Detailed information for compound 155468

Basic information

Technical information
  • TDR Targets ID: 155468
  • Name: (2R)-2-[(4-but-2-ynoxyphenyl)sulfonylamino]-N ,3-dihydroxybutanamide
  • MW: 342.368 | Formula: C14H18N2O6S
  • H donors: 4 H acceptors: 5 LogP: 0.12 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)[C@@H](C(O)C)NS(=O)(=O)c1ccc(cc1)OCC#CC
  • InChi: 1S/C14H18N2O6S/c1-3-4-9-22-11-5-7-12(8-6-11)23(20,21)16-13(10(2)17)14(18)15-19/h5-8,10,13,16-17,19H,9H2,1-2H3,(H,15,18)/t10?,13-/m1/s1
  • InChiKey: VMOSDDURWLNMNG-JLOHTSLTSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R)-2-[(4-but-2-ynoxyphenyl)sulfonylamino]-3-hydroxy-butanehydroxamic acid
  • (2R)-2-[(4-but-2-ynoxyphenyl)sulfonylamino]-3-hydroxybutanehydroxamic acid
  • (2R)-2-[(4-but-2-ynoxyphenyl)sulfonylamino]-N,3-dihydroxy-butanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ADAM metallopeptidase domain 17 Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 1 (interstitial collagenase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) Starlite/ChEMBL References
Homo sapiens matrix metallopeptidase 13 (collagenase 3) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni ADAM17 peptidase (M12 family) Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus granulosus Blood coagulation inhibitor Disintegrin Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus multilocularis adam 17 protease Get druggable targets OG5_132656 All targets in OG5_132656
Schistosoma japonicum ko:K06059 a disintegrin and metalloproteinase domain 17, putative Get druggable targets OG5_132656 All targets in OG5_132656
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132656 All targets in OG5_132656
Echinococcus granulosus adam 17 protease Get druggable targets OG5_132656 All targets in OG5_132656
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Matrixin family protein matrix metallopeptidase 1 (interstitial collagenase) 403 aa 401 aa 27.7 %
Echinococcus granulosus matrix metallopeptidase 7 M10 family matrix metallopeptidase 13 (collagenase 3) 471 aa 448 aa 34.1 %
Brugia malayi Disintegrin family protein ADAM metallopeptidase domain 17 824 aa 724 aa 27.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi mothers against decapentaplegic homolog 3 0.0062 0.0248 0.0245
Mycobacterium ulcerans bacterioferritin BfrA 0.002 0.0041 0.0048
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0425 0.0422
Trichomonas vaginalis penicillin-binding protein, putative 0.0103 0.0453 0.5402
Brugia malayi hypothetical protein 0.0087 0.0374 0.0371
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0012 0.0003 0.0002
Loa Loa (eye worm) MH1 domain-containing protein 0.0138 0.0627 0.0624
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0062 0.0248 0.109
Loa Loa (eye worm) hypothetical protein 0.0466 0.225 0.2248
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0059 0.0234 0.0331
Loa Loa (eye worm) latrophilin receptor protein 2 0.0547 0.2652 0.265
Loa Loa (eye worm) doublecortin family protein 0.0014 0.001 0.0007
Loa Loa (eye worm) nuclear factor I 0.0076 0.0321 0.0318
Mycobacterium leprae conserved hypothetical protein 0.0103 0.0453 0.0683
Brugia malayi beta-lactamase family protein 0.0103 0.0453 0.045
Schistosoma mansoni ferritin 0.002 0.0041 0.0058
Onchocerca volvulus 0.0103 0.0453 0.2004
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0017 0.0028 0.0025
Brugia malayi CXXC zinc finger family protein 0.002 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.005 0.0189 0.0186
Echinococcus granulosus bloom syndrome protein 0.0021 0.0045 0.0061
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0103 0.0453 0.045
Schistosoma mansoni hypothetical protein 0.005 0.0188 0.0267
Onchocerca volvulus Matrilysin homolog 0.0433 0.209 0.9286
Schistosoma mansoni cpg binding protein 0.0021 0.0047 0.0066
Toxoplasma gondii hypothetical protein 0.0056 0.0219 0.3982
Loa Loa (eye worm) hypothetical protein 0.0547 0.2652 0.265
Schistosoma mansoni dep domain containing protein 0.0017 0.0028 0.0039
Echinococcus granulosus microtubule associated protein 2 0.0995 0.4875 0.6933
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0151 0.0215
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0353 0.1694 0.7524
Loa Loa (eye worm) hypothetical protein 0.0037 0.0126 0.0123
Echinococcus granulosus cpg binding protein 0.0021 0.0047 0.0064
Mycobacterium tuberculosis Conserved protein 0.0103 0.0453 0.0683
Echinococcus multilocularis ferritin 0.002 0.0041 0.004
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0014 0.0009 0.0006
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0054 0.0207 0.0293
Schistosoma mansoni ferritin 0.002 0.0041 0.0058
Brugia malayi Hemopexin family protein 0.0172 0.0793 0.079
Schistosoma mansoni rab6-interacting 0.0014 0.001 0.0014
Brugia malayi DIX domain containing protein 0.0017 0.0028 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0529 0.6308
Brugia malayi hypothetical protein 0.0014 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0103 0.0453 0.045
