Detailed information for compound 1553509

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 509.619 | Formula: C23H35N5O6S
  • H donors: 1 H acceptors: 6 LogP: 0.3 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H](N1C[C@H](C)[C@H](OCc2cn(CCCC1=O)nn2)CN(S(=O)(=O)c1cccc(c1)OC)C)C
  • InChi: 1S/C23H35N5O6S/c1-17-12-28(18(2)15-29)23(30)9-6-10-27-13-19(24-25-27)16-34-22(17)14-26(3)35(31,32)21-8-5-7-20(11-21)33-4/h5,7-8,11,13,17-18,22,29H,6,9-10,12,14-16H2,1-4H3/t17-,18+,22+/m0/s1
  • InChiKey: RLIRIECCVMDDQV-NJNPRVFISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0025 0.0092 0.0092
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0034 0.0092
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0127 0.0127
Leishmania major DNA polymerase kappa, putative 0.0019 0.0034 0.0092
Brugia malayi Pre-SET motif family protein 0.0206 0.1877 0.1877
Plasmodium vivax SET domain protein, putative 0.0029 0.0137 0.0368
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0197 0.0197
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0137 0.1198 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0137 0.0137
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0053 0.0053
Trypanosoma brucei heat shock protein, putative 0.0036 0.0204 0.0546
Schistosoma mansoni hypothetical protein 0.0034 0.0179 0.0179
Brugia malayi heat shock protein 90 0.0036 0.0204 0.0204
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0333 0.0333
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0392 0.0392
Leishmania major heat shock protein 83-1 0.0036 0.0204 0.0546
Schistosoma mansoni hypothetical protein 0.0167 0.15 0.15
Schistosoma mansoni heat shock protein 0.0036 0.0204 0.0204
Trypanosoma brucei heat shock protein, putative 0.0036 0.0204 0.0546
Loa Loa (eye worm) hypothetical protein 0.0028 0.0119 0.0119
Echinococcus multilocularis snurportin 1 0.0304 0.285 0.285
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0053 0.0053
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0099 0.0264
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0092
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0034 0.0034
Leishmania major heat shock protein 83-1 0.0036 0.0204 0.0546
Trypanosoma brucei heat shock protein, putative 0.0036 0.0204 0.0546
Loa Loa (eye worm) hypothetical protein 0.0028 0.0119 0.0119
Brugia malayi hypothetical protein 0.0016 0.0005 0.0005
Leishmania major GTP-binding protein, putative 0.0021 0.0053 0.0142
Leishmania major heat shock protein 83-1 0.0036 0.0204 0.0546
Trichomonas vaginalis ran, putative 0.0021 0.0053 0.0088
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.1028 1 1
Entamoeba histolytica hypothetical protein 0.0036 0.0197 0.9188
Echinococcus granulosus heat shock protein 90 0.0026 0.0099 0.0099
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0053 0.0142
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0053 0.0142
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0393 0.3728 1
Schistosoma mansoni hypothetical protein 0.0304 0.285 0.285
Leishmania major basic transcription factor 3a, putative 0.0035 0.0187 0.0502
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0092 0.0246
Echinococcus granulosus geminin 0.0167 0.15 0.15
Echinococcus multilocularis neuropeptide receptor A26 0.0457 0.4358 0.4358
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0187 0.072
Brugia malayi Probable DNA topoisomerase II 0.0037 0.0212 0.0212
Trypanosoma cruzi DNA topoisomerase II, putative 0.0028 0.0119 0.032
Schistosoma mansoni importin beta-1 0.0028 0.0127 0.0127
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0393 0.3728 1
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0082 0.0654 0.0654
Leishmania major DNA topoisomerase ii 0.0028 0.0119 0.032
Loa Loa (eye worm) dihydrofolate reductase 0.1028 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0092 0.0246
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0045 0.0289 0.0193
Leishmania major heat shock protein 83-1 0.0036 0.0204 0.0546
Loa Loa (eye worm) hypothetical protein 0.0028 0.0127 0.0127
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0197 0.0197
Echinococcus granulosus heat shock protein 90 0.0036 0.0204 0.0204
Trypanosoma brucei heat shock protein, putative 0.0036 0.0204 0.0546
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0034 0.0034
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0187 0.8629
Toxoplasma gondii heat shock protein 90, putative 0.0036 0.0204 0.0546
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0034 0.0034
Trypanosoma brucei heat shock protein, putative 0.0036 0.0204 0.0546
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0092 0.0246
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0074 0.0188
Mycobacterium ulcerans DNA gyrase subunit B 0.0137 0.1198 0.1168
