Detailed information for compound 15534

Basic information

Technical information
  • TDR Targets ID: 15534
  • Name: 2,2-dioxo-1-(propoxymethyl)benzo[c][1,2,6]thi adiazin-4-one
  • MW: 270.305 | Formula: C11H14N2O4S
  • H donors: 1 H acceptors: 3 LogP: 1.16 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOCN1c2ccccc2C(=O)NS1(=O)=O
  • InChi: 1S/C11H14N2O4S/c1-2-7-17-8-13-10-6-4-3-5-9(10)11(14)12-18(13,15)16/h3-6H,2,7-8H2,1H3,(H,12,14)
  • InChiKey: IVPNVRGHLBEOEJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2,2-dioxo-1-(propoxymethyl)-4-benzo[c][1,2,6]thiadiazinone
  • 2,2-diketo-1-(propoxymethyl)benzo[c][1,2,6]thiadiazin-4-one
  • 2,2-dioxo-1-(propoxymethyl)benzo[d][1,2,6]thiadiazin-4-one
  • 2,2-dioxo-1-(propoxymethyl)-4-benzo[d][1,2,6]thiadiazinone
  • 2,2-diketo-1-(propoxymethyl)benzo[d][1,2,6]thiadiazin-4-one
  • 1-(Benzyloxymethyl)-2,1,3-benzothiadiazin-4(3H)-one 2,2-dioxide
  • AIDS-123235
  • AIDS123235

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor 0.0036 0.0201 0.0201
Onchocerca volvulus Protein ultraspiracle homolog 0.0077 0.0544 0.1678
Echinococcus granulosus RNA directed DNA polymerase 0.008 0.0576 0.1788
Leishmania major heat shock protein 83-1 0.0013 0.0005 0.0005
Loa Loa (eye worm) integrin beta-2 0.0315 0.2566 0.2566
Schistosoma mansoni integrin alpha 0.0154 0.1199 0.3724
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0042 0.0038
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0392 0.322 0.3217
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0203 0.1089
Brugia malayi hypothetical protein 0.004 0.0238 0.0238
Brugia malayi nuclear receptor NHR-88 0.0036 0.0201 0.0201
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0193 0.1528 0.1528
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0013 0.0005 0.0005
Brugia malayi kinase, mitochondrial precursor 0.0233 0.1871 0.1871
Mycobacterium tuberculosis Conserved protein 0.0013 0.0005 0.0024
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0077 0.0544 0.169
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.003 0.0025
Trypanosoma brucei Sterol methyltransferase, putative 0.0193 0.1528 0.1528
Echinococcus granulosus metabotropic glutamate receptor 5 0.0049 0.031 0.0963
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0077 0.0544 0.0544
Mycobacterium leprae Probable lipase LipE 0.0036 0.0203 0.3025
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0077 0.0544 0.0544
Brugia malayi Protein kinase domain containing protein 0.0017 0.0042 0.0042
Leishmania major heat shock protein 83-1 0.0013 0.0005 0.0005
Onchocerca volvulus 0.0045 0.028 0.0855
Echinococcus multilocularis heat shock protein 0.0013 0.0005 0.0014
Schistosoma mansoni inositol monophosphatase 0.0037 0.0211 0.0656
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.003 0.003
Brugia malayi ecdysteroid receptor 0.0077 0.0544 0.0544
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.003 0.003
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0203 0.0199
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0077 0.0544 0.169
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.003 0.0093
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0233 0.1871 0.5811
Plasmodium falciparum DNA topoisomerase 2 0.0013 0.0005 0.0014
Echinococcus granulosus fatty acid amide hydrolase 1 0.0103 0.0768 0.2386
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0066 0.0452 0.0452
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.015 0.0467
Echinococcus granulosus integrin beta 2 0.0233 0.1874 0.582
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0042 0.0038
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0036 0.0201 0.0624
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0193 0.1528 0.1528
Entamoeba histolytica steroid 5-alpha reductase, putative 0.1192 1 1
Entamoeba histolytica protein kinase, putative 0.0017 0.0042 0.0038
Brugia malayi photoreceptor-specific nuclear receptor 0.0077 0.0544 0.0544
Plasmodium falciparum DNA gyrase subunit B 0.0013 0.0005 0.0014
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0042 0.0131
Brugia malayi Protein kinase domain containing protein 0.0013 0.0002 0.0002
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0116 0.0881 0.0881
Loa Loa (eye worm) hypothetical protein 0.0094 0.0691 0.0691
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0203 0.0631
Brugia malayi N-terminal motif family protein 0.0176 0.1387 0.1387
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1192 1 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0211 0.0211
Loa Loa (eye worm) AGC/AKT protein kinase 0.0017 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0092 0.0672 0.0672
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0392 0.322 1
Mycobacterium ulcerans two component sensor kinase MprB 0.0013 0.0005 0.0005
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.015 0.0467
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0048 0.0301 0.0301
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0024 0.0097 0.0303
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0082 0.0586 0.0586
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0022 0.0084 0.0261
Loa Loa (eye worm) hypothetical protein 0.0048 0.0301 0.0301
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0036 0.0201 0.0201
Onchocerca volvulus 0.0036 0.0201 0.0611
Leishmania major heat shock protein 83-1 0.0013 0.0005 0.0005
Brugia malayi Protein kinase c protein 2 0.0096 0.0705 0.0705
Schistosoma mansoni unc-13 (munc13) 0.0017 0.0037 0.0115
Schistosoma mansoni endothelin-converting enzyme-related 0.0022 0.0084 0.0261
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0452 0.1405
Loa Loa (eye worm) hypothetical protein 0.0036 0.0203 0.0203
Brugia malayi Synaptic glycoprotein SC2 0.0392 0.322 0.322
Schistosoma mansoni nuclear receptor 0.0036 0.0201 0.0624
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0022 0.0084 0.0261
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0211 0.0656