Brugia malayi Doublecortin family protein 0.0014 0.001 0.0007
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0017 0.0028 0.0027
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.1149 0.1632
Brugia malayi RNA binding protein 0.143 0.7031 0.703
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0112 0.0497 0.2977
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.005 0.0189 0.0276
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0243 0.1147 0.1631
Trypanosoma cruzi major cysteine proteinase, putative 0.0031 0.0098 0.0571
Onchocerca volvulus 0.005 0.0189 0.0827
Onchocerca volvulus Matrix metalloproteinase homolog 0.0346 0.1659 0.7368
Schistosoma mansoni cpg binding protein 0.002 0.0041 0.0058
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0103 0.0453 0.0683
Echinococcus multilocularis mothers against decapentaplegic 2 0.0062 0.0248 0.0255
Trichomonas vaginalis esterase, putative 0.0103 0.0453 0.5402
Giardia lamblia Replication factor C, subunit 1 0.005 0.0189 0.5
Echinococcus granulosus son of sevenless 1 0.0012 0.0003 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0425 0.0439
Echinococcus granulosus Polycystic kidney disease protein 0.0014 0.001 0.0012
Mycobacterium tuberculosis Chorismate mutase 0.0473 0.2285 0.3497
Plasmodium falciparum replication factor C subunit 1, putative 0.005 0.0189 0.3414
Echinococcus granulosus lipoxygenase domain containing protein 0.0014 0.001 0.0012
Schistosoma mansoni topbp1 0.005 0.0189 0.0268
Loa Loa (eye worm) hypothetical protein 0.0103 0.0453 0.045
Schistosoma mansoni smad1 5 8 and 0.0138 0.0627 0.0892
Schistosoma mansoni smad1 5 8 and 0.0138 0.0627 0.0892
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.005 0.0189 0.2229
Loa Loa (eye worm) hypothetical protein 0.0243 0.1147 0.1144
Leishmania major hypothetical protein, conserved 0.0119 0.0534 0.3177
Brugia malayi Latrophilin receptor protein 2 0.0547 0.2652 0.265
Brugia malayi N-terminal motif family protein 0.0353 0.1694 0.1691
Trypanosoma cruzi cruzipain precursor, putative 0.004 0.014 0.0827
Schistosoma mansoni smad 0.0062 0.0248 0.0352
Schistosoma mansoni chromosome transmission fidelity factor 0.005 0.0189 0.0268
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0183 0.0284
Schistosoma mansoni lipoxygenase 0.0058 0.0227 0.0323
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0425 0.0605
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0425 0.0439
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0096 0.0416 0.059
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0006
Plasmodium vivax replication factor C subunit 1, putative 0.005 0.0189 0.3414
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0063 0.0254 0.0262
Onchocerca volvulus 0.0131 0.0589 0.2607
Mycobacterium ulcerans hypothetical protein 0.0183 0.0847 0.1288
Schistosoma mansoni hypothetical protein 0.0059 0.0234 0.0333
Schistosoma mansoni hypothetical protein 0.0547 0.2652 0.3772
Echinococcus granulosus subfamily M12B unassigned peptidase 0.005 0.0189 0.0267
Onchocerca volvulus 0.0466 0.225 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0321 0.0318
Echinococcus multilocularis adam 17 protease 0.0223 0.1047 0.1084
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0529 0.6308
Echinococcus granulosus regulator of G protein signaling 7 0.0017 0.0028 0.0037
Plasmodium vivax hypothetical protein, conserved 0.0103 0.0453 0.846
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0151 0.0148
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0054 0.0207 0.0213
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1728 0.8507 0.8507
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.019 0.0884 0.1345
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0017 0.0028 0.0039
Echinococcus multilocularis RUN 0.0014 0.001 0.0009
Onchocerca volvulus 0.002 0.0041 0.0169
Echinococcus granulosus intermediate filament protein 0.0131 0.0589 0.0835
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0189 0.2229
Echinococcus multilocularis dnaJ subfamily B 0.0286 0.1359 0.1407
Entamoeba histolytica hypothetical protein 0.0059 0.0234 0.609
Mycobacterium leprae Conserved hypothetical protein 0.1326 0.6518 1
Echinococcus granulosus dnaJ subfamily B 0.0286 0.1359 0.1931
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0605 0.2941 0.4181
Schistosoma mansoni cellular tumor antigen P53 0.0074 0.0309 0.0439
Plasmodium falciparum ataxin-2 like protein, putative 0.0119 0.0534 1
Brugia malayi ADAMTS-like protease 0.0037 0.0126 0.0123
Loa Loa (eye worm) matrixin family protein 0.0415 0.1998 0.1995
Mycobacterium tuberculosis Probable esterase LipL 0.0103 0.0453 0.0683
Echinococcus multilocularis lipoxygenase domain containing protein 0.0014 0.001 0.0009
Brugia malayi MH1 domain containing protein 0.0076 0.0321 0.0318
Trypanosoma cruzi cysteine peptidase, putative 0.004 0.014 0.0827
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.005 0.0189 0.0186
