Detailed information for compound 1554323

Basic information

Technical information
  • TDR Targets ID: 1554323
  • Name: 2,6-dichloro-9-phenylpurine
  • MW: 265.098 | Formula: C11H6Cl2N4
  • H donors: 0 H acceptors: 3 LogP: 3.63 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1nc(Cl)c2c(n1)n(cn2)c1ccccc1
  • InChi: 1S/C11H6Cl2N4/c12-9-8-10(16-11(13)15-9)17(6-14-8)7-4-2-1-3-5-7/h1-6H
  • InChiKey: PUARFAPITOZVIH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,6-dichloro-9-phenyl-purine
  • 6971-26-2
  • NSC19098

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nibrin 0.0021 0.1043 0.1253
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0021 0.1043 0.706
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.1444 1
Plasmodium vivax replication factor C subunit 1, putative 0.0021 0.1043 0.648
Loa Loa (eye worm) hypothetical protein 0.0021 0.1043 0.0972
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0037 0.215 0.2692
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.1342 0.849
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0079 0.0546
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0433 0.046
Brugia malayi Latrophilin receptor protein 2 0.0037 0.215 0.2665
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.1043 0.2688
Schistosoma mansoni hypothetical protein 0.0037 0.215 0.2692
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0021 0.1043 0.1253
Entamoeba histolytica hypothetical protein 0.0115 0.7774 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0877 0.6071
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.1444 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0037 0.215 0.2692
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.215 0.2665
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.1444 0.3807
Entamoeba histolytica hypothetical protein 0.0115 0.7774 1
Echinococcus granulosus replication factor c subunit 1 0.0021 0.1043 0.1253
Giardia lamblia Kinase, CMGC MAPK 0.0058 0.3666 1
Onchocerca volvulus 0.0021 0.1043 0.706
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.1444 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0371 0.1966
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.3666 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.1567 0.15
Brugia malayi hypothetical protein 0.0021 0.1043 0.124
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.3666 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.1444 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0371 0.038
Brugia malayi Pax transcription activation domain interacting protein 0.0021 0.1043 0.124
Schistosoma mansoni DNA helicase recq5 0.0012 0.0371 0.038
Echinococcus multilocularis bloom syndrome protein 0.0029 0.1595 0.197
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.1444 0.1775
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0058 0.3666 1
Trichomonas vaginalis replication factor C large subunit, putative 0.0021 0.1043 0.2688
Schistosoma mansoni hypothetical protein 0.0079 0.5213 0.6672
Trypanosoma cruzi FHA domain containing protein, putative 0.0021 0.1043 0.2688
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0058 0.3666 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0433 0.046
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0956 0.5894
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.092 0.5655
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.1595 0.4226
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.1595 0.195
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.1043 0.2688
Toxoplasma gondii ATPase, AAA family protein 0.0021 0.1043 0.2688
Schistosoma mansoni hypothetical protein 0.0013 0.0433 0.046
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0058 0.3666 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0956 0.0884
Entamoeba histolytica hypothetical protein 0.0115 0.7774 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.1444 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0624 0.1521
Echinococcus multilocularis GPCR, family 2 0.0037 0.215 0.2692
Schistosoma mansoni hypothetical protein 0.0037 0.215 0.2692
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0079 0.0546
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0079 0.0546
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0115 0.7774 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0956 0.0884
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0877 0.6071
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0079 0.0546
Brugia malayi Calcitonin receptor-like protein seb-1 0.0116 0.7852 1
Mycobacterium ulcerans hypothetical protein 0.0027 0.1444 1
Onchocerca volvulus 0.0027 0.1444 1
Brugia malayi hypothetical protein 0.0018 0.0838 0.0977
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.1444 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.3666 0.4662
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0371 0.038
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.3666 1
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0021 0.1043 0.2688
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.3666 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.1444 0.1376
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0079 0.0546
Giardia lamblia Replication factor C, subunit 1 0.0021 0.1043 0.2038
Loa Loa (eye worm) hypothetical protein 0.0021 0.1043 0.0972
Echinococcus granulosus GPCR family 2 0.0037 0.215 0.2692
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0956 0.6421
Loa Loa (eye worm) hypothetical protein 0.0079 0.5213 0.5175
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.1444 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.1043 0.2688
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.3666 1
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0021 0.1043 0.124
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.1444 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0877 0.6071
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.1567 1
Schistosoma mansoni hypothetical protein 0.0037 0.215 0.2692
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.215 0.2692
Brugia malayi AMP-binding enzyme family protein 0.0027 0.1444 0.1757
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.1043 0.2688
Brugia malayi hypothetical protein 0.0021 0.1043 0.124
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0371 0.0816
