Detailed information for compound 1553368

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 301.377 | Formula: C14H20FNO3S
  • H donors: 0 H acceptors: 2 LogP: 2.05 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC[C@H]1COCCS(=O)(=O)N1Cc1ccc(cc1)F
  • InChi: 1S/C14H20FNO3S/c1-2-3-14-11-19-8-9-20(17,18)16(14)10-12-4-6-13(15)7-5-12/h4-7,14H,2-3,8-11H2,1H3/t14-/m0/s1
  • InChiKey: SYGVGOXDRUDQQI-AWEZNQCLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0399 0.4652
Onchocerca volvulus 0.0012 0.0016 0.0189
Onchocerca volvulus 0.0012 0.0016 0.0189
Echinococcus multilocularis chromobox protein 1 0.0072 0.0744 0.0744
Trichomonas vaginalis tubulin gamma chain, putative 0.0144 0.1611 0.539
Echinococcus multilocularis Tubulin beta 2C chain 0.0257 0.2975 0.2975
Echinococcus multilocularis tubulin alpha 3 chain 0.0206 0.2356 0.2356
Echinococcus multilocularis tubulin alpha chain 0.0206 0.2356 0.2356
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0016 0.0036
Schistosoma mansoni chromobox protein 0.0072 0.0744 0.1649
Echinococcus granulosus Tubulin beta 2C chain 0.0257 0.2975 0.6597
Echinococcus granulosus chromobox protein 1 0.0072 0.0744 0.1649
Giardia lamblia Beta tubulin 0.0257 0.2975 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0206 0.2356 0.2356
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0036
Echinococcus granulosus alpha tubulin 0.0206 0.2356 0.5225
Echinococcus multilocularis GPCR, family 2 0.0016 0.0071 0.0071
Brugia malayi CHD4 protein 0.0012 0.0016 0.0036
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0016 0.0036
Trichomonas vaginalis tubulin epsilon chain, putative 0.0206 0.2356 0.7908
Leishmania major beta tubulin 0.0257 0.2975 1
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0016 0.0016
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0063 0.0632 0.1402
Loa Loa (eye worm) alpha-tubulin 0.0206 0.2356 0.5225
Loa Loa (eye worm) hypothetical protein 0.0032 0.0256 0.0568
Leishmania major alpha tubulin 0.0206 0.2356 0.7363
Brugia malayi Cell division protein ftsZ 0.0062 0.0628 0.1393
Leishmania major alpha tubulin 0.0206 0.2356 0.7363
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.014 0.1559 0.1559
Echinococcus multilocularis tubulin beta 1 chain 0.0257 0.2975 0.2975
Onchocerca volvulus 0.0012 0.0016 0.0189
Schistosoma mansoni chromobox protein 0.0072 0.0744 0.1649
Trypanosoma cruzi epsilon tubulin, putative 0.0144 0.1611 0.4188
Trypanosoma brucei alpha tubulin 0.0206 0.2356 0.7363
Echinococcus granulosus Tubulin alpha 1 chain 0.0206 0.2356 0.5225
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0496 0.1101
Giardia lamblia Beta tubulin 0.0257 0.2975 1
Brugia malayi Tubulin alpha-2 chain 0.0206 0.2356 0.5225
Leishmania major alpha tubulin 0.0206 0.2356 0.7363
Echinococcus granulosus tubulin epsilon chain 0.0144 0.1611 0.3572
Echinococcus granulosus Tubulin beta 2C chain 0.0257 0.2975 0.6597
Toxoplasma gondii alpha-tubulin I, putative 0.0206 0.2356 0.7908
Toxoplasma gondii beta tubulin 0.0257 0.2975 1
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0384 0.451 1
Trypanosoma cruzi beta tubulin, putative 0.0257 0.2975 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0143 0.1602 0.5359
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.0157
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0081 0.0857 0.2841
Leishmania major beta tubulin 0.0257 0.2975 1
Entamoeba histolytica tubulin alpha chain, putative 0.0206 0.2356 0.7908
Mycobacterium ulcerans cell division protein FtsZ 0.0062 0.0628 0.5
Echinococcus granulosus GPCR family 2 0.0016 0.0071 0.0157
