Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0141 | 0.4011 | 0.4011 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0027 | 0.0349 | 0.0336 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0063 | 0.1521 | 0.1214 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0035 | 0.0586 | 0.1428 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.4011 | 0.3891 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.1521 | 0.129 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.0686 | 0.2023 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0079 | 0.2019 | 0.1802 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0076 | 0.1941 | 0.1649 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0038 | 0.0686 | 0.0149 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0326 | 1 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0052 | 0.114 | 0.0833 |
Brugia malayi | beta-lactamase | 0.0038 | 0.0686 | 0.0686 |
Echinococcus granulosus | zinc finger protein | 0.0042 | 0.0816 | 0.0484 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0685 | 0.9121 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0036 | 0.0642 | 0.0304 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0686 | 0.05 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0039 | 0.0717 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.0717 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0686 | 0.05 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0039 | 0.0717 | 0.2466 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0038 | 0.0686 | 0.0149 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0038 | 0.0686 | 0.0149 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0027 | 0.0349 | 0.0156 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0717 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0027 | 0.0348 | 0.0328 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0686 | 0.9145 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0079 | 0.2019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.1572 | 0.1403 |
Schistosoma mansoni | zinc finger protein | 0.0033 | 0.0522 | 0.0264 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0038 | 0.0686 | 0.0149 |
Trypanosoma brucei | ISWI complex protein | 0.0033 | 0.0522 | 0.5411 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0326 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0685 | 0.0432 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0685 | 0.0348 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0039 | 0.0717 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0686 | 0.9262 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0079 | 0.2019 | 1 |
Onchocerca volvulus | 0.0038 | 0.0686 | 0.5 | |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.0349 | 0.1362 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.0686 | 0.3209 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0685 | 0.0348 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0065 | 0.1572 | 0.1267 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0065 | 0.1572 | 0.1572 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0717 | 0.0465 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0717 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0038 | 0.0686 | 0.0149 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0039 | 0.0717 | 0.0236 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.2403 | 0.2251 |
Echinococcus multilocularis | GPCR, family 2 | 0.0065 | 0.1572 | 0.1267 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.2019 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0065 | 0.1572 | 0.1267 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.0686 | 0.9262 |
Echinococcus granulosus | GPCR family 2 | 0.0065 | 0.1572 | 0.1267 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.0717 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0686 | 0.9262 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0036 | 0.0642 | 0.0304 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0038 | 0.0686 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0686 | 0.05 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.4333 | 0.422 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0686 | 0.0349 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.2019 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0685 | 0.0432 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0079 | 0.2019 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.1572 | 0.1342 |
Leishmania major | hypothetical protein, conserved | 0.0033 | 0.0522 | 0.1875 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.3236 | 0.3236 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0685 | 0.9121 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.0686 | 0.2284 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0642 | 0.0388 |
Onchocerca volvulus | 0.0038 | 0.0686 | 0.5 | |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.0196 | 0.0196 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0063 | 0.1521 | 0.1214 |
Echinococcus multilocularis | zinc finger protein | 0.0042 | 0.0816 | 0.0484 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0686 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0686 | 0.05 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0076 | 0.1941 | 0.1649 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.1521 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0326 | 1 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.0717 | 0.0381 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0291 | 0.0291 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0027 | 0.0349 | 0.0336 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.0349 | 0.0472 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0686 | 0.0149 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0052 | 0.114 | 0.0833 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.2271 | 0.2117 |
Brugia malayi | Flap endonuclease-1 | 0.0027 | 0.0349 | 0.0349 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0048 | 0.102 | 0.0695 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0079 | 0.2019 | 0.173 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0686 | 0.05 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.2019 | 1 |
Brugia malayi | Inositol-1 | 0.0039 | 0.0717 | 0.0717 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0686 | 0.0349 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0063 | 0.1521 | 0.1404 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0686 | 0.9145 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0686 | 0.0432 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.3236 | 0.3101 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.2019 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.0686 | 0.0686 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0127 | 0.3575 | 0.3343 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0686 | 0.0686 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0686 | 0.0149 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0036 | 0.0642 | 0.0388 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.3236 | 0.3101 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.2019 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.1521 | 0.6264 |
Trypanosoma cruzi | ISWI complex protein | 0.0033 | 0.0522 | 0.5411 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0686 | 0.9145 |
Onchocerca volvulus | 0.0038 | 0.0686 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0889 | 0.0641 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0686 | 0.05 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0127 | 0.3575 | 0.3343 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0038 | 0.0686 | 0.0149 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.0349 | 0.1362 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.0686 | 0.2284 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0052 | 0.114 | 0.082 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0686 | 0.05 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0717 | 0.0465 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0241 | 0.724 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0326 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0326 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0044 | 0.0889 | 0.0706 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0027 | 0.0348 | 0.0328 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0642 | 0.0455 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.0717 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0685 | 0.9121 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0291 | 0.0097 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.1521 | 0.6264 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0206 | 0.6113 | 0.6113 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0052 | 0.114 | 0.082 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0048 | 0.102 | 0.0695 |
Mycobacterium tuberculosis | Conserved protein | 0.0038 | 0.0686 | 0.0149 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0063 | 0.1521 | 0.6264 |
Plasmodium falciparum | flap endonuclease 1 | 0.0027 | 0.0349 | 0.0336 |
Schistosoma mansoni | zinc finger protein | 0.0042 | 0.0816 | 0.0566 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.1572 | 0.1342 |
Brugia malayi | PHD-finger family protein | 0.0053 | 0.1183 | 0.1183 |
Toxoplasma gondii | hypothetical protein | 0.0027 | 0.0348 | 0.0328 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0065 | 0.1572 | 0.1267 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0048 | 0.102 | 0.0776 |
Schistosoma mansoni | bromodomain containing protein | 0.0135 | 0.3822 | 0.3654 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0686 | 0.05 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.2019 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0079 | 0.2019 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0082 | 0.2104 | 0.2104 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0027 | 0.0349 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0642 | 0.0388 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0063 | 0.1521 | 0.129 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.6113 | 0.6035 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0036 | 0.0642 | 0.0304 |
Trypanosoma cruzi | ISWI complex protein | 0.0033 | 0.0522 | 0.5411 |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.0717 | 0.0532 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.2019 | 0.1859 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0686 | 0.9145 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0642 | 0.0304 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0685 | 0.0685 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0052 | 0.114 | 0.4744 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0065 | 0.1572 | 0.1267 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0522 | 0.0264 |
Brugia malayi | Probable ClpP-like protease | 0.0079 | 0.2019 | 0.2019 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.1572 | 0.1342 |
Trichomonas vaginalis | esterase, putative | 0.0038 | 0.0686 | 0.9145 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0326 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0065 | 0.1572 | 0.1403 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0036 | 0.0642 | 0.0388 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.1572 | 0.1342 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0079 | 0.2019 | 0.173 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0038 | 0.0685 | 0.0498 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0686 | 0.0686 |
Brugia malayi | Bromodomain containing protein | 0.016 | 0.4628 | 0.4628 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0206 | 0.6113 | 0.6035 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.4011 | 0.3848 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0685 | 0.9121 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.1521 | 0.7117 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0.0686 | 0.2023 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0065 | 0.1572 | 0.1572 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0079 | 0.2019 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0717 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0717 | 0.3465 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.2108 | 0.1951 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0326 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0686 | 0.9145 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0206 | 0.6113 | 0.6113 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 ug ml-1 | Compound was evaluated for cytotoxicity against vincristine- resistant (KB/VJ300) human oral epidermoid carcinoma cell line; poor activity or moderate activity | ChEMBL. | 9873619 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.