Brugia malayi Endoplasmin precursor 0.0013 0.0005 0.0005
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0082 0.0586 0.0586
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.015 0.0146
Loa Loa (eye worm) hypothetical protein 0.0068 0.0469 0.0469
Mycobacterium tuberculosis Conserved protein 0.0036 0.0203 0.1089
Loa Loa (eye worm) hypothetical protein 0.0176 0.1387 0.1387
Loa Loa (eye worm) zinc metallopeptidase 4 0.0022 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0068 0.0469 0.0469
Echinococcus granulosus serine:threonine protein kinase N2 0.0017 0.0042 0.0131
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0287 0.0891
Onchocerca volvulus 0.0077 0.0544 0.1678
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0018 0.0055
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0077 0.0544 0.169
Echinococcus granulosus ecdysone induced protein 78C 0.0077 0.0544 0.169
Loa Loa (eye worm) hypothetical protein 0.004 0.0238 0.0238
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0013 0.0005 0.0216
Loa Loa (eye worm) hypothetical protein 0.004 0.0238 0.0238
Brugia malayi Integrin beta pat-3 precursor 0.0315 0.2566 0.2566
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.1192 1 1
Onchocerca volvulus 0.0392 0.322 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0211 0.0207
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0077 0.0544 0.169
Loa Loa (eye worm) heat shock protein 90 0.0013 0.0005 0.0005
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0033 0.0177 0.055
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0077 0.0544 0.169
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.0005 0.0005
Onchocerca volvulus 0.0015 0.0021 0.005
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0203 0.1089
Mycobacterium ulcerans hypothetical protein 0.0036 0.0203 0.0203
Brugia malayi nuclear receptor RXR 0.004 0.0238 0.0238
Echinococcus multilocularis unc 13 (munc13) 0.0015 0.0021 0.0064
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0083 0.0601 0.0601
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0077 0.0544 0.0544
Brugia malayi Hr1 repeat family protein 0.0017 0.0042 0.0042
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0203 0.0631
Echinococcus multilocularis serine:threonine protein kinase 38 0.0017 0.0042 0.0131
Echinococcus granulosus integrin alpha ps 0.0069 0.0479 0.1489
Brugia malayi S-adenosyl-methionine cycloartenol-C24-methyltransferase 0.0094 0.0691 0.0691
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0084 0.0261
Entamoeba histolytica protein kinase, putative 0.0017 0.0042 0.0038
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0013 0.0005 0.0068
Onchocerca volvulus 0.0036 0.0203 0.0618
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0118 0.0352
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0103 0.0768 0.0768
Loa Loa (eye worm) hypothetical protein 0.004 0.0238 0.0238
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0042 0.0038
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0046 0.0287 0.0891
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0211 0.0211
Brugia malayi nuclear hormone receptor family member odr-7 0.0036 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.008 0.0576 0.0576
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0013 0.0002 0.0002
Echinococcus granulosus integrin alpha 3 0.0118 0.0895 0.2778
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0013 0.0005 0.0005
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0013 0.0005 0.0005
Loa Loa (eye worm) integrin alpha pat-2 0.0237 0.1905 0.1905
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.0005 0.0005
Brugia malayi Inositol-1 0.0037 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0201
Schistosoma mansoni pyruvate dehydrogenase 0.022 0.1761 0.547
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0077 0.0544 0.169
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.1387 0.43
Trypanosoma brucei rac serine-threonine kinase, putative 0.0017 0.0042 0.0042
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0017 0.0042 0.0042
Brugia malayi Pre-SET motif family protein 0.003 0.015 0.015
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0005 0.0014
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0017 0.0042 0.0042
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0082 0.0586 0.0586
Brugia malayi peptidase family M13 containing protein 0.0022 0.0084 0.0084
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0077 0.0544 0.169
Brugia malayi Isocitrate dehydrogenase 0.0016 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0201
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0017 0.0042 0.0131
Brugia malayi hypothetical protein 0.0036 0.0201 0.0201
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.0005 0.0005
Brugia malayi Kelch motif family protein 0.0048 0.0301 0.0301
Leishmania major heat shock protein 83-1 0.0013 0.0005 0.0005
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0103 0.0768 0.2386
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.003 0.0161
Brugia malayi protein kinase C II. 0.0032 0.0168 0.0168
Echinococcus multilocularis integrin alpha ps 0.0033 0.0175 0.0543
Leishmania major heat shock protein 83-1 0.0013 0.0005 0.0005
Echinococcus granulosus nuclear receptor nhr 48 0.0036 0.0201 0.0624
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0178 0.265
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0203 0.3025
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.003 0.0093
Onchocerca volvulus 0.0036 0.0203 0.0618
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0203 0.1089
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0092 0.0672 0.2086
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.0452 0.0452
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0201
Schistosoma mansoni protein kinase C 0.0015 0.0021 0.0064
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0017 0.0042 0.0131
Loa Loa (eye worm) hypothetical protein 0.0069 0.0482 0.0482
