Detailed information for compound 1554564

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 327.416 | Formula: C19H18FNOS
  • H donors: 1 H acceptors: 2 LogP: 4.48 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)C(c1scc(n1)c1ccc(c(c1)C)C)(O)C
  • InChi: 1S/C19H18FNOS/c1-12-7-8-14(9-13(12)2)17-11-23-18(21-17)19(3,22)15-5-4-6-16(20)10-15/h4-11,22H,1-3H3
  • InChiKey: IEMYDZAIROAKGQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0661 0.0476
Onchocerca volvulus Cathepsin F homolog 0.0039 0.0517 0.0935
Schistosoma mansoni cathepsin F (C01 family) 0.0039 0.0517 0.0626
Leishmania major cathepsin L-like protease 0.015 0.3826 0.3704
Loa Loa (eye worm) TK/FAK protein kinase 0.0302 0.8366 1
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0032 0.0303 0.011
Schistosoma mansoni DNA polymerase eta 0.0076 0.1601 0.1938
Trypanosoma brucei DNA polymerase IV, putative 0.0046 0.0702 0.0517
Onchocerca volvulus 0.0039 0.0517 0.0935
Onchocerca volvulus Huntingtin homolog 0.0145 0.3664 0.7043
Onchocerca volvulus 0.0039 0.0517 0.0935
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0702 0.0517
Loa Loa (eye worm) hypothetical protein 0.0026 0.0128 0.0153
Leishmania major cathepsin L-like protease 0.0039 0.0517 0.0329
Brugia malayi hypothetical protein 0.0177 0.4634 0.5539
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0052 0.0885 0.1071
Echinococcus multilocularis dna polymerase eta 0.0076 0.1601 0.1938
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0517 0.4546
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0037 0.0459 0.027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.015 0.3826 0.3704
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0279 0.0086
Onchocerca volvulus 0.0039 0.0517 0.0935
Toxoplasma gondii ThiF family protein 0.0037 0.0459 0.4126
Entamoeba histolytica deoxycytidyl transferase, putative 0.0046 0.0702 0.6704
Loa Loa (eye worm) ctsf protein 0.0039 0.0517 0.0618
Leishmania major DNA polymerase eta, putative 0.0044 0.0661 0.0476
Onchocerca volvulus 0.0177 0.4634 0.8926
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0196 0.5187 0.62
Brugia malayi hypothetical protein 0.0145 0.3664 0.4379
Loa Loa (eye worm) hypothetical protein 0.0026 0.0128 0.0153
Onchocerca volvulus Cathepsin L homolog 0.0039 0.0517 0.0935
Echinococcus multilocularis L aminoadipate semialdehyde 0.0196 0.5187 0.628
Echinococcus granulosus dna polymerase kappa 0.0046 0.0702 0.085
Brugia malayi Cathepsin L-like precursor 0.0039 0.0517 0.0618
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0357 1 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.4205 0.5027
Echinococcus granulosus cathepsin l cysteine peptidase 0.0039 0.0517 0.0626
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0702 0.0517
Brugia malayi Cathepsin L-like cysteine proteinase 0.0026 0.0128 0.0153
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0035 0.0043
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0055 0.0984 0.0791
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0702 0.0517
Trichomonas vaginalis DNA helicase recq1, putative 0.0054 0.094 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0055 0.0984 1
Trypanosoma cruzi cysteine peptidase, putative 0.015 0.3826 0.3704
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0055 0.0984 0.8847
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0517 0.4794
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.0661 0.5946
Toxoplasma gondii hypothetical protein 0.0058 0.1059 0.9519
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0517 0.4794
Schistosoma mansoni inositol monophosphatase 0.0044 0.0643 0.0778
Echinococcus multilocularis cysteine protease 0.0039 0.0517 0.0626
Plasmodium falciparum cysteine proteinase falcipain 3 0.0039 0.0517 0.4648
Schistosoma mansoni blooms syndrome DNA helicase 0.0042 0.0603 0.073
Plasmodium vivax vivapain-2 0.0039 0.0517 0.4473
Schistosoma mansoni tyrosine kinase 0.0299 0.826 1
Echinococcus multilocularis bloom syndrome protein 0.0054 0.094 0.1138
Echinococcus granulosus dna polymerase eta 0.0076 0.1601 0.1938
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0517 0.4794
Brugia malayi Inositol-1 0.0044 0.0643 0.0769
Trypanosoma brucei unspecified product 0.0046 0.0702 0.0517
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0357 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0169 0.4385 0.4273
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.015 0.3826 0.3704
Echinococcus granulosus inositol monophosphatase 1 0.0044 0.0643 0.0778
Trypanosoma cruzi major cysteine proteinase, putative 0.0118 0.2866 0.2725
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.0702 0.0839
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0039 0.0517 0.4794
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0055 0.0984 0.8847
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0037 0.0459 0.4126