Loa Loa (eye worm) hypothetical protein 0.0103 0.0453 0.045
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.005 0.0189 0.0319
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.005 0.0189 0.3406
Schistosoma mansoni microtubule-associated protein tau 0.0995 0.4875 0.6933
Schistosoma mansoni hypothetical protein 0.0096 0.0416 0.0592
Schistosoma mansoni hypothetical protein 0.0346 0.1658 0.2358
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.1149 0.1189
Loa Loa (eye worm) disintegrin family protein 0.0074 0.031 0.0307
Mycobacterium ulcerans hydrolase 0.019 0.0884 0.1345
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0112 0.0497 0.0513
Schistosoma mansoni hypothetical protein 0.0172 0.0793 0.1127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0425 0.0602
Loa Loa (eye worm) hypothetical protein 0.0037 0.0126 0.0123
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0014 0.0009 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0529 0.6308
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0836 1
Echinococcus multilocularis lamin 0.0131 0.0589 0.0609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0425 0.0605
Trypanosoma cruzi hypothetical protein, conserved 0.0103 0.0453 0.2715
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0836 1
Schistosoma mansoni dishevelled 0.0017 0.0028 0.0039
Brugia malayi hypothetical protein 0.005 0.0189 0.0186
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0011 0.0028
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.018 0.0836 0.0834
Echinococcus granulosus ferritin 0.002 0.0041 0.0055
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.143 0.7031 0.703
Schistosoma mansoni tar DNA-binding protein 0.143 0.7031 1
Brugia malayi MH2 domain containing protein 0.0138 0.0627 0.0624
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.005 0.0189 0.0276
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0347 0.1661 1
Brugia malayi Matrixin family protein 0.0415 0.1998 0.1995
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0012 0.0003 0.0004
Brugia malayi Matrixin family protein 0.0156 0.0716 0.0713
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.005 0.0189 1
Echinococcus multilocularis lamin dm0 0.0131 0.0589 0.0609
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0189 0.2229
Trichomonas vaginalis D-aminoacylase, putative 0.0103 0.0453 0.5402
Brugia malayi RNA recognition motif domain containing protein 0.143 0.7031 0.703
Echinococcus granulosus expressed protein 0.002 0.0041 0.0055
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0105 0.0463 0.0659
Echinococcus granulosus replication factor c subunit 1 0.005 0.0189 0.0266
Mycobacterium tuberculosis Conserved hypothetical protein 0.0183 0.0847 0.1288
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0164 0.0755 0.4537
Schistosoma mansoni ferritin 0.002 0.0041 0.0058
Echinococcus multilocularis adam 0.0087 0.0374 0.0386
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0017 0.0028 0.011
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0138 0.0627 0.0892
Echinococcus granulosus lamin dm0 0.0131 0.0589 0.0835
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0836 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0043 0.0153 0.0217
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0151 0.0215
Loa Loa (eye worm) hypothetical protein 0.0156 0.0716 0.0713
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0014 0.0009 0.0011
Brugia malayi Matrixin family protein 0.0156 0.0716 0.0713
Trypanosoma cruzi hypothetical protein, conserved 0.0103 0.0453 0.2715
Leishmania major hypothetical protein, conserved 0.0103 0.0453 0.2689
Schistosoma mansoni tar DNA-binding protein 0.143 0.7031 1
Schistosoma mansoni tar DNA-binding protein 0.143 0.7031 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0145 0.0149
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1728 0.8507 0.8507
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0529 0.6308
Loa Loa (eye worm) hypothetical protein 0.0103 0.0453 0.045
Toxoplasma gondii LsmAD domain-containing protein 0.0119 0.0534 1
Trichomonas vaginalis D-aminoacylase, putative 0.0103 0.0453 0.5402
Loa Loa (eye worm) hypothetical protein 0.0061 0.0242 0.0239
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0208 0.0972 0.138
Schistosoma mansoni z-protein (S1r protein) 0.0017 0.0028 0.0039
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0547 0.2652 0.377
Loa Loa (eye worm) hypothetical protein 0.0128 0.0577 0.0574
Schistosoma mansoni survival motor neuron protein 0.005 0.0188 0.0267
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0103 0.0453 0.0645
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0659 0.3211 0.4919
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0836 1
Schistosoma mansoni ferritin light chain 0.002 0.0041 0.0058
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0105 0.0463 0.0461
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0014 0.0009 0.0011
Brugia malayi Matrixin family protein 0.0156 0.0716 0.0713