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.015 0.0467
Mycobacterium tuberculosis Probable two component sensor kinase 0.0013 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0077 0.0544 0.0544
Onchocerca volvulus 0.003 0.015 0.0454
Schistosoma mansoni integrin alpha-ps 0.0036 0.0199 0.0618
Brugia malayi heat shock protein 90 0.0013 0.0005 0.0005
Brugia malayi Protein kinase domain containing protein 0.0017 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0392 0.322 0.322
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0203 0.0203
Brugia malayi nuclear hormone receptor family member nhr-6 0.0036 0.0201 0.0201
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0322 0.0322
Leishmania major heat shock protein 83-1 0.0013 0.0005 0.0005
Mycobacterium ulcerans beta-lactamase 0.0036 0.0203 0.0203
Echinococcus multilocularis integrin alpha ps 0.0069 0.0479 0.1489
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0013 0.0005 0.0005
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0018 0.0055
Leishmania major hypothetical protein, conserved 0.0013 0.0005 0.0005
Mycobacterium ulcerans zinc metalloprotease 0.0092 0.0672 0.0672
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0084 0.0261
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0017 0.0042 0.0131
Schistosoma mansoni nuclear receptor nhr-48 0.0036 0.0201 0.0624
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0036 0.0201 0.0624
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.0005 1
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0013 0.0005 0.0005
Brugia malayi amidase 0.0103 0.0768 0.0768
Trypanosoma brucei heat shock protein, putative 0.0013 0.0005 0.0005
Echinococcus granulosus endothelin converting enzyme 1 0.0092 0.0672 0.2086
Schistosoma mansoni nuclear receptor 0.0036 0.0201 0.0624
Loa Loa (eye worm) hypothetical protein 0.003 0.015 0.015
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.0005 0.0005
Brugia malayi Carboxylesterase family protein 0.0066 0.0452 0.0452
Echinococcus granulosus GPCR family 2 0.0016 0.003 0.0093
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0092 0.0672 0.0672
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0193 0.1528 0.1528
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0201
Brugia malayi beta-lactamase family protein 0.0036 0.0203 0.0203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0077 0.0544 0.0544
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0203 0.0631
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0392 0.322 0.3217
Schistosoma mansoni integrin alpha-ps 0.0069 0.0479 0.1489
Echinococcus granulosus heat shock protein 0.0013 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Brugia malayi Nuclear hormone receptor-like 1 0.0077 0.0544 0.0544
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0013 0.0005 0.0068
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0203 0.1089
Brugia malayi Steroid receptor seven-up type 2 0.0077 0.0544 0.0544
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.004 0.0238 0.0738
Leishmania major developmentally regulated phosphoprotein-like protein 0.0233 0.1871 0.1871
Echinococcus multilocularis FTZ F1 alpha 0.0077 0.0544 0.169
Loa Loa (eye worm) hypothetical protein 0.0036 0.0203 0.0203
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0211 0.0656
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0092 0.0672 0.36
Loa Loa (eye worm) hypothetical protein 0.0077 0.0544 0.0544
Echinococcus granulosus thyroid hormone receptor alpha 0.0036 0.0201 0.0624
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0392 0.322 0.3217
Schistosoma mansoni neprilysin 0.0024 0.0097 0.0303
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0013 0.0005 0.0024
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0118 0.0366
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0013 0.0005 0.0014
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0036 0.0201 0.0624
Brugia malayi nuclear receptor RXR 0.0036 0.0201 0.0201
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0015 0.0021 0.0064
Entamoeba histolytica protein kinase, putative 0.0017 0.0042 0.0038
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1192 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0036 0.0201 0.0624
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0042 0.0038
Echinococcus multilocularis protein kinase c epsilon type 0.0032 0.0168 0.0523
Echinococcus granulosus geminin 0.0341 0.2786 0.8653
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0118 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.085 0.2639
Echinococcus granulosus FTZ F1 alpha 0.0077 0.0544 0.169
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0077 0.0544 0.169
Echinococcus multilocularis heat shock protein 90 0.0013 0.0005 0.0014
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0013 0.0005 0.0024
Loa Loa (eye worm) glutamate receptor 0.0016 0.0027 0.0027
Echinococcus multilocularis integrin beta 2 0.0233 0.1874 0.582
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.003 0.003
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.003 0.0093
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0211 0.0211
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0077 0.0544 0.0544
Leishmania major heat shock protein 83-1 0.0013 0.0005 0.0005
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.015 0.0467
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0452 0.1405
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0203 0.0631
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0077 0.0544 0.0544
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.003 0.0025
Echinococcus multilocularis serine threonine protein kinase 0.01 0.0745 0.2314
Schistosoma mansoni flap endonuclease-1 0.0024 0.0096 0.0299
Trypanosoma brucei heat shock protein 90, putative 0.0013 0.0005 0.0005
Trypanosoma cruzi heat shock protein 85, putative 0.0013 0.0005 0.0005
Echinococcus multilocularis serine:threonine protein kinase N2 0.0017 0.0042 0.0131
