Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.269 | 0.5946 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0402 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.4486 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.269 | 0.108 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.269 | 0.108 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.0402 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0056 | 0.139 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.269 | 0.5946 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.0056 | 0.5 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0102 | 0.4486 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.269 | 0.5946 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0402 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0102 | 0.4486 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0102 | 0.4486 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0102 | 0.4486 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.0402 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.0056 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.269 | 0.5602 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0402 | 0.5 |
Brugia malayi | RNA binding protein | 0.0068 | 0.269 | 0.5602 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.0402 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0402 | 0.0781 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.0402 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0102 | 0.4486 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0102 | 0.4486 | 0.2457 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.269 | 0.108 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0102 | 0.4486 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.4486 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0102 | 0.4486 | 0.3272 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.269 | 0.108 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.269 | 0.108 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0402 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.4486 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0402 | 0.0781 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0402 | 0.0781 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.269 | 0.5602 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.4486 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.0402 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0402 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0102 | 0.4486 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0056 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0102 | 0.4486 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0402 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.4486 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0402 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0102 | 0.4486 | 0.2457 |
Giardia lamblia | Kinase, PLK | 0.0102 | 0.4486 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.4486 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.4486 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1836 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.