Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0091 | 0.037 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0124 | 0.0592 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0091 | 0.037 | 0.4503 |
Echinococcus multilocularis | acetylcholinesterase | 0.0536 | 0.3167 | 0.3167 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0026 | 0.0081 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0025 | 0.0025 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0228 | 0.1232 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0025 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0091 | 0.037 | 0.1169 |
Brugia malayi | Cytochrome P450 family protein | 0.0053 | 0.0135 | 0.0426 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0025 | 0.0079 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0299 | 0.168 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0536 | 0.3167 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.0105 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0091 | 0.037 | 0.037 |
Onchocerca volvulus | 0.0091 | 0.037 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.037 | 0.1169 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0025 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0026 | 0.0081 |
Brugia malayi | Carboxylesterase family protein | 0.0091 | 0.037 | 0.1169 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0026 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.037 | 0.1169 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0429 | 0.1353 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.037 | 0.1169 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.023 | 0.0727 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0142 | 0.0691 | 0.402 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0026 | 0.0081 |
Echinococcus granulosus | geminin | 0.0522 | 0.308 | 0.9728 |
Brugia malayi | Carboxylesterase family protein | 0.0091 | 0.037 | 0.1169 |
Onchocerca volvulus | 0.0091 | 0.037 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.2767 | 0.8736 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0536 | 0.3167 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0091 | 0.037 | 0.1169 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0091 | 0.037 | 0.2856 |
Echinococcus multilocularis | acetylcholinesterase | 0.0536 | 0.3167 | 0.3167 |
Echinococcus granulosus | neuroligin | 0.0091 | 0.037 | 0.1169 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.0429 | 0.1353 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0026 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0091 | 0.037 | 0.1169 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0091 | 0.037 | 0.2856 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0142 | 0.0691 | 0.402 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.023 | 0.0727 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0026 | 0.0081 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0472 | 0.2767 | 0.2767 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0142 | 0.0691 | 0.402 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0025 | 0.0079 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0026 | 0.0081 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.0429 | 0.1353 |
Brugia malayi | Carboxylesterase family protein | 0.0091 | 0.037 | 0.1169 |
Echinococcus granulosus | acetylcholinesterase | 0.0536 | 0.3167 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0026 | 0.0081 |
Brugia malayi | Carboxylesterase family protein | 0.0091 | 0.037 | 0.1169 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.037 | 0.1169 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0091 | 0.037 | 0.037 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0091 | 0.037 | 0.1169 |
Echinococcus granulosus | acetylcholinesterase | 0.0536 | 0.3167 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.037 | 0.1169 |
Brugia malayi | hypothetical protein | 0.0091 | 0.037 | 0.1169 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0091 | 0.037 | 0.1169 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0091 | 0.037 | 0.1169 |
Schistosoma mansoni | hypothetical protein | 0.0522 | 0.308 | 0.9728 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.037 | 0.1169 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0026 | 0.0081 |
Brugia malayi | Muscleblind-like protein | 0.0472 | 0.2767 | 0.8736 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0053 | 0.0135 | 0.0426 |
Loa Loa (eye worm) | carboxylesterase | 0.0091 | 0.037 | 0.1169 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.023 | 0.0727 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0026 | 0.0081 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0536 | 0.3167 | 1 |
Onchocerca volvulus | 0.0091 | 0.037 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0522 | 0.308 | 0.9728 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.0429 | 0.1353 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0299 | 0.168 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0157 | 0.0791 | 0.6343 |
Mycobacterium ulcerans | hypothetical protein | 0.0157 | 0.0791 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0091 | 0.037 | 0.1169 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0091 | 0.037 | 0.1169 |
Loa Loa (eye worm) | hypothetical protein | 0.0536 | 0.3167 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0026 | 0.0081 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0299 | 0.168 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0026 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.037 | 0.1169 |
Echinococcus granulosus | muscleblind protein | 0.0472 | 0.2767 | 0.8736 |
Loa Loa (eye worm) | carboxylesterase | 0.0091 | 0.037 | 0.1169 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0026 | 0.0081 |
Brugia malayi | Carboxylesterase family protein | 0.0536 | 0.3167 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0066 | 0.0243 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0299 | 0.168 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0025 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.2767 | 0.8736 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0091 | 0.037 | 0.1169 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0026 | 0.0081 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0025 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0026 | 0.0081 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0536 | 0.3167 | 0.3167 |
Loa Loa (eye worm) | hypothetical protein | 0.0536 | 0.3167 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0026 | 0.0081 |
Loa Loa (eye worm) | carboxylesterase | 0.0536 | 0.3167 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0066 | 0.0243 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0091 | 0.037 | 0.037 |
Echinococcus multilocularis | geminin | 0.0522 | 0.308 | 0.308 |
Brugia malayi | Carboxylesterase family protein | 0.0536 | 0.3167 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0026 | 0.0026 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0042 | 0.0066 | 0.0243 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0025 | 0.0079 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0091 | 0.037 | 0.2856 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0091 | 0.037 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0091 | 0.037 | 0.1169 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0042 | 0.0066 | 0.0243 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0026 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0091 | 0.037 | 0.037 |
Onchocerca volvulus | 0.0091 | 0.037 | 1 | |
Onchocerca volvulus | 0.0091 | 0.037 | 1 | |
Echinococcus multilocularis | muscleblind protein | 0.0472 | 0.2767 | 0.2767 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0025 | 0.0079 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0026 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.