Detailed information for compound 1555582

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 562.534 | Formula: C28H29F3N2O7
  • H donors: 1 H acceptors: 5 LogP: 1.41 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.COc1ccc(cc1)c1ccc(cc1)[C@@H]1[C@H]2C(=O)N(C(=O)[C@H]2[C@]2(N1CCC2)C(=O)OC)CC
  • InChi: 1S/C26H28N2O5.C2HF3O2/c1-4-27-23(29)20-21(24(27)30)26(25(31)33-3)14-5-15-28(26)22(20)18-8-6-16(7-9-18)17-10-12-19(32-2)13-11-17;3-2(4,5)1(6)7/h6-13,20-22H,4-5,14-15H2,1-3H3;(H,6,7)/t20-,21-,22+,26-;/m0./s1
  • InChiKey: WBEWWMRMGIZCPU-FKHNWUCXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0524 0.3041 0.5821
Schistosoma mansoni hypothetical protein 0.0025 0.0047 0.0116
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0175 0.0262
Plasmodium vivax acyl-CoA synthetase, putative 0.0056 0.0235 0.2934
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0031 0.0078
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0349 0.0617
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1815 0.3023
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0161 0.0862 0.1649
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0127 0.0661 0.0661
Brugia malayi hypothetical protein 0.0018 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0034 0.0101 0.0194
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.003 0.0135
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0012 0.0029
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0111 0.0566 0.0566
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.08 0.1983
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.01 0.0192
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.003 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.01 0.0192
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0128 0.0668 0.12
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.003 0.0135
Loa Loa (eye worm) transcription factor SMAD2 0.0252 0.1408 0.2695
Echinococcus granulosus neurogenic locus notch protein 0.0161 0.0862 0.2136
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0019 0.0141
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.003 0.0034
Trichomonas vaginalis D-aminoacylase, putative 0.0146 0.0772 0.1267
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0031 0.0078
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0161 0.0862 0.2136
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.003 0.0034
Onchocerca volvulus Slit protein homolog 0.0161 0.0862 0.1403
Mycobacterium ulcerans lipase LipD 0.0146 0.0772 0.9235
Echinococcus granulosus expressed protein 0.0436 0.2512 0.623
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0031 0.0021
Echinococcus multilocularis protein jagged 1 0.0161 0.0862 0.0862
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0088 0.0219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.01 0.0192
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.01 0.0192
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1768 0.2945
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0661 0.164
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.01 0.0249
Brugia malayi hypothetical protein 0.0247 0.138 0.2642
Loa Loa (eye worm) acetyltransferase 0.015 0.08 0.1531
Onchocerca volvulus 0.101 0.596 1
Brugia malayi ecdysteroid receptor 0.0034 0.01 0.0192
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0005 0.0009
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0136 0.0652
Schistosoma mansoni hypothetical protein 0.0032 0.0088 0.0219
Schistosoma mansoni coup transcription factor 0.0034 0.01 0.0249
Loa Loa (eye worm) hypothetical protein 0.0075 0.0349 0.0668
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0031 0.0078
Echinococcus granulosus zinc finger protein 0.0027 0.0061 0.015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0216 0.0374
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1768 0.2945
Loa Loa (eye worm) hypothetical protein 0.0022 0.0031 0.006
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0356 0.0682
Brugia malayi Animal haem peroxidase family protein 0.0497 0.2882 0.5517
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0075 0.0349 0.4049
Loa Loa (eye worm) hypothetical protein 0.0022 0.0031 0.006
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0031 0.0078
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0349 0.4463
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1815 0.3023
Onchocerca volvulus Dual oxidase homolog 0.0497 0.2882 0.481
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0031 0.0078
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.011 0.0559 0.107
Mycobacterium ulcerans beta-lactamase 0.0146 0.0772 0.9235
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0175 0.0433
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0031 0.006
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0181 0.0181
Echinococcus multilocularis zinc finger protein 0.0027 0.0061 0.0061
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0012 0.0012
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0006 0.0011
Entamoeba histolytica acyl-coA synthetase, putative 0.0075 0.0349 0.1838
Schistosoma mansoni hypothetical protein 0.0032 0.0088 0.0219
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0031 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0225 0.0347
Schistosoma mansoni flap endonuclease-1 0.0024 0.0039 0.0097
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0158 0.0392
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0559 0.0909
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1815 0.3023
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0156 0.0834 1