Brugia malayi Probable isocitrate dehydrogenase 0.0014 0.0009 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0189 0.2229
Onchocerca volvulus Matrilysin homolog 0.0156 0.0716 0.3172
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0103 0.0453 0.0683
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0547 0.2652 0.377
Echinococcus multilocularis son of sevenless 1 0.0012 0.0003 0.0002
Trichomonas vaginalis penicillin-binding protein, putative 0.0103 0.0453 0.5402
Echinococcus granulosus beta LACTamase domain containing family member 0.0103 0.0453 0.0643
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0836 1
Echinococcus granulosus tar DNA binding protein 0.143 0.7031 1
Brugia malayi Probable isocitrate dehydrogenase 0.0014 0.0009 0.0006
Brugia malayi hypothetical protein 0.0243 0.1149 0.1146
Onchocerca volvulus 0.0014 0.001 0.003
Schistosoma mansoni intermediate filament proteins 0.0131 0.0589 0.0837
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0041 0.0145 0.0205
Echinococcus multilocularis Protein son of sevenless 0.0012 0.0003 0.0002
Trypanosoma cruzi PAB1-binding protein , putative 0.0119 0.0534 0.3202
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0425 0.0602
Treponema pallidum DNA ligase (lig) 0.005 0.0189 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0138 0.0627 0.089
Trypanosoma brucei PAB1-binding protein , putative 0.0119 0.0534 0.2589
Mycobacterium ulcerans chorismate mutase 0.0473 0.2285 0.3497
Schistosoma mansoni rab6-interacting 0.0014 0.001 0.0014
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0547 0.2652 0.2748
Brugia malayi MH2 domain containing protein 0.0138 0.0627 0.0624
Brugia malayi latrophilin 2 splice variant baaae 0.1181 0.5797 0.5796
Schistosoma mansoni hypothetical protein 0.0286 0.1359 0.1933
Schistosoma mansoni dihydroceramide desaturase 0.0124 0.0557 0.0793
Brugia malayi Calcitonin receptor-like protein seb-1 0.1728 0.8507 0.8507
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0112 0.0497 0.2952
Onchocerca volvulus 0.0103 0.0453 0.2004
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.002 0.0041 0.1755
Loa Loa (eye worm) hypothetical protein 0.0061 0.0242 0.0239
Schistosoma mansoni Smad4 0.0062 0.0248 0.0352
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0017 0.0028 0.0025
Loa Loa (eye worm) RNA binding protein 0.143 0.7031 0.703
Brugia malayi Intermediate filament tail domain containing protein 0.0131 0.0589 0.0586
Toxoplasma gondii isocitrate dehydrogenase 0.0112 0.0497 0.9288
Toxoplasma gondii ATPase, AAA family protein 0.005 0.0189 0.3406
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0012 0.0003 0.0002
Echinococcus multilocularis tumor protein p63 0.0506 0.245 0.2539
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0112 0.0497 0.9289
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0082 0.035 0.0362
Brugia malayi hypothetical protein 0.0119 0.0534 0.0531
Loa Loa (eye worm) matrixin family protein 0.0346 0.1659 0.1656
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0547 0.2652 0.265
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0223 0.1047 0.1489
Loa Loa (eye worm) hypothetical protein 0.0536 0.2601 0.2598
Brugia malayi MH1 domain containing protein 0.0138 0.0627 0.0624
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0164 0.0755 0.4045
Schistosoma mansoni hypothetical protein 0.0054 0.0207 0.0295
Entamoeba histolytica hypothetical protein 0.005 0.0189 0.4894
Onchocerca volvulus 0.005 0.0188 0.0822
Echinococcus granulosus lamin 0.0131 0.0589 0.0835
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0112 0.0497 0.2344
Brugia malayi ADAM-TS Spacer 1 family protein 0.0037 0.0126 0.0123
Brugia malayi angiogenesis inhibito 0.0037 0.0126 0.0123
Echinococcus granulosus adam 0.0087 0.0374 0.053
Echinococcus multilocularis Smad4 0.0138 0.0627 0.0648
Echinococcus granulosus segment polarity protein dishevelled 0.0017 0.0028 0.0037
Loa Loa (eye worm) transcription factor SMAD2 0.2029 1 1
Brugia malayi regulator of G-protein signaling egl-10 0.0017 0.0028 0.0025
Onchocerca volvulus 0.0103 0.0453 0.2004
Echinococcus multilocularis expressed protein 0.002 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.005 0.0189 0.0186
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0189 0.112
Mycobacterium tuberculosis Bacterioferritin BfrB 0.002 0.0041 0.0048
Schistosoma mansoni polycystin 1-related 0.0014 0.001 0.0014
Loa Loa (eye worm) DIX domain-containing protein 0.0017 0.0028 0.0025
Onchocerca volvulus 0.0074 0.0309 0.136
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0189 0.112
Echinococcus granulosus ras GTP exchange factor 0.0012 0.0003 0.0002
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0112 0.0497 0.2977
Plasmodium vivax ataxin-2 like protein, putative 0.0119 0.0534 1
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.019 0.0884 0.0882
Brugia malayi isocitrate dehydrogenase 0.0112 0.0497 0.0494
Entamoeba histolytica hypothetical protein 0.0059 0.0234 0.609