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0033 0.0175 0.0175
Mycobacterium tuberculosis Conserved protein 0.0036 0.0203 0.1089
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0203 0.0199
Echinococcus granulosus flap endonuclease 1 0.0026 0.0118 0.0366
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0042 0.0038
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0077 0.0544 0.169
Mycobacterium ulcerans DNA gyrase subunit B 0.0013 0.0005 0.0005
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0017 0.0042 0.0131
Plasmodium vivax heat shock protein 86, putative 0.0013 0.0005 0.0014
Brugia malayi ecdysone receptor 0.0036 0.0201 0.0201
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0013 0.0005 0.0216
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0013 0.0002 0.0007
Plasmodium vivax DNA topoisomerase II, putative 0.0013 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.015 0.0467
Loa Loa (eye worm) steroid hormone receptor 0.0077 0.0544 0.0544
Schistosoma mansoni retinoic acid receptor RXR 0.0077 0.0544 0.169
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.003 0.0093
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0077 0.0544 0.0544
Echinococcus multilocularis endothelin converting enzyme 1 0.0092 0.0672 0.2086
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0042 0.0038
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0013 0.0005 0.0005
Mycobacterium leprae probable zinc metalloprotease 0.0092 0.0672 1
Mycobacterium ulcerans lipase LipD 0.0036 0.0203 0.0203
Echinococcus granulosus heat shock protein 90 0.0013 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0005
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.0005 0.0005
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0017 0.0042 0.0131
Loa Loa (eye worm) hypothetical protein 0.0036 0.0203 0.0203
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0392 0.322 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0077 0.0544 0.0544
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0201
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0203 0.1089
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.003 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0077 0.0544 0.0544
Loa Loa (eye worm) hypothetical protein 0.0045 0.028 0.028
Trypanosoma brucei Heat shock protein 83, putative 0.0013 0.0005 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0203 0.0203
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0017 0.0039 0.0035
Loa Loa (eye worm) inositol-1 0.0037 0.0211 0.0211
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0203 0.0203
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0036 0.0201 0.0624
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0018 0.0055
Trypanosoma cruzi Heat shock protein 83, putative 0.0013 0.0005 0.0005
Echinococcus multilocularis integrin alpha ps 0.0069 0.0479 0.1489
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0193 0.1528 0.1528
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0392 0.322 0.3217
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0193 0.1528 0.1528
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0002 0.0007
Brugia malayi Protein kinase domain containing protein 0.0015 0.0021 0.0021
Trypanosoma cruzi heat shock protein 85, putative 0.0013 0.0005 0.0005
Loa Loa (eye worm) glutamate receptor 0.004 0.0232 0.0232
Echinococcus granulosus Ankyrin 0.0015 0.0019 0.0059
Onchocerca volvulus 0.0036 0.0201 0.0611
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0013 0.0005 0.0024
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0019 0.0059
Brugia malayi nuclear hormone receptor 0.0077 0.0544 0.0544
Echinococcus granulosus protein kinase c epsilon type 0.0032 0.0168 0.0523
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0392 0.322 0.3217
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.003
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0017 0.0042 0.0042
Echinococcus granulosus Nuclear hormone receptor HR96 0.0036 0.0201 0.0624
Schistosoma mansoni endoplasmin 0.0013 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.005 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0077 0.0544 0.0544
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0201 0.0624
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.004 0.0238 0.0738
Leishmania major heat shock protein 83-1 0.0013 0.0005 0.0005
Giardia lamblia Synaptic glycoprotein SC2 0.0392 0.322 1
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.0452 0.1405
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0077 0.0544 0.0544
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.003 0.0093
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.1678 0.1678
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0077 0.0544 0.169
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0211 0.0211
Echinococcus granulosus protein kinase C gamma type 0.01 0.0745 0.2314
Loa Loa (eye worm) hypothetical protein 0.0015 0.0018 0.0018
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.0526 0.1633
Echinococcus granulosus fatty acid amide hydrolase 1 0.0103 0.0768 0.2386
Echinococcus multilocularis synaptic glycoprotein sc2 0.0392 0.322 1
Schistosoma mansoni endoplasmin 0.0013 0.0005 0.0014
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0077 0.0544 0.169
Schistosoma mansoni nuclear hormone receptor 0.0077 0.0544 0.169
Brugia malayi Uncoordinated protein 44 0.0015 0.0018 0.0018
Echinococcus granulosus metabotropic glutamate receptor 2 0.0033 0.0177 0.055
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0203 0.0203
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0178 0.0954
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0118 0.0113
Leishmania major heat shock protein 83-1 0.0013 0.0005 0.0005
Brugia malayi nuclear hormone receptor 0.0036 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0392 0.322 0.322
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.003 0.0093
