TDR Targets

Basic information

Technical information

TDR Targets ID: 1553887
Name: N-(5,5-dioxo-2-phenyl-4,6-dihydrothieno[3,4-d ]pyrazol-3-yl)cyclopropanecarboxamide
MW: 317.363 | Formula: C15H15N3O3S
H donors: 1 H acceptors: 4 LogP: 0.64 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C1CC1)Nc1c2CS(=O)(=O)Cc2nn1c1ccccc1
InChi: 1S/C15H15N3O3S/c19-15(10-6-7-10)16-14-12-8-22(20,21)9-13(12)17-18(14)11-4-2-1-3-5-11/h1-5,10H,6-9H2,(H,16,19)
InChiKey: JAGJPWFDNVRXMG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(5,5-diketo-2-phenyl-4,6-dihydrothieno[3,4-d]pyrazol-3-yl)cyclopropanecarboxamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ubiquitin specific peptidase 1	Starlite/ChEMBL	No references
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0158	0.0126
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0228	0.0196
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0014	0.0086	0.0053
Plasmodium vivax	aldehyde reductase, putative	0.0296	0.2862	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1023	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.1023	1	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0228	0.0196
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0228	0.0196
Trichomonas vaginalis	aldo-keto reductase, putative	0.0296	0.2862	0.2843
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0065	0.0586	0.0555
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0296	0.2862	0.2839
Schistosoma mansoni	hypothetical protein	0.0201	0.1927	0.1927
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0485	0.0485
Echinococcus multilocularis	aldo keto reductase	0.1023	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0296	0.2862	0.2843
Echinococcus multilocularis	cpg binding protein	0.0036	0.0306	0.0274
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.1023	1	1
Onchocerca volvulus		0.1023	1	1
Onchocerca volvulus		0.1023	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0158	0.0126
Plasmodium falciparum	acyl-CoA synthetase	0.0021	0.0158	0.0443
Trichomonas vaginalis	aldo-keto reductase, putative	0.1023	1	1
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0296	0.2862	0.2839
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0228	0.0196
Trichomonas vaginalis	conserved hypothetical protein	0.0296	0.2862	0.2843
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0158	0.0126
Trichomonas vaginalis	aldo-keto reductase, putative	0.1023	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0228	0.0196
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0251	0.0218
Schistosoma mansoni	microtubule-associated protein tau	0.0819	0.7995	0.7995
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0008	0.0033	0.0011
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0028	0.0228	0.0196
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0028	0.0228	0.0207
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1023	1	1
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0296	0.2862	0.2839
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.002	0.0147	0.0126
Plasmodium falciparum	aldehyde reductase, putative	0.0296	0.2862	1
Schistosoma mansoni	hypothetical protein	0.0201	0.1927	0.1927
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1023	1	1
Echinococcus multilocularis	microtubule associated protein 2	0.0819	0.7995	0.7989
Toxoplasma gondii	aldose reductase, putative	0.1023	1	1
Echinococcus granulosus	microtubule associated protein 2	0.0819	0.7995	0.7989
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1023	1	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0072	0.0662	0.0662
Trichomonas vaginalis	aldo-keto reductase, putative	0.1023	1	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0963	0.9404	0.9402
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1023	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0158	0.0126
Plasmodium falciparum	aldo-keto reductase, putative	0.0296	0.2862	1
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0056	0.0023
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0296	0.2862	1
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.1023	1	1
Echinococcus granulosus	aldo keto reductase	0.1023	1	1
Onchocerca volvulus		0.1023	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1023	1	1
Echinococcus multilocularis	aldo keto reductase	0.1023	1	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.1023	1	1
Onchocerca volvulus		0.0179	0.1713	0.1686
Echinococcus granulosus	aldo keto reductase	0.1023	1	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.1023	1	1
Onchocerca volvulus		0.1023	1	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0028	0.0228	0.0196
Entamoeba histolytica	acyl-coA synthetase, putative	0.0028	0.0228	0.0196
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0251	0.077
Loa Loa (eye worm)	oxidoreductase	0.1023	1	1
Echinococcus granulosus	hypothetical protein	0.1023	1	1
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0296	0.2862	0.2839
