Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.1014 | 0.3866 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.3039 | 0.3039 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.1022 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.2622 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.1022 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.2622 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.1014 | 0.3866 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.1022 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.1022 | 0.1022 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.1022 | 0.3363 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.1022 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3039 | 0.3039 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.1022 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.1022 | 0.1022 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.1022 | 0.3897 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.2622 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.2622 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.1014 | 0.3866 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.2622 | 0.863 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.4784 | 0.4784 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.1022 | 0.3897 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.4784 | 0.4784 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.1022 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.1014 | 0.1014 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.1014 | 0.3866 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.1022 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.1022 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.1022 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.2622 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.2622 | 0.863 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.1022 | 0.3363 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1014 | 0.3336 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 1 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.1014 | 0.3866 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1014 | 0.3336 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.4784 | 0.4784 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.3039 | 1 |
Brugia malayi | hypothetical protein | 0.0037 | 0.2622 | 0.2622 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.4784 | 0.4784 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.1014 | 0.1014 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.2622 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.1014 | 0.3866 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1014 | 0.3336 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.1022 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.1014 | 0.3336 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.1014 | 0.1014 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.1022 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.1022 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1014 | 0.1014 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.1022 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.1022 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.