Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0041 | 0.126 | 0.126 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1405 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1746 | 0.1678 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0172 | 1 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0069 | 0.3091 | 0.3091 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.9552 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.9552 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.793 | 0.7913 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0229 | 0.0229 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0716 | 0.064 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1777 | 0.171 |
Schistosoma mansoni | bromodomain containing protein | 0.0073 | 0.3367 | 0.3525 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0081 | 0.0085 |
Echinococcus multilocularis | geminin | 0.0165 | 0.9552 | 0.9552 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1405 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0086 | 0.427 | 0.4024 |
Brugia malayi | hypothetical protein | 0.0141 | 0.793 | 0.7841 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0229 | 0.0229 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1405 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0041 | 0.126 | 0.126 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.793 | 0.7913 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1746 | 0.1392 |
Onchocerca volvulus | Huntingtin homolog | 0.0141 | 0.793 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0229 | 0.0239 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.394 | 0.389 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.163 | 0.1562 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1405 | 0.1405 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1405 | 0.1405 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0069 | 0.3091 | 0.3091 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0716 | 0.075 |
Echinococcus multilocularis | muscleblind protein | 0.0172 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1405 | 0.1037 |
Brugia malayi | Bromodomain containing protein | 0.0044 | 0.1442 | 0.1076 |
Onchocerca volvulus | Huntingtin homolog | 0.0141 | 0.793 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1405 | 0.1471 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1746 | 0.1678 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1405 | 0.1471 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1448 | 0.1378 |
Echinococcus granulosus | muscleblind protein | 0.0172 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0165 | 0.9552 | 0.9552 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0716 | 0.0318 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1405 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1746 | 0.1392 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.