Detailed information for compound 1556099

Basic information

Technical information
  • TDR Targets ID: 1556099
  • Name: T5266288
  • MW: 446.517 | Formula: C22H26N2O6S
  • H donors: 1 H acceptors: 4 LogP: 1.51 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)S(=O)(=O)N1CCOCC1)CCCOc1ccc(cc1)C(=O)C
  • InChi: 1S/C22H26N2O6S/c1-17(25)18-7-9-20(10-8-18)30-13-3-6-22(26)23-19-4-2-5-21(16-19)31(27,28)24-11-14-29-15-12-24/h2,4-5,7-10,16H,3,6,11-15H2,1H3,(H,23,26)
  • InChiKey: GMWBTIUUQXDJKR-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0512 0.1007
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0079 0.0588
Schistosoma mansoni tar DNA-binding protein 0.0141 0.1641 0.1626
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0051 0.0542 0.0525
Loa Loa (eye worm) hypothetical protein 0.0041 0.0412 0.0793
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0079 0.0588
Loa Loa (eye worm) RNA binding protein 0.0141 0.1641 0.3429
Entamoeba histolytica hypothetical protein 0.0039 0.0397 0.2787
Plasmodium vivax importin-beta 2, putative 0.0032 0.0301 0.1829
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0108 0.0061
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0043 0.0025
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0059 0.0042
Echinococcus granulosus GPCR family 2 0.0019 0.0145 0.0128
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0278 0.1888
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0656
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0106 0.1219 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.014
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0199 0.105
Echinococcus multilocularis protein kinase shaggy 0.0106 0.1219 0.1203
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0108 0.0091
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0051 0.0542 0.0525
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0015 0.0096 0.0143
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0096 0.0079
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0199 0.1206
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0512 0.0496
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0051 0.0542 0.0525
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0301 0.2086
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0015 0.0096 0.0079
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0121 0.0173
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0228 0.1815
Schistosoma mansoni cpg binding protein 0.0036 0.0352 0.0336
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0301 0.2471
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0199 0.1206
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0059 0.0036
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0108 0.0091
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0108 0.0091
Echinococcus multilocularis 0.0015 0.0096 0.0079
Echinococcus multilocularis geminin 0.0202 0.2391 0.2378
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0358 0.2886
Schistosoma mansoni retinoic acid receptor RXR 0.0051 0.0542 0.0525
Brugia malayi Steroid receptor seven-up type 2 0.0051 0.0542 0.1074
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0102 0.0773
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0066 0.0055
Brugia malayi nuclear receptor NHR-88 0.0051 0.0542 0.1074
Loa Loa (eye worm) TAR-binding protein 0.0141 0.1641 0.3429
Schistosoma mansoni hypothetical protein 0.0202 0.2391 0.2378
Schistosoma mansoni hypothetical protein 0.0019 0.0145 0.0128
Echinococcus granulosus lamin dm0 0.0032 0.0308 0.0292
Echinococcus granulosus lamin 0.0032 0.0308 0.0292
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0051 0.0542 0.0525
Schistosoma mansoni microtubule-associated protein tau 0.0823 1 1
Echinococcus granulosus cpg binding protein 0.0036 0.0352 0.0336
Plasmodium falciparum thioredoxin reductase 0.0017 0.0121 0.0537
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0301 0.2471
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0108 0.0091
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.014
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0051 0.0542 0.0525
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0008 0.0000000004934
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0118
Echinococcus granulosus intermediate filament protein 0.0032 0.0308 0.0292
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0199 0.1633
Entamoeba histolytica hypothetical protein 0.0039 0.0397 0.2787
Schistosoma mansoni RAR-like nuclear receptor 0.0051 0.0542 0.0525
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0145 0.0223
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0542 0.0525
Trichomonas vaginalis ran, putative 0.0023 0.0199 0.1576
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0079 0.0588
Loa Loa (eye worm) steroid hormone receptor 0.0051 0.0542 0.1071
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0358 0.2886
