Detailed information for compound 155564

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 454.58 | Formula: C25H43O5P
  • H donors: 0 H acceptors: 2 LogP: 6.51 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCC(=O)OC(CP(=O)(OCCCC)OCCCC)CCCc1ccccc1
  • InChi: 1S/C25H43O5P/c1-4-7-11-19-25(26)30-24(18-14-17-23-15-12-10-13-16-23)22-31(27,28-20-8-5-2)29-21-9-6-3/h10,12-13,15-16,24H,4-9,11,14,17-22H2,1-3H3
  • InChiKey: VKIWMORBFATFNZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0541 0.2714 0.7964
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0265 0.1338
Schistosoma mansoni nuclear receptor 0.0035 0.0043 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0073 0.0248 0.0228
Brugia malayi hypothetical protein 0.0039 0.0065 0.0045
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0073 0.0248 0.0673
Schistosoma mansoni Smad4 0.0055 0.0151 0.0193
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0126 0.0311
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.0121 0.0608
Plasmodium vivax metacaspase 1, putative 0.0049 0.0121 0.0608
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0026
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0043 0.0034
Echinococcus granulosus smad 0.0123 0.0511 0.1451
Onchocerca volvulus 0.0035 0.0043 0.0664
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0402 0.1983 1
Echinococcus granulosus Smad4 0.0123 0.0511 0.1451
Schistosoma mansoni thyroid hormone receptor 0.0073 0.0248 0.0336
Echinococcus granulosus caspase 3 0.0081 0.0288 0.0791
Loa Loa (eye worm) Smad1 0.0123 0.0511 0.0495
Loa Loa (eye worm) RNA binding protein 0.0671 0.3403 0.3391
Echinococcus granulosus caspase 8 0.0049 0.0121 0.0295
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0265 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0608 0.3069 0.9011
Toxoplasma gondii isocitrate dehydrogenase 0.0402 0.1983 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0073 0.0248 0.0228
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0121 0.0123
Brugia malayi hypothetical protein 0.018 0.081 0.0791
Brugia malayi isocitrate dehydrogenase 0.0402 0.1983 0.1967
Echinococcus multilocularis Glycosyl transferase, family 8 0.0073 0.0246 0.0665
Brugia malayi TAR-binding protein 0.0671 0.3403 0.3389
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.013 0.0548 0.156
Plasmodium falciparum ataxin-2 like protein, putative 0.018 0.081 0.4085
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0021 0.0003
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0039 0.0065 0.0048
Echinococcus granulosus ubiquitin specific protease 41 0.0083 0.0297 0.0819
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0083 0.0297 0.0819
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0121 0.0123
Loa Loa (eye worm) nuclear factor I 0.0068 0.022 0.0203
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0035 0.0043 0.0664
Brugia malayi nuclear receptor RXR 0.0035 0.0043 0.0023
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0073 0.0248 0.0336
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0083 0.0297 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0026
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0049 0.0118 0.0289
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0073 0.0248 0.0673
Brugia malayi hypothetical protein 0.0116 0.0474 0.0454
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0265 0.1338
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0081 0.0286 0.0786
Brugia malayi hypothetical protein 0.0035 0.0043 0.0023
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0073 0.0248 0.0673
Brugia malayi Latrophilin receptor protein 2 0.0608 0.3069 0.3054
Schistosoma mansoni hypothetical protein 0.0608 0.3069 0.4502
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0035 0.0043 0.0067
Trypanosoma brucei PAB1-binding protein , putative 0.018 0.081 0.3702
Brugia malayi nuclear hormone receptor family member odr-7 0.0035 0.0043 0.0023
Loa Loa (eye worm) hypothetical protein 0.1921 1 1
Brugia malayi nuclear receptor RXR 0.0039 0.0065 0.0045
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0026
Echinococcus multilocularis caspase 2 0.0095 0.0363 0.1012
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0121 0.0123
Brugia malayi orphan nuclear receptor NR2E1 0.0035 0.0043 0.0023
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0035 0.0043 0.0067
Brugia malayi ecdysteroid receptor 0.0073 0.0248 0.0228
Schistosoma mansoni isocitrate dehydrogenase 0.0049 0.0118 0.0144
Echinococcus multilocularis apoptotic protease activating factor 1 0.0046 0.0103 0.0243
Schistosoma mansoni unc-13 (munc13) 0.0049 0.0118 0.0144
Echinococcus granulosus Glycosyltransferase protein LARGE1 0.0054 0.0146 0.0371
Loa Loa (eye worm) hypothetical protein 0.0049 0.0118 0.0101
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0083 0.0297 0.095
Brugia malayi hypothetical protein 0.0039 0.0065 0.0045
Schistosoma mansoni caspase-3 (C14 family) 0.013 0.0548 0.0779
Schistosoma mansoni hypothetical protein 0.0046 0.0103 0.0121
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0608 0.3069 0.3054
