Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.019 | 0.1062 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0406 | 0.2897 | 0.4947 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0753 | 0.5856 | 1 |
Onchocerca volvulus | 0.0066 | 0 | 0.5 | |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.124 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0066 | 0 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0406 | 0.2897 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0406 | 0.2897 | 0.4947 |
Onchocerca volvulus | Peroxidase homolog | 0.0066 | 0 | 0.5 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.019 | 0.1062 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0066 | 0 | 0.5 |
Onchocerca volvulus | 0.0066 | 0 | 0.5 | |
Schistosoma mansoni | patched 1 | 0.0167 | 0.0864 | 0.0875 |
Echinococcus multilocularis | protein dispatched 1 | 0.0167 | 0.0864 | 0.1476 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.019 | 0.1062 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0167 | 0.0864 | 0.0875 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0167 | 0.0864 | 0.1476 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0406 | 0.2897 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0066 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0753 | 0.5856 | 1 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0223 | 0.1339 | 0.1356 |
Onchocerca volvulus | 0.0066 | 0 | 0.5 | |
Onchocerca volvulus | Peroxidase homolog | 0.0066 | 0 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0167 | 0.0864 | 0.1476 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0167 | 0.0864 | 0.0864 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0406 | 0.2897 | 0.5 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0406 | 0.2897 | 0.2897 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.2897 | 0.2897 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0167 | 0.0864 | 0.1476 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0753 | 0.5856 | 0.5856 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0753 | 0.5856 | 0.5856 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0406 | 0.2897 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0864 | 0.0864 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.1225 | 0.9876 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0406 | 0.2897 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0753 | 0.5856 | 0.5929 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.019 | 0.1062 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0406 | 0.2897 | 0.2933 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0167 | 0.0864 | 0.1476 |
Onchocerca volvulus | Peroxidasin homolog | 0.0066 | 0 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0167 | 0.0864 | 0.1476 |
Brugia malayi | CHE-14 protein | 0.0167 | 0.0864 | 0.0864 |
Echinococcus multilocularis | protein patched | 0.0167 | 0.0864 | 0.1476 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 40 mg kg-1 | Anti-tetrabenazine (TBZ) activity, ability to prevent TBZ-induced ptosis in mice | ChEMBL. | 6471069 |
IC50 (functional) | > 10 uM | In vitro inhibition of norepinephrine uptake in rat brain synaptosomes using [3H]-NE | ChEMBL. | 6471069 |
IC50 (functional) | > 10 uM | In vitro inhibition of 5-HT uptake in rat brain synaptosomes using [3H]- 5-hydroxytryptamine | ChEMBL. | 6471069 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.