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0042
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0027 0.0134 0.0163
Echinococcus multilocularis cathepsin L cysteine protease 0.0039 0.0517 0.0626
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0046 0.0702 0.0439
Brugia malayi Cathepsin L-like precursor 0.0026 0.0128 0.0153
Schistosoma mansoni hypothetical protein 0.0023 0.0035 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.015 0.3826 0.3704
Onchocerca volvulus 0.0196 0.5187 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.015 0.3826 0.3704
Echinococcus granulosus cathepsin l1 0.0026 0.0128 0.0155
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0517 0.4546
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0055 0.0984 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0517 0.4794
Trichomonas vaginalis DNA helicase recq, putative 0.0054 0.094 1
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0035 0.0043
Mycobacterium ulcerans DNA polymerase IV 0.0046 0.0702 0.0136
Leishmania major phosphopantetheinyl transferase-like protein 0.0055 0.0984 0.0805
Trichomonas vaginalis DNA polymerase eta, putative 0.0046 0.0702 0.7068
Leishmania major cysteine peptidase A (CPA) 0.0039 0.0517 0.0329
Brugia malayi Cathepsin L-like precursor 0.0039 0.0517 0.0618
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0139 0.3502 0.424
Loa Loa (eye worm) ThiF family protein 0.0037 0.0459 0.0549
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0517 0.4794
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0517 0.4794
Mycobacterium tuberculosis Conserved hypothetical protein 0.0046 0.0702 0.0439
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0037 0.0459 0.3934
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0039 0.0517 0.4648
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0035 0.0043
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0042
Echinococcus multilocularis inositol monophosphatase 1 0.0044 0.0643 0.0778
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0702 0.0517
Plasmodium vivax ubiquitin activating enzyme, putative 0.0057 0.1041 0.9338
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0643 0.6346
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0702 0.0517
Schistosoma mansoni loxhd1 0.0023 0.0035 0.0043
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0057 0.1041 0.126
Toxoplasma gondii cathepsin CPL 0.0039 0.0517 0.4648
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0037 0.0459 0.0556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0517 0.4794
Echinococcus granulosus RUN 0.0023 0.0035 0.0043
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0044 0.0643 0.5782
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0517 0.4794
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0039 0.0517 0.0626
Loa Loa (eye worm) hypothetical protein 0.0196 0.5187 0.62
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0643 0.0458
Brugia malayi cathepsin L-like precursor 0.0026 0.0128 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0702 0.0517
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0057 0.1041 0.9359
Loa Loa (eye worm) fibroinase 0.0039 0.0517 0.0618
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0702 0.0517
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0838 0.0657
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.015 0.3826 0.3704
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0517 0.4794
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0046 0.0702 0.085
Plasmodium falciparum ataxin-2 like protein, putative 0.0059 0.1112 1
Entamoeba histolytica cysteine protease, putative 0.0039 0.0517 0.4546
Trypanosoma cruzi DNA polymerase eta, putative 0.0076 0.1601 0.1434
Brugia malayi Bloom's syndrome protein homolog 0.0054 0.094 0.1123
Leishmania major hypothetical protein, conserved 0.0059 0.1112 0.0936
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0057 0.1041 0.126
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0039 0.0517 0.0626
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0046 0.0702 0.085
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0838 0.0657
Brugia malayi hypothetical protein 0.0038 0.0484 0.0578
Trypanosoma cruzi cysteine peptidase, putative 0.015 0.3826 0.3704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0517 0.4794
Loa Loa (eye worm) hypothetical protein 0.0145 0.3664 0.4379
Trypanosoma cruzi PAB1-binding protein , putative 0.0059 0.1112 0.0936
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0643 0.6346
Trypanosoma brucei DNA polymerase IV, putative 0.0046 0.0702 0.0517
Loa Loa (eye worm) hypothetical protein 0.0026 0.0128 0.0153
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0046 0.0702 0.085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.015 0.3826 0.3704
