Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuronal acetylcholine receptor; alpha4/beta2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.091 | 0.2667 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0083 | 0.0059 | 0.022 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.3236 | 1 | 0.5 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.091 | 0.2667 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.007 | 0.002 | 0.002 |
Loa Loa (eye worm) | oxidoreductase | 0.007 | 0.002 | 0.002 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.091 | 0.2667 | 0.5 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.091 | 0.2667 | 1 |
Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0147 | 0.0261 | 0.0586 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.091 | 0.2667 | 0.5 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.091 | 0.2667 | 0.5 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.091 | 0.2667 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.091 | 0.2667 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3236 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0064 | 0.0001 | 0.0003 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.091 | 0.2667 | 0.5 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.3236 | 1 | 0.5 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.3236 | 1 | 0.5 |
Brugia malayi | maoC like domain containing protein | 0.0163 | 0.0313 | 0.0313 |
Mycobacterium ulcerans | (3R)-hydroxyacyl-ACP dehydratase subunit HadC | 0.0064 | 0.0001 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.0313 | 0.0313 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0083 | 0.0059 | 0.022 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0083 | 0.0059 | 0.0059 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.091 | 0.2667 | 1 |
Mycobacterium ulcerans | (3R)-hydroxyacyl-ACP dehydratase subunit HadA | 0.0064 | 0.0001 | 0.0003 |
Mycobacterium tuberculosis | Probable 3-hydroxyacyl-thioester dehydratase HtdY | 0.0163 | 0.0313 | 0.1173 |
Trypanosoma brucei | hypothetical protein, conserved | 0.091 | 0.2667 | 0.5 |
Onchocerca volvulus | 0.3236 | 1 | 1 | |
Mycobacterium ulcerans | hypothetical protein | 0.0163 | 0.0313 | 0.1175 |
Mycobacterium ulcerans | hypothetical protein | 0.0064 | 0.0001 | 0.0003 |
Mycobacterium ulcerans | hypothetical protein | 0.0064 | 0.0001 | 0.0003 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0083 | 0.0059 | 0.0217 |
Loa Loa (eye worm) | short chain dehydrogenase/reductase family oxidoreductase | 0.0083 | 0.0059 | 0.0059 |
Mycobacterium ulcerans | dehydratase | 0.0163 | 0.0313 | 0.1175 |
Mycobacterium ulcerans | hypothetical protein | 0.0064 | 0.0001 | 0.0003 |
Mycobacterium leprae | conserved hypothetical protein | 0.091 | 0.2667 | 1 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.091 | 0.2667 | 1 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.091 | 0.2667 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. | 0.0163 | 0.0313 | 0.1173 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.18 nM | Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 in rat brain using [3H]-cytisine as radioligand | ChEMBL. | 9873625 |
Ki (binding) | = 0.18 nM | Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 in rat brain using [3H]-cytisine as radioligand | ChEMBL. | 9873625 |
Ki (binding) | = 21 pM | Binding affinity for alpha4 beta2 nAChR using [3H]-epibatidine in rat brain | ChEMBL. | 9733494 |
Ki (binding) | = 21 pM | Binding affinity for alpha4 beta2 nAChR using [3H]-epibatidine in rat brain | ChEMBL. | 9733494 |
MED (functional) | > 19 uM kg-1 | Analgesic activity in a mouse hot plate assay | ChEMBL. | 9873625 |
MED (functional) | > 19 uM kg-1 | Analgesic activity in a mouse hot plate assay | ChEMBL. | 9873625 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.