Schistosoma mansoni nuclear receptor 0.0035 0.0043 0.0034
Brugia malayi nuclear hormone receptor 0.0035 0.0043 0.0023
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0231
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0071 0.0233 0.0629
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0073 0.0248 0.0336
Brugia malayi Probable isocitrate dehydrogenase 0.0049 0.0118 0.0098
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0073 0.0248 0.0228
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0073 0.0248 0.0228
Schistosoma mansoni thyroid hormone receptor 0.0073 0.0248 0.0336
Echinococcus multilocularis mothers against decapentaplegic 6 0.0055 0.0151 0.0387
Brugia malayi ecdysone receptor 0.0035 0.0043 0.0023
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0608 0.3069 0.9011
Schistosoma mansoni smad 0.0123 0.0511 0.0725
Brugia malayi latrophilin 2 splice variant baaae 0.1313 0.6792 0.6785
Echinococcus multilocularis mothers against decapentaplegic 2 0.0055 0.0151 0.0387
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0073 0.0248 0.0673
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0073 0.0248 0.0231
Plasmodium falciparum metacaspase 1 0.0049 0.0121 0.0608
Brugia malayi Probable isocitrate dehydrogenase 0.0049 0.0118 0.0098
Brugia malayi Cell death protein 3 precursor 0.0095 0.0363 0.0343
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0073 0.0248 0.0228
Loa Loa (eye worm) nuclear hormone receptor 0.0502 0.251 0.2496
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0043 0.0067
Echinococcus granulosus tar DNA binding protein 0.0671 0.3403 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0402 0.1983 1
Loa Loa (eye worm) hypothetical protein 0.0562 0.2825 0.2812
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0402 0.1983 0.5803
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0402 0.1983 0.5803
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0083 0.0297 0.0819
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0121 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0073 0.0248 0.0228
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0655 0.3318 0.9748
Loa Loa (eye worm) hypothetical protein 0.0039 0.0065 0.0048
Loa Loa (eye worm) TAR-binding protein 0.0671 0.3403 0.3391
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0671 0.3403 0.4995
Loa Loa (eye worm) hypothetical protein 0.1313 0.6792 0.6786
Brugia malayi Nuclear hormone receptor E75 0.0035 0.0043 0.0023
Brugia malayi Tyrosine-protein kinase abl-1 0.0397 0.1957 0.194
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0121 0.0123
Plasmodium falciparum ataxin-2 like protein, putative 0.018 0.081 0.4085
Brugia malayi MH1 domain containing protein 0.0123 0.0511 0.0492
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.0121 0.0608
Schistosoma mansoni hypothetical protein 0.0081 0.0286 0.0393
Schistosoma mansoni Smad4 0.0123 0.0511 0.0725
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0083 0.0297 0.5
Schistosoma mansoni tar DNA-binding protein 0.0671 0.3403 0.4995
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0402 0.1983 0.5803
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0049 0.0118 0.0289
Echinococcus multilocularis ecdysone induced protein 78C 0.0073 0.0248 0.0673
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0049 0.0118 0.0289
Echinococcus multilocularis thyroid hormone receptor alpha 0.0073 0.0248 0.0673
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0265 0.0724
Schistosoma mansoni nuclear hormone receptor 0.0073 0.0248 0.0336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0073 0.0248 0.0231
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0073 0.0248 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0073 0.0248 0.0228
Loa Loa (eye worm) MH1 domain-containing protein 0.0055 0.0151 0.0134
Brugia malayi conserved hypotetical protein 0.0035 0.0043 0.0023
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0071 0.0233 0.0629
Brugia malayi Isocitrate dehydrogenase 0.0402 0.1983 0.1967
Loa Loa (eye worm) MH2 domain-containing protein 0.0055 0.0151 0.0134
Echinococcus multilocularis smad 0.0123 0.0511 0.1451
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0402 0.1983 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0073 0.0248 0.0231
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0126 0.4744
Brugia malayi nuclear hormone receptor family member nhr-6 0.0035 0.0043 0.0023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0073 0.0248 0.0673
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0073 0.0248 0.0231
Echinococcus multilocularis tar DNA binding protein 0.0671 0.3403 1
Echinococcus granulosus caspase 2 0.0095 0.0363 0.1012
Echinococcus granulosus thyroid hormone receptor alpha 0.0035 0.0043 0.0067
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0123 0.0511 0.0725
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0065 0.0045
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0049 0.0118 0.0101
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0035 0.0043 0.0067
Onchocerca volvulus 0.0046 0.0103 0.2399
