Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Werner syndrome, RecQ helicase-like | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | bloom syndrome protein | 0.0029 | 0.1153 | 0.0884 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.7043 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0473 | 0.5 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0012 | 0.0296 | 0.5 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.002 | 0.068 | 0.5 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0006 | 0 | 0.5 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0473 | 0.5 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0029 | 0.1153 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0296 | 0.4422 |
Echinococcus multilocularis | bloom syndrome protein | 0.0029 | 0.1153 | 0.0884 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.0668 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0015 | 0.0473 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0015 | 0.0473 | 0.5 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0029 | 0.1153 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0029 | 0.1153 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0023 | 0.0846 | 0.0846 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0025 | 0.0976 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0296 | 0.4422 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0012 | 0.0296 | 0.0296 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0012 | 0.0296 | 0.0296 |
Loa Loa (eye worm) | RecQ helicase | 0.0029 | 0.1153 | 0.1271 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.3078 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.