Detailed information for compound 1555224

Basic information

Technical information
  • TDR Targets ID: 1555224
  • Name: ethyl 2-[2-[(4-bromophenyl)sulfonylamino]-1,3 -thiazol-4-yl]acetate
  • MW: 405.287 | Formula: C13H13BrN2O4S2
  • H donors: 1 H acceptors: 4 LogP: 2.69 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)Cc1csc(n1)NS(=O)(=O)c1ccc(cc1)Br
  • InChi: 1S/C13H13BrN2O4S2/c1-2-20-12(17)7-10-8-21-13(15-10)16-22(18,19)11-5-3-9(14)4-6-11/h3-6,8H,2,7H2,1H3,(H,15,16)
  • InChiKey: PGUXTMPTPRTMHK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[2-[(4-bromophenyl)sulfonylamino]thiazol-4-yl]acetate
  • 2-[2-[(4-bromophenyl)sulfonylamino]-4-thiazolyl]acetic acid ethyl ester
  • 2-[2-[(4-bromophenyl)sulfonylamino]thiazol-4-yl]acetic acid ethyl ester
  • ethyl 2-[2-[(4-bromophenyl)sulfonylamino]-1,3-thiazol-4-yl]ethanoate
  • SMR000298581
  • ethyl (2-{[(4-bromophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate
  • ZINC01183127
  • STK016400
  • MLS000689885

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear hormone receptor 0.0062 0.0105 0.0758
Echinococcus multilocularis Niemann Pick C1 protein 0.0149 0.034 0.0519
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0074 0.0605
Echinococcus multilocularis zinc finger protein 0.0025 0.0005 0.0003
Entamoeba histolytica hypothetical protein 0.0075 0.014 0.567
Brugia malayi hypothetical protein 0.0075 0.014 0.205
Schistosoma mansoni coup transcription factor 0.0062 0.0105 0.0758
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0105 0.1506
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.0229 0.0348
Brugia malayi Pre-SET motif family protein 0.0032 0.0024 0.0267
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0093 0.0916
Echinococcus granulosus zinc finger protein 0.0025 0.0005 0.0016
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0261
Brugia malayi hypothetical protein 0.0033 0.0027 0.0305
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.0017 0.0261
Brugia malayi ecdysone receptor 0.0029 0.0017 0.0161
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0093 1
Brugia malayi beta-lactamase 0.0108 0.0229 0.3423
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0036 0.0029
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0017 0.0104
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0229 0.1691
Loa Loa (eye worm) hypothetical protein 0.0033 0.0027 0.0404
Loa Loa (eye worm) hypothetical protein 0.0108 0.0229 0.349
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0017 0.0104
Loa Loa (eye worm) DR-78 0.0029 0.0017 0.0261
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0093 0.0916
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0418 0.6147
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0212 0.3153
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0027 0.0174
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.0017 0.0104
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0229 0.3113
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0093 0.1324
Brugia malayi acetyltransferase, GNAT family protein 0.0164 0.038 0.5742
Loa Loa (eye worm) hypothetical protein 0.0104 0.022 0.334
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0065 0.0096
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0024 0.0156
Plasmodium vivax SET domain protein, putative 0.0032 0.0024 0.078
Toxoplasma gondii exonuclease III APE 0.0057 0.0093 0.0086
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0062 0.0105 0.0758
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0393 0.5753
Loa Loa (eye worm) hypothetical protein 0.0062 0.0105 0.1592
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.046 0.0704
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0062 0.0105 0.0758
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0261
Schistosoma mansoni RAR-like nuclear receptor 0.0062 0.0105 0.0758
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0105 0.1506
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0065 0.0901
Schistosoma mansoni hypothetical protein 0.0047 0.0065 0.0464
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0017 0.0161
Schistosoma mansoni hypothetical protein 0.0047 0.0065 0.0464
Loa Loa (eye worm) beta-lactamase 0.0108 0.0229 0.349
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0017 0.0104
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0073 0.0519
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.0376 0.2786
Loa Loa (eye worm) DnaJ domain-containing protein 0.0061 0.0103 0.1571
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0105 0.1506
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0261
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.0027 0.0036
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0261
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.0229 0.3423
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0093 0.3869
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0261
Loa Loa (eye worm) hypothetical protein 0.0062 0.0105 0.1592