Chlamydia trachomatis DNA gyrase subunit B 0.0137 0.1198 0.0479
Leishmania major heat shock protein 83-1 0.0036 0.0204 0.0546
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0092
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0037 0.0212 0.0212
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0392 0.0392
Trichomonas vaginalis DNA topoisomerase II, putative 0.0037 0.0212 0.0834
Echinococcus granulosus dna polymerase eta 0.0019 0.0034 0.0034
Entamoeba histolytica DNA topoisomerase II, putative 0.0037 0.0212 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0034 0.0092
Brugia malayi hypothetical protein 0.0036 0.0197 0.0197
Leishmania major heat shock protein 83-1 0.0036 0.0204 0.0546
Echinococcus granulosus heat shock protein 0.0036 0.0204 0.0204
Schistosoma mansoni hypothetical protein 0.0167 0.15 0.15
Brugia malayi Importin beta-1 subunit 0.0028 0.0127 0.0127
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0137 0.0137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0137 0.0137
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0187 0.0502
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0034 0.0034
Plasmodium vivax heat shock protein 86, putative 0.0036 0.0204 0.0546
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.1028 1 1
Leishmania major heat shock protein 83-1 0.0036 0.0204 0.0546
Brugia malayi Pre-SET motif family protein 0.0029 0.0137 0.0137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0137 0.0137
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0034 0.0179 0.0179
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0034 0.0092
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0037 0.0212 0.0367
Schistosoma mansoni hypothetical protein 0.0082 0.0654 0.0654
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0392 0.0392
Loa Loa (eye worm) endoplasmin 0.0036 0.0204 0.0204
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0034 0.0092
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0074 0.0198
Entamoeba histolytica hypothetical protein 0.0036 0.0197 0.9188
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0099 0.0098
Chlamydia trachomatis dihydrofolate reductase 0.1028 1 1
Leishmania major heat shock protein 83-1 0.0036 0.0204 0.0546
Echinococcus multilocularis geminin 0.0167 0.15 0.15
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0082 0.0655 0.1756
Trypanosoma brucei unspecified product 0.0019 0.0034 0.0092
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0034 0.0034
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0137 0.0137
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0037 0.0212 0.0212
Leishmania major heat shock protein 83-1 0.0036 0.0204 0.0546
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0034 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0187 0.072
Leishmania major DNA polymerase eta, putative 0.0019 0.0034 0.0092
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0179 0.0179
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0392 0.0392
Trypanosoma brucei Heat shock protein 83, putative 0.0036 0.0204 0.0546
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1011 0.1011
Schistosoma mansoni ran 0.0021 0.0053 0.0053
Plasmodium vivax DNA gyrase subunit B, putative 0.0137 0.1198 0.3213
Loa Loa (eye worm) hypothetical protein 0.0025 0.0092 0.0092
Loa Loa (eye worm) heat shock protein 90 0.0036 0.0204 0.0204
Schistosoma mansoni heat shock protein 0.0036 0.0204 0.0204
Loa Loa (eye worm) TOPoisomerase family member 0.0037 0.0212 0.0212
Leishmania major heat shock protein 83-1 0.0036 0.0204 0.0546
Plasmodium falciparum importin beta, putative 0.0028 0.0127 0.0341
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0053 0.1109
Loa Loa (eye worm) apoptosis regulator protein 0.0082 0.0654 0.0654
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0034 0.0092
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.285 0.285
Echinococcus granulosus dihydrofolate reductase 0.1028 1 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0099 0.0099
Entamoeba histolytica hypothetical protein 0.0035 0.0187 0.8629
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0082 0.0654 0.0654
Leishmania major heat shock protein 83-1 0.0036 0.0204 0.0546
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0053 0.0142
Leishmania major heat shock protein 83-1 0.0036 0.0204 0.0546
Trypanosoma cruzi Heat shock protein 83, putative 0.0036 0.0204 0.0546
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0137 0.0368
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0393 0.3728 1
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0204 0.0546
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0099 0.0303
Schistosoma mansoni transcription factor btf3 0.0035 0.0187 0.0187
Trichomonas vaginalis heat shock protein, putative 0.0036 0.0204 0.0797