Onchocerca volvulus Putative cubilin 0.0161 0.0862 0.1403
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0019 0.0141
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.003 0.0135
Loa Loa (eye worm) animal heme peroxidase 0.0497 0.2882 0.5517
Echinococcus granulosus GPCR family 2 0.0032 0.0088 0.0219
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0559 0.0909
Mycobacterium ulcerans hypothetical protein 0.0075 0.0349 0.4049
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.01 0.01
Schistosoma mansoni ap endonuclease 0.002 0.0019 0.0046
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.01 0.0249
Brugia malayi RNA binding protein 0.0076 0.0356 0.0682
Onchocerca volvulus Huntingtin homolog 0.0247 0.138 0.2277
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1815 0.3023
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0088 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0031 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0148 0.0785 0.1946
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.003 0.0074
Echinococcus multilocularis muscleblind protein 1 0.0324 0.1843 0.1843
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0054 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0146 0.0772 1
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.031 0.0594
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.01 0.0249
Brugia malayi Delta serrate ligand family protein 0.0161 0.0862 0.1649
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Echinococcus granulosus protein jagged 1 0.0161 0.0862 0.2136
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0088 0.0088
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0031 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.01 0.0192
Echinococcus granulosus FTZ F1 alpha 0.0034 0.01 0.0249
Onchocerca volvulus Serine\/threonine kinase homolog 0.011 0.0559 0.0892
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0031 0.006
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0146 0.0772 0.1477
Schistosoma mansoni peroxidasin 0.0497 0.2882 0.7147
Brugia malayi EGF-like domain containing protein 0.0161 0.0862 0.1649
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0351 0.0351
Schistosoma mansoni nuclear hormone receptor 0.0034 0.01 0.0249
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0075 0.0349 0.4049
Loa Loa (eye worm) hypothetical protein 0.0497 0.2882 0.5517
Entamoeba histolytica hypothetical protein 0.011 0.0555 0.2988
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0082 0.0392 0.2079
Loa Loa (eye worm) hypothetical protein 0.0056 0.0235 0.0449
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0034 0.0034
Brugia malayi isocitrate dehydrogenase 0.0019 0.0012 0.0022
Schistosoma mansoni hypothetical protein 0.0161 0.0862 0.2136
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.003 0.0135
Brugia malayi beta-lactamase 0.0146 0.0772 0.1477
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0181 0.045
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0031 0.006
Loa Loa (eye worm) MH2 domain-containing protein 0.0252 0.1408 0.2695
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0356 0.0682
Schistosoma mansoni ap endonuclease 0.002 0.0019 0.0046
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0559 0.0909
Loa Loa (eye worm) hypothetical protein 0.0101 0.0501 0.096
Brugia malayi beta-lactamase family protein 0.0146 0.0772 0.1477
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.003 0.0135
Entamoeba histolytica acyl-CoA synthetase, putative 0.0075 0.0349 0.1838
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0031 0.0078
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0088 0.0219
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0034 0.0083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0752 0.1864
Mycobacterium tuberculosis Conserved protein 0.0146 0.0772 0.1389
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0012 0.0029
Brugia malayi nuclear hormone receptor 0.0034 0.01 0.0192
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Brugia malayi AMP-binding enzyme family protein 0.0022 0.003 0.0057
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0005 0.0011
Brugia malayi TAR-binding protein 0.0076 0.0356 0.0682
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.01 0.0192
Echinococcus granulosus survival motor neuron protein 1 0.0524 0.3041 0.7541
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0054 0.0503
Brugia malayi Animal haem peroxidase family protein 0.0497 0.2882 0.5517
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.08 0.08
Loa Loa (eye worm) beta-lactamase 0.0146 0.0772 0.1477
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0031 0.0078
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1815 0.3023
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.003 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.01 0.0192
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0031 0.0078
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0144 0.0144
Echinococcus granulosus fibropellin Ia 0.0161 0.0862 0.2136
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0031 0.006
Echinococcus multilocularis neurogenic locus protein delta 0.0161 0.0862 0.0862
Schistosoma mansoni zinc finger protein 0.0018 0.0008 0.002
Brugia malayi Animal haem peroxidase family protein 0.0497 0.2882 0.5517
Brugia malayi Bromodomain containing protein 0.005 0.0196 0.0376
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0031 0.0031
Onchocerca volvulus Peroxidasin homolog 0.0497 0.2882 0.481
Trichomonas vaginalis penicillin-binding protein, putative 0.0146 0.0772 0.1267
Entamoeba histolytica hypothetical protein 0.011 0.0555 0.2988