Trichomonas vaginalis set domain proteins, putative 0.0251 0.0614 0.9303
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0074 0.3001
Trypanosoma brucei glucosidase, putative 0.0036 0.0036 0.1314
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0105 0.0156
Brugia malayi MH2 domain containing protein 0.012 0.0263 0.3943
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.0017 0.0104
Echinococcus granulosus histone acetyltransferase KAT2B 0.0157 0.0361 0.2677
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.0229 0.0138
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0056 0.1099
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0062 0.0105 0.1506
Loa Loa (eye worm) hypothetical protein 0.0045 0.0059 0.0904
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0632 0.9586
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0393 0.5753
Onchocerca volvulus 0.0094 0.0192 0.2925
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0062 0.0105 0.0156
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0065 0.0901
Onchocerca volvulus 0.0152 0.0349 0.5567
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0261
Brugia malayi nuclear receptor RXR 0.0033 0.0027 0.0305
Echinococcus granulosus dnaJ subfamily C 6 0.0061 0.0103 0.0748
Echinococcus multilocularis FTZ F1 alpha 0.0062 0.0105 0.0156
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.0393 0.6304
Schistosoma mansoni steroid hormone receptor ad4bp 0.0062 0.0105 0.0758
Mycobacterium ulcerans glutaminase 0.0267 0.0657 0.057
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0632 0.9586
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0689 0.1794 0.1717
Brugia malayi Steroid receptor seven-up type 2 0.0062 0.0105 0.1506
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0062 0.0105 0.1592
Schistosoma mansoni hypothetical protein 0.0043 0.0055 0.0387
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0062 0.0105 0.0758
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0062 0.0105 0.0758
Loa Loa (eye worm) hypothetical protein 0.0033 0.0027 0.0404
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0036 0.005
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0062 0.0105 0.0156
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0024 0.0156
Schistosoma mansoni hypothetical protein 0.0521 0.1341 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0261
Onchocerca volvulus 0.0108 0.0229 0.3556
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.0017 0.0104
Echinococcus multilocularis ecdysone induced protein 78C 0.0062 0.0105 0.0156
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0062 0.0105 0.0758
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0393 0.5753
Loa Loa (eye worm) glutaminase 2 0.0267 0.0657 1
Echinococcus multilocularis GPCR, family 2 0.0047 0.0065 0.0096
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0059 0.0904
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0073 0.0107
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0093 0.1413
Onchocerca volvulus 0.0108 0.0229 0.3556
Brugia malayi beta-lactamase family protein 0.0108 0.0229 0.3423
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0261
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0017 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0393 0.5753
Schistosoma mansoni alpha-glucosidase 0.014 0.0315 0.2331
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0093 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.0376 0.0574
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0105 0.1506
Brugia malayi hypothetical protein 0.0152 0.0349 0.5268
Echinococcus multilocularis expressed conserved protein 0.0098 0.0203 0.0307
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.0229 0.0138
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0041 0.0285
Schistosoma mansoni patched 1 0.0045 0.0059 0.042
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.0017 0.0104
Mycobacterium ulcerans beta-lactamase 0.0108 0.0229 0.0138
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.0229 0.0138
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0074 0.0525
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.014 0.0211
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.0229 0.0138
Schistosoma mansoni hypothetical protein 0.0061 0.0103 0.0748
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0021 0.0132
Echinococcus multilocularis Niemann Pick C1 protein 0.0104 0.022 0.0333
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0229 0.3113
Schistosoma mansoni zinc finger protein 0.0025 0.0005 0.0016
Loa Loa (eye worm) hypothetical protein 0.0062 0.0105 0.1592
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0027 0.0305
Loa Loa (eye worm) hypothetical protein 0.0108 0.0229 0.349
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0261
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0093 0.3869
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.0632 0.9605
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0261