Brugia malayi alpha-tubulin 0.0206 0.2356 0.5225
Leishmania major beta tubulin 0.0257 0.2975 1
Toxoplasma gondii beta-1 tubulin, putative 0.0257 0.2975 1
Entamoeba histolytica hypothetical protein 0.0037 0.0323 0.1037
Echinococcus granulosus muscleblind protein 0.0154 0.1739 0.3857
Brugia malayi hypothetical protein 0.0037 0.0323 0.0716
Leishmania major beta tubulin 0.0257 0.2975 1
Plasmodium vivax tubulin alpha chain, putative 0.0206 0.2356 0.7908
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0071 0.0157
Mycobacterium leprae cell division protein FtsZ 0.0062 0.0628 0.5
Trichomonas vaginalis tubulin beta chain, putative 0.0206 0.2356 0.7908
Leishmania major beta tubulin 0.0257 0.2975 1
Trichomonas vaginalis tubulin beta chain, putative 0.0081 0.0857 0.2841
Echinococcus granulosus tubulin beta 4A class IVa 0.0257 0.2975 0.6597
Echinococcus multilocularis tubulin alpha 0.0144 0.1611 0.1611
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0016 0.0036
Echinococcus granulosus tubulin alpha 1C chain 0.0206 0.2356 0.5225
Echinococcus granulosus potassium voltage gated channel subfamily KQT 0.0063 0.0632 0.1402
Loa Loa (eye worm) tubulin gamma chain 0.0144 0.1611 0.3572
Echinococcus granulosus tubulin alpha 0.0144 0.1611 0.3572
Loa Loa (eye worm) beta-tubulin 0.0257 0.2975 0.6597
Echinococcus multilocularis Chromo domain 0.0012 0.0016 0.0016
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0062 0.0628 0.5
Loa Loa (eye worm) hypothetical protein 0.0154 0.1739 0.3857
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0062 0.0628 0.2068
Loa Loa (eye worm) hypothetical protein 0.0052 0.0496 0.1101
Echinococcus granulosus tubulin alpha chain 0.0206 0.2356 0.5225
Brugia malayi Tubulin beta chain 0.0062 0.0628 0.1393
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0323 0.0716
Trichomonas vaginalis tubulin epsilon chain, putative 0.0206 0.2356 0.7908
Echinococcus multilocularis peroxisome assembly protein 26 0.0206 0.2356 0.2356
Echinococcus granulosus tubulin alpha 3 chain 0.0206 0.2356 0.5225
Loa Loa (eye worm) tubulin alpha-3 chain 0.0124 0.1373 0.3045
Leishmania major alpha tubulin 0.0206 0.2356 0.7363
Loa Loa (eye worm) tubulin alpha-2 chain 0.0206 0.2356 0.5225
Trypanosoma brucei alpha tubulin, putative 0.0081 0.0857 0.0974
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0016 0.0036
Giardia lamblia Beta tubulin 0.0257 0.2975 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0144 0.1611 0.539
Leishmania major beta tubulin 0.0257 0.2975 1
Brugia malayi Tubulin alpha-2 chain 0.0206 0.2356 0.5225
Leishmania major beta tubulin 0.0257 0.2975 1
Schistosoma mansoni hypothetical protein 0.0035 0.0299 0.0664
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0496 0.1101
Brugia malayi chromobox protein homolog 3 0.004 0.0361 0.0802
Loa Loa (eye worm) BEN-1 protein 0.0257 0.2975 0.6597
Brugia malayi beta-tubulin, identical 0.0257 0.2975 0.6597
Entamoeba histolytica tubulin family protein 0.0257 0.2975 1
Echinococcus granulosus tubulin alpha 3 chain 0.0206 0.2356 0.5225
Trypanosoma brucei beta tubulin 0.0257 0.2975 1
Schistosoma mansoni tubulin subunit beta 0.0257 0.2975 0.6597
Echinococcus granulosus chromobox protein 1 0.0072 0.0744 0.1649
Schistosoma mansoni tubulin subunit delta 0.0062 0.0628 0.1393
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0744 0.1649
Schistosoma mansoni tubulin subunit gamma 0.0144 0.1611 0.3572
Echinococcus granulosus Chromobox protein 3 0.0012 0.0016 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0219 0.0686
Entamoeba histolytica hypothetical protein 0.0037 0.0323 0.1037