Loa Loa (eye worm) hypothetical protein 0.0247 0.138 0.2642
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.003 0.0034
Echinococcus granulosus beta LACTamase domain containing family member 0.0146 0.0772 0.1913
Echinococcus granulosus peregrin 0.0041 0.014 0.0348
Brugia malayi jmjC domain containing protein 0.0044 0.0158 0.0303
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0752 0.1864
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1125 0.1862
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1815 0.3023
Onchocerca volvulus Peroxidase homolog 0.0497 0.2882 0.481
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0075 0.0349 0.0617
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.1768 0.3385
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0146 0.0772 0.1913
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0019 0.0036
Loa Loa (eye worm) hypothetical protein 0.0032 0.0088 0.0169
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0031 0.0078
Mycobacterium tuberculosis Probable esterase LipL 0.0146 0.0772 0.1389
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.01 0.0192
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0175 0.1918
Schistosoma mansoni hypothetical protein 0.0107 0.0538 0.1335
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0501 0.096
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0349 0.0668
Loa Loa (eye worm) oxidoreductase 0.0022 0.003 0.0057
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0031 0.0078
Schistosoma mansoni notch 0.0161 0.0862 0.2136
Loa Loa (eye worm) hypothetical protein 0.0324 0.1843 0.3528
Onchocerca volvulus 0.0107 0.0538 0.0858
Schistosoma mansoni hypothetical protein 0.0034 0.0101 0.0251
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0127 0.0661 0.164
Entamoeba histolytica hypothetical protein 0.0022 0.0031 0.0071
Loa Loa (eye worm) hypothetical protein 0.0058 0.0247 0.0473
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0054 0.0198
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1768 0.2945
Brugia malayi Calcium binding EGF domain containing protein 0.0161 0.0862 0.1649
Loa Loa (eye worm) notch protein 0.0161 0.0862 0.1649
Brugia malayi MH2 domain containing protein 0.0252 0.1408 0.2695
Loa Loa (eye worm) hypothetical protein 0.0034 0.01 0.0192
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1125 0.1862
Brugia malayi hypothetical protein 0.011 0.0555 0.1063
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0158 0.0303
Leishmania major hypothetical protein, conserved 0.0146 0.0772 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.01 0.0192
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.003 0.0285
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Onchocerca volvulus 0.0497 0.2882 0.481
Plasmodium vivax SET domain protein, putative 0.0127 0.0661 0.8548
Onchocerca volvulus Neurogenic locus notch homolog 0.0161 0.0862 0.1403
Loa Loa (eye worm) hypothetical protein 0.0022 0.0031 0.006
Echinococcus granulosus histone lysine methyltransferase setb 0.0148 0.0785 0.1946
Echinococcus multilocularis microtubule associated protein 2 0.0689 0.4033 0.4033
Loa Loa (eye worm) hypothetical protein 0.0034 0.01 0.0192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0752 0.1864
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.003 0.0285
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0031 0.0021
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0128 0.0668 0.1656
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.01 0.0192
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0175 0.2145
Loa Loa (eye worm) hypothetical protein 0.0247 0.138 0.2642
Loa Loa (eye worm) hypothetical protein 0.0148 0.0785 0.1502
Loa Loa (eye worm) hypothetical protein 0.0497 0.2882 0.5517
Schistosoma mansoni thyroid hormone receptor 0.0034 0.01 0.0249
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1125 0.1862
Schistosoma mansoni slit 0.0161 0.0862 0.2136
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.003 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0031 0.0021
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.01 0.0192
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0349 0.0668
Schistosoma mansoni cell polarity protein 0.0161 0.0862 0.2136
Onchocerca volvulus Chorion peroxidase homolog 0.0497 0.2882 0.481
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.0758 0.1879
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.01 0.01
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0148 0.0785 0.1946
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0031 0.0031
Trichomonas vaginalis D-aminoacylase, putative 0.0146 0.0772 0.1267
Loa Loa (eye worm) hypothetical protein 0.0497 0.2882 0.5517
Brugia malayi PXA domain containing protein 0.0022 0.0031 0.006
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0019 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0356 0.0883
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0019 0.0036
Echinococcus multilocularis neural cadherin 0.0161 0.0862 0.0862
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0054 0.0198
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.032 0.1815 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.006 0.006
Plasmodium falciparum acyl-CoA synthetase 0.0056 0.0235 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.003 0.0034
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0148 0.0785 0.0785
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0031 0.0078
Brugia malayi hypothetical protein 0.0022 0.0031 0.006
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1768 0.2945