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0013 0.0002 0.0007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0322 0.0322
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0211 0.0211
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0201 0.0624
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0017 0.0042 0.0042
Loa Loa (eye worm) DR-78 0.0036 0.0201 0.0201
Trypanosoma brucei heat shock protein 90, putative 0.0013 0.0005 0.0005
Brugia malayi tailless protein 0.0036 0.0201 0.0201
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.1192 1 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0118 0.0113
Loa Loa (eye worm) hypothetical protein 0.0077 0.0544 0.0544
Schistosoma mansoni amidase 0.0103 0.0768 0.2386
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1192 1 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.003 0.003
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.008 0.0576 0.1788
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0211 0.0207
Leishmania major heat shock protein 83-1 0.0013 0.0005 0.0005
Schistosoma mansoni heat shock protein 0.0013 0.0005 0.0014
Trypanosoma brucei DNA topoisomerase ii 0.0013 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0203 0.0203
Schistosoma mansoni zinc finger protein 0.0036 0.0201 0.0624
Brugia malayi hypothetical protein 0.0036 0.0201 0.0201
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.0093
Echinococcus multilocularis RNA directed DNA polymerase 0.008 0.0576 0.1788
Brugia malayi hypothetical protein 0.0048 0.0301 0.0301
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0118 0.0118
Brugia malayi orphan nuclear receptor NR2E1 0.0036 0.0201 0.0201
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.0005 1
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0018 0.0055
Schistosoma mansoni hypothetical protein 0.0024 0.0097 0.0303
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.0093
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0002 0.0007
Schistosoma mansoni serine/threonine kinase 0.0017 0.0042 0.0131
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0077 0.0544 0.169
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0077 0.0544 0.0544
Loa Loa (eye worm) nuclear receptor NHR-67 0.0036 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.004 0.0238 0.0238
Schistosoma mansoni hypothetical protein 0.0033 0.0175 0.0543
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0201
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0141 0.0438
Brugia malayi steroid hormone receptor 0.0077 0.0544 0.0544
Brugia malayi Carboxylesterase family protein 0.0066 0.0452 0.0452
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.003 0.003
Schistosoma mansoni thyroid hormone receptor 0.0077 0.0544 0.169
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0013 0.0005 0.0216
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0094 0.0695 0.0691
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0018 0.0055
Mycobacterium tuberculosis Conserved protein 0.0036 0.0203 0.1089
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0017 0.0042 0.0131
Loa Loa (eye worm) hypothetical protein 0.0093 0.068 0.068
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.1192 1 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0203 0.1089
Brugia malayi Metabotropic glutamate receptor precursor. 0.004 0.0232 0.0232
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0118 0.0118
Echinococcus multilocularis integrin alpha 3 0.0118 0.0895 0.2778
Leishmania major mitochondrial DNA topoisomerase II 0.0013 0.0005 0.0005
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0042 0.0038
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.003 0.0093
Schistosoma mansoni RAR-like nuclear receptor 0.0077 0.0544 0.169
Plasmodium falciparum flap endonuclease 1 0.0026 0.0118 0.0366
Plasmodium vivax polyprenol reductase, putative 0.0392 0.322 1
Loa Loa (eye worm) hypothetical protein 0.0233 0.1871 0.1871
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0013 0.0005 0.0005
Schistosoma mansoni protein kinase C mu 0.0013 0.0002 0.0007
Schistosoma mansoni fatty-acid amide hydrolase 0.0103 0.0768 0.2386
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0013 0.0005 0.0005
Loa Loa (eye worm) AGC/PKN protein kinase 0.0017 0.0042 0.0042
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0211 0.0207
Loa Loa (eye worm) hypothetical protein 0.0077 0.0544 0.0544
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0036 0.0201 0.0201
Leishmania major heat shock protein 83-1 0.0013 0.0005 0.0005
Leishmania major heat shock protein 83-1 0.0013 0.0005 0.0005
Brugia malayi hypothetical protein 0.004 0.0238 0.0238
Brugia malayi Flap endonuclease-1 0.0026 0.0118 0.0118
Schistosoma mansoni integrin beta subunit 0.0186 0.1468 0.4559
Onchocerca volvulus 0.0036 0.0203 0.0618
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0013 0.0002 0.0002
Loa Loa (eye worm) endoplasmin 0.0013 0.0005 0.0005
Leishmania major sterol 24-c-methyltransferase, putative 0.0193 0.1528 0.1528
Schistosoma mansoni hypothetical protein 0.0034 0.0187 0.058
Schistosoma mansoni metabotropic glutamate receptor 0.0019 0.0059 0.0183
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0233 0.1871 0.5811
Trypanosoma brucei heat shock protein, putative 0.0013 0.0005 0.0005
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0077 0.0544 0.169
Schistosoma mansoni DNA topoisomerase II 0.0013 0.0005 0.0014
Brugia malayi metabotropic glutamate receptor type 2 0.0019 0.0059 0.0059
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0084 0.0261
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0013 0.0005 0.0024
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.0452 0.1405
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0203 0.0203
Trypanosoma cruzi heat shock protein 85, putative 0.0013 0.0005 0.0005
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0211 0.0207
Schistosoma mansoni pyruvate dehydrogenase 0.022 0.1761 0.547
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.1866 1
