Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAR-binding protein | 0.0072 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.2555 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.4859 | 0.4859 |
Onchocerca volvulus | 0.0027 | 0.2555 | 1 | |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.2555 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.1064 | 0.1064 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.4859 | 1 |
Brugia malayi | hypothetical protein | 0.0041 | 0.4859 | 0.4859 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1064 | 0.1064 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.4859 | 0.4859 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.1064 | 0.1064 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.1064 | 0.1064 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.2555 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.4859 | 0.4859 |
Loa Loa (eye worm) | RNA binding protein | 0.0072 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0072 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0072 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1429 | 0.1429 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.1064 | 0.1064 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.4859 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2555 | 0.2555 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.1064 | 0.1064 |
Echinococcus multilocularis | tar DNA binding protein | 0.0072 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.2555 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.1064 | 0.1064 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1429 | 0.1429 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.2555 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.7465 | 0.7465 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.1064 | 0.1064 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1429 | 0.1429 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.2555 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.4503 | 0.4503 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.1429 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2555 | 0.2555 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1429 | 0.1429 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.2555 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.4859 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.1429 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.2555 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.1064 | 0.1064 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.1064 | 0.1064 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.4859 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.2555 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.4859 | 0.4859 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.2555 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.2555 | 0.2555 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.2555 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.7465 | 0.7465 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.2555 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2555 | 0.2555 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.1429 | 0.1429 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0072 | 1 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.1429 | 0.139 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.2555 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.1064 | 0.1064 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.1064 | 0.1064 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.1429 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.2555 | 0.2555 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0072 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.4503 | 0.4503 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.2555 | 0.2555 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.1064 | 0.1064 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.2555 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.2555 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.1064 | 0.1064 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.7465 | 0.7465 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.4503 | 0.4503 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.7465 | 0.7465 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.