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0034 0.0092
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0187 0.0502
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1877 0.1877
Echinococcus multilocularis dna polymerase eta 0.0019 0.0034 0.0034
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0092 0.0246
Loa Loa (eye worm) hypothetical protein 0.0082 0.0654 0.0654
Echinococcus multilocularis endoplasmin 0.0026 0.0099 0.0099
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0092
Schistosoma mansoni apoptosis regulator bax 0.0082 0.0654 0.0654
Entamoeba histolytica heat shock protein 90, putative 0.0036 0.0204 0.9554
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0053 0.0142
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0037 0.0212 0.0367
Echinococcus multilocularis transcription factor btf3 0.0035 0.0187 0.0187
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0099 0.0303
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0392 0.0392
Schistosoma mansoni DNA topoisomerase II 0.0037 0.0212 0.0212
Schistosoma mansoni dihydrofolate reductase 0.1028 1 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0127 0.0341
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0333 0.0333
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0037 0.0212 0.0367
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0092
Echinococcus multilocularis heat shock protein 90 0.0036 0.0204 0.0204
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0074 0.0188
Entamoeba histolytica hypothetical protein 0.0023 0.0074 0.2249
Entamoeba histolytica hypothetical protein 0.0036 0.0197 0.9188
Leishmania major heat shock protein 83-1 0.0036 0.0204 0.0546
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0028 0.0119 0.032
Brugia malayi Endoplasmin precursor 0.0036 0.0204 0.0204
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0053 0.0142
Trypanosoma cruzi heat shock protein 90, putative 0.0036 0.0204 0.0546
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0392 0.0392
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0099 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0187 0.072
Brugia malayi MH2 domain containing protein 0.0118 0.1011 0.1011
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0137 0.0137
Leishmania major hypothetical protein, conserved 0.0025 0.0092 0.0246
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0034 0.0092
Entamoeba histolytica heat shock protein 90, putative 0.0036 0.0204 0.9554
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0082 0.0654 0.0654
Trichomonas vaginalis endoplasmin, putative 0.0024 0.0081 0.022
Trypanosoma brucei heat shock protein, putative 0.0036 0.0204 0.0546
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0204 0.0546
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0137 0.1198 0.1198
Leishmania major importin beta-1 subunit, putative 0.0023 0.0074 0.0198
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0127 0.0127
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2157 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0074 0.0188
Trypanosoma brucei heat shock protein, putative 0.0036 0.0204 0.0546
Leishmania major heat shock protein 83-1 0.0036 0.0204 0.0546
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0099 0.3797
Trypanosoma brucei DNA topoisomerase ii 0.0082 0.0655 0.1756
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0037 0.0212 0.0212
Schistosoma mansoni ran 0.0021 0.0053 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0092
Echinococcus granulosus dna polymerase kappa 0.0019 0.0034 0.0034
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0187 0.0502
Plasmodium vivax importin-beta 2, putative 0.0028 0.0127 0.0341
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0127 0.0341
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0137 0.1198 1
Echinococcus multilocularis heat shock protein 90 0.0026 0.0099 0.0099
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.1028 1 1
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0393 0.3728 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0028 0.0119 0.032
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0082 0.0654 0.0654
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0187 0.0502
Echinococcus multilocularis neuropeptide s receptor 0.0457 0.4358 0.4358
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0099 0.0264
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0034 0.0092
Brugia malayi RNA, U transporter 1 0.0081 0.0646 0.0646
Plasmodium falciparum heat shock protein 90 0.0036 0.0204 0.0546
Leishmania major heat shock protein 83-1 0.0036 0.0204 0.0546
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1011 0.1011
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0393 0.3728 1