Schistosoma mansoni	hypothetical protein	0.0014	0.0086	0.0086
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0296	0.2862	0.2839
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0035	0.0002
Mycobacterium ulcerans	hypothetical protein	0.0028	0.0228	0.0196
Brugia malayi	hypothetical protein	0.0179	0.1713	0.1686
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1023	1	1
Brugia malayi	CXXC zinc finger family protein	0.0034	0.0287	0.0254
Onchocerca volvulus		0.1023	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.1023	1	1
Giardia lamblia	Aldose reductase	0.1023	1	0.5
Mycobacterium tuberculosis	Conserved protein	0.0296	0.2862	0.2847
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1023	1	1
Loa Loa (eye worm)	hypothetical protein	0.1023	1	1
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0008	0.0033	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0179	0.1713	0.1686
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0028	0.0228	0.0196
Echinococcus granulosus	dnaJ subfamily B	0.0486	0.4719	0.4702
Trypanosoma cruzi	aldo/keto reductase, putative	0.0296	0.2862	0.2839
Echinococcus multilocularis	dnaJ subfamily B	0.0486	0.4719	0.4702
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0251	0.0218
Trichomonas vaginalis	aldo/keto reductase, putative	0.1023	1	1
Schistosoma mansoni	cpg binding protein	0.0036	0.0306	0.0306
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1023	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.1023	1	1
Schistosoma mansoni	acetyl-CoA synthetase	0.0008	0.0033	0.0033
Entamoeba histolytica	aldose reductase, putative	0.1023	1	1
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0033	0.0011
Schistosoma mansoni	aldo-keto reductase	0.1023	1	1
Trypanosoma brucei	prostaglandin f synthase	0.1023	1	1
Schistosoma mansoni	hypothetical protein	0.0486	0.4719	0.4719
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0008	0.0033	0.0011
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.002	0.0147	0.0126
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0028	0.0228	0.0196
Brugia malayi	NADH-dependent xylose reductase	0.0296	0.2862	0.2839
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0054	0.0021
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0035	0.0002
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.1023	1	1
Entamoeba histolytica	aldose reductase, putative	0.1023	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1023	1	1
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0228	0.0196
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0228	0.0196
Schistosoma mansoni	potassium channel beta	0.0296	0.2862	0.2862
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1023	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.0485	0.0454
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1023	1	1
Echinococcus multilocularis	aldehyde reductase	0.0727	0.709	0.708
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0008	0.0033	0.0011
Onchocerca volvulus		0.0028	0.0228	0.0196
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0251	0.077
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.1023	1	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.1023	1	1
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0033	0.0011
Echinococcus granulosus	voltage gated potassium channel subunit	0.0296	0.2862	0.2839
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0296	0.2862	0.2839
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.002	0.0147	0.0126
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1023	1	1
Loa Loa (eye worm)	oxidoreductase	0.1023	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1023	1	1
Trypanosoma brucei	aldo/keto reductase, putative	0.0296	0.2862	0.2839
Schistosoma mansoni	cpg binding protein	0.0036	0.0306	0.0306
Brugia malayi	hypothetical protein	0.002	0.0145	0.0112
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0028	0.0228	0.0196
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0008	0.0033	0.0011
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0054	0.0485	0.0454
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1023	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.1023	1	1
Toxoplasma gondii	aldo-keto reductase	0.0296	0.2862	0.2839
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0035	0.0035
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.0485	0.0454
Onchocerca volvulus		0.0296	0.2862	0.2839
Mycobacterium tuberculosis	Probable oxidoreductase	0.1023	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0251	0.0218
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0056	0.0023
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0251	0.0218
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0296	0.2862	0.2839
Entamoeba histolytica	aldose reductase, putative	0.1023	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1023	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0485	0.0485