Schistosoma mansoni smad1 5 8 and 0.0138 0.0627 0.0892
Loa Loa (eye worm) hypothetical protein 0.0062 0.0248 0.0245
Loa Loa (eye worm) hypothetical protein 0.0131 0.0589 0.0586
Loa Loa (eye worm) TAR-binding protein 0.143 0.7031 0.703
Schistosoma mansoni topbp1 0.005 0.0189 0.0268
Toxoplasma gondii ABC1 family protein 0.0103 0.0453 0.8458
Plasmodium falciparum ataxin-2 like protein, putative 0.0119 0.0534 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0007
Schistosoma mansoni lamin 0.0131 0.0589 0.0837
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0112 0.0497 0.0513
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0105 0.0463 0.0657
Brugia malayi Matrixin family protein 0.0156 0.0716 0.0713
Schistosoma mansoni transcription factor LCR-F1 0.0059 0.0234 0.0333
Loa Loa (eye worm) hypothetical protein 0.005 0.0189 0.0186
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0063 0.0254 0.0359
Toxoplasma gondii isocitrate dehydrogenase 0.0112 0.0497 0.9288
Loa Loa (eye worm) intermediate filament protein 0.0131 0.0589 0.0586
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0208 0.0972 0.1006
Schistosoma mansoni lipoxygenase 0.0082 0.035 0.0498
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0012 0.0003 0.0002
Brugia malayi GnHR receptor homolog 0.1376 0.6766 0.6765
Loa Loa (eye worm) hypothetical protein 0.0119 0.0534 0.0531
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.005 0.0189 0.2229
Brugia malayi Pax transcription activation domain interacting protein 0.005 0.0189 0.0186
Echinococcus granulosus Smad4 0.0138 0.0627 0.089
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0112 0.0497 0.0706
Echinococcus multilocularis Polycystic kidney disease protein 0.0014 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0063 0.0254 0.0251
Echinococcus granulosus lipoxygenase domain containing protein 0.0014 0.001 0.0012
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0089 0.0383 1
Loa Loa (eye worm) hypothetical protein 0.0243 0.1149 0.1146
Echinococcus multilocularis segment polarity protein dishevelled 0.0017 0.0028 0.0027
Echinococcus granulosus Protein son of sevenless 0.0012 0.0003 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0836 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0605 0.2941 0.3048
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.005 0.0189 0.0269
Echinococcus granulosus geminin 0.0346 0.1658 0.2357
Echinococcus granulosus GPCR family 2 0.0547 0.2652 0.377
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0089 0.0383 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0189 0.0186
Brugia malayi hypothetical protein 0.0017 0.0028 0.0025
Loa Loa (eye worm) MH1 domain-containing protein 0.0062 0.0248 0.0245
Mycobacterium ulcerans bacterioferritin BfrB 0.002 0.0041 0.0048
Brugia malayi DKFZp564C0469 protein 0.005 0.0189 0.0186
Schistosoma mansoni thyroid hormone receptor 0.0103 0.0454 0.0646
Schistosoma mansoni tar DNA-binding protein 0.143 0.7031 1
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0014 0.0009 0.0006
Brugia malayi Smad1 0.0138 0.0627 0.0624
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.005 0.0189 0.2229
Echinococcus granulosus mothers against decapentaplegic 6 0.0062 0.0248 0.035
Echinococcus granulosus mothers against decapentaplegic 2 0.0062 0.0248 0.035
Echinococcus multilocularis isocitrate dehydrogenase 0.0112 0.0497 0.0513
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.002 0.0041 0.0048
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0103 0.0453 0.0683
Loa Loa (eye worm) hypothetical protein 0.1728 0.8507 0.8507
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0025
Onchocerca volvulus 0.0131 0.0589 0.2607
Loa Loa (eye worm) beta-lactamase 0.0103 0.0453 0.045
Trypanosoma cruzi FHA domain containing protein, putative 0.005 0.0189 0.112
Mycobacterium leprae Probable lipase LipE 0.0103 0.0453 0.0683
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0103 0.0453 0.0683
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0045 0.0045
Brugia malayi cytoplasmic intermediate filament protein 0.007 0.0288 0.0285
Brugia malayi Disintegrin family protein 0.0124 0.0557 0.0555
Toxoplasma gondii histone lysine methyltransferase SET1 0.0038 0.013 0.2284
Schistosoma mansoni hypothetical protein 0.0547 0.2652 0.3772
Schistosoma mansoni smad 0.0138 0.0627 0.0892
Trypanosoma brucei hypothetical protein, conserved 0.0103 0.0453 0.2058
Trichomonas vaginalis D-aminoacylase, putative 0.0103 0.0453 0.5402
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0529 0.6308
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0082 0.035 0.0496
Mycobacterium tuberculosis Conserved protein 0.0103 0.0453 0.0683
Brugia malayi MH2 domain containing protein 0.0062 0.0248 0.0245
Echinococcus multilocularis nibrin 0.005 0.0189 0.0194
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.005 0.0189 0.112
Schistosoma mansoni hypothetical protein 0.0547 0.2652 0.3772
Brugia malayi TAR-binding protein 0.143 0.7031 0.703
