Detailed information for compound 1555093

Basic information

Technical information
  • TDR Targets ID: 1555093
  • Name: N-(4,6-dimethylpyrimidin-2-yl)-2-ethoxyacetam ide
  • MW: 209.245 | Formula: C10H15N3O2
  • H donors: 1 H acceptors: 3 LogP: 0.76 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOCC(=O)Nc1nc(C)cc(n1)C
  • InChi: 1S/C10H15N3O2/c1-4-15-6-9(14)13-10-11-7(2)5-8(3)12-10/h5H,4,6H2,1-3H3,(H,11,12,13,14)
  • InChiKey: GDULOGJVSZURHV-UHFFFAOYSA-N  

Network

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Synonyms

  • N-(4,6-dimethylpyrimidin-2-yl)-2-ethoxy-acetamide
  • N-(4,6-dimethyl-2-pyrimidinyl)-2-ethoxyacetamide
  • N-(4,6-dimethylpyrimidin-2-yl)-2-ethoxy-ethanamide
  • ZINC02191134
  • STK126723
  • MLS000703990
  • SMR000226831

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.3342 0.3342
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.3214 0.9615
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.4093 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.3214 0.3214
Loa Loa (eye worm) hypothetical protein 0.0027 0.4093 0.4093
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.1777 0.1777
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.3342 0.3342
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.3342 0.3342
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.075 0.115
Schistosoma mansoni ap endonuclease 0.0023 0.3214 0.3214
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.075 0.1034
Entamoeba histolytica hypothetical protein 0.0041 0.7258 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.2628 1
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.075 0.075
Loa Loa (eye worm) hypothetical protein 0.002 0.2628 0.2628
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.4093 0.4093
Loa Loa (eye worm) hypothetical protein 0.0011 0.075 0.075
Brugia malayi hypothetical protein 0.0041 0.7258 0.7258
Loa Loa (eye worm) hypothetical protein 0.0027 0.4093 0.4093
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.3342 0.3342
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.3342 0.3342
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.075 0.075
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.3342 0.3342
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.3214 0.7851
Toxoplasma gondii exonuclease III APE 0.0023 0.3214 0.4928
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.3342 0.8165
Entamoeba histolytica hypothetical protein 0.0011 0.075 0.1034
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.075 0.2245
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.3214 0.9615
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.3342 0.8165
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.4093 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 1 1
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.075 0.075
Brugia malayi hypothetical protein 0.0011 0.075 0.075
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.3342 0.3342
Loa Loa (eye worm) hypothetical protein 0.0054 1 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.3214 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.3342 0.3342
Mycobacterium ulcerans hypothetical protein 0.0027 0.4093 1
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.3342 0.3342
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.4093 0.4093
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.075 0.115
Loa Loa (eye worm) hypothetical protein 0.0011 0.075 0.075
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.2392 0.5844
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.3342 0.3342
Brugia malayi topoisomerase 0.0011 0.075 0.075
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.1777 0.1777
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.3342 0.8165
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0011 0.075 0.1833
Brugia malayi DKFZp564C0469 protein 0.0011 0.075 0.075
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.7258 0.7258
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.7258 0.7258
Plasmodium falciparum acyl-CoA synthetase 0.002 0.2628 0.8178
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.3342 0.3342
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.4093 1
Echinococcus granulosus nibrin 0.0011 0.075 0.075
Schistosoma mansoni hypothetical protein 0.0041 0.7258 0.7258
Echinococcus multilocularis dna polymerase eta 0.0054 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.2392 0.5844
Loa Loa (eye worm) hypothetical protein 0.002 0.2628 0.2628
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.2392 0.5844
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.3342 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.4093 0.4093
Leishmania major DNA polymerase eta, putative 0.0054 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.4093 0.4093
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.4093 1
Leishmania major DNA polymerase eta, putative 0.0038 0.6522 0.6522
Trypanosoma cruzi FHA domain containing protein, putative 0.0011 0.075 0.075
Leishmania major DNA polymerase kappa, putative 0.0023 0.3342 0.3342
Plasmodium vivax replication factor C subunit 1, putative 0.0011 0.075 0.2335
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.6522 0.6522
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.3214 0.4428
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.3214 0.3214
Onchocerca volvulus 0.0027 0.4093 1
Echinococcus granulosus dna polymerase kappa 0.0023 0.3342 0.3342
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.075 0.075
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.2392 0.5844
