Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | geminin | 0.017 | 0.1329 | 0.1329 |
Trypanosoma cruzi | prolyl-tRNA synthetase, putative | 0.0037 | 0.019 | 0.0298 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0033 | 0.0154 | 0.0242 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0032 | 0.0151 | 0.0151 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.118 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0212 | 0.1694 | 0.1694 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0154 | 0.1973 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0759 | 0.6384 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0759 | 0.6384 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0033 | 0.0154 | 0.0242 |
Plasmodium vivax | calcium-dependent protein kinase 3, putative | 0.0033 | 0.0151 | 0.0236 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0759 | 0.6384 | 1 |
Schistosoma mansoni | protein kinase | 0.0032 | 0.0151 | 0.0151 |
Plasmodium vivax | CDK-related protein kinase 6, putative | 0.045 | 0.3737 | 0.5854 |
Trypanosoma cruzi | hexose transporter, putative | 0.0033 | 0.0154 | 0.0242 |
Trypanosoma cruzi | prolyl-tRNA synthetase, putative | 0.0037 | 0.019 | 0.0298 |
Plasmodium vivax | hexose transporter | 0.0106 | 0.0783 | 0.1226 |
Echinococcus granulosus | calcium dependent protein kinase | 0.003 | 0.0134 | 0.0134 |
Brugia malayi | hypothetical protein | 0.0101 | 0.0739 | 0.0739 |
Brugia malayi | Sugar transporter family protein | 0.0106 | 0.0783 | 0.0783 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0106 | 0.0783 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0033 | 0.0154 | 0.0242 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0106 | 0.0783 | 0.0783 |
Schistosoma mansoni | dihydrofolate reductase | 0.118 | 1 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0106 | 0.0783 | 0.0783 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0008 | 0.0008 |
Brugia malayi | lysyl-tRNA synthetase | 0.0024 | 0.0075 | 0.0075 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0759 | 0.6384 | 1 |
Brugia malayi | Cam kinase protein 1 | 0.0032 | 0.0151 | 0.0151 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0032 | 0.0151 | 0.0151 |
Schistosoma mansoni | glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) | 0.0032 | 0.0145 | 0.0145 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0106 | 0.0783 | 0.0783 |
Trypanosoma brucei | glucose transporter 1E | 0.0033 | 0.0154 | 0.0242 |
Mycobacterium ulcerans | lysyl-tRNA synthetase | 0.0024 | 0.0075 | 0.0075 |
Schistosoma mansoni | transcription factor btf3 | 0.0035 | 0.0173 | 0.0173 |
Entamoeba histolytica | prolyl-tRNA synthetase, putative | 0.0032 | 0.0145 | 0.719 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0106 | 0.0783 | 0.1226 |
Brugia malayi | thymidylate synthase | 0.0212 | 0.1694 | 0.1694 |
Trypanosoma cruzi | lysyl-tRNA synthetase, putative | 0.0024 | 0.0075 | 0.0118 |
Trypanosoma brucei | bifunctional aminoacyl-tRNA synthetase, putative | 0.0037 | 0.019 | 0.0298 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0008 | 0.0008 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type 1 | 0.0032 | 0.0151 | 0.0151 |
Echinococcus granulosus | transcription factor btf3 | 0.0035 | 0.0173 | 0.0173 |
Mycobacterium tuberculosis | Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) | 0.002 | 0.0045 | 0.0045 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0035 | 0.0173 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0.0173 | 0.2204 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0106 | 0.0783 | 0.0783 |
Plasmodium falciparum | protein kinase 7 | 0.03 | 0.2445 | 0.383 |
Trichomonas vaginalis | lysyl-tRNA synthetase, putative | 0.0021 | 0.005 | 0.0641 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0101 | 0.0739 | 0.0739 |
Plasmodium vivax | calcium-dependent protein kinase 4, putative | 0.0033 | 0.0151 | 0.0236 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0035 | 0.0173 | 0.027 |