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0356 0.0682
Echinococcus multilocularis neurogenic locus protein delta 0.0161 0.0862 0.0862
Brugia malayi PHD-finger family protein 0.0034 0.0101 0.0194
Loa Loa (eye worm) hypothetical protein 0.0497 0.2882 0.5517
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.003 0.0135
Onchocerca volvulus 0.0161 0.0862 0.1403
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0054 0.0608
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Plasmodium vivax hypothetical protein, conserved 0.0146 0.0772 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0056 0.0235 0.2648
Loa Loa (eye worm) hypothetical protein 0.0497 0.2882 0.5517
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.01 0.0249
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.01 0.0249
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.0752 0.1439
Trypanosoma brucei hypothetical protein, conserved 0.0146 0.0772 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0075 0.0349 0.4049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1815 0.3023
Loa Loa (eye worm) hypothetical protein 0.0056 0.0235 0.0449
Schistosoma mansoni hypothetical protein 0.0161 0.0862 0.2136
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.003 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.01 0.0192
Echinococcus granulosus neurogenic locus notch protein 0.0161 0.0862 0.2136
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0031 0.0078
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0351 0.0871
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.003 0.0135
Loa Loa (eye worm) hypothetical protein 0.0146 0.0772 0.1477
Brugia malayi serine/threonine-protein kinase plk-2 0.011 0.0559 0.107
Brugia malayi PXA domain containing protein 0.0022 0.0031 0.006
Echinococcus granulosus neurogenic locus protein delta 0.0161 0.0862 0.2136
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0031 0.0021
Schistosoma mansoni notch 0.0161 0.0862 0.2136
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0101 0.0251
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.01 0.01
Loa Loa (eye worm) blistered cuticle protein 3 0.0497 0.2882 0.5517
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0031 0.0078
Loa Loa (eye worm) hypothetical protein 0.0146 0.0772 0.1477
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0555 0.1377
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0156 0.0834 1
Trichomonas vaginalis set domain proteins, putative 0.101 0.596 1
Echinococcus granulosus slit 2 protein 0.0161 0.0862 0.2136
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0501 0.096
Trypanosoma cruzi hypothetical protein, conserved 0.0146 0.0772 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0034 0.0064
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0175 0.1918
Schistosoma mansoni hypothetical protein 0.0161 0.0862 0.2136
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0012 0.0047
Loa Loa (eye worm) hypothetical protein 0.0146 0.0772 0.1477
Echinococcus granulosus serine:threonine protein kinase PLK1 0.011 0.0559 0.1386
Brugia malayi Cadherin domain containing protein 0.0161 0.0862 0.1649
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0559 0.0909
Brugia malayi jmjC domain containing protein 0.0111 0.0566 0.1084
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0012 0.0047
Brugia malayi Muscle positioning protein 4 0.0161 0.0862 0.1649
Giardia lamblia Fructose-bisphosphate aldolase 0.032 0.1815 1
Schistosoma mansoni microtubule-associated protein tau 0.0689 0.4033 1
Onchocerca volvulus 0.0497 0.2882 0.481
Loa Loa (eye worm) hypothetical protein 0.0497 0.2882 0.5517
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0005 0.0005
Brugia malayi GCC2 and GCC3 family protein 0.0161 0.0862 0.1649
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.032 0.1815 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0021 0.0051
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.01 0.0119
Brugia malayi hypothetical protein 0.0524 0.3041 0.5821
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.01 0.0192
Loa Loa (eye worm) hypothetical protein 0.0497 0.2882 0.5517
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.01 0.0192
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0101 0.1056
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0031 0.006
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0101 0.1056
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0012 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1125 0.1862
Loa Loa (eye worm) hypothetical protein 0.0022 0.0031 0.006
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0019 0.0014
Schistosoma mansoni laminin gamma-3 chain 0.0161 0.0862 0.2136
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1768 0.2945
Echinococcus multilocularis muscleblind protein 0.0324 0.1843 0.1843
Toxoplasma gondii aldehyde dehydrogenase 0.0128 0.0668 0.7721
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.1768 0.3385
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.003 0.0074
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0047 0.0089
Echinococcus granulosus lysine specific demethylase 5A 0.0044 0.0158 0.0392
Mycobacterium tuberculosis Probable hydrolase 0.0146 0.0772 0.1389
Echinococcus multilocularis notch 0.0161 0.0862 0.0862
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.01 0.0192
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.01 0.0249
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0931 0.5484 1
Echinococcus multilocularis fibropellin Ia 0.0161 0.0862 0.0862
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.01 0.0249
Brugia malayi Bromodomain containing protein 0.0094 0.0462 0.0885