Plasmodium vivax tubulin epsilon chain, putative 0.0144 0.1611 0.539
Leishmania major alpha tubulin 0.0206 0.2356 0.7363
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0036
Echinococcus multilocularis Tubulin beta 2C chain 0.0257 0.2975 0.2975
Trichomonas vaginalis tubulin beta chain, putative 0.0206 0.2356 0.7908
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0016 0.0036
Schistosoma mansoni tubulin subunit alpha 0.0206 0.2356 0.5225
Schistosoma mansoni alpha tubulin 0.0206 0.2356 0.5225
Loa Loa (eye worm) tubulin alpha 2 0.0143 0.1602 0.3552
Brugia malayi Protein cec-1. 0.0012 0.0016 0.0036
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0744 0.2459
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0361 0.1167
Trypanosoma brucei alpha tubulin 0.0206 0.2356 0.7363
Plasmodium falciparum tubulin delta chain, putative 0.0062 0.0628 0.2068
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0124 0.1373 0.4586
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0036
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0744 0.2459
Echinococcus granulosus tubulin subunit beta 0.0257 0.2975 0.6597
Loa Loa (eye worm) tubulin beta chain 0.0257 0.2975 0.6597
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0016 0.0036
Trichomonas vaginalis tubulin beta chain, putative 0.0257 0.2975 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0071 0.0157
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0219 0.0686
Echinococcus multilocularis tubulin alpha chain 0.0206 0.2356 0.2356
Echinococcus multilocularis Tubulin beta 2C chain 0.0257 0.2975 0.2975
Trichomonas vaginalis tubulin beta chain, putative 0.0206 0.2356 0.7908
Trypanosoma cruzi alpha tubulin, putative 0.0206 0.2356 0.7363
Echinococcus granulosus Tubulin beta 2C chain 0.0257 0.2975 0.6597
Plasmodium vivax tubulin gamma chain, putative 0.0144 0.1611 0.539
Leishmania major beta tubulin 0.0257 0.2975 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0384 0.451 1
Trichomonas vaginalis tubulin, putative 0.0081 0.0857 0.2841
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.014 0.1559 0.3458
Trichomonas vaginalis tubulin beta chain, putative 0.0206 0.2356 0.7908
Loa Loa (eye worm) hypothetical protein 0.0063 0.0632 0.1402
Echinococcus granulosus Tubulin beta 2C chain 0.0257 0.2975 0.6597
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0071 0.0071
Leishmania major beta tubulin 0.0257 0.2975 1
Trypanosoma brucei beta tubulin 0.0257 0.2975 1
Plasmodium falciparum tubulin beta chain 0.0257 0.2975 1
Loa Loa (eye worm) tubulin alpha 2 0.0143 0.1602 0.3552
Echinococcus multilocularis Tubulin alpha 1 chain 0.0206 0.2356 0.2356
Brugia malayi Tubulin gamma chain 0.0144 0.1611 0.3572
Trichomonas vaginalis tubulin alpha chain, putative 0.0081 0.0857 0.2841
Loa Loa (eye worm) tubulin alpha 2 0.0062 0.0619 0.1373
Schistosoma mansoni chromobox protein 0.0012 0.0016 0.0036
Entamoeba histolytica hypothetical protein 0.0037 0.0323 0.1037
Schistosoma mansoni alpha tubulin 0.0206 0.2356 0.5225
Brugia malayi tubulin alpha chain - mouse 0.0206 0.2356 0.5225
Brugia malayi tubulin alpha-2 chain 0.0206 0.2356 0.5225
Schistosoma mansoni tubulin subunit beta 0.0257 0.2975 0.6597
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.0157
Trypanosoma brucei beta tubulin 0.0144 0.1611 0.4188
Echinococcus multilocularis beta tubulin 0.0257 0.2975 0.2975
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0143 0.1602 0.3552
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0384 0.451 0.451
Echinococcus granulosus tubulin alpha chain 0.0206 0.2356 0.5225