Plasmodium falciparum | mitogen-activated protein kinase 2 | 0.0171 | 0.1344 | 0.2105 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0.0008 | 0.0012 |
Leishmania major | prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative | 0.0037 | 0.019 | 0.0298 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0032 | 0.0151 | 0.0151 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0759 | 0.6384 | 1 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0035 | 0.0173 | 0.027 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0035 | 0.0173 | 0.027 |
Trypanosoma brucei | glucose transporter, putative | 0.0033 | 0.0154 | 0.0242 |
Echinococcus multilocularis | calcium dependent protein kinase | 0.003 | 0.0134 | 0.0134 |
Trichomonas vaginalis | lysyl-tRNA synthetase, putative | 0.0024 | 0.0075 | 0.0961 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0035 | 0.0173 | 0.027 |
Plasmodium falciparum | calcium-dependent protein kinase 3 | 0.0033 | 0.0151 | 0.0236 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0008 | 0.0008 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0.0008 | 0.0012 |
Brugia malayi | Dihydrofolate reductase | 0.118 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.118 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.118 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.118 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0008 | 0.0008 |
Giardia lamblia | Prolyl-tRNA synthetase | 0.0032 | 0.0145 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0151 | 0.0151 |
Mycobacterium tuberculosis | Lysyl-tRNA synthetase 2 LysX | 0.002 | 0.0045 | 0.0045 |
Onchocerca volvulus | 0.0212 | 0.1694 | 1 | |
Toxoplasma gondii | calcium-dependent protein kinase CDPK2B | 0.0033 | 0.0151 | 0.0236 |
Toxoplasma gondii | calcium-dependent protein kinase CDPK3 | 0.0033 | 0.0151 | 0.0236 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0.0173 | 0.2204 |
Trichomonas vaginalis | sugar transporter, putative | 0.0033 | 0.0154 | 0.1973 |
Brugia malayi | Bifunctional aminoacyl-tRNA synthetase | 0.0032 | 0.0145 | 0.0145 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0033 | 0.0154 | 0.0242 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0035 | 0.0173 | 0.027 |
Wolbachia endosymbiont of Brugia malayi | major facilitator superfamily permease | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0.0008 | 0.0012 |
Toxoplasma gondii | lysine-tRNA ligase | 0.0024 | 0.0075 | 0.0118 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0212 | 0.1694 | 0.1694 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0032 | 0.0151 | 0.0151 |
Plasmodium vivax | mitogen-activated protein kinase 2, putative | 0.0171 | 0.1344 | 0.2105 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0.0173 | 0.2204 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0008 | 0.0008 |
Giardia lamblia | Lysyl-tRNA synthetase | 0.0024 | 0.0075 | 0.5182 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0008 | 0.0012 |
Toxoplasma gondii | calcium-dependent protein kinase CDPK2A | 0.0033 | 0.0151 | 0.0236 |
Trichomonas vaginalis | sugar transporter, putative | 0.0033 | 0.0154 | 0.1973 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0106 | 0.0783 | 0.0783 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0212 | 0.1694 | 0.1694 |
Leishmania major | prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative | 0.0037 | 0.019 | 0.0298 |
Leishmania major | glucose transporter, lmgt1 | 0.0033 | 0.0154 | 0.0242 |
Brugia malayi | Calcium/calmodulin-dependent protein kinase type II alpha chain | 0.0032 | 0.0151 | 0.0151 |
Trypanosoma brucei | calcium/calmodulin-dependent protein kinase, putative | 0.0032 | 0.0151 | 0.0236 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0212 | 0.1694 | 0.1657 |
Trypanosoma brucei | glucose transporter, putative | 0.0033 | 0.0154 | 0.0242 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0106 | 0.0783 | 0.0783 |