Brugia malayi beta-NAC-like protein 0.0035 0.0187 0.0187
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0034 0.0092
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0034
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0197 0.0197
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0082 0.0655 0.1756
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0333 0.0333
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0187 0.0187
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0053 0.0053
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0392 0.0392
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0082 0.0654 0.0654
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0092 0.0246
Echinococcus multilocularis heat shock protein 0.0036 0.0204 0.0204
Toxoplasma gondii DNA topoisomerase 2, putative 0.0037 0.0212 0.0567
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0081 0.022
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0053 0.0053
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0034 0.0092
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0034 0.0034
Echinococcus granulosus neuropeptide s receptor 0.0457 0.4358 0.4358
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0082 0.0654 0.0654
Echinococcus granulosus transcription factor btf3 0.0035 0.0187 0.0187
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0187 0.0502
Schistosoma mansoni hypothetical protein 0.0036 0.0197 0.0197
Echinococcus multilocularis dihydrofolate reductase 0.1028 1 1
Giardia lamblia Grp94/Hsp90 0.0026 0.0099 0.3797
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0029 0.0137 0.0137
Toxoplasma gondii heat shock protein HSP90 0.0036 0.0204 0.0546
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0092
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0127 0.0341
Echinococcus granulosus endoplasmin 0.0026 0.0099 0.0099
Entamoeba histolytica hypothetical protein 0.0036 0.0197 0.9188
Trypanosoma brucei heat shock protein 90, putative 0.0036 0.0204 0.0546
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0092 0.0246
Plasmodium vivax endoplasmin, putative 0.0036 0.0204 0.0546
Trypanosoma cruzi heat shock protein 85, putative 0.0036 0.0204 0.0546
Entamoeba histolytica Ran family GTPase 0.0021 0.0053 0.1059
Schistosoma mansoni endoplasmin 0.0036 0.0204 0.0204
Plasmodium falciparum DNA topoisomerase 2 0.0037 0.0212 0.0567
Schistosoma mansoni DNA polymerase eta 0.0019 0.0034 0.0034
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0037 0.0212 0.0212
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0092
Leishmania major heat shock protein 83-1 0.0036 0.0204 0.0546
Schistosoma mansoni hypothetical protein 0.0082 0.0654 0.0654
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0137 0.0137
Leishmania major mitochondrial DNA topoisomerase II 0.0082 0.0655 0.1756
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0082 0.0655 0.1756
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0092 0.0246
Brugia malayi Dihydrofolate reductase 0.1028 1 1
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0099 0.0303
Giardia lamblia Heat shock protein HSP 90-alpha 0.0036 0.0204 1
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0028 0.0119 0.032
Trypanosoma brucei heat shock protein 90, putative 0.0036 0.0204 0.0546
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0099 0.0264
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0082 0.0654 0.0654
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0392 0.0392
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0393 0.3728 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0053 0.0142
Plasmodium vivax DNA topoisomerase II, putative 0.0037 0.0212 0.0567
Onchocerca volvulus 0.0234 0.2157 1
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0074 0.0197
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0187 0.0502
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0034 0.0092
Plasmodium falciparum endoplasmin, putative 0.0024 0.0081 0.0217
Giardia lamblia DNA topoisomerase II 0.0026 0.0107 0.4264
Trypanosoma brucei heat shock protein, putative 0.0036 0.0204 0.0546
Echinococcus granulosus snurportin 1 0.0304 0.285 0.285
Schistosoma mansoni endoplasmin 0.0036 0.0204 0.0204
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0034 0.0034
Echinococcus granulosus neuropeptide receptor A26 0.0457 0.4358 0.4358
Echinococcus granulosus importin subunit beta 1 0.0028 0.0127 0.0127
Leishmania major heat shock protein 83-1 0.0036 0.0204 0.0546
Loa Loa (eye worm) hypothetical protein 0.0049 0.0333 0.0333
Plasmodium falciparum DNA gyrase subunit B 0.0137 0.1198 0.3213

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.4125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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