Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAR-binding protein | 0.0066 | 0.5116 | 0.5116 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.5116 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.5116 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0082 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.5116 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.5116 | 0.5116 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0082 | 1 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0082 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.5116 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0082 | 1 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0082 | 1 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0082 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0066 | 0.5116 | 0.5116 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0082 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.5116 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.5116 | 0.5116 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.5116 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.5116 | 0.5116 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0082 | 1 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.5116 | 0.5 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0918 | 0.0918 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.5116 | 0.5116 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 88.1 uM | In vitro inhibition of Collagen (10 ug/mL) induced platelet aggregatory activity. | ChEMBL. | 12873516 |
Inhibition (functional) | = 9 % | Percentage inhibition against thrombin induced platelet aggregatory activity | ChEMBL. | 12873516 |
Inhibition (functional) | = 20 % | Percentage inhibition against platelet activating factor (2 ng/mL) induced platelet aggregatory activity | ChEMBL. | 12873516 |
Inhibition (functional) | = 27 % | In vitro inhibition of Archidonic acid (100 uM) induced platelet aggregatory activity. | ChEMBL. | 12873516 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.