Plasmodium falciparum | hexose transporter | 0.0106 | 0.0783 | 0.1226 |
Plasmodium falciparum | calcium-dependent protein kinase 2 | 0.0033 | 0.0151 | 0.0236 |
Echinococcus multilocularis | thymidylate synthase | 0.0212 | 0.1694 | 0.1694 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0032 | 0.0151 | 0.1927 |
Leishmania major | basic transcription factor 3a, putative | 0.0035 | 0.0173 | 0.027 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0173 | 1 |
Plasmodium falciparum | lysine--tRNA ligase | 0.0024 | 0.0075 | 0.0118 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0106 | 0.0783 | 0.0783 |
Plasmodium vivax | proline--tRNA ligase, putative | 0.0037 | 0.019 | 0.0298 |
Entamoeba histolytica | protein kinase, putative | 0.0032 | 0.0151 | 0.777 |
Plasmodium vivax | calcium-dependent protein kinase 1, putative | 0.0033 | 0.0151 | 0.0236 |
Plasmodium falciparum | calcium-dependent protein kinase 1 | 0.0033 | 0.0151 | 0.0236 |
Echinococcus multilocularis | dihydrofolate reductase | 0.118 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0008 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0075 | 0.0075 |
Trypanosoma cruzi | hexose transporter, putative | 0.0018 | 0.0026 | 0.0041 |
Plasmodium vivax | lysine--tRNA ligase, putative | 0.0024 | 0.0075 | 0.0118 |
Plasmodium vivax | calcium-dependent protein kinase, putative | 0.0033 | 0.0151 | 0.0236 |
Loa Loa (eye worm) | ICD-1 protein | 0.0035 | 0.0173 | 0.0173 |
Toxoplasma gondii | prolyl-tRNA synthetase (ProRS) | 0.0037 | 0.019 | 0.0298 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0008 | 0.0012 |
Loa Loa (eye worm) | thymidylate synthase | 0.0212 | 0.1694 | 0.1694 |
Mycobacterium leprae | Probable prolyl tRNA synthetase ProS | 0.0032 | 0.0145 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | CAMK/CAMK2 protein kinase | 0.0032 | 0.0151 | 0.0151 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.1329 | 0.1329 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0008 | 0.0008 |
Trichomonas vaginalis | prolyl-tRNA synthetase, putative | 0.0032 | 0.0145 | 0.1855 |
Toxoplasma gondii | cell-cycle-associated protein kinase MAPK, putative | 0.0171 | 0.1344 | 0.2105 |
Schistosoma mansoni | protein kinase | 0.0032 | 0.0151 | 0.0151 |
Schistosoma mansoni | glucose transport protein | 0.0106 | 0.0783 | 0.0783 |
Trypanosoma brucei | lysyl-tRNA synthetase, putative | 0.0024 | 0.0075 | 0.0118 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0032 | 0.0151 | 0.0151 |
Echinococcus granulosus | General substrate transporter | 0.0091 | 0.0655 | 0.0655 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0145 | 0.0145 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.0154 | 0.1973 |
Echinococcus granulosus | glutamyl tRNA synthetase cytoplasmic | 0.0032 | 0.0145 | 0.0145 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0033 | 0.0154 | 0.0242 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.0008 | 0.0012 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0032 | 0.0151 | 0.0151 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0.0008 | 0.0012 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0759 | 0.6384 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0212 | 0.1694 | 0.1694 |
Trypanosoma brucei | glucose transporter 2A | 0.0033 | 0.0154 | 0.0242 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0008 | 0.0008 |
Trypanosoma cruzi | hexose transporter | 0.0033 | 0.0154 | 0.0242 |
Schistosoma mansoni | glucose transport protein | 0.0106 | 0.0783 | 0.0783 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.1329 | 0.1329 |
Echinococcus multilocularis | General substrate transporter | 0.0091 | 0.0655 | 0.0655 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0101 | 0.0739 | 0.9439 |
Brugia malayi | bifunctional aminoacyl-tRNA synthetase | 0.0032 | 0.0145 | 0.0145 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.0783 | 0.0783 |