Echinococcus granulosus dna polymerase eta 0.0054 1 1
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.075 0.075
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.075 0.2245
Schistosoma mansoni ap endonuclease 0.0023 0.3214 0.3214
Loa Loa (eye worm) hypothetical protein 0.002 0.2628 0.2628
Schistosoma mansoni topbp1 0.0011 0.075 0.075
Trypanosoma brucei unspecified product 0.0016 0.1777 0.1777
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.075 0.2245
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.075 0.075
Brugia malayi AMP-binding enzyme family protein 0.0027 0.4093 0.4093
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.3214 1
Onchocerca volvulus 0.0011 0.075 0.1833
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.3214 0.3214
Loa Loa (eye worm) hypothetical protein 0.0011 0.075 0.075
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.3214 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.7258 0.7258
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.075 0.2245
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.4093 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.4093 0.4093
Loa Loa (eye worm) hypothetical protein 0.0011 0.075 0.075
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.3214 0.7851
Echinococcus granulosus replication factor c subunit 1 0.0011 0.075 0.075
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.3342 0.3342
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.4093 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.075 0.075
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.4093 0.564
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.075 0.2245
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.3342 0.3342
Loa Loa (eye worm) hypothetical protein 0.0011 0.075 0.075
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.3342 0.3342
Loa Loa (eye worm) hypothetical protein 0.002 0.2628 0.2628
Giardia lamblia DINP protein human, muc B family 0.0023 0.3342 1
Echinococcus multilocularis nibrin 0.0011 0.075 0.075
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.075 0.075
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.3342 0.3342
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.075 0.2245
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.3214 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.4093 1
Entamoeba histolytica hypothetical protein 0.0041 0.7258 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.4093 0.564
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.075 0.2245
Entamoeba histolytica hypothetical protein 0.0041 0.7258 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.3214 0.3214
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.3214 0.3214
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.075 0.075
Schistosoma mansoni DNA ligase IV 0.0011 0.075 0.075
Loa Loa (eye worm) hypothetical protein 0.002 0.2628 0.2628
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.3342 0.3342
Trypanosoma brucei DNA polymerase eta, putative 0.0054 1 1
Trypanosoma brucei unspecified product 0.0016 0.1777 0.1777
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.3214 0.9504
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.3342 0.3342
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.075 0.2245
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.3342 0.3342
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.1777 0.1777
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.3342 0.3342
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.4093 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.4093 0.564
Echinococcus multilocularis dna polymerase kappa 0.0023 0.3342 0.3342
Schistosoma mansoni DNA polymerase eta 0.0054 1 1
Plasmodium falciparum replication factor C subunit 1, putative 0.0011 0.075 0.2335
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0011 0.075 0.1833
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.3342 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.3342 0.3342
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.4093 0.4093
Brugia malayi hypothetical protein 0.0011 0.075 0.075
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.3214 0.3214
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.3342 0.3342
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.075 0.2245
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.3342 0.3342
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.2628 0.6421
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.2628 0.8178
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.075 0.2245
Schistosoma mansoni topbp1 0.0011 0.075 0.075
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.3214 0.3214
Trypanosoma brucei unspecified product 0.0023 0.3342 0.3342
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.3214 0.3214
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.4093 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.6522 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.4093 1
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.3342 0.8165
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.3342 0.4605
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.2628 0.6421
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.3342 0.3342
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.4093 1
Entamoeba histolytica hypothetical protein 0.0041 0.7258 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.3342 0.3342

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0056 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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