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0216 0.0374
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0031 0.0031
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.1191 0.1973
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.006 0.015
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0123 0.0633 0.157
Echinococcus multilocularis slit 2 protein 0.0161 0.0862 0.0862
Loa Loa (eye worm) hypothetical protein 0.0053 0.0214 0.041
Schistosoma mansoni peroxidasin 0.0497 0.2882 0.7147
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0031 0.006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0752 0.1864
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.0668 0.7962
Toxoplasma gondii ABC1 family protein 0.0146 0.0772 0.8941
Echinococcus multilocularis beta LACTamase domain containing family member 0.0146 0.0772 0.0772
Treponema pallidum fructose-bisphosphate aldolase 0.032 0.1815 1
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.1125 0.1847
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0349 0.0668
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0146 0.0772 0.1389
Echinococcus multilocularis peroxidasin 0.0497 0.2882 0.2882
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Echinococcus multilocularis peregrin 0.0041 0.014 0.014
Brugia malayi notch-like transmembrane receptor 0.0161 0.0862 0.1649
Entamoeba histolytica hypothetical protein 0.011 0.0555 0.2988
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.01 0.01
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.01 0.0249
Schistosoma mansoni serine/threonine protein kinase 0.011 0.0559 0.1386
Echinococcus granulosus microtubule associated protein 2 0.0689 0.4033 1
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0054 0.0104
Echinococcus granulosus tar DNA binding protein 0.0076 0.0356 0.0883
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.003 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.1191 0.1973
Schistosoma mansoni jumonji domain containing protein 0.0089 0.0429 0.1063
Loa Loa (eye worm) Notch2 0.0161 0.0862 0.1649
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0031 0.0078
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0349 0.3967
Loa Loa (eye worm) hypothetical protein 0.0034 0.01 0.0192
Loa Loa (eye worm) hypothetical protein 0.0146 0.0772 0.1477
Schistosoma mansoni notch 0.0161 0.0862 0.2136
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.003 0.0135
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1125 0.1862
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0107 0.0538 0.103
Schistosoma mansoni hypothetical protein 0.0069 0.031 0.0769
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0031 0.0031
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0101 0.1181
Echinococcus multilocularis geminin 0.036 0.2055 0.2055
Plasmodium falciparum flap endonuclease 1 0.0026 0.0054 0.1918
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0088 0.0169
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.01 0.0249
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0021 0.0051
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0136 0.5569
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.003 0.0813
Echinococcus granulosus geminin 0.036 0.2055 0.5095
Mycobacterium leprae conserved hypothetical protein 0.0146 0.0772 0.9225
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.01 0.01
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0349 0.4463
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0559 0.0909
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0146 0.0772 0.1389
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0175 0.0262
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.08 0.1531
Brugia malayi PHD-finger family protein 0.0034 0.0099 0.019
Brugia malayi Calcium binding EGF domain containing protein 0.0161 0.0862 0.1649
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0034 0.0083
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0021 0.0021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0146 0.0772 0.1913
Loa Loa (eye worm) hypothetical protein 0.0082 0.0392 0.075
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0146 0.0772 0.1477
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.0668 0.7962
Mycobacterium tuberculosis Probable lipase LipD 0.0146 0.0772 0.1389
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.01 0.0192
Loa Loa (eye worm) hypothetical protein 0.0497 0.2882 0.5517
Loa Loa (eye worm) hypothetical protein 0.0056 0.0235 0.0449
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0356 0.0356
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0559 0.0909
Toxoplasma gondii propionate-CoA ligase 0.0022 0.003 0.0213
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.01 0.0249
Brugia malayi Peroxidasin 0.0497 0.2882 0.5517
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.003 0.0135
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0501 0.096
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.003 0.0135
Brugia malayi Bromodomain containing protein 0.0041 0.014 0.0268
Schistosoma mansoni notch 0.0161 0.0862 0.2136
Loa Loa (eye worm) hypothetical protein 0.0497 0.2882 0.5517
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.003 0.0057
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0031 0.0031
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.003 0.0285
Entamoeba histolytica hypothetical protein 0.011 0.0555 0.2988
Plasmodium falciparum phd finger protein, putative 0.0034 0.0101 0.4026
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.01 0.0192
Onchocerca volvulus 0.0161 0.0862 0.1403