Trichomonas vaginalis | glucose transporter, putative | 0.0033 | 0.0154 | 0.1973 |
Trypanosoma brucei | glucose transporter, putative | 0.0033 | 0.0154 | 0.0242 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0008 | 0.0008 |
Echinococcus multilocularis | geminin | 0.017 | 0.1329 | 0.1329 |
Entamoeba histolytica | protein kinase, putative | 0.0032 | 0.0151 | 0.777 |
Trypanosoma cruzi | hexose transporter, putative | 0.0033 | 0.0154 | 0.0242 |
Plasmodium falciparum | calcium-dependent protein kinase 4 | 0.0033 | 0.0151 | 0.0236 |
Echinococcus multilocularis | glutamyl tRNA synthetase cytoplasmic | 0.0032 | 0.0145 | 0.0145 |
Leishmania major | lysyl-tRNA synthetase, putative | 0.0024 | 0.0075 | 0.0118 |
Trypanosoma cruzi | hexose transporter, putative | 0.0033 | 0.0154 | 0.0242 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0101 | 0.0739 | 0.1157 |
Echinococcus multilocularis | lysyl tRNA synthetase | 0.0024 | 0.0075 | 0.0075 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0032 | 0.0151 | 0.0151 |
Mycobacterium ulcerans | lysyl-tRNA synthetase | 0.0024 | 0.0075 | 0.0075 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.118 | 1 | 1 |
Trichomonas vaginalis | sugar transporter, putative | 0.0033 | 0.0154 | 0.1973 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.0008 | 0.0012 |
Schistosoma mansoni | lysyl-tRNA synthetase | 0.0024 | 0.0075 | 0.0075 |
Leishmania major | protein kinase, putative | 0.0032 | 0.0151 | 0.0236 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0008 | 0.0012 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0106 | 0.0783 | 0.0783 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.0008 | 0.0008 |
Trichomonas vaginalis | glucose transporter, putative | 0.0033 | 0.0154 | 0.1973 |
Trypanosoma brucei | glucose transporter, putative | 0.0033 | 0.0154 | 0.0242 |
Leishmania major | glucose transporter, lmgt3 | 0.0033 | 0.0154 | 0.0242 |
Plasmodium falciparum | calcium-dependent protein kinase 5 | 0.0033 | 0.0151 | 0.0236 |
Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0033 | 0.0154 | 0.0242 |
Trypanosoma brucei | glucose transporter, putative | 0.0033 | 0.0154 | 0.0242 |
Mycobacterium leprae | Possible lysyl-tRNA synthetase 2 LysX | 0.0024 | 0.0075 | 0.0031 |
Trypanosoma brucei | glucose transporter, putative | 0.0033 | 0.0154 | 0.0242 |
Leishmania major | glucose transporter, lmgt2 | 0.0033 | 0.0154 | 0.0242 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0032 | 0.0151 | 0.0151 |
Schistosoma mansoni | protein kinase | 0.0032 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | sugar transporter | 0.0106 | 0.0783 | 0.0783 |
Schistosoma mansoni | glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) | 0.0032 | 0.0145 | 0.0145 |
Loa Loa (eye worm) | calcium/calmodulin-dependent protein kinase ID | 0.0032 | 0.0151 | 0.0151 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0106 | 0.0783 | 0.0783 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.118 | 1 | 1 |
Brugia malayi | beta-NAC-like protein | 0.0035 | 0.0173 | 0.0173 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0008 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0145 | 0.0145 |
Echinococcus multilocularis | transcription factor btf3 | 0.0035 | 0.0173 | 0.0173 |
Plasmodium falciparum | protein kinase 6 | 0.045 | 0.3737 | 0.5854 |
Schistosoma mansoni | lysyl-tRNA synthetase | 0.0024 | 0.0075 | 0.0075 |
Toxoplasma gondii | NAC domain-containing protein | 0.0035 | 0.0173 | 0.027 |
Echinococcus granulosus | lysyl tRNA synthetase | 0.0024 | 0.0075 | 0.0075 |
Toxoplasma gondii | protein kinase, putative | 0.03 | 0.2445 | 0.383 |
Plasmodium falciparum | proline--tRNA ligase | 0.0037 | 0.019 | 0.0298 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 43 ug ml-1 | Mammalian cell cytotoxicity test in chinese hamster V79 cells (clonogenic cytotoxicity) | ChEMBL. | 1469702 |
MIC (functional) | = 0.013 ug ml-1 | Antibacterial activity was determined against gram negative organism, E. cloacae MA2646 | ChEMBL. | 1848296 |
