Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0072 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0072 | 1 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0072 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0069 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0072 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0069 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0072 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0072 | 1 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0069 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0072 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.