Loa Loa (eye worm) RNA binding protein 0.0076 0.0356 0.0682
Trichomonas vaginalis penicillin-binding protein, putative 0.0146 0.0772 0.1267
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1125 0.1862
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.003 0.0057
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0111 0.0566 0.1404
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0012 0.0047
Giardia lamblia Kinase, PLK 0.011 0.0559 0.3008
Loa Loa (eye worm) hypothetical protein 0.0034 0.01 0.0192
Onchocerca volvulus 0.0161 0.0862 0.1403
Schistosoma mansoni hypothetical protein 0.0161 0.0862 0.2136
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.003 0.0135
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.003 0.0019
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0555 0.1377
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.003 0.0285
Loa Loa (eye worm) hypothetical protein 0.0069 0.031 0.0594
Brugia malayi beta-lactamase family protein 0.0146 0.0772 0.1477
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0075 0.0349 0.4049
Brugia malayi Flap endonuclease-1 0.0026 0.0054 0.0104
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0752 0.1864
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.003 0.0239
Brugia malayi AMP-binding enzyme family protein 0.0022 0.003 0.0057
Schistosoma mansoni hypothetical protein 0.0018 0.0008 0.002
Schistosoma mansoni hypothetical protein 0.011 0.0555 0.1377
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0012 0.0047
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0031 0.0078
Mycobacterium tuberculosis Conserved protein 0.0146 0.0772 0.1389
Schistosoma mansoni septate junction protein 0.0161 0.0862 0.2136
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0158 0.0392
Onchocerca volvulus 0.0161 0.0862 0.1403
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0146 0.0772 0.9235
Onchocerca volvulus 0.0497 0.2882 0.481
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.003 0.0034
Onchocerca volvulus 0.0075 0.0349 0.0538
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0021 0.0051
Echinococcus multilocularis expressed protein 0.0436 0.2512 0.2512
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0034 0.0064
Echinococcus granulosus flap endonuclease 1 0.0026 0.0054 0.0135
Mycobacterium ulcerans esterase/lipase LipP 0.0146 0.0772 0.9235
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Loa Loa (eye worm) hypothetical protein 0.0022 0.0031 0.006
Echinococcus granulosus neurogenic locus notch protein 4 0.0161 0.0862 0.2136
Loa Loa (eye worm) bromodomain containing protein 0.0025 0.0047 0.009
Loa Loa (eye worm) hypothetical protein 0.0075 0.0349 0.0668
Brugia malayi nuclear receptor NHR-88 0.0034 0.01 0.0192
Loa Loa (eye worm) animal heme peroxidase 0.0497 0.2882 0.5517
Brugia malayi EGF-like domain containing protein 0.0161 0.0862 0.1649
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0031 0.0031
Loa Loa (eye worm) animal heme peroxidase 0.0497 0.2882 0.5517
Brugia malayi EGF-like domain containing protein 0.0161 0.0862 0.1649
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.003 0.0135
Brugia malayi Calcium binding EGF domain containing protein 0.0161 0.0862 0.1649
Giardia lamblia High cysteine protein 0.0161 0.0862 0.4693
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.01 0.0249
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.0752 0.1439
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0356 0.0883
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0031 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.01 0.0192
Onchocerca volvulus 0.0161 0.0862 0.1403
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0752 0.0752
Echinococcus granulosus muscleblind protein 0.0324 0.1843 0.457
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0012 0.0047
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0034 0.0064
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.011 0.0559 0.7215
Mycobacterium leprae Probable lipase LipE 0.0146 0.0772 0.9225
Loa Loa (eye worm) hypothetical protein 0.0056 0.0235 0.0449
Brugia malayi Cadherin domain containing protein 0.0161 0.0862 0.1649
Echinococcus granulosus peroxidasin 0.0497 0.2882 0.7147
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0057
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0888 0.5224 1
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.01 0.0192
Trypanosoma cruzi polo-like protein kinase, putative 0.011 0.0559 0.7215
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0057
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0009
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0019 0.0094
Schistosoma mansoni hypothetical protein 0.036 0.2055 0.5095
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0349 0.4049
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.0668 0.1656
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0054 0.0608
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.003 0.0034
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.003 0.0135
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.0668 0.1656
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0034 0.0083
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.003 0.003
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0019 0.0319
Brugia malayi Pre-SET motif family protein 0.0888 0.5224 1
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0319 0.061
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.006 0.015
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0012 0.0012
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0031 0.0078
Brugia malayi steroid hormone receptor 0.0034 0.01 0.0192
