Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.2529 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0.0312 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0093 | 0.7738 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.9842 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0084 | 0.6874 | 0.8837 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0093 | 0.7738 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0084 | 0.6874 | 0.8837 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0093 | 0.7738 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0093 | 0.7738 | 1 |
Brugia malayi | glutathione reductase | 0.0037 | 0.2529 | 0.2569 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0037 | 0.2574 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0084 | 0.6874 | 0.8837 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.2529 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0013 | 0.0312 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0013 | 0.0312 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0084 | 0.6874 | 0.8837 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0013 | 0.0312 | 0.0317 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.9842 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0084 | 0.6874 | 0.8837 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.2529 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.2529 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0037 | 0.2529 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.2529 | 0.2569 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0013 | 0.0312 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.2529 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0.0312 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0013 | 0.0312 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0013 | 0.0312 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0037 | 0.2529 | 0.2985 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.9842 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0037 | 0.2574 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0084 | 0.6874 | 0.8837 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0037 | 0.2529 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0013 | 0.0312 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0013 | 0.0312 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0013 | 0.0312 | 0.5 |
Leishmania major | trypanothione reductase | 0.0037 | 0.2529 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.47 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.895 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.813 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.574 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.371 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.307 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.