Echinococcus multilocularis microtubule associated protein 2 0.0995 0.4875 0.5053
Brugia malayi beta-lactamase 0.0103 0.0453 0.045
Schistosoma mansoni apoferritin-2 0.002 0.0041 0.0058
Leishmania major mitochondrial DNA polymerase beta 0.0347 0.1661 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0164 0.0755 0.4518
Echinococcus granulosus adam 17 protease 0.0273 0.1295 0.184
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0017 0.0028 0.0025
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0112 0.0497 0.0749
Schistosoma mansoni tar DNA-binding protein 0.143 0.7031 1
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0189 0.2229
Echinococcus granulosus nibrin 0.005 0.0189 0.0266
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0112 0.0497 0.0704
Onchocerca volvulus 0.0017 0.0028 0.011
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.005 0.0189 0.0195
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0045 0.0501
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0529 0.6308
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.018 0.0836 0.0834
Leishmania major cathepsin L-like protease 0.004 0.014 0.0794
Echinococcus multilocularis ras GTP exchange factor 0.0012 0.0003 0.0002
Schistosoma mansoni regulator of G protein signaling 0.0017 0.0028 0.0039
Echinococcus multilocularis GPCR, family 2 0.0547 0.2652 0.2748
Mycobacterium ulcerans lipase LipD 0.0103 0.0453 0.0683
Echinococcus multilocularis mothers against decapentaplegic 6 0.0062 0.0248 0.0255
Echinococcus multilocularis mothers against decapentaplegic 5 0.0138 0.0627 0.0648
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0012 0.0003 0.0004
Schistosoma mansoni lamin 0.0131 0.0589 0.0837
Echinococcus granulosus regulator of G protein signaling 7 0.0017 0.0028 0.0037
Brugia malayi hypothetical protein 0.0077 0.0324 0.0321
Loa Loa (eye worm) hypothetical protein 0.0037 0.0126 0.0123
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0347 0.1661 1
Loa Loa (eye worm) matrix metalloproteinase 0.0156 0.0716 0.0713
Schistosoma mansoni ferritin 0.002 0.0041 0.0058
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0183 0.1087
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0012 0.0003 0.0002
Schistosoma mansoni loxhd1 0.0014 0.001 0.0014
Echinococcus granulosus tumor protein p63 0.0506 0.245 0.3483
Loa Loa (eye worm) hypothetical protein 0.0089 0.0383 0.038
Brugia malayi hypothetical protein 0.0059 0.0234 0.0231
Loa Loa (eye worm) CXXC zinc finger family protein 0.002 0.0041 0.0038
Schistosoma mansoni DNA ligase IV 0.005 0.0189 0.0268
Echinococcus multilocularis tar DNA binding protein 0.143 0.7031 0.7289
Onchocerca volvulus Glucosylceramidase homolog 0.0118 0.0529 0.2339
Brugia malayi MH1 domain containing protein 0.0138 0.0627 0.0624
Brugia malayi jmjC domain containing protein 0.0042 0.0151 0.0148
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1957 0.9646 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0138 0.0627 0.0648
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0105 0.0463 0.0479
Loa Loa (eye worm) hypothetical protein 0.019 0.0884 0.0882
Trypanosoma cruzi cysteine peptidase, putative 0.004 0.014 0.0827
Brugia malayi hypothetical protein 0.005 0.0189 0.0186
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0425 0.0422
Echinococcus multilocularis regulator of G protein signaling 7 0.0017 0.0028 0.0027
Loa Loa (eye worm) RecQ helicase 0.0021 0.0045 0.0042
Loa Loa (eye worm) MH2 domain-containing protein 0.0062 0.0248 0.0245
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0014 0.0009 0.0006
Loa Loa (eye worm) hypothetical protein 0.0103 0.0453 0.045
Echinococcus multilocularis beta LACTamase domain containing family member 0.0103 0.0453 0.0468
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0012 0.0003 0.0004
Schistosoma mansoni hypothetical protein 0.1181 0.5797 0.8245
Echinococcus multilocularis regulator of G protein signaling 7 0.0017 0.0028 0.0027
Loa Loa (eye worm) MH2 domain-containing protein 0.2029 1 1
Brugia malayi hypothetical protein 0.0017 0.0028 0.0025
Schistosoma mansoni hypothetical protein 0.0014 0.001 0.0014
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.005 0.0189 0.0269
Echinococcus granulosus segment polarity protein dishevelled 0.0017 0.0028 0.0037
Mycobacterium tuberculosis Chorismate mutase 0.1326 0.6518 1
Echinococcus granulosus RUN 0.0014 0.001 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0529 0.6308
Mycobacterium tuberculosis Probable lipase LipD 0.0103 0.0453 0.0683
Mycobacterium tuberculosis Conserved protein 0.0103 0.0453 0.0683
Mycobacterium tuberculosis Probable hydrolase 0.0103 0.0453 0.0683
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0131 0.0589 0.0586
Entamoeba histolytica hypothetical protein 0.0059 0.0234 0.609
Loa Loa (eye worm) hypothetical protein 0.0074 0.0309 0.0306
Loa Loa (eye worm) hypothetical protein 0.0353 0.1694 0.1691
Echinococcus granulosus disintegrin and metalloproteinase 0.0124 0.0557 0.0791