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.003 0.0213
Schistosoma mansoni hypothetical protein 0.0032 0.0088 0.0219
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.003 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0031 0.0021
Brugia malayi Pre-SET motif family protein 0.0127 0.0661 0.1266
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0012 0.0022
Onchocerca volvulus Peroxidasin homolog 0.0497 0.2882 0.481
Toxoplasma gondii exonuclease III APE 0.002 0.0019 0.0084
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0101 0.0251
Loa Loa (eye worm) hypothetical protein 0.0497 0.2882 0.5517
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0056 0.0235 0.0408
Echinococcus multilocularis fat cadherin tumor suppressor 0.0161 0.0862 0.0862
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0101 0.0101
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.01 0.0119
Brugia malayi hypothetical protein 0.0018 0.0005 0.0009
Entamoeba histolytica hypothetical protein 0.0022 0.0031 0.0071
Loa Loa (eye worm) hypothetical protein 0.0056 0.0235 0.0449
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.01 0.01
Entamoeba histolytica hypothetical protein 0.0022 0.0031 0.0071
Mycobacterium tuberculosis Probable lipase LipE 0.0146 0.0772 0.1389
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0034 0.01 0.0192
Loa Loa (eye worm) hypothetical protein 0.0022 0.0031 0.006
Echinococcus multilocularis protein jagged 2 0.0161 0.0862 0.0862
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0146 0.0772 0.1389
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0101 0.0194
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.01 0.01
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0157 0.039
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0031 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.01 0.0192
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1125 0.1862
Loa Loa (eye worm) hypothetical protein 0.0085 0.041 0.0784
Brugia malayi Blistered cuticle protein 3 0.0497 0.2882 0.5517
Echinococcus granulosus neural cadherin 0.0161 0.0862 0.2136
Loa Loa (eye worm) hypothetical protein 0.0146 0.0772 0.1477
Loa Loa (eye worm) hypothetical protein 0.0497 0.2882 0.5517
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0349 0.4463
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0082 0.0392 0.2079
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.01 0.0192
Loa Loa (eye worm) hypothetical protein 0.0497 0.2882 0.5517
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0054 0.0608
Schistosoma mansoni kinase 0.0056 0.0233 0.0579
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.01 0.01
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.01 0.0249
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0034 0.0083
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.01 0.0249
Schistosoma mansoni hypothetical protein 0.036 0.2055 0.5095
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0088 0.0088
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0054 0.0563
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.003 0.0034
Echinococcus multilocularis neurogenic locus notch protein 4 0.0161 0.0862 0.0862
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0056 0.0235 0.5
Brugia malayi EGF-like domain containing protein 0.0161 0.0862 0.1649
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.003 0.0213
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0031 0.0078
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.003 0.0135
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.003 0.0061
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Onchocerca volvulus 0.0146 0.0772 0.1251
Entamoeba histolytica acyl-CoA synthetase, putative 0.0075 0.0349 0.1838
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0356 0.0883
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.003 0.0034
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0012 0.0012
Onchocerca volvulus Peroxidase homolog 0.0497 0.2882 0.481
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0349 0.4049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0009
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.003 0.0034
Loa Loa (eye worm) hypothetical protein 0.0075 0.0349 0.0668
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0128 0.0668 0.8641
Brugia malayi AMP-binding enzyme family protein 0.0022 0.003 0.0057
Echinococcus multilocularis neurogenic locus notch protein 0.0161 0.0862 0.0862
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0088 0.0169
Schistosoma mansoni hypothetical protein 0.0032 0.0088 0.0219
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0019 0.0019
Echinococcus multilocularis survival motor neuron protein 1 0.0524 0.3041 0.3041
Brugia malayi Muscleblind-like protein 0.0324 0.1843 0.3528
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0157 0.0157
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0216 0.0374
Onchocerca volvulus 0.0034 0.01 0.0119
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0012 0.0001
Onchocerca volvulus 0.0146 0.0772 0.1251
Loa Loa (eye worm) hypothetical protein 0.0034 0.01 0.0192
Brugia malayi EGF-like domain containing protein 0.0161 0.0862 0.1649
Schistosoma mansoni thyroid hormone receptor 0.0034 0.01 0.0249
Entamoeba histolytica serine/threonine protein kinase, putative 0.011 0.0559 0.3008
Loa Loa (eye worm) hypothetical protein 0.0324 0.1843 0.3528
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.011 0.0559 0.0559
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.003 0.0135
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0019 0.0141