Loa Loa (eye worm) hypothetical protein 0.0077 0.0265 0.0248
Loa Loa (eye worm) transcription factor SMAD2 0.181 0.9413 0.9412
Echinococcus multilocularis tyrosine protein kinase Abl 0.0267 0.127 0.3694
Schistosoma mansoni tyrosine kinase 0.0646 0.3268 0.4797
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0035 0.0043 0.0067
Loa Loa (eye worm) steroid hormone receptor 0.0073 0.0248 0.0231
Brugia malayi nuclear hormone receptor 0.0073 0.0248 0.0228
Loa Loa (eye worm) glycosyl transferase family 8 protein 0.0073 0.0246 0.0228
Brugia malayi Steroid receptor seven-up type 2 0.0541 0.2714 0.2699
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0043 0.0067
Echinococcus granulosus apoptotic protease activating factor 1 0.0046 0.0103 0.0243
Brugia malayi MH2 domain containing protein 0.0123 0.0511 0.0492
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0402 0.1983 0.2899
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0121 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0073 0.0248 0.0228
Schistosoma mansoni RAR-like nuclear receptor 0.0073 0.0248 0.0336
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0073 0.0248 0.0228
Loa Loa (eye worm) hypothetical protein 0.0608 0.3069 0.3056
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0049 0.0118 0.0098
Trypanosoma cruzi PAB1-binding protein , putative 0.018 0.081 0.3702
Echinococcus multilocularis conserved hypothetical protein 0.0054 0.0146 0.0371
Brugia malayi hypothetical protein 0.0035 0.0043 0.0023
Loa Loa (eye worm) MH1 domain-containing protein 0.0123 0.0511 0.0495
Echinococcus multilocularis isocitrate dehydrogenase 0.0402 0.1983 0.5803
Schistosoma mansoni smad1 5 8 and 0.0123 0.0511 0.0725
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0073 0.0248 0.0673
Brugia malayi steroid hormone receptor 0.0073 0.0248 0.0228
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0402 0.1983 0.5803
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0073 0.0248 0.0228
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0126 0.0041
Echinococcus multilocularis caspase 3 0.0081 0.0288 0.0791
Schistosoma mansoni glycosyltransferase-related 0.0073 0.0246 0.0332
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0026
Leishmania major metacaspase, putative 0.0049 0.0121 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0121 0.0123
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0049 0.0121 0.01
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0231
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0049 0.0118 0.0144
Onchocerca volvulus 0.0035 0.0043 0.0664
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0126 0.0311
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0402 0.1983 1
Toxoplasma gondii LsmAD domain-containing protein 0.018 0.081 0.4085
Plasmodium falciparum metacaspase-like protein 0.0049 0.0121 0.0608
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0265 0.0724
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0083 0.0297 0.0409
Echinococcus granulosus Glycosyl transferase family 8 0.0073 0.0246 0.0665
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0265 1
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.0071 0.0233 0.0629
Schistosoma mansoni hypothetical protein 0.1313 0.6792 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0049 0.0121 0.0148
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0121 0.0123
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0083 0.0297 0.095
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0073 0.0248 0.0673
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0026
Echinococcus multilocularis GPCR, family 2 0.0608 0.3069 0.9011
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0035 0.0043 0.0034
Echinococcus multilocularis mothers against decapentaplegic 5 0.0123 0.0511 0.1451
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0265 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0073 0.0248 0.0231
Schistosoma mansoni smad 0.0055 0.0151 0.0193
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0065 0.0045
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0026
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0035 0.0043 0.0026
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0511 0.0495
Onchocerca volvulus Cell death protein 3 homolog 0.0095 0.0363 1
Leishmania major hypothetical protein, conserved 0.018 0.081 0.3709
Brugia malayi Glycosyl transferase family 8 protein 0.0073 0.0246 0.0225
Brugia malayi Tyrosine-protein kinase abl-1 0.0267 0.127 0.1252
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0402 0.1983 1
Schistosoma mansoni smad1 5 8 and 0.0123 0.0511 0.0725
Onchocerca volvulus 0.0073 0.0248 0.6649
Echinococcus multilocularis nuclear receptor nhr 48 0.0035 0.0043 0.0067
Toxoplasma gondii isocitrate dehydrogenase 0.0402 0.1983 1
Brugia malayi nuclear receptor NHR-67 0.0035 0.0043 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0073 0.0248 0.0228
Schistosoma mansoni nuclear receptor nhr-48 0.0035 0.0043 0.0034
Schistosoma mansoni hypothetical protein 0.0608 0.3069 0.4502
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0049 0.0118 0.0289