Schistosoma mansoni alpha-glucosidase 0.014 0.0315 0.2331
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.0017 0.0261
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0164 0.038 0.2818
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.012 0.0871
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0062 0.0105 0.0758
Schistosoma mansoni retinoic acid receptor RXR 0.0062 0.0105 0.0758
Brugia malayi beta-lactamase family protein 0.0108 0.0229 0.3423
Loa Loa (eye worm) hypothetical protein 0.0062 0.0105 0.1592
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0093 0.5
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.3739 1 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.0349 0.5316
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.0017 0.0161
Brugia malayi hypothetical protein 0.0029 0.0017 0.0161
Schistosoma mansoni alpha glucosidase 0.0036 0.0036 0.0245
Brugia malayi hypothetical protein 0.0033 0.0027 0.0305
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0418 0.6147
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0261
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0263 0.4005
Schistosoma mansoni hypothetical protein 0.0075 0.014 0.1023
Loa Loa (eye worm) hypothetical protein 0.0062 0.0105 0.1592
Brugia malayi glutaminase DH11.1 0.0267 0.0657 1
Echinococcus granulosus Niemann Pick C1 protein 0.0104 0.022 0.1617
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0036 0.045
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0632 0.9586
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0229 0.3113
Loa Loa (eye worm) hypothetical protein 0.0062 0.0105 0.1592
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0027 0.0305
Schistosoma mansoni ap endonuclease 0.0057 0.0093 0.067
Brugia malayi nuclear receptor NHR-67 0.0029 0.0017 0.0161
Loa Loa (eye worm) hypothetical protein 0.0047 0.0065 0.0993
Brugia malayi Bromodomain containing protein 0.0045 0.0059 0.0801
Brugia malayi steroid hormone receptor 0.0062 0.0105 0.1506
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0093 0.3869
Schistosoma mansoni nuclear receptor 0.0029 0.0017 0.0104
Onchocerca volvulus 0.0251 0.0614 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.0017 0.0161
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.0017 0.0021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.0338 0.5144
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0036 0.1314
Loa Loa (eye worm) hypothetical protein 0.0108 0.0229 0.349
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.014 0.1023
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.0027 0.0404
Brugia malayi nuclear hormone receptor 0.0062 0.0105 0.1506
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0229 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0071 0.1083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0105 0.0758
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.046 0.3418
Mycobacterium tuberculosis Conserved protein 0.0108 0.0229 0.0138
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0062 0.0105 0.0758
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.0532 0.8095
Loa Loa (eye worm) hypothetical protein 0.0062 0.0105 0.1592
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0065 0.0993
Loa Loa (eye worm) hypothetical protein 0.0033 0.0027 0.0404
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0065 0.0464
Schistosoma mansoni ap endonuclease 0.0057 0.0093 0.067
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0632 0.9586
Onchocerca volvulus 0.0032 0.0024 0.0116
Loa Loa (eye worm) hypothetical protein 0.005 0.0073 0.1106
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0229 0.3113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0062 0.0105 0.1592
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.3739 1 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0074 0.0067
Echinococcus multilocularis protein dispatched 1 0.0051 0.0076 0.0113
Brugia malayi conserved hypotetical protein 0.0029 0.0017 0.0161
Brugia malayi tailless protein 0.0029 0.0017 0.0161
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.014 0.1023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0073 0.0519
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0036 0.0245
Loa Loa (eye worm) steroid hormone receptor 0.0062 0.0105 0.1592
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.0027 0.0174
Trichomonas vaginalis esterase, putative 0.0108 0.0229 0.3113
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0036 0.1314
Entamoeba histolytica hypothetical protein 0.0075 0.014 0.567
Brugia malayi nuclear receptor NHR-88 0.0029 0.0017 0.0161
Schistosoma mansoni hypothetical protein 0.0043 0.0055 0.0387
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0062 0.0105 0.1592
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0093 0.31
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0036 0.0547
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.0632 0.9609
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0062 0.0105 0.1592