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0201 0.0624
Mycobacterium leprae Probable two component sensor kinase MprB 0.0013 0.0005 0.0068
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0077 0.0544 0.169
Brugia malayi Pre-SET motif family protein 0.021 0.1678 0.1678
Schistosoma mansoni neprilysin-2 (M13 family) 0.0046 0.0287 0.0891
Schistosoma mansoni unc-13 (munc13) 0.0015 0.0021 0.0064
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0077 0.0544 0.169
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0103 0.0768 0.2386
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1192 1 1
Mycobacterium ulcerans hypothetical protein 0.1192 1 1
Trypanosoma brucei heat shock protein, putative 0.0013 0.0005 0.0005
Trypanosoma brucei heat shock protein, putative 0.0013 0.0005 0.0005
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0013 0.0005 0.0005
Mycobacterium ulcerans two component regulator - sensor kinase 0.0013 0.0005 0.0005
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0113 0.085 0.2639
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0013 0.0005 0.0005
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0013 0.0005 0.0005
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.01 0.0746 0.0746
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0392 0.322 0.322
Trichomonas vaginalis conserved hypothetical protein 0.0392 0.322 0.3217
Trichomonas vaginalis set domain proteins, putative 0.0239 0.1925 0.1921
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0036 0.0201 0.0611
Leishmania major heat shock protein 83-1 0.0013 0.0005 0.0005
Schistosoma mansoni coup transcription factor 0.0077 0.0544 0.169
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0013 0.0005 0.0024
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0018 0.0018
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0203 0.0199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0077 0.0544 0.0544
Echinococcus granulosus acetylcholinesterase 0.0066 0.0452 0.1405
Loa Loa (eye worm) hypothetical protein 0.0092 0.0672 0.0672
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.003 0.0093
Brugia malayi C1-like domain containing protein 0.0013 0.0002 0.0002
Brugia malayi Integrin alpha pat-2 precursor 0.0154 0.1199 0.1199
Echinococcus multilocularis thyroid hormone receptor alpha 0.0077 0.0544 0.169
Mycobacterium ulcerans putative regultory protein 0.0013 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0024 0.0097 0.0303
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0013 0.0005 0.0024
Brugia malayi Protein kinase domain containing protein 0.0017 0.0042 0.0042
Plasmodium falciparum endoplasmin, putative 0.0013 0.0005 0.0014
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0077 0.0544 0.169
Echinococcus granulosus acetylcholinesterase 0.0066 0.0452 0.1405
Loa Loa (eye worm) AGC/NDR protein kinase 0.0017 0.0042 0.0042
Onchocerca volvulus Bile acid receptor homolog 0.0077 0.0544 0.1678
Loa Loa (eye worm) hypothetical protein 0.0069 0.0482 0.0482
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0013 0.0005 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.004 0.0238 0.0738
Schistosoma mansoni hypothetical protein 0.0015 0.0018 0.0055
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0042 0.0038
Brugia malayi Death domain containing protein 0.0015 0.0018 0.0018
Brugia malayi Nuclear hormone receptor E75 0.0036 0.0201 0.0201
Toxoplasma gondii ABC1 family protein 0.0036 0.0203 0.0199
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0085 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0034 0.0187 0.0187
Trypanosoma brucei heat shock protein, putative 0.0013 0.0005 0.0005
Schistosoma mansoni atypical protein kinase C 0.003 0.0147 0.0456
Echinococcus multilocularis ecdysone induced protein 78C 0.0077 0.0544 0.169
Brugia malayi Latrophilin receptor protein 2 0.0016 0.003 0.003
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.003 0.0093
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0013 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0069 0.0482 0.0482
Echinococcus granulosus unc 13 munc13 0.0015 0.0021 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0077 0.0544 0.0544
Loa Loa (eye worm) hypothetical protein 0.0068 0.0469 0.0469
Mycobacterium tuberculosis Possible two component sensor kinase 0.0013 0.0005 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0077 0.0544 0.0544
Trypanosoma cruzi heat shock protein 90, putative 0.0013 0.0005 0.0005
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0238 0.0238
Schistosoma mansoni hypothetical protein 0.0024 0.0097 0.0303
Loa Loa (eye worm) TOPoisomerase family member 0.0013 0.0005 0.0005
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.0097 0.0303
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0238 0.0238
Leishmania major heat shock protein 83-1 0.0013 0.0005 0.0005
Plasmodium falciparum polyprenol reductase, putative 0.0392 0.322 1
Brugia malayi beta-lactamase 0.0036 0.0203 0.0203
Loa Loa (eye worm) peptidase family M13 containing protein 0.0068 0.0469 0.0469
Trichomonas vaginalis esterase, putative 0.0036 0.0203 0.0199
Schistosoma mansoni hypothetical protein 0.0051 0.0328 0.1018
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0238 0.0738
Schistosoma mansoni pyruvate dehydrogenase 0.0233 0.1871 0.5811
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.0093
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0036 0.0201 0.0624
Plasmodium vivax DNA gyrase subunit B, putative 0.0013 0.0005 0.0014
Schistosoma mansoni hypothetical protein 0.0024 0.0097 0.0303
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0201 0.0624
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0203 0.0203
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0203 0.0199
Schistosoma mansoni hypothetical protein 0.0024 0.0097 0.0303
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0049 0.031 0.0963
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.004 0.0238 0.0238
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.0093