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0103 0.0453 0.0645
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0012 0.0003 0.0004
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0041 0.0145 0.0149
Loa Loa (eye worm) hypothetical protein 0.005 0.0189 0.0186
Onchocerca volvulus 0.0156 0.0716 0.3172
Schistosoma mansoni apoferritin-2 0.002 0.0041 0.0058
Leishmania major cathepsin L-like protease 0.004 0.014 0.0794
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.005 0.0189 0.0269
Schistosoma mansoni unc-13 (munc13) 0.0014 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0025
Brugia malayi Isocitrate dehydrogenase 0.0112 0.0497 0.0494
Schistosoma mansoni Smad4 0.0138 0.0627 0.0892
Echinococcus multilocularis disintegrin and metalloproteinase 0.0124 0.0557 0.0576
Loa Loa (eye worm) hypothetical protein 0.0103 0.0453 0.045
Trichomonas vaginalis ferritin, putative 0.002 0.0041 0.045
Echinococcus multilocularis cpg binding protein 0.0021 0.0047 0.0047
Entamoeba histolytica hypothetical protein 0.0059 0.0234 0.609
Trichomonas vaginalis replication factor C large subunit, putative 0.005 0.0189 0.2229
Loa Loa (eye worm) hypothetical protein 0.005 0.0189 0.0186
Schistosoma mansoni thyroid hormone receptor 0.0103 0.0454 0.0646
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0112 0.0497 0.9289
Echinococcus multilocularis geminin 0.0346 0.1658 0.1718
Echinococcus granulosus Pleckstrin G protein interacting region 0.0017 0.0028 0.0037
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0014 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0156 0.0716 0.0713
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0189 0.2229
Loa Loa (eye worm) reprolysin 0.005 0.0189 0.0186
Mycobacterium ulcerans beta-lactamase 0.0103 0.0453 0.0683
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0087 0.0374 0.0532
Schistosoma mansoni ferritin light chain 0.002 0.0041 0.0058
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0096 0.0416 0.043
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0112 0.0497 0.0513
Schistosoma mansoni cpg binding protein 0.0021 0.0047 0.0066
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0236 0.1406
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0151 0.0213
Entamoeba histolytica tartrate dehydrogenase, putative 0.0014 0.0009 0.0157
Trichomonas vaginalis glucosylceramidase, putative 0.0125 0.056 0.6687
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0037 0.0123 0.0723
Mycobacterium ulcerans esterase/lipase LipP 0.0103 0.0453 0.0683
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.007 0.0288 0.0285
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0183 0.1087
Schistosoma mansoni jumonji domain containing protein 0.0041 0.0145 0.0207
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0103 0.0453 0.045
Loa Loa (eye worm) hypothetical protein 0.005 0.0189 0.0186
Echinococcus multilocularis thyroid hormone receptor alpha 0.0103 0.0454 0.0469
Echinococcus multilocularis lipoxygenase domain containing protein 0.0014 0.001 0.0009
Mycobacterium leprae PROBABLE HYDROLASE 0.019 0.0884 0.1345
Schistosoma mansoni dishevelled 0.0017 0.0028 0.0039
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0021
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.005 0.0189 0.2229
Echinococcus multilocularis smad 0.0138 0.0627 0.0648
Trypanosoma cruzi PAB1-binding protein , putative 0.0119 0.0534 0.3202
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0112 0.0497 0.0513
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0045 0.0042
Schistosoma mansoni isocitrate dehydrogenase 0.0014 0.0009 0.0013
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0014 0.0009 0.0006
Onchocerca volvulus 0.0172 0.0793 0.3514
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0014 0.0009 0.0013
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0112 0.0497 0.2344
Brugia malayi intermediate filament protein 0.0131 0.0589 0.0586
Echinococcus granulosus smad 0.0138 0.0627 0.089
Schistosoma mansoni hypothetical protein 0.0346 0.1658 0.2358
Loa Loa (eye worm) hypothetical protein 0.1181 0.5797 0.5796
Brugia malayi beta-lactamase family protein 0.0103 0.0453 0.045
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0014 0.0009 0.0071
Mycobacterium ulcerans hypothetical protein 0.0103 0.0453 0.0683
Schistosoma mansoni ras GTP exchange factor 0.0012 0.0003 0.0004
Echinococcus multilocularis replication factor c subunit 1 0.005 0.0189 0.0194
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0032 0.0426
Trichomonas vaginalis glucosylceramidase, putative 0.0125 0.056 0.6687
Loa Loa (eye worm) isocitrate dehydrogenase 0.0112 0.0497 0.0494
Brugia malayi jmjC domain containing protein 0.0041 0.0145 0.0142
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0547 0.2652 0.2748
Loa Loa (eye worm) Smad1 0.0138 0.0627 0.0624
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.002 0.0041 0.0048
Brugia malayi hypothetical protein 0.0014 0.001 0.0007
Schistosoma mansoni hypothetical protein 0.0547 0.2652 0.3772