Schistosoma mansoni zinc finger protein 0.0027 0.0061 0.015
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.01 0.0249
Loa Loa (eye worm) hypothetical protein 0.0034 0.01 0.0192
Trypanosoma cruzi polo-like protein kinase, putative 0.011 0.0559 0.7215
Echinococcus multilocularis neurogenic locus notch protein 0.0161 0.0862 0.0862
Echinococcus multilocularis GPCR, family 2 0.0032 0.0088 0.0088
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0005 0.0009
Trichomonas vaginalis esterase, putative 0.0146 0.0772 0.1267
Onchocerca volvulus Alhambra homolog 0.0034 0.0101 0.0121
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0127 0.0661 0.7643
Trichomonas vaginalis D-aminoacylase, putative 0.0146 0.0772 0.1267
Brugia malayi nuclear receptor RXR 0.0018 0.0005 0.0009
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.003 0.0034
Loa Loa (eye worm) hypothetical protein 0.0055 0.0228 0.0436
Giardia lamblia PHD finger protein 15 0.0034 0.0101 0.046
Loa Loa (eye worm) hypothetical protein 0.0046 0.0175 0.0335
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.01 0.0249
Toxoplasma gondii EGF family domain-containing protein 0.0161 0.0862 1
Loa Loa (eye worm) animal heme peroxidase 0.0497 0.2882 0.5517
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.003 0.0285
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.003 0.0285
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0012 0.0022
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.01 0.0192
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0054 0.006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0005 0.0011
Schistosoma mansoni hypothetical protein 0.0161 0.0862 0.2136
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0031 0.006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0019 0.0141
Loa Loa (eye worm) hypothetical protein 0.0497 0.2882 0.5517
Brugia malayi hypothetical protein 0.0022 0.0031 0.006
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.003 0.0034
Loa Loa (eye worm) hypothetical protein 0.0146 0.0772 0.1477
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0349 0.3967
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.01 0.0249
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.01 0.0192
Echinococcus granulosus protein jagged 1 0.0161 0.0862 0.2136
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.01 0.01
Schistosoma mansoni hypothetical protein 0.0161 0.0862 0.2136
Echinococcus granulosus protein jagged 2 0.0161 0.0862 0.2136
Mycobacterium tuberculosis Conserved protein 0.0146 0.0772 0.1389
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0156 0.0834 0.1503
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0555 0.0555
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0031 0.0031
Trypanosoma brucei polo-like protein kinase 0.011 0.0559 0.7215
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0225 0.0347
Brugia malayi EGF-like domain containing protein 0.0161 0.0862 0.1649
Brugia malayi AMP-binding enzyme family protein 0.0022 0.003 0.0057
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0031 0.006
Loa Loa (eye worm) hypothetical protein 0.0497 0.2882 0.5517
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0136 0.0652
Mycobacterium ulcerans hypothetical protein 0.0146 0.0772 0.9235
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0216 0.0374
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0752 0.0752
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.01 0.0119
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.003 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.01 0.0192
Onchocerca volvulus 0.0127 0.0661 0.1065
Onchocerca volvulus Huntingtin homolog 0.0247 0.138 0.2277
Echinococcus granulosus notch 0.0161 0.0862 0.2136
Schistosoma mansoni survival motor neuron protein 0.0107 0.0538 0.1335
Brugia malayi hypothetical protein 0.0497 0.2882 0.5517
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0559 0.0909
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0356 0.0883
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.003 0.0135
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0031 0.0078
Schistosoma mansoni notch 0.0161 0.0862 0.2136
Echinococcus granulosus protein jagged 2 0.0161 0.0862 0.2136
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0128 0.0668 0.0668
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1768 0.2945
Schistosoma mansoni bromodomain containing protein 0.008 0.0377 0.0936
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0356 0.0883
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.0668 0.7962
Schistosoma mansoni notch 0.0161 0.0862 0.2136
Brugia malayi Animal haem peroxidase family protein 0.0497 0.2882 0.5517
Brugia malayi Animal haem peroxidase family protein 0.0497 0.2882 0.5517
Onchocerca volvulus 0.0146 0.0772 0.1251
Echinococcus granulosus delta-like protein 1 0.0161 0.0862 0.2136
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0349 0.4049
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0161 0.0862 0.1649
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1815 0.3023
Schistosoma mansoni hypothetical protein 0.0161 0.0862 0.2136
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0019 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.01 0.0249
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.01 0.0192
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0161 0.0862 0.1403
Echinococcus multilocularis protein jagged 1 0.0161 0.0862 0.0862
Brugia malayi EGF-like domain containing protein 0.0161 0.0862 0.1649

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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