Detailed information for compound 1555347

Basic information

Technical information
  • TDR Targets ID: 1555347
  • Name: 5-hydroxy-3,4-di(phenyl)cyclopent-2-en-1-one
  • MW: 250.292 | Formula: C17H14O2
  • H donors: 1 H acceptors: 2 LogP: 2.62 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C=C(C(C1O)c1ccccc1)c1ccccc1
  • InChi: 1S/C17H14O2/c18-15-11-14(12-7-3-1-4-8-12)16(17(15)19)13-9-5-2-6-10-13/h1-11,16-17,19H
  • InChiKey: MLZONHYJHOUBOQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-hydroxy-3,4-di(phenyl)-1-cyclopent-2-enone
  • 5-Hydroxy-3,4-diphenyl-2-cyclopenten-1-one
  • AIDS-160031
  • AIDS160031
  • NSC129685

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0169 0.4144 0.4144
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0028 0.0229 0.0546
Loa Loa (eye worm) hypothetical protein 0.0169 0.4144 1
Brugia malayi hypothetical protein 0.0167 0.407 0.9823
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0028 0.0231 1
Trichomonas vaginalis CMGC family protein kinase 0.0028 0.0229 0.992
Loa Loa (eye worm) hypothetical protein 0.008 0.1664 0.4012
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0169 0.4144 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.008 0.1664 0.1664
Leishmania major mitochondrial DNA polymerase beta 0.0284 0.7315 1
Onchocerca volvulus Huntingtin homolog 0.0068 0.1323 0.1329
Echinococcus granulosus mitogen activated protein kinase 3 0.0028 0.0229 0.0229
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0028 0.0231 0.0557
Loa Loa (eye worm) hypothetical protein 0.008 0.1664 0.4012
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0028 0.0229 0.3162
Schistosoma mansoni biogenic amine (5HT) receptor 0.0078 0.1602 0.1602
Loa Loa (eye worm) transcription factor SMAD2 0.0066 0.1275 0.3073
Echinococcus granulosus Nuclear hormone receptor HR96 0.008 0.1664 0.1664
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0169 0.4144 0.4144
Brugia malayi hypothetical protein 0.0089 0.193 0.4657
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0028 0.0231 1
Echinococcus multilocularis mitogen activated protein kinase 0.0028 0.0229 0.0229
Loa Loa (eye worm) MH2 domain-containing protein 0.0066 0.1275 0.3073
Brugia malayi nuclear hormone receptor family member nhr-6 0.008 0.1664 0.4016
Loa Loa (eye worm) hypothetical protein 0.008 0.1664 0.4012
Loa Loa (eye worm) hypothetical protein 0.0169 0.4144 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.1602 0.3863
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0169 0.4144 0.4144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0169 0.4144 1
Leishmania major lanosterol synthase, putative 0.0023 0.0095 0.0126
Brugia malayi Nuclear hormone receptor-like 1 0.0089 0.193 0.4657
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0169 0.4144 0.4144
Brugia malayi ecdysteroid receptor 0.0169 0.4144 1
Loa Loa (eye worm) hypothetical protein 0.008 0.1664 0.4012
Schistosoma mansoni nuclear receptor 0.008 0.1664 0.1664
Loa Loa (eye worm) hypothetical protein 0.008 0.1664 0.4012
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0169 0.4144 1
Onchocerca volvulus Bile acid receptor homolog 0.0169 0.4144 1
Brugia malayi MH2 domain containing protein 0.0066 0.1275 0.3077
Loa Loa (eye worm) hypothetical protein 0.008 0.1664 0.4012
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0169 0.4144 0.4144
Echinococcus granulosus mitogen activated protein kinase 0.0028 0.0229 0.0229
Trypanosoma brucei DNA polymerase beta thumb, putative 0.004 0.0556 0.0757
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0028 0.0229 0.0309
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0028 0.0231 1
Schistosoma mansoni hypothetical protein 0.0189 0.4686 0.4686
Brugia malayi nuclear receptor NHR-88 0.0169 0.4144 1
Leishmania major farnesyltransferase beta subunit 0.0028 0.0231 0.0312
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0981 0.0981
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0169 0.4144 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0089 0.193 0.193
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.008 0.1664 0.1664
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0169 0.4144 0.4144
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0169 0.4144 0.4144