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.0229 0.0138
Brugia malayi Niemann-Pick C1 protein precursor 0.0104 0.022 0.3272
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.046 0.3418
Entamoeba histolytica hypothetical protein 0.0075 0.014 0.567
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0065 0.0464
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0062 0.0105 0.1466
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0062 0.0105 0.0156
Schistosoma mansoni hypothetical protein 0.0043 0.0055 0.0387
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.0229 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.0229 0.0138
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.0229 0.0138
Brugia malayi PHD-finger family protein 0.003 0.0021 0.0214
Schistosoma mansoni bromodomain containing protein 0.0071 0.013 0.0947
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0105 0.0758
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0093 0.3869
Echinococcus granulosus geminin 0.0521 0.1341 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0229 0.349
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0062 0.0105 0.1506
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.0376 0.0574
Trichomonas vaginalis glutaminase, putative 0.0267 0.0657 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0024 0.0017
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.0027 0.0174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0062 0.0105 0.1592
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0062 0.0105 0.1592
Loa Loa (eye worm) hypothetical protein 0.0108 0.0229 0.349
Onchocerca volvulus Protein ultraspiracle homolog 0.0062 0.0105 0.1466
Loa Loa (eye worm) glutaminase 0.0267 0.0657 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.046 0.3418
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0062 0.0105 0.1506
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0632 0.9586
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0093 0.067
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0017 0.0161
Brugia malayi photoreceptor-specific nuclear receptor 0.0062 0.0105 0.1506
Onchocerca volvulus Bile acid receptor homolog 0.0062 0.0105 0.1466
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0263 0.4005
Entamoeba histolytica hypothetical protein 0.0075 0.014 0.567
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0105 0.1506
Toxoplasma gondii pantoate-beta-alanine ligase 0.3739 1 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.0017 0.0161
Leishmania major hypothetical protein, conserved 0.0108 0.0229 1
Echinococcus granulosus ecdysone induced protein 78C 0.0062 0.0105 0.0758
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0041 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0062 0.0105 0.1506
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0062 0.0105 0.1506
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0062 0.0105 0.0758
Loa Loa (eye worm) hypothetical protein 0.0033 0.0027 0.0404
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0194 0.046 0.7007
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0017 0.0104
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0104 0.022 1
Brugia malayi Bromodomain containing protein 0.0083 0.0163 0.2408
Echinococcus granulosus expressed conserved protein 0.0098 0.0203 0.149
Echinococcus multilocularis protein patched 0.0045 0.0059 0.0087
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.0229 0.1691
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.0338 0.5094
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0059 0.042
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0229 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.0229 0.349
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0017 0.0104
Schistosoma mansoni nuclear receptor 0.0029 0.0017 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0059 0.0377
Loa Loa (eye worm) hypothetical protein 0.0101 0.0212 0.3223
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.046 0.3418
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.046 0.3418
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0093 0.3869
Brugia malayi DnaJ domain containing protein 0.0061 0.0103 0.1484
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.0229 0.0138
Schistosoma mansoni hypothetical protein 0.0047 0.0065 0.0464
Schistosoma mansoni hypothetical protein 0.0043 0.0055 0.0387
Loa Loa (eye worm) acetyltransferase 0.0164 0.038 0.5786
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0024 0.0032
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.0017 0.0161
Brugia malayi nuclear hormone receptor 0.0029 0.0017 0.0161
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.046 0.0704
Schistosoma mansoni hypothetical protein 0.0101 0.0212 0.1559
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2436 0.6494 1
Echinococcus multilocularis dnaJ subfamily C 6 0.0061 0.0103 0.0154
Mycobacterium ulcerans hypothetical protein 0.0108 0.0229 0.0138
