Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0756 | 0.8192 | 0.8192 |
Echinococcus granulosus | GPCR family 2 | 0.0249 | 0.2311 | 0.2311 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0249 | 0.2311 | 0.1721 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0249 | 0.2311 | 0.211 |
Brugia malayi | RNA binding protein | 0.0756 | 0.8192 | 0.8145 |
Schistosoma mansoni | tar DNA-binding protein | 0.0756 | 0.8192 | 0.8192 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0911 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0756 | 0.8192 | 0.8192 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0756 | 0.8192 | 0.8145 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0911 | 1 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0911 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0538 | 0.5664 | 0.5551 |
Brugia malayi | TAR-binding protein | 0.0756 | 0.8192 | 0.8145 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.2311 | 0.1721 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0111 | 0.0713 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0249 | 0.2311 | 0.2311 |
Schistosoma mansoni | kinase | 0.0463 | 0.4797 | 0.4797 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0787 | 0.8555 | 0.8517 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0111 | 0.0713 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0787 | 0.8555 | 0.8517 |
Schistosoma mansoni | tar DNA-binding protein | 0.0756 | 0.8192 | 0.8192 |
Schistosoma mansoni | hypothetical protein | 0.0249 | 0.2311 | 0.2311 |
Loa Loa (eye worm) | hypothetical protein | 0.0787 | 0.8555 | 0.8444 |
Trypanosoma brucei | polo-like protein kinase | 0.0911 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0756 | 0.8192 | 0.8053 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0111 | 0.0713 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0756 | 0.8192 | 0.8192 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0911 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0249 | 0.2311 | 0.2311 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0911 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0756 | 0.8192 | 0.8053 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0911 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0756 | 0.8192 | 0.8053 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.1695 | 0.1058 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0111 | 0.0713 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0249 | 0.2311 | 0.2311 |
Schistosoma mansoni | hypothetical protein | 0.0249 | 0.2311 | 0.2311 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0911 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0249 | 0.2311 | 0.2311 |
Schistosoma mansoni | tar DNA-binding protein | 0.0756 | 0.8192 | 0.8192 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0911 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0756 | 0.8192 | 0.8192 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0911 | 1 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0911 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0911 | 1 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0196 | 0.1695 | 0.1478 |
Loa Loa (eye worm) | hypothetical protein | 0.0538 | 0.5664 | 0.5332 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0911 | 1 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0911 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0911 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0911 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0249 | 0.2311 | 0.2311 |
Brugia malayi | hypothetical protein | 0.0111 | 0.0713 | 0.047 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0249 | 0.2311 | 0.2311 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0911 | 1 | 1 |
Giardia lamblia | Kinase, PLK | 0.0911 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0249 | 0.2311 | 0.2311 |
Schistosoma mansoni | hypothetical protein | 0.0538 | 0.5664 | 0.5664 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0787 | 0.8555 | 0.8444 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0249 | 0.2311 | 0.211 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 10 uM | Tested for Concentration required for the inhibition of ADP-induced aggregation of human platelets | ChEMBL. | 11133092 |
IC50 (functional) | > 10 uM | Tested for Concentration required for the inhibition of ADP-induced aggregation of human platelets | ChEMBL. | 11133092 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 11133092 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.