MIC (functional) | = 0.013 ug ml-1 | Antibacterial activity was determined against gram negative organism, E. coli vogel | ChEMBL. | 1848296 |
MIC (functional) | = 0.013 ug ml-1 | Antibacterial activity was determined against gram negative organism, E. coli vogel | ChEMBL. | 1848296 |
MIC (functional) | = 0.025 ug ml-1 | Antibacterial activity was determined against gram negative organism, K. pneumonia MGH-2 | ChEMBL. | 1848296 |
MIC (functional) | = 0.025 ug ml-1 | Antibacterial activity was determined against gram positive organism, S. aureus UC76 | ChEMBL. | 1848296 |
MIC (functional) | = 0.03 ug ml-1 | Antibacterial activity against five Gram-negative bacteria | ChEMBL. | 1469702 |
MIC (functional) | = 0.05 ug ml-1 | Antibacterial activity against five Gram-positive bacteria targeting topoisomerase II (DNA gyrase B GyrB) | ChEMBL. | 1469702 |
MIC (functional) | = 0.05 ug ml-1 | Antibacterial activity was determined against gram negative organism, P. rettgeri. M1771 | ChEMBL. | 1848296 |
MIC (functional) | = 0.05 ug ml-1 | Antibacterial activity was determined against gram positive organism, S. pneumonia SV-1 | ChEMBL. | 1848296 |
MIC (functional) | = 0.05 ug ml-1 | Antibacterial activity was determined against gram positive organism, S. pyogenes C203 | ChEMBL. | 1848296 |
MIC (functional) | = 0.05 ug ml-1 | Antibacterial activity against five Gram-positive bacteria targeting topoisomerase II (DNA gyrase B GyrB) | ChEMBL. | 1469702 |
MIC (functional) | = 0.1 ug ml-1 | Antibacterial activity was determined against gram positive organism, S. auerus H228 | ChEMBL. | 1848296 |
MIC (functional) | = 0.1 ug ml-1 | Antibacterial activity was determined against gram positive organism, S. faecalis MGH-2 | ChEMBL. | 1848296 |
MIC (functional) | = 0.2 ug ml-1 | Antibacterial activity was determined against gram negative organism, P. aeruginosa UI-18 | ChEMBL. | 1848296 |
MIC (functional) | = 0.5 ug ml-1 | Minimum inhibitory concentration against E. coli DNA-gyrase in supercoiling assay | ChEMBL. | 1848296 |
MIC (functional) | = 0.5 ug ml-1 | Minimum inhibitory concentration against E. coli DNA-gyrase in supercoiling assay | ChEMBL. | 1848296 |
PD50 (functional) | = 0.5 mg kg-1 | The in vivo potency was determined in female charles river CD-1 mice infected with E. coli after sc administration | ChEMBL. | 1848296 |
PD50 (functional) | = 0.5 mg kg-1 | The in vivo potency was determined in female charles river CD-1 mice infected with E. coli after sc administration | ChEMBL. | 1848296 |
PD50 (functional) | = 2 mg kg-1 | The in vivo potency was determined in female charles river CD-1 mice infected with E. coli after peroral administration | ChEMBL. | 1848296 |
PD50 (functional) | = 2 mg kg-1 | The in vivo potency was determined in female charles river CD-1 mice infected with E. coli after peroral administration | ChEMBL. | 1848296 |
PD50 (functional) | = 11 mg kg-1 | The in vivo potency was determined in female charles river CD-1 mice infected with S. pyogenes after sc administration | ChEMBL. | 1848296 |
PD50 (functional) | = 18 mg kg-1 | The in vivo potency was determined in female charles river CD-1 mice infected with S. pneumoniae after sc administration | ChEMBL. | 1848296 |
PD50 (functional) | = 90 mg kg-1 | The in vivo potency was determined in female charles river CD-1 mice infected with S. pyogenes after peroral administration | ChEMBL. | 1848296 |
PD50 (functional) | = 107 mg kg-1 | The in vivo potency was determined in female charles river CD-1 mice infected with S. pneumoniae after peroral administration | ChEMBL. | 1848296 |
Ratio (functional) | = 0.034 | MIC ratio measured as the mean MICs of gram-negative | ChEMBL. | 1848296 |
Ratio (functional) | = 0.057 | MIC ratio measured as the mean MICs of gram-positive values | ChEMBL. | 1848296 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.