Loa Loa (eye worm) tubulin beta chain 0.0062 0.0628 0.1393
Echinococcus multilocularis tubulin delta chain 0.0062 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0036
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0257 0.2975 0.2975
Brugia malayi hypothetical protein 0.0012 0.0016 0.0036
Schistosoma mansoni tubulin subunit beta 0.0062 0.0628 0.1393
Plasmodium falciparum tubulin gamma chain 0.0144 0.1611 0.539
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0012 0.0016 0.0036
Echinococcus granulosus tubulin alpha chain 0.0206 0.2356 0.5225
Leishmania major alpha tubulin 0.0206 0.2356 0.7363
Onchocerca volvulus 0.0032 0.0256 0.299
Leishmania major alpha tubulin 0.0206 0.2356 0.7363
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0062 0.0628 0.2068
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0071 0.0157
Echinococcus granulosus tubulin alpha 1C chain 0.0206 0.2356 0.5225
Trypanosoma brucei epsilon tubulin 0.0144 0.1611 0.4188
Schistosoma mansoni tubulin subunit beta 0.0257 0.2975 0.6597
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0016 0.0036
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0496 0.1101
Onchocerca volvulus 0.0081 0.0857 1
Leishmania major epsilon tubulin, putative 0.0144 0.1611 0.4188
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0628 0.2068
Schistosoma mansoni tubulin subunit beta 0.0257 0.2975 0.6597
Echinococcus multilocularis tubulin epsilon chain 0.0144 0.1611 0.1611
Leishmania major alpha tubulin 0.0206 0.2356 0.7363
Trichomonas vaginalis tubulin epsilon chain, putative 0.0257 0.2975 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0071 0.0157
Leishmania major beta tubulin 0.0257 0.2975 1
Echinococcus granulosus tubulin subunit TubB 0.0206 0.2356 0.5225
Trichomonas vaginalis tubulin epsilon chain, putative 0.0062 0.0628 0.2068
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.0157
Trichomonas vaginalis tubulin gamma chain, putative 0.0144 0.1611 0.539
Leishmania major alpha tubulin 0.0206 0.2356 0.7363
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0323 0.0323
Echinococcus granulosus peroxisome assembly protein 26 0.0206 0.2356 0.5225
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0399 0.1292
Echinococcus granulosus tubulin alpha chain 0.0206 0.2356 0.5225
Trichomonas vaginalis tubulin, putative 0.0257 0.2975 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0157
Echinococcus multilocularis tubulin subunit beta 0.0257 0.2975 0.2975
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0036
Echinococcus multilocularis tubulin alpha chain 0.0206 0.2356 0.2356
Echinococcus multilocularis tubulin alpha chain 0.0206 0.2356 0.2356
Schistosoma mansoni tubulin subunit beta 0.0257 0.2975 0.6597
Echinococcus multilocularis hypothetical protein 0.0206 0.2356 0.2356
Plasmodium vivax tubulin beta chain, putative 0.0257 0.2975 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0632 0.1402
Trichomonas vaginalis tubulin alpha chain, putative 0.0081 0.0857 0.2841
Loa Loa (eye worm) tubulin alpha chain 0.0206 0.2356 0.5225
Echinococcus granulosus chromobox protein 2 0.0012 0.0016 0.0036
Trichomonas vaginalis tubulin beta chain, putative 0.0206 0.2356 0.7908
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0361 0.422
Entamoeba histolytica tubulin alpha-1 chain 0.0206 0.2356 0.7908
Echinococcus multilocularis muscleblind protein 1 0.0154 0.1739 0.1739
Trypanosoma brucei beta tubulin 0.0257 0.2975 1
Plasmodium falciparum tubulin epsilon chain, putative 0.0144 0.1611 0.539
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0384 0.451 1