Echinococcus granulosus TGF beta signal transducer SmadC 0.0138 0.0627 0.089
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0059 0.0234 0.0241
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0347 0.1661 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0188 0.0185
Echinococcus multilocularis musashi 0.0131 0.0589 0.0609
Leishmania major cathepsin L-like protease 0.004 0.014 0.0794
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0183 0.1087
Chlamydia trachomatis DNA ligase 0.005 0.0189 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.0627 0.0624
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0045 0.0501
Mycobacterium ulcerans hypothetical protein 0.1326 0.6518 1
Onchocerca volvulus 0.0014 0.001 0.003
Toxoplasma gondii hypothetical protein 0.0017 0.0028 0.033
Brugia malayi hypothetical protein 0.0466 0.225 0.2248
Schistosoma mansoni Smad4 0.0062 0.0248 0.0352
Trypanosoma cruzi cysteine peptidase, putative 0.004 0.014 0.0827
Echinococcus multilocularis segment polarity protein dishevelled 0.0017 0.0028 0.0027
Brugia malayi MH1 domain containing protein 0.0076 0.0321 0.0318
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.005 0.0189 0.4894
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0425 0.0605
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0023 0.0033
Mycobacterium tuberculosis Probable lipase LipE 0.0103 0.0453 0.0683
Brugia malayi topoisomerase 0.005 0.0189 0.0186

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 10 mg kg-1 Compound was reproducibly active at reducing clinical severity scores in mouse p.o. ChEMBL. 12873518
Activity (functional) = 10 mg kg-1 Compound was reproducibly active at reducing clinical severity scores in mouse p.o. ChEMBL. 12873518
Activity (functional) = 20 mg kg-1 Compound was reproducibly active at reducing clinical severity scores expressed as efficacy in mouse p.o. ChEMBL. 12873518
Activity (functional) = 20 mg kg-1 Compound was reproducibly active at reducing clinical severity scores expressed as efficacy in mouse p.o. ChEMBL. 12873518
ED50 (functional) = 3 mg kg-1 Effective dose of the compound was determined in mouse ChEMBL. 12873518
ED50 (functional) = 3 mg kg-1 Effective dose of the compound was determined in mouse ChEMBL. 12873518
F (ADMET) = 17 % Oralbioavailabilty in monkey at 10 mg/kg of the compound ChEMBL. 12873518
F (ADMET) = 46 % Oralbioavailabilty in rat at 10 mg/kg of the compound ChEMBL. 12873518
F (ADMET) = 75 % Oralbioavailabilty in dog at 10 mg/kg of the compound ChEMBL. 12873518
F (ADMET) = 100 % Oralbioavailabilty in mouse at 10 mg/kg of the compound ChEMBL. 12873518
F (ADMET) = 100 % Oralbioavailabilty in mouse at 10 mg/kg of the compound ChEMBL. 12873518
IC50 (binding) = 5.61 Inhibition of MMP1 (unknown origin) ChEMBL. 17275314
IC50 (binding) = 6.11 Inhibition of MMP9 (unknown origin) ChEMBL. 17275314
IC50 (binding) = 10 nM In vitro inhibition of tumor necrosis factor-alpha converting enzyme ChEMBL. 12873518
IC50 (binding) = 10 nM In vitro inhibition of tumor necrosis factor-alpha converting enzyme ChEMBL. 12873518
IC50 (binding) = 86 nM In vitro inhibition of Matrix metalloprotein 13 ChEMBL. 12873518
IC50 (binding) = 86 nM In vitro inhibition of Matrix metalloprotein 13 ChEMBL. 12873518
IC50 (binding) = 777 nM In vitro inhibition of Matrix metalloprotein-9 ChEMBL. 12873518
IC50 (binding) = 777 nM In vitro inhibition of Matrix metalloprotein-9 ChEMBL. 12873518
IC50 (binding) = 2471 nM In vitro inhibition of Matrix metalloprotein 1 ChEMBL. 12873518
IC50 (binding) = 2471 nM In vitro inhibition of Matrix metalloprotein 1 ChEMBL. 12873518
IC50 (functional) = 1 uM Inhibitory concentration of the compound against LPS-stimulated TNF-alpha production in human whole blood ChEMBL. 12873518
IC50 (functional) = 1 uM Inhibitory concentration of the compound against LPS-stimulated TNF-alpha production in human whole blood ChEMBL. 12873518
Inhibition (binding) Inhibitory activity against TACE[ADAM metallopeptidase domain 17] in isolated enzyme assay ChEMBL. 16084720
Inhibition (functional) = 50 % Inhibition of LPS-stimulated production of TNF-alpha, at the dose of 1 uM concentration ChEMBL. 12873518
Inhibition (functional) < 50 % In vivo percent inhibition of the compound against LPS-stimulated production of TNF-alpha in a mouse at a dose of 24 mg/Kg p.o. ChEMBL. 12873518
Inhibition (functional) = 50 % Inhibition of LPS-stimulated production of TNF-alpha, at the dose of 1 uM concentration ChEMBL. 12873518
Inhibition (functional) < 50 % In vivo percent inhibition of the compound against LPS-stimulated production of TNF-alpha in a mouse at a dose of 24 mg/Kg p.o. ChEMBL. 12873518
log(1/IC50) (binding) = 5.61 Inhibition of MMP1 (unknown origin) ChEMBL. 17275314
log(1/IC50) (binding) = 6.11 Inhibition of MMP9 (unknown origin) ChEMBL. 17275314

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 12873518

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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