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0981 0.0981
Loa Loa (eye worm) hypothetical protein 0.008 0.1664 0.4012
Brugia malayi nuclear receptor NHR-67 0.008 0.1664 0.4016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0169 0.4144 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0169 0.4144 0.4144
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.008 0.1664 0.1664
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0169 0.4144 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0981 0.2368
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0028 0.0231 0.3187
Schistosoma mansoni coup transcription factor 0.0169 0.4144 0.4144
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0089 0.193 0.4653
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0028 0.0231 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0169 0.4144 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0169 0.4144 0.4144
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0028 0.0231 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.008 0.1664 0.1664
Echinococcus granulosus biogenic amine 5HT receptor 0.0078 0.1602 0.1602
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0028 0.0229 0.0309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0169 0.4144 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0028 0.0229 0.0309
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0028 0.0231 0.0312
Trypanosoma brucei protein kinase, putative 0.0028 0.0229 0.0309
Loa Loa (eye worm) hypothetical protein 0.008 0.1664 0.4012
Echinococcus multilocularis mitogen activated protein kinase 3 0.0028 0.0229 0.0229
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0169 0.4144 0.4144
Trichomonas vaginalis CMGC family protein kinase 0.0028 0.0229 0.992
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0028 0.0229 0.0309
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.008 0.1664 0.1664
Loa Loa (eye worm) hypothetical protein 0.0089 0.193 0.4653
Loa Loa (eye worm) hypothetical protein 0.0089 0.193 0.4653
Loa Loa (eye worm) hypothetical protein 0.0068 0.1323 0.3188
Loa Loa (eye worm) DR-78 0.008 0.1664 0.4012
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0028 0.0231 0.0231
Schistosoma mansoni microtubule-associated protein tau 0.0381 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0169 0.4144 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.004 0.0556 0.0757
Echinococcus multilocularis lysosomal alpha glucosidase 0.009 0.1941 0.1941
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0089 0.193 0.193
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.002 0.0003 0.0116
Mycobacterium ulcerans hypothetical protein 0.0149 0.3593 0.5
Echinococcus multilocularis Nuclear hormone receptor HR96 0.008 0.1664 0.1664
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0169 0.4144 1
Onchocerca volvulus Huntingtin homolog 0.0068 0.1323 0.1329
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.008 0.1664 0.2378
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0028 0.0231 1
Schistosoma mansoni nuclear hormone receptor 0.008 0.1664 0.1664
Brugia malayi Nuclear hormone receptor E75 0.008 0.1664 0.4016
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0284 0.7315 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0169 0.4144 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.009 0.1941 0.4684
Trypanosoma brucei lanosterol synthase 0.0031 0.0307 0.0416
Brugia malayi hypothetical protein 0.0089 0.193 0.4657
Brugia malayi nuclear hormone receptor family member odr-7 0.008 0.1664 0.4016
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0028 0.0231 0.0231
Echinococcus multilocularis microtubule associated protein 2 0.0381 1 1
Schistosoma mansoni alpha-glucosidase 0.0077 0.1594 0.1594
Loa Loa (eye worm) hypothetical protein 0.008 0.1664 0.4012
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.004 0.0556 0.0757
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0028 0.0231 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0169 0.4144 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.002 0.0003 0.0006
Brugia malayi hypothetical protein 0.008 0.1664 0.4016
Brugia malayi Nuclear hormone receptor-like 1 0.0089 0.193 0.4657