Leishmania major alpha tubulin 0.0206 0.2356 0.7363
Entamoeba histolytica tubulin gamma chain 0.0144 0.1611 0.539
Schistosoma mansoni hypothetical protein 0.0012 0.0016 0.0036
Echinococcus multilocularis tubulin gamma 1 chain 0.0144 0.1611 0.1611
Loa Loa (eye worm) hypothetical protein 0.0035 0.0299 0.0664
Loa Loa (eye worm) hypothetical protein 0.0154 0.1739 0.3857
Leishmania major gamma-tubulin 0.0144 0.1611 0.4188
Giardia lamblia Gamma tubulin 0.0144 0.1611 0.4188
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0016 0.0036
Echinococcus granulosus tubulin beta 1 chain 0.0257 0.2975 0.6597
Brugia malayi SET domain containing protein 0.0012 0.0016 0.0036
Schistosoma mansoni tubulin subunit epsilon 0.0144 0.1611 0.3572
Echinococcus multilocularis tubulin alpha chain 0.0206 0.2356 0.2356
Trypanosoma cruzi epsilon tubulin, putative 0.0144 0.1611 0.4188
Leishmania major beta tubulin 0.0257 0.2975 1
Echinococcus granulosus Tubulin beta 2C chain 0.0257 0.2975 0.6597
Echinococcus multilocularis chromobox protein 1 0.0072 0.0744 0.0744
Loa Loa (eye worm) hypothetical protein 0.0143 0.1602 0.3552
Leishmania major beta tubulin 0.0257 0.2975 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0257 0.2975 0.2975
Brugia malayi Heterochromatin protein 1 0.0072 0.0744 0.1649
Plasmodium falciparum alpha tubulin 2 0.0206 0.2356 0.7908
Trypanosoma cruzi tubulin gamma chain 0.0144 0.1611 0.4188
Entamoeba histolytica tubulin family protein 0.0257 0.2975 1
Echinococcus multilocularis tubulin subunit TubB 0.0206 0.2356 0.2356
Echinococcus multilocularis beta tubulin 0.0257 0.2975 0.2975
Loa Loa (eye worm) tubulin beta-1 chain 0.0257 0.2975 0.6597
Echinococcus granulosus tubulin delta chain 0.0062 0.0628 0.1393
Schistosoma mansoni tubulin subunit alpha 0.0206 0.2356 0.5225
Echinococcus multilocularis tubulin alpha 1C chain 0.0206 0.2356 0.2356
Echinococcus granulosus tubulin alpha chain 0.0206 0.2356 0.5225
Echinococcus granulosus Tubulin alpha 1 chain 0.0206 0.2356 0.5225
Schistosoma mansoni tubulin subunit alpha 0.0206 0.2356 0.5225
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0012 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0037 0.0323 0.0716
Toxoplasma gondii alpha tubulin TUBA1 0.0206 0.2356 0.7908
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0323 0.0716
Mycobacterium tuberculosis Cell division protein FtsZ 0.0062 0.0628 0.5
Trichomonas vaginalis tubulin alpha chain, putative 0.0257 0.2975 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0036
Trypanosoma brucei epsilon tubulin 0.0144 0.1611 0.4188
Trypanosoma brucei tubulin gamma chain 0.0144 0.1611 0.4188
Brugia malayi Tubulin alpha chain 0.0206 0.2356 0.5225
Leishmania major beta tubulin 0.0257 0.2975 1
Plasmodium falciparum alpha tubulin 1 0.0206 0.2356 0.7908
Echinococcus granulosus Tubulin alpha 1 chain 0.0206 0.2356 0.5225
Trichomonas vaginalis tubulin beta chain, putative 0.0206 0.2356 0.7908
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0016 0.0036
Treponema pallidum cell division protein FtsZ 0.0062 0.0628 0.5
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0144 0.1611 0.539
Plasmodium vivax delta tubulin, putative 0.0062 0.0628 0.2068
Echinococcus multilocularis Tubulin beta 2C chain 0.0257 0.2975 0.2975
Leishmania major alpha tubulin 0.0206 0.2356 0.7363
Schistosoma mansoni alpha tubulin 0.0206 0.2356 0.5225
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0071 0.0157
Trichomonas vaginalis tubulin, putative 0.0081 0.0857 0.2841
Loa Loa (eye worm) tubulin beta-4 chain 0.0257 0.2975 0.6597