Schistosoma mansoni caspase-7 (C14 family) 0.0095 0.0363 0.0505
Loa Loa (eye worm) intermediate filament protein 0.003 0.0021 0.0003
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0265 0.0362
Loa Loa (eye worm) hypothetical protein 0.0083 0.0297 0.028
Loa Loa (eye worm) DR-78 0.0035 0.0043 0.0026
Loa Loa (eye worm) hypothetical protein 0.0248 0.1172 0.1156
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0231
Brugia malayi photoreceptor-specific nuclear receptor 0.0562 0.2825 0.281
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0608 0.3069 0.9011
Echinococcus granulosus TGF beta signal transducer SmadC 0.0123 0.0511 0.1451
Brugia malayi MH1 domain containing protein 0.0068 0.022 0.02
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0121 0.0608
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0123 0.0511 0.1451
Schistosoma mansoni smad1 5 8 and 0.0123 0.0511 0.0725
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0083 0.0297 0.0277
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0026
Loa Loa (eye worm) nuclear receptor NHR-67 0.0035 0.0043 0.0026
Schistosoma mansoni caspase-7 (C14 family) 0.013 0.0548 0.0779
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0065 0.0066
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0073 0.0248 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0121 0.0123
Schistosoma mansoni hypothetical protein 0.0608 0.3069 0.4502
Brugia malayi RNA binding protein 0.0671 0.3403 0.3389
Echinococcus multilocularis Smad4 0.0123 0.0511 0.1451
Echinococcus granulosus mothers against decapentaplegic 6 0.0055 0.0151 0.0387
Onchocerca volvulus Protein ultraspiracle homolog 0.0073 0.0248 0.6649
Echinococcus multilocularis FTZ F1 alpha 0.0073 0.0248 0.0673
Loa Loa (eye worm) hypothetical protein 0.0046 0.0103 0.0085
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0402 0.1983 1
Brugia malayi MH2 domain containing protein 0.0055 0.0151 0.0131
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0073 0.0248 0.0673
Echinococcus granulosus glycosyltransferase protein LARGE2 0.0071 0.0233 0.0629
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.0121 0.0608
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0265 0.5
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0083 0.0297 0.0819
Trypanosoma cruzi PAB1-binding protein , putative 0.018 0.081 0.3702
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0081 0.0286 0.0786
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0043 0.0034
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0265 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0073 0.0248 0.0673
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0049 0.0118 0.0098
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0049 0.0118 0.4458
Echinococcus granulosus Nuclear hormone receptor HR96 0.0035 0.0043 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0073 0.0248 0.0231
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0055 0.0151 0.3822
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0073 0.0248 0.6649
Loa Loa (eye worm) hypothetical protein 0.0039 0.0065 0.0048
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0026
Loa Loa (eye worm) hypothetical protein 0.018 0.081 0.0794
Brugia malayi MH2 domain containing protein 0.0123 0.0511 0.0492
Echinococcus multilocularis ubiquitin specific protease 41 0.0083 0.0297 0.0819
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0121 0.0123
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0121 0.0123
Echinococcus multilocularis caspase 8 0.0049 0.0121 0.0295
Echinococcus granulosus mothers against decapentaplegic 5 0.0123 0.0511 0.1451
Schistosoma mansoni zinc finger protein 0.0035 0.0043 0.0034
Brugia malayi MH1 domain containing protein 0.0068 0.022 0.02
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0083 0.0297 0.0961
Echinococcus granulosus Nuclear hormone receptor HR96 0.0035 0.0043 0.0067
Echinococcus granulosus tyrosine protein kinase ABL1 0.0655 0.3318 0.9748
Brugia malayi Calcitonin receptor-like protein seb-1 0.1921 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0073 0.0248 0.0228
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0039 0.0065 0.0066
Schistosoma mansoni tar DNA-binding protein 0.0671 0.3403 0.4995
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0083 0.0297 0.0409
Schistosoma mansoni retinoic acid receptor RXR 0.0073 0.0248 0.0336
Echinococcus granulosus FTZ F1 alpha 0.0073 0.0248 0.0673
Brugia malayi Nuclear hormone receptor-like 1 0.0073 0.0248 0.0228
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0231
Loa Loa (eye worm) hypothetical protein 0.0068 0.022 0.0203
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0073 0.0248 0.0673
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0265 0.1338
Plasmodium vivax ataxin-2 like protein, putative 0.018 0.081 0.4085
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0073 0.0248 0.0228
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.013 0.0548 0.156
Loa Loa (eye worm) TK/ABL protein kinase 0.0655 0.3318 0.3306
Echinococcus granulosus caspase 0.013 0.0548 0.156