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0039 0.0517 0.4648
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0044 0.0643 0.6018
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0055 0.0984 0.1074
Onchocerca volvulus Huntingtin homolog 0.0145 0.3664 0.7043
Leishmania major cathepsin L-like protease 0.0039 0.0517 0.0329
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0517 0.4794
Leishmania major cathepsin L-like protease 0.0039 0.0517 0.0329
Loa Loa (eye worm) hypothetical protein 0.0059 0.1112 0.1329
Leishmania major cathepsin L-like protease 0.015 0.3826 0.3704
Brugia malayi Protein kinase domain containing protein 0.0302 0.8366 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0036 0.0422 0.3587
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0838 0.0657
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0055 0.0984 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.015 0.3826 0.3704
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0039 0.0517 0.0618
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0517 0.4794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0517 0.4794
Schistosoma mansoni polycystin 1-related 0.0023 0.0035 0.0043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0517 0.4794
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0047 0.0745 0.6703
Brugia malayi ImpB/MucB/SamB family protein 0.0076 0.1601 0.1914
Trypanosoma brucei unspecified product 0.0031 0.0279 0.0086
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0061 0.1166 0.0991
Schistosoma mansoni hypothetical protein 0.0027 0.0134 0.0163
Loa Loa (eye worm) hypothetical protein 0.0039 0.0517 0.0618
Echinococcus multilocularis RUN 0.0023 0.0035 0.0043
Brugia malayi Cathepsin L-like precursor 0.0026 0.0128 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0702 0.0517
Trypanosoma brucei unspecified product 0.0031 0.0279 0.0086
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0643 0.0458
Onchocerca volvulus 0.0039 0.0517 0.0935
Onchocerca volvulus Cathepsin L homolog 0.0039 0.0517 0.0935
Toxoplasma gondii LsmAD domain-containing protein 0.0059 0.1112 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0039 0.0517 0.0626
Plasmodium falciparum ataxin-2 like protein, putative 0.0059 0.1112 1
Loa Loa (eye worm) RecQ helicase 0.0054 0.094 0.1123
Loa Loa (eye worm) hypothetical protein 0.0177 0.4634 0.5539
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0035 0.0042
Leishmania major cathepsin L-like protease 0.015 0.3826 0.3704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0517 0.4794
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0139 0.3502 0.424
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0702 0.0517
Plasmodium vivax ataxin-2 like protein, putative 0.0059 0.1112 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0137 0.3437 0.3307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.015 0.3826 0.3704
Schistosoma mansoni lipoxygenase 0.0139 0.3502 0.424
Mycobacterium ulcerans hypothetical protein 0.0188 0.4955 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0046 0.0702 0.7068
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0039 0.0517 0.4794
Onchocerca volvulus 0.0026 0.0128 0.0179
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0702 0.0517
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0169 0.4385 0.4273
Schistosoma mansoni rab6-interacting 0.0023 0.0035 0.0043
Entamoeba histolytica hypothetical protein 0.0055 0.0984 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0046 0.0702 0.0517
Echinococcus multilocularis dna polymerase kappa 0.0046 0.0702 0.085
Toxoplasma gondii hypothetical protein 0.0057 0.1041 0.9359
Trypanosoma brucei PAB1-binding protein , putative 0.0059 0.1112 0.0936
Brugia malayi Doublecortin family protein 0.0023 0.0035 0.0042
Echinococcus granulosus protein tyrosine kinase 0.0299 0.826 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0188 0.4955 1
Echinococcus granulosus cathepsin l1 0.0039 0.0517 0.0626
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0039 0.0517 0.0618
Trypanosoma cruzi DNA polymerase kappa, putative 0.0046 0.0702 0.0517
Loa Loa (eye worm) inositol-1 0.0044 0.0643 0.0769
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0194 0.0822
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0035 0.0043
Loa Loa (eye worm) cysteine protease 0.0039 0.0517 0.0618
Trypanosoma cruzi PAB1-binding protein , putative 0.0059 0.1112 0.0936
Schistosoma mansoni terminal deoxycytidyl transferase 0.0046 0.0702 0.085
Onchocerca volvulus 0.0039 0.0517 0.0935
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0196 0.5187 0.628
Leishmania major cathepsin L-like protease 0.0039 0.0517 0.0329
Schistosoma mansoni cathepsin F (C01 family) 0.0039 0.0517 0.0626
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0279 0.0086
Schistosoma mansoni lipoxygenase 0.0097 0.225 0.2724