Echinococcus granulosus ecdysone induced protein 78C 0.0169 0.4144 0.4144
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0169 0.4144 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0134 0.3172 0.4335
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0169 0.4144 1
Echinococcus multilocularis geminin 0.0189 0.4686 0.4686
Trichomonas vaginalis CMGC family protein kinase 0.0028 0.0229 0.992
Toxoplasma gondii hypothetical protein 0.0046 0.0718 1
Loa Loa (eye worm) hypothetical protein 0.008 0.1664 0.4012
Loa Loa (eye worm) hypothetical protein 0.0169 0.4144 1
Echinococcus granulosus nuclear receptor nhr 48 0.008 0.1664 0.1664
Mycobacterium tuberculosis Conserved hypothetical protein 0.0149 0.3593 1
Echinococcus granulosus FTZ F1 alpha 0.0169 0.4144 0.4144
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0981 0.0981
Loa Loa (eye worm) hypothetical protein 0.0089 0.193 0.4653
Loa Loa (eye worm) hypothetical protein 0.0169 0.4144 1
Onchocerca volvulus 0.0169 0.4144 1
Brugia malayi hypothetical protein 0.0068 0.1323 0.3193
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0089 0.193 0.193
Echinococcus multilocularis Nuclear hormone receptor HR96 0.008 0.1664 0.1664
Trichomonas vaginalis CMGC family protein kinase 0.0028 0.0229 0.992
Loa Loa (eye worm) hypothetical protein 0.008 0.1664 0.4012
Onchocerca volvulus 0.0167 0.407 0.9774
Schistosoma mansoni retinoic acid receptor RXR 0.0169 0.4144 0.4144
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0169 0.4144 0.4144
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0089 0.193 0.193
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0169 0.4144 0.4144
Onchocerca volvulus 0.008 0.1664 0.2378
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0169 0.4144 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0169 0.4144 0.4144
Schistosoma mansoni nuclear receptor nhr-48 0.008 0.1664 0.1664
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.009 0.1941 0.468
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0169 0.4144 0.4144
Echinococcus multilocularis neutral alpha glucosidase AB 0.002 0.0003 0.0003
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.008 0.1664 0.1664
Echinococcus granulosus thyroid hormone receptor alpha 0.008 0.1664 0.1664
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0169 0.4144 0.4144
Schistosoma mansoni zinc finger protein 0.008 0.1664 0.1664
Trypanosoma cruzi lanosterol synthase, putative 0.0031 0.0307 0.0416
Brugia malayi MAP kinase sur-1 0.0028 0.0229 0.0553
Brugia malayi photoreceptor-specific nuclear receptor 0.0169 0.4144 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0981 0.0981
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0169 0.4144 0.4144
Loa Loa (eye worm) hypothetical protein 0.0169 0.4144 1
Onchocerca volvulus 0.008 0.1664 0.2378
Loa Loa (eye worm) hypothetical protein 0.0169 0.4144 1
Schistosoma mansoni RAR-like nuclear receptor 0.0169 0.4144 0.4144
Schistosoma mansoni alpha-glucosidase 0.0077 0.1594 0.1594
Brugia malayi nuclear hormone receptor 0.0169 0.4144 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.4144 1
Brugia malayi nuclear hormone receptor 0.008 0.1664 0.4016
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0284 0.7315 1
Echinococcus multilocularis nuclear receptor nhr 48 0.008 0.1664 0.1664
Brugia malayi tailless protein 0.008 0.1664 0.4016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0981 0.0981
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0028 0.0231 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0981 0.0981
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0981 0.2363
Echinococcus granulosus geminin 0.0189 0.4686 0.4686
Echinococcus multilocularis FTZ F1 alpha 0.0169 0.4144 0.4144
Schistosoma mansoni nuclear hormone receptor 0.0169 0.4144 0.4144
Echinococcus granulosus neutral alpha glucosidase AB 0.002 0.0003 0.0003
Trypanosoma cruzi lanosterol synthase, putative 0.0031 0.0307 0.0416
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0169 0.4144 0.4144
Brugia malayi conserved hypotetical protein 0.008 0.1664 0.4016
Schistosoma mansoni thyroid hormone receptor 0.0169 0.4144 0.4144
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0169 0.4144 0.4144
Brugia malayi hypothetical protein 0.008 0.1664 0.4016