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0102
Loa Loa (eye worm) hypothetical protein 0.0033 0.0027 0.0404
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0093 0.5
Echinococcus granulosus GPCR family 2 0.0047 0.0065 0.0464
Onchocerca volvulus 0.0108 0.0229 0.3556
Loa Loa (eye worm) hypothetical protein 0.0148 0.0338 0.5144
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0393 0.5753
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.0017 0.0104
Mycobacterium ulcerans lipase LipD 0.0108 0.0229 0.0138
Schistosoma mansoni hypothetical protein 0.0047 0.0065 0.0464
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0073 0.0519
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0062 0.0105 0.1592
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0105 0.1506
Mycobacterium tuberculosis Conserved protein 0.0108 0.0229 0.0138
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.0229 0.0138
Brugia malayi nuclear receptor RXR 0.0029 0.0017 0.0161
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0229 1
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0036 0.1314
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0093 0.0138
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0194 0.046 0.6976
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0074 0.0067
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0393 0.5753
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.012 0.018
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.0017 0.0021
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.0338 0.5094
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0017 0.0021
Brugia malayi nuclear receptor NHR-88 0.0062 0.0105 0.1506
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0056 0.5738
Brugia malayi ecdysteroid receptor 0.0062 0.0105 0.1506
Loa Loa (eye worm) hypothetical protein 0.0047 0.0066 0.1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0062 0.0105 0.0156
Loa Loa (eye worm) hypothetical protein 0.0108 0.0229 0.349
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0062 0.0105 0.0156
Brugia malayi CHE-14 protein 0.0045 0.0059 0.081
Mycobacterium tuberculosis Conserved protein 0.0108 0.0229 0.0138
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0105 0.0758
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0062 0.0105 0.0758
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0105 0.0758
Schistosoma mansoni glutaminase 0.0267 0.0657 0.4889
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0229 0.3113
Loa Loa (eye worm) hypothetical protein 0.0075 0.0141 0.2138
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0062 0.0105 0.1506
Schistosoma mansoni zinc finger protein 0.0029 0.0017 0.0104
Loa Loa (eye worm) hypothetical protein 0.0055 0.0086 0.1316
Brugia malayi hypothetical protein 0.0029 0.0017 0.0161
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0105 0.0156
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0164 0.038 0.0581
Loa Loa (eye worm) hypothetical protein 0.0041 0.0048 0.0736
Onchocerca volvulus 0.0062 0.0105 0.1466
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0017 0.0021
Echinococcus granulosus FTZ F1 alpha 0.0062 0.0105 0.0758
Echinococcus multilocularis geminin 0.0521 0.1341 0.2061
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0632 0.9586
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0059 0.0087
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.0376 0.5719
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0062 0.0105 0.0758
Schistosoma mansoni hypothetical protein 0.0521 0.1341 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0229 0.1691
Echinococcus granulosus Niemann Pick C1 protein 0.0149 0.034 0.2517
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0062 0.0105 0.0758
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0062 0.0105 0.1506
Toxoplasma gondii ABC1 family protein 0.0108 0.0229 0.0223
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0074 0.0605
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.0017 0.0104
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0106 0.0224 0.1649
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0393 0.5753
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0261
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0065 0.0096
Loa Loa (eye worm) hypothetical protein 0.0062 0.0105 0.1592
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.0376 0.5675
Trichomonas vaginalis protein kinase inhibitor, putative 0.0061 0.0103 0.1083
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0261
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.0017 0.0261
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0059 0.042
Brugia malayi Pre-SET motif family protein 0.022 0.0532 0.8075
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.0017 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0105 0.1506

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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