Echinococcus granulosus cathepsin L cysteine proteinase 0.0039 0.0517 0.0626
Brugia malayi hypothetical protein 0.0059 0.1112 0.1329
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0037 0.0459 0.0556
Echinococcus granulosus bloom syndrome protein 0.0054 0.094 0.1138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0517 0.4794
Brugia malayi Cathepsin L-like precursor 0.0039 0.0517 0.0618
Brugia malayi ThiF family protein 0.0037 0.0459 0.0549
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0357 1 1
Brugia malayi ThiF family protein 0.0057 0.1041 0.1244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.015 0.3826 0.3704
Leishmania major DNA polymerase kappa, putative 0.0046 0.0702 0.0517
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.015 0.3826 0.3704
Trypanosoma cruzi cysteine peptidase, putative 0.0039 0.0517 0.0329
Mycobacterium ulcerans DNA polymerase IV 0.0046 0.0702 0.0136
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0643 0.0458
Trypanosoma brucei DNA polymerase IV, putative 0.0046 0.0702 0.0517
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0128 0.0155
Schistosoma mansoni inositol monophosphatase 0.0044 0.0643 0.0778
Brugia malayi hypothetical protein 0.0023 0.0035 0.0042
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0036 0.0409 0.3675
Giardia lamblia DINP protein human, muc B family 0.0046 0.0702 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0517 0.4794
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0517 0.4794
Entamoeba histolytica recQ family helicase, putative 0.0029 0.0194 0.0779
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0517 0.4794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0517 0.4794
Brugia malayi Cathepsin L-like precursor 0.0039 0.0517 0.0618
Leishmania major cathepsin L-like protease 0.0039 0.0517 0.0329
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0055 0.0984 0.881
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.015 0.3826 0.3704
Plasmodium vivax vivapain-2 0.0039 0.0517 0.4473
Echinococcus multilocularis protein tyrosine kinase 0.0299 0.826 1
Trypanosoma cruzi cruzipain precursor, putative 0.015 0.3826 0.3704
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0055 0.0984 0.8847
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0037 0.0459 0.027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0517 0.4794
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0037 0.0459 0.0556
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0035 0.0043
Schistosoma mansoni rab6-interacting 0.0023 0.0035 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0279 0.0086
Echinococcus multilocularis cysteine protease 0.0039 0.0517 0.0626
Leishmania major ubiquitin-activating enzyme-like protein 0.0037 0.0459 0.027
Loa Loa (eye worm) hypothetical protein 0.0145 0.3664 0.4379
Trichomonas vaginalis inositol monophosphatase, putative 0.0044 0.0643 0.6346
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0517 0.4794
Onchocerca volvulus 0.0039 0.0517 0.0935
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0035 0.0043
Leishmania major DNA polymerase eta, putative 0.0076 0.1601 0.1434
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0643 0.0458
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0035 0.0317
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.015 0.3826 0.3704
Trypanosoma brucei DNA polymerase beta thumb, putative 0.005 0.0838 0.0657
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0702 0.0517
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0169 0.4385 0.4273
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0517 0.0618
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0055 0.0984 0.0791
Trypanosoma brucei DNA polymerase eta, putative 0.0076 0.1601 0.1434
Trypanosoma brucei hypothetical protein, conserved 0.0055 0.0984 0.0805
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0046 0.0702 0.0839
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0702 0.0517
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0057 0.1041 0.126
Mycobacterium leprae conserved hypothetical protein 0.0055 0.0984 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0196 0.5187 0.628
Onchocerca volvulus 0.0039 0.0517 0.0935
Loa Loa (eye worm) hypothetical protein 0.0076 0.1601 0.1914
Loa Loa (eye worm) hypothetical protein 0.0057 0.1041 0.1244
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0027 0.0134 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0517 0.4794
Brugia malayi Cathepsin L-like precursor 0.0039 0.0517 0.0618
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0702 0.0517
Brugia malayi Cathepsin L-like precursor 0.0039 0.0517 0.0618
Brugia malayi hypothetical protein 0.0023 0.0035 0.0042

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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