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.1567 0.4147
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0021 0.1043 0.2688
Brugia malayi hypothetical protein 0.0029 0.1567 0.1914
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0021 0.1043 0.5
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.3666 0.4662
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0079 0.0546
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0624 0.1521
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.1595 0.4226
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.1444 1
Schistosoma mansoni chromosome transmission fidelity factor 0.0021 0.1043 0.1253
Brugia malayi latrophilin 2 splice variant baaae 0.0079 0.5213 0.6605
Brugia malayi hypothetical protein 0.0115 0.7774 0.9899
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.1444 0.3807
Schistosoma mansoni hypothetical protein 0.0037 0.215 0.2692
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.3666 0.3616
Plasmodium falciparum replication factor C subunit 1, putative 0.0021 0.1043 0.648
Loa Loa (eye worm) RecQ helicase 0.0029 0.1595 0.1528
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0956 0.5894
Schistosoma mansoni DNA ligase IV 0.0021 0.1043 0.1253
Loa Loa (eye worm) hypothetical protein 0.0012 0.0371 0.0295
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0116 0.7852 1
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.1043 0.2688
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.1043 0.2688
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.1157 0.1401
Echinococcus multilocularis replication factor c subunit 1 0.0021 0.1043 0.1253
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0116 0.7852 0.7835
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.1567 0.4147
Brugia malayi DKFZp564C0469 protein 0.0021 0.1043 0.124
Treponema pallidum DNA ligase (lig) 0.0021 0.1043 0.5
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.3666 0.4662
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0371 0.0295
Loa Loa (eye worm) hypothetical protein 0.002 0.0956 0.0884
Brugia malayi AMP-binding enzyme family protein 0.0027 0.1444 0.1757
Loa Loa (eye worm) hypothetical protein 0.0116 0.7852 0.7835
Leishmania major hypothetical protein, conserved 0.0029 0.1567 0.4147
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.1444 0.3807
Brugia malayi topoisomerase 0.0021 0.1043 0.124
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0624 0.1521
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.1043 0.2688
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0371 0.0376
Schistosoma mansoni topbp1 0.0021 0.1043 0.1253
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.1043 0.2688
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.3666 0.4662
Entamoeba histolytica hypothetical protein 0.0021 0.1043 0.1253
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.1567 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0371 0.0816
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0956 0.6617
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.3666 1
Brugia malayi MAP kinase sur-1 0.0058 0.3666 0.4615
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.1043 0.2688
Schistosoma mansoni transcription factor LCR-F1 0.0115 0.7774 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0956 0.0884
Loa Loa (eye worm) hypothetical protein 0.0037 0.215 0.2088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0079 0.0546
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.1567 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.215 0.2088
Schistosoma mansoni topbp1 0.0021 0.1043 0.1253
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0079 0.0546
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0624 0.1521
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0058 0.3666 1
Chlamydia trachomatis DNA ligase 0.0021 0.1043 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.1444 0.1775
Loa Loa (eye worm) hypothetical protein 0.0021 0.1043 0.0972
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0079 0.0546
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.1444 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0058 0.3666 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0115 0.7774 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.1567 0.4147
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.1444 0.1775
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0079 0.0546
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0624 0.0709
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.3666 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0956 0.0884
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.1043 0.2688
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.1043 0.2688
Loa Loa (eye worm) hypothetical protein 0.0027 0.1444 0.1376
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.1444 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.1043 0.0972
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.3666 0.4662
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.1567 0.4147
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0021 0.1043 0.706
Loa Loa (eye worm) hypothetical protein 0.0027 0.1444 0.1376
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0371 0.038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0877 0.6071
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0079 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.1043 0.2688
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0904 0.2299
Trypanosoma brucei protein kinase, putative 0.0058 0.3666 1
Schistosoma mansoni DNA helicase recq1 0.0012 0.0371 0.038
Loa Loa (eye worm) hypothetical protein 0.0021 0.1043 0.0972
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0371 0.0376
Entamoeba histolytica hypothetical protein 0.0115 0.7774 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0371 0.038
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.215 0.2692
Loa Loa (eye worm) hypothetical protein 0.0021 0.1043 0.0972
Echinococcus multilocularis nibrin 0.0021 0.1043 0.1253
Schistosoma mansoni hypothetical protein 0.0115 0.7774 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.1444 0.1757
Echinococcus granulosus bloom syndrome protein 0.0029 0.1595 0.197

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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