothetical protein 0.0076 0.0327 0.0814
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.0547 0.1362
Loa Loa (eye worm) hypothetical protein 0.0047 0.0159 0.049
Trichomonas vaginalis set domain proteins, putative 0.0518 0.2859 0.9005
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0074 0.0228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0074 0.0228
Leishmania major hypothetical protein, conserved 0.0033 0.008 0.0912
Loa Loa (eye worm) hypothetical protein 0.0588 0.3257 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0097 0.0449 0.0449
Chlamydia trachomatis phosphoglycerate kinase 0.0173 0.088 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0074 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0159 0.0502
Schistosoma mansoni intermediate filament proteins 0.0032 0.0073 0.0181
Leishmania major metacaspase, putative 0.0032 0.0075 0.0856
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0075 0.0856
Schistosoma mansoni phosphatidylserine receptor 0.0033 0.008 0.02
Brugia malayi Pre-SET motif family protein 0.0455 0.2498 0.7672
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0033 0.008 0.008
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.008 0.0912
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Loa Loa (eye worm) hypothetical protein 0.0031 0.0069 0.0213
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0159 0.0502
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0047 0.0159 0.1811
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0074 0.0185
Schistosoma mansoni jumonji domain containing protein 0.0123 0.0598 0.149
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0173 0.088 0.2774
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0266 0.0266
Echinococcus granulosus phd:f box containing protein 0.0033 0.008 0.02
Schistosoma mansoni hypothetical protein 0.0067 0.0275 0.0686
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0111 0.0529 0.1318
Echinococcus granulosus lysine specific demethylase 5A 0.0123 0.0598 0.149
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0075 0.0238
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0194 0.1753
Loa Loa (eye worm) hypothetical protein 0.0588 0.3257 1
Onchocerca volvulus 0.0177 0.0904 0.2612
Brugia malayi Phosphoglycerate kinase 0.0063 0.0255 0.0782
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0547 0.3308
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.0547 0.6212
Schistosoma mansoni caspase-7 (C14 family) 0.0032 0.0075 0.0188
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0074 0.0074
Plasmodium vivax SET domain protein, putative 0.0065 0.0266 0.2611
Schistosoma mansoni hypothetical protein 0.0076 0.0327 0.0814
Brugia malayi Muscle positioning protein 4 0.0076 0.0327 0.1003
Mycobacterium ulcerans glutaminase 0.0573 0.3174 1
Loa Loa (eye worm) hypothetical protein 0.0212 0.1104 0.3389
Schistosoma mansoni phosphoglycerate kinase 0.0173 0.088 0.2193
Plasmodium vivax sentrin-specific protease 1, putative 0.0047 0.0159 0.1332
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Schistosoma mansoni glutaminase 0.0573 0.3174 0.7907
Echinococcus multilocularis neurogenic locus protein delta 0.0076 0.0327 0.0327
Echinococcus granulosus neurogenic locus notch protein 4 0.0076 0.0327 0.0814
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0074 0.0185
Echinococcus granulosus peroxidasin 0.0588 0.3257 0.8111
Onchocerca volvulus 0.0065 0.0266 0.0607
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0275 0.0275
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0069 0.0244
Echinococcus multilocularis notch 0.0076 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0032 0.0074 0.0228
Entamoeba histolytica hypothetical protein 0.0026 0.004 0.0244
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0074 0.0185
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0074 0.0005
Loa Loa (eye worm) hypothetical protein 0.0173 0.088 0.2704
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0123 0.0598 0.149
Echinococcus multilocularis phd:f box containing protein 0.0033 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0588 0.3257 1
Trypanosoma brucei phosphoglycerate kinase 0.0063 0.0255 0.2894
Echinococcus multilocularis protein jagged 1 0.0076 0.0327 0.0327
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0076 0.0327 0.0814
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0547 0.1723
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1003
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0047 0.0159 0.0502
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0194 0.2208
Onchocerca volvulus 0.0076 0.0327 0.0798
Trypanosoma cruzi metacaspase, putative 0.0032 0.0075 0.0856
Loa Loa (eye worm) hypothetical protein 0.0588 0.3257 1
Onchocerca volvulus Neurogenic locus notch homolog 0.0076 0.0327 0.0798
Loa Loa (eye worm) hypothetical protein 0.0067 0.0275 0.0846
Schistosoma mansoni hypothetical protein 0.0042 0.0133 0.0331
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0074 0.0185
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0123 0.0598 0.0598
Echinococcus granulosus protein jagged 1 0.0076 0.0327 0.0814
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.048 0.2905
Schistosoma mansoni lamin 0.0032 0.0073 0.0181
Onchocerca volvulus 0.0076 0.0327 0.0798
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.1653 0.5207
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0075 0.0238
Echinococcus multilocularis lamin dm0 0.0032 0.0073 0.0073
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0047 0.0159 0.1811

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.73 uM PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2599, AID434973, AID489001] ChEMBL. No reference
IC50 (functional) = 0.755 uM PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2599, AID434973, AID489001] ChEMBL. No reference
IC50 (functional) = 0.77 uM PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2575] ChEMBL. No reference
IC50 (functional) = 0.78 uM PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2582, AID2599] ChEMBL. No reference
IC50 (functional) = 0.91 uM PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 7 (SENP7) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID434973, AID434986] ChEMBL. No reference
IC50 (functional) = 6.06 uM PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 7 (SENP7) using a Luminescent assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID434973, AID434986] ChEMBL. No reference
IC50 (functional) = 9.04 uM PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2575] ChEMBL. No reference
IC50 (functional) = 15.4 uM PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2582, AID2599] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.