Trichomonas vaginalis	aldo-keto reductase, putative	0.0296	0.2862	0.2843
Trichomonas vaginalis	aldo-keto reductase, putative	0.1023	1	1
Echinococcus multilocularis	aldo keto reductase	0.1023	1	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0035	0.0002
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.1023	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1023	1	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0033	0.0011
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0028	0.0228	0.0196
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1023	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.0485	0.0454
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.0485	0.0454
Echinococcus multilocularis	geminin	0.0201	0.1927	0.19
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.1023	1	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0021	0.0158	0.5
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.002	0.0147	0.0126
Leishmania major	aldo-keto reductase-like protein	0.1023	1	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0054	0.0485	0.0454
Echinococcus granulosus	aldehyde reductase	0.0727	0.709	0.708
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0485	0.0485
Echinococcus granulosus	aldo keto reductase	0.1023	1	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0251	0.0218
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0296	0.2862	0.2843
Trichomonas vaginalis	aldo-keto reductase, putative	0.1023	1	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0228	0.0196
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0.0033	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0158	0.0126
Loa Loa (eye worm)	oxidoreductase	0.1023	1	1
Echinococcus granulosus	geminin	0.0201	0.1927	0.19
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0008	0.0033	0.0011
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0021	0.0158	0.0137
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0014	0.0086	0.0053
Plasmodium vivax	acyl-CoA synthetase, putative	0.0021	0.0158	0.0443
Trichomonas vaginalis	aldo-keto reductase, putative	0.1023	1	1
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0008	0.0033	0.0011
Onchocerca volvulus		0.0034	0.0287	0.0254
Mycobacterium ulcerans	oxidoreductase	0.1023	1	1
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0228	0.0196
Schistosoma mansoni	cpg binding protein	0.0034	0.0287	0.0287
Schistosoma mansoni	pol-related	0.1023	1	1
Mycobacterium leprae	Possible oxidoreductase	0.0296	0.2862	0.2839
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0228	0.0196
Echinococcus multilocularis	aldo keto reductase	0.1023	1	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0056	0.0023
Mycobacterium leprae	Conserved hypothetical protein	0.0727	0.709	0.708
Onchocerca volvulus		0.1023	1	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.1023	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.1023	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.1023	1	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0251	0.077
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0296	0.2862	0.2839
Brugia malayi	hypothetical protein	0.003	0.0251	0.0218
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0296	0.2862	0.2839
Trypanosoma brucei	aldo-keto reductase, putative	0.1023	1	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0035	0.0002
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0.0033	0.0005
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0021	0.0158	0.0126
Echinococcus granulosus	cpg binding protein	0.0036	0.0306	0.0274
Trypanosoma cruzi	aldo/keto reductase, putative	0.1023	1	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0228	0.0196
Leishmania major	hypothetical protein, conserved	0.003	0.0251	0.0218
Giardia lamblia	Aldose reductase	0.1023	1	0.5
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0034	0.0287	0.0254
Loa Loa (eye worm)	oxidoreductase	0.1023	1	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.1023	1	1
Schistosoma mansoni	aldo-keto reductase	0.1023	1	1
Trypanosoma cruzi	aldo-keto reductase	0.1023	1	1
Loa Loa (eye worm)	oxidoreductase	0.1023	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.1023	1	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0028	0.0228	0.0196
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0033	0.0011
Mycobacterium ulcerans	hypothetical protein	0.0296	0.2862	0.2839
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0228	0.0196
Trichomonas vaginalis	aldo-keto reductase, putative	0.1023	1	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0028	0.0228	0.0196
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0028	0.0228	0.0207
Leishmania major	prostaglandin f synthase, putative	0.1023	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0891 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.2512 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1901459

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1553887