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.004 0.0556 0.0757
Brugia malayi nuclear receptor RXR 0.0089 0.193 0.4657
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.008 0.1664 0.2378
Brugia malayi nuclear receptor RXR 0.008 0.1664 0.4016
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0028 0.0231 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0169 0.4144 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0169 0.4144 1
Schistosoma mansoni nuclear receptor 0.008 0.1664 0.1664
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0798 0.1087
Echinococcus granulosus nuclear receptor 2DBD gamma 0.008 0.1664 0.1664
Brugia malayi Steroid receptor seven-up type 2 0.0169 0.4144 1
Schistosoma mansoni nuclear hormone receptor 0.008 0.1664 0.1664
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0169 0.4144 0.4144
Loa Loa (eye worm) hypothetical protein 0.008 0.1664 0.4012
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0089 0.193 0.4653
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0169 0.4144 1
Loa Loa (eye worm) steroid hormone receptor 0.0169 0.4144 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.1323 0.3188
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0169 0.4144 1
Echinococcus multilocularis serotonin receptor 0.0078 0.1602 0.1602
Loa Loa (eye worm) hypothetical protein 0.0167 0.407 0.9823
Brugia malayi Nuclear hormone receptor E75 0.008 0.1664 0.4016
Schistosoma mansoni thyroid hormone receptor 0.0169 0.4144 0.4144
Echinococcus multilocularis thyroid hormone receptor alpha 0.0169 0.4144 0.4144
Loa Loa (eye worm) hypothetical protein 0.0089 0.193 0.4653
Loa Loa (eye worm) hypothetical protein 0.008 0.1664 0.4012
Trypanosoma cruzi protein farnesyltransferase, putative 0.0028 0.0231 0.0312
Loa Loa (eye worm) hypothetical protein 0.0078 0.1602 0.3863
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0169 0.4144 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0169 0.4144 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0169 0.4144 0.4144
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0028 0.0231 0.0551
Loa Loa (eye worm) hypothetical protein 0.0169 0.4144 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.008 0.1664 0.4012
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0134 0.3172 0.4335
Schistosoma mansoni hypothetical protein 0.0189 0.4686 0.4686
Brugia malayi Nuclear hormone receptor-like 1 0.0169 0.4144 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.002 0.0003 0.0116
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0134 0.3172 0.4335
Brugia malayi ecdysone receptor 0.008 0.1664 0.4016
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0284 0.7315 1
Giardia lamblia Prenyltransferase 0.0028 0.0231 1
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0028 0.0231 1
Brugia malayi orphan nuclear receptor NR2E1 0.008 0.1664 0.4016
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0028 0.0229 0.0309
Schistosoma mansoni alpha glucosidase 0.002 0.0003 0.0003
Echinococcus multilocularis serotonin receptor 0.0078 0.1602 0.1602
Loa Loa (eye worm) nuclear hormone receptor 0.008 0.1664 0.4012
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0169 0.4144 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0169 0.4144 0.4144
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0981 0.0981
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0028 0.0229 0.0309
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0028 0.0229 0.0309
Trypanosoma cruzi protein farnesyltransferase, putative 0.0028 0.0231 0.0312
Echinococcus granulosus lysosomal alpha glucosidase 0.009 0.1941 0.1941
Loa Loa (eye worm) nuclear receptor nhr-7B 0.008 0.1664 0.4012
Brugia malayi steroid hormone receptor 0.0169 0.4144 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.008 0.1664 0.4016
Echinococcus multilocularis lysosomal alpha glucosidase 0.009 0.1941 0.1941
Brugia malayi nuclear receptor NHR-88 0.008 0.1664 0.4016
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.008 0.1664 0.1664

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 53 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.122 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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