Entamoeba histolytica protein kinase, putative 0.0017 0.0042 0.0038
Echinococcus granulosus Nuclear hormone receptor HR96 0.0036 0.0201 0.0624
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0187 0.0187
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0203 0.0199
Loa Loa (eye worm) hypothetical protein 0.1192 1 1
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.0005 0.0005
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.015 0.0467
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0392 0.322 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0201
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0013 0.0005 1
Brugia malayi p70 ribosomal S6 kinase beta 0.0017 0.0042 0.0042
Echinococcus granulosus death domain containing protein 0.0015 0.0018 0.0055
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0005 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0201
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.003 0.0093
Schistosoma mansoni steroid hormone receptor ad4bp 0.0077 0.0544 0.169
Plasmodium vivax endoplasmin, putative 0.0013 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0116 0.0881 0.0881
Trypanosoma cruzi heat shock protein 90, putative 0.0013 0.0005 0.0005
Echinococcus multilocularis protein kinase c iota type 0.003 0.0147 0.0456
Echinococcus multilocularis GPCR, family 2 0.0016 0.003 0.0093
Mycobacterium leprae Probable two-component sensor kinase 0.0013 0.0005 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0077 0.0544 0.0544
Leishmania major DNA topoisomerase ii 0.0013 0.0005 0.0005
Loa Loa (eye worm) peptidase family M13 containing protein 0.0068 0.0469 0.0469
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0018 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0168 0.0523
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0042 0.0038
Echinococcus granulosus protein kinase c iota type 0.003 0.0147 0.0456
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0392 0.322 1
Leishmania major heat shock protein 83-1 0.0013 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0069 0.0482 0.0482
Brugia malayi nuclear receptor NHR-67 0.0036 0.0201 0.0201
Echinococcus multilocularis Ankyrin 0.0015 0.0019 0.0059
Entamoeba histolytica hypothetical protein 0.0392 0.322 0.3217
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0042 0.0131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0077 0.0544 0.0544
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.003 0.0093
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0077 0.0544 0.169
Schistosoma mansoni metabotropic glutamate receptor 0.0033 0.0177 0.055
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0392 0.322 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0077 0.0544 0.0544
Schistosoma mansoni thyroid hormone receptor 0.0077 0.0544 0.169
Loa Loa (eye worm) hypothetical protein 0.0069 0.0482 0.0482
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0233 0.1871 0.5811
Brugia malayi conserved hypotetical protein 0.0036 0.0201 0.0201
Trypanosoma brucei heat shock protein, putative 0.0013 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0068 0.0469 0.0469
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0233 0.1871 0.1871
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0211 0.0207
Brugia malayi beta-lactamase family protein 0.0036 0.0203 0.0203
Echinococcus multilocularis serine:threonine protein kinase N2 0.0017 0.0042 0.0131
Echinococcus granulosus Protein kinase C brain isozyme 0.0113 0.085 0.2639
Loa Loa (eye worm) hypothetical protein 0.0049 0.031 0.031
Plasmodium falciparum heat shock protein 90 0.0013 0.0005 0.0014
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0013 0.0005 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0077 0.0544 0.0544
Toxoplasma gondii AGC kinase 0.0017 0.0042 0.0038
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0203 0.0203
Leishmania major heat shock protein 83-1 0.0013 0.0005 0.0005
Schistosoma mansoni netrin receptor unc5 0.0015 0.0018 0.0055
Trypanosoma brucei heat shock protein, putative 0.0013 0.0005 0.0005
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.003 0.003
Leishmania major hypothetical protein, conserved 0.0036 0.0203 0.0203
Brugia malayi isocitrate dehydrogenase 0.0016 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0203 0.0203
Leishmania major heat shock protein 83-1 0.0013 0.0005 0.0005
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0013 0.0005 0.0024
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0045 0.0278 0.0864
Brugia malayi Nuclear hormone receptor E75 0.0036 0.0201 0.0201
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0042 0.0038
Loa Loa (eye worm) hypothetical protein 0.0036 0.0199 0.0199
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0392 0.322 0.3217
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0036 0.0201 0.0624
Loa Loa (eye worm) hypothetical protein 0.0077 0.0544 0.0544
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0042 0.0038
Plasmodium vivax SET domain protein, putative 0.003 0.015 0.0467
Echinococcus granulosus integrin alpha ps 0.0033 0.0175 0.0543
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0036 0.0201 0.0611
Trypanosoma brucei heat shock protein, putative 0.0013 0.0005 0.0005
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0077 0.0544 0.169
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0015 0.0021 0.0064
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0013 0.0005 0.0024
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0013 0.0005 0.0005
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0392 0.322 0.3217
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.015 0.0467
Loa Loa (eye worm) beta-lactamase 0.0036 0.0203 0.0203
Schistosoma mansoni hypothetical protein 0.0341 0.2786 0.8653
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0203 0.1089
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0392 0.322 0.322
Loa Loa (eye worm) hypothetical protein 0.0092 0.0672 0.0672