Echinococcus multilocularis caspase 0.013 0.0548 0.156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0073 0.0248 0.0231
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0083 0.0297 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0402 0.1983 0.1969
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0265 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0026
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0035 0.0043 0.0067
Schistosoma mansoni hypothetical protein 0.0608 0.3069 0.4502
Schistosoma mansoni tar DNA-binding protein 0.0671 0.3403 0.4995
Brugia malayi nuclear receptor NHR-88 0.0073 0.0248 0.0228
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0265 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0083 0.0297 0.0819
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1921 1 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0402 0.1983 1
Loa Loa (eye worm) MH2 domain-containing protein 0.181 0.9413 0.9412
Brugia malayi Smad1 0.0123 0.0511 0.0492
Loa Loa (eye worm) latrophilin receptor protein 2 0.0608 0.3069 0.3056
Loa Loa (eye worm) hypothetical protein 0.0049 0.0121 0.0103
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0121 0.0123
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0083 0.0297 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0026
Brugia malayi nuclear receptor NHR-88 0.0035 0.0043 0.0023
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0049 0.0118 0.0098
Brugia malayi mothers against decapentaplegic homolog 3 0.0055 0.0151 0.0131
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.0121 0.0123
Brugia malayi hypothetical protein 0.0046 0.0103 0.0082
Loa Loa (eye worm) hypothetical protein 0.0039 0.0065 0.0048
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0026
Echinococcus granulosus mothers against decapentaplegic 2 0.0055 0.0151 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0121 0.0123
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0231
Schistosoma mansoni steroid hormone receptor ad4bp 0.0073 0.0248 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0297 1
Loa Loa (eye worm) hypothetical protein 0.0506 0.2532 0.2518
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0035 0.0043 0.0664
Loa Loa (eye worm) hypothetical protein 0.0073 0.0248 0.0231
Loa Loa (eye worm) hypothetical protein 0.0095 0.0363 0.0346
Echinococcus multilocularis Glycosyltransferase protein LARGE1 0.0054 0.0146 0.0371
Brugia malayi MH2 domain containing protein 0.181 0.9413 0.9412
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0402 0.1983 0.5803
Loa Loa (eye worm) hypothetical protein 0.0039 0.0065 0.0048
Echinococcus granulosus GPCR family 2 0.0608 0.3069 0.9011
Onchocerca volvulus Bile acid receptor homolog 0.0073 0.0248 0.6649
Brugia malayi Probable ClpP-like protease 0.0077 0.0265 0.0245
Echinococcus granulosus ecdysone induced protein 78C 0.0073 0.0248 0.0673
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0126 0.0041
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0608 0.3069 0.9011
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0039 0.0065 0.0132
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0073 0.0248 0.0336
Schistosoma mansoni Smad4 0.0055 0.0151 0.0193
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0402 0.1983 1
Echinococcus granulosus nuclear receptor nhr 48 0.0035 0.0043 0.0067
Brugia malayi MH1 domain containing protein 0.0123 0.0511 0.0492
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0035 0.0043 0.0034
Brugia malayi RNA recognition motif domain containing protein 0.0671 0.3403 0.3389
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0035 0.0043 0.0023
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0671 0.3403 0.3391
Schistosoma mansoni tar DNA-binding protein 0.0671 0.3403 0.4995
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0265 0.1338
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0083 0.0297 0.095
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0073 0.0248 0.0673
Brugia malayi tailless protein 0.0035 0.0043 0.0023
Schistosoma mansoni coup transcription factor 0.0073 0.0248 0.0336
Loa Loa (eye worm) hypothetical protein 0.0055 0.0151 0.0134
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0026
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0073 0.0248 0.0336
Loa Loa (eye worm) hypothetical protein 0.003 0.0021 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0121 0.0123
Brugia malayi Nuclear hormone receptor E75 0.0035 0.0043 0.0023
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0039 0.0065 0.0132
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0541 0.2714 0.7964

Activities

Activity type Activity value Assay description Source Reference
Kb (functional) > 1000 nM Inhibition of contractions induced by K+ depolarization in rat dorsal aorta ChEMBL. No reference
Ki (binding) > 1000 nM The compound was tested in vitro for its ability to displace [3H]-PN-200-110 from Calcium Channel in rat brain membranes. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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