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0384 0.451 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0081 0.0857 0.2841
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0206 0.2356 0.5225
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0063 0.0632 0.0632
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0206 0.2356 0.7908
Trichomonas vaginalis tubulin gamma chain, putative 0.0062 0.0628 0.2068
Brugia malayi Tubulin alpha chain 0.0062 0.0628 0.1393
Giardia lamblia Alpha-tubulin 0.0206 0.2356 0.7363
Trypanosoma brucei beta tubulin 0.0257 0.2975 1
Toxoplasma gondii beta-tubulin, putative 0.0257 0.2975 1
Trichomonas vaginalis tubulin, putative 0.0062 0.0628 0.2068
Schistosoma mansoni chromobox protein 0.0012 0.0016 0.0036
Schistosoma mansoni tubulin subunit beta 0.0257 0.2975 0.6597
Echinococcus multilocularis tubulin alpha 3 chain 0.0206 0.2356 0.2356
Entamoeba histolytica hypothetical protein 0.0037 0.0323 0.1037
Leishmania major beta tubulin 0.0257 0.2975 1
Loa Loa (eye worm) CHromoDomain protein family member 0.0012 0.0016 0.0036
Leishmania major beta tubulin 0.0257 0.2975 1
Brugia malayi Tubulin beta chain 0.0081 0.0857 0.19
Loa Loa (eye worm) BEN-1 protein 0.0257 0.2975 0.6597
Leishmania major alpha tubulin 0.0206 0.2356 0.7363
Echinococcus granulosus Chromo domain 0.0012 0.0016 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0628 0.2068
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.014 0.1559 0.3458
Echinococcus multilocularis chromobox protein 2 0.0012 0.0016 0.0016
Echinococcus multilocularis muscleblind protein 0.0154 0.1739 0.1739
Echinococcus granulosus beta tubulin 0.0257 0.2975 0.6597
Loa Loa (eye worm) hypothetical protein 0.004 0.0361 0.0802
Trichomonas vaginalis tubulin gamma chain, putative 0.0257 0.2975 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.1373 0.3045
Trypanosoma brucei epsilon tubulin 0.0144 0.1611 0.4188
Loa Loa (eye worm) tubulin beta-2A chain 0.0257 0.2975 0.6597
Leishmania major beta tubulin 0.0257 0.2975 1
Loa Loa (eye worm) alpha-tubulin 0.0206 0.2356 0.5225
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0062 0.0628 0.2068
Loa Loa (eye worm) helicase 0.0012 0.0016 0.0036
Trypanosoma brucei alpha tubulin 0.0206 0.2356 0.7363
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0016 0.0036
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.014 0.1559 0.3458
Trypanosoma brucei alpha tubulin 0.0206 0.2356 0.7363
Leishmania major beta tubulin 0.0257 0.2975 1
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0299 0.0664
Echinococcus multilocularis Tubulin alpha 1 chain 0.0206 0.2356 0.2356
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0399 0.1292
Leishmania major beta tubulin 0.0257 0.2975 1
Brugia malayi Tubulin beta-1 chain 0.0257 0.2975 0.6597
Echinococcus granulosus beta tubulin 0.0257 0.2975 0.6597
Brugia malayi Muscleblind-like protein 0.0154 0.1739 0.3857
Loa Loa (eye worm) voltage-gated potassium channel 0.0137 0.1531 0.3395
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0361 0.1167
Loa Loa (eye worm) tubulin alpha chain 0.0206 0.2356 0.5225
Plasmodium vivax tubulin alpha chain, putative 0.0206 0.2356 0.7908
Schistosoma mansoni tubulin subunit alpha 0.0062 0.0628 0.1393
Giardia lamblia Alpha-tubulin 0.0206 0.2356 0.7363
Trichomonas vaginalis tubulin epsilon chain, putative 0.0257 0.2975 1
Echinococcus granulosus tubulin gamma 1 chain 0.0144 0.1611 0.3572
Echinococcus multilocularis tubulin alpha 1C chain 0.0206 0.2356 0.2356

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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