Brugia malayi Peptidase family M13 containing protein 0.0092 0.0672 0.0672
Loa Loa (eye worm) hypothetical protein 0.0077 0.0544 0.0544
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0013 0.0005 0.0024
Schistosoma mansoni inositol monophosphatase 0.0037 0.0211 0.0656
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0032 0.0168 0.0168
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.0526 0.1633
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0042 0.0131
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.003 0.0093
Brugia malayi Probable DNA topoisomerase II 0.0013 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0201
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0392 0.322 0.3217
Echinococcus multilocularis geminin 0.0341 0.2786 0.8653
Toxoplasma gondii peptidase family M13 protein 0.0092 0.0672 0.0667
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1192 1 1
Loa Loa (eye worm) carboxylesterase 0.0066 0.0452 0.0452
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0203 0.0631
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0082 0.0586 0.0581
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0287 0.0891
Loa Loa (eye worm) RasGEF domain-containing protein 0.0014 0.0017 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.085 0.2639
Brugia malayi protein kinase C3,putative 0.0013 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0121 0.0919 0.0919
Schistosoma mansoni heat shock protein 0.0013 0.0005 0.0014
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0118 0.0113
Loa Loa (eye worm) hypothetical protein 0.0077 0.0544 0.0544
Schistosoma mansoni hypothetical protein 0.0341 0.2786 0.8653
Loa Loa (eye worm) hypothetical protein 0.0066 0.0452 0.0452
Echinococcus granulosus NDR protein kinase 0.0017 0.0042 0.0131
Loa Loa (eye worm) hypothetical protein 0.0069 0.0482 0.0482
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0211 1
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0118 0.0366
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0013 0.0005 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0077 0.0544 0.0544
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0077 0.0544 0.0544
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0036 0.0201 0.0624
Onchocerca volvulus 0.024 0.1926 0.5975
Loa Loa (eye worm) hypothetical protein 0.004 0.0238 0.0238
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0077 0.0544 0.1678
Leishmania major sterol 24-c-methyltransferase, putative 0.0193 0.1528 0.1528
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0042 0.0131
Echinococcus granulosus synaptic glycoprotein sc2 0.0392 0.322 1
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0036 0.02 0.02
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0046 0.0287 0.0891
Loa Loa (eye worm) hypothetical protein 0.0036 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0036 0.0201 0.0201
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.003 0.003
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0013 0.0005 0.0014
Brugia malayi nuclear receptor NHR-88 0.0077 0.0544 0.0544
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0118 0.0118
Trypanosoma brucei developmentally regulated phosphoprotein 0.0233 0.1871 0.1871
Echinococcus granulosus carboxylesterase 5A 0.0066 0.0452 0.1405
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0077 0.0544 0.169
Loa Loa (eye worm) hypothetical protein 0.0017 0.0042 0.0042
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0392 0.322 1
Trichomonas vaginalis conserved hypothetical protein 0.0392 0.322 0.3217

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) > 50 ug ml-1 The concentration required to reduce cell growth by 50% was measured on Human Embryonic Lung (HEL) cells ChEMBL. 10197958
CC50 (functional) > 50 ug ml-1 The concentration required to reduce cell growth by 50% was measured on Human Embryonic Lung (HEL) cells ChEMBL. 10197958
CC50 (functional) > 200 ug ml-1 The concentration required to reduce 50% cell viability on CEM cells of Human T-lymphocyte ChEMBL. 10197958
CC50 (functional) > 200 ug ml-1 The concentration required to reduce 50% cell viability on CEM cells of Human T-lymphocyte ChEMBL. 10197958
EC50 (functional) > 40 ug ml-1 Concentration of the required to protect CEM cells of Human T-lymphocyte against Cytopathogenicity of HIV-1(III-B) by 50% ChEMBL. 10197958
EC50 (functional) > 40 ug ml-1 Concentration of the required to protect CEM cells of Human T-lymphocyte against Cytopathogenicity of HIV-2 by 50% ChEMBL. 10197958
IC50 (functional) > 50 ug ml-1 The concentration required to reduce virus plaque formation by 50% was measured on AD-169 strains of human cytomegalovirus ChEMBL. 10197958
IC50 (functional) > 50 ug ml-1 The concentration required to reduce virus plaque formation by 50% was measured on Davis strains of human cytomegalovirus ChEMBL. 10197958
IC50 (functional) > 50 ug ml-1 The concentration required to reduce virus plaque formation by 50% was measured on OKA strain of VZV expressing viral thymidine kinase(TK+) ChEMBL. 10197958
IC50 (functional) > 50 ug ml-1 The concentration required to reduce virus plaque formation by 50% was measured on YS strain of VZV expressing viral thymidine kinase(TK+) ChEMBL. 10197958
IC50 (functional) > 50 ug ml-1 The concentration required to reduce virus plaque formation by 50% was measured on 07/1 strain of VZV expressing viral thymidine kinase(TK-) ChEMBL. 10197958
IC50 (functional) > 50 ug ml-1 The concentration required to reduce virus plaque formation by 50% was measured on YS/Rstrain of VZV expressing viral thymidine kinase(TK-) ChEMBL. 10197958
MCC (functional) > 50 ug ml-1 The minimum cytotoxic concentration was measured on Human Embryonic Lung (HEL) cells ChEMBL. 10197958
MCC (functional) > 50 ug ml-1 The minimum cytotoxic concentration was measured on Human Embryonic Lung (HEL) cells ChEMBL. 10197958

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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