Brugia malayi nuclear receptor RXR 0.0035 0.0348 0.0659
Onchocerca volvulus Bile acid receptor homolog 0.0391 0.4704 1
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.1219 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0358 0.2886
Mycobacterium tuberculosis Probable reductase 0.0111 0.1278 0.8837
Echinococcus granulosus survival motor neuron protein 1 0.0282 0.337 0.3359
Schistosoma mansoni hypothetical protein 0.0019 0.0145 0.0128
Brugia malayi nuclear hormone receptor 0.0016 0.0108 0.0143
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0145 0.0128
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0397 0.038
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0358 0.2441
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.1191 0.1175
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0051 0.0542 0.0525
Schistosoma mansoni hypothetical protein 0.0337 0.4043 0.4032
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0015 0.0096 0.0079
Brugia malayi RNA recognition motif domain containing protein 0.0141 0.1641 0.3431
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0015 0.0096 0.0315
Brugia malayi hypothetical protein 0.0035 0.0348 0.0659
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.1911 0.4012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0051 0.0542 0.1071
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0066 0.0055
Brugia malayi conserved hypotetical protein 0.0016 0.0108 0.0143
Loa Loa (eye worm) hypothetical protein 0.0032 0.0308 0.057
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0015 0.0096 0.0315
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0542 0.1074
Brugia malayi steroid hormone receptor 0.0051 0.0542 0.1074
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0096 0.0723
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0079 0.0588
Loa Loa (eye worm) hypothetical protein 0.0015 0.0093 0.0109
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0223 0.1409
Echinococcus granulosus FTZ F1 alpha 0.0051 0.0542 0.0525
Schistosoma mansoni hypothetical protein 0.0057 0.0619 0.0603
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0051 0.0542 0.1074
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0121 0.5
Schistosoma mansoni tar DNA-binding protein 0.0141 0.1641 0.1626
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0191 0.0174
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0121 0.0537
Schistosoma mansoni steroid hormone receptor ad4bp 0.0051 0.0542 0.0525
Brugia malayi photoreceptor-specific nuclear receptor 0.0051 0.0542 0.1074
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0265 0.0481
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0542 0.1074
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0104 0.1191 0.2463
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.1191 0.1175
Trichomonas vaginalis CMGC family protein kinase 0.0106 0.1219 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0278 0.1744
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0121 0.0935
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.1191 0.1175
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0121 0.0369
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0265 0.2123
Echinococcus multilocularis FTZ F1 alpha 0.0051 0.0542 0.0525
Echinococcus granulosus tar DNA binding protein 0.0141 0.1641 0.1626
Brugia malayi RNA binding protein 0.0141 0.1641 0.3431
Brugia malayi intermediate filament protein 0.0032 0.0308 0.0574
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0108 0.0091
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0348 0.0659
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.0542 0.0525
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0008 0.0000000004934
Brugia malayi hypothetical protein 0.0016 0.0108 0.0143
Brugia malayi glutathione reductase 0.0049 0.0512 0.101
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0106 0.1219 0.1203
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0008 0.0000000004934
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0512 0.0496
Schistosoma mansoni hypothetical protein 0.0481 0.5817 0.5809
Toxoplasma gondii thioredoxin reductase 0.0049 0.0512 0.3905
Brugia malayi nuclear hormone receptor 0.0051 0.0542 0.1074
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0121 0.0369
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0008 0.0000000004934
Onchocerca volvulus 0.0016 0.0108 0.0061
Schistosoma mansoni hypothetical protein 0.0013 0.0077 0.006
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0102 0.0196
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0057 0.0619 0.124
Entamoeba histolytica Ran family GTPase 0.0023 0.0199 0.105
Schistosoma mansoni hypothetical protein 0.0041 0.0412 0.0396
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0512 0.2985
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0512 0.3707
Brugia malayi nuclear receptor RXR 0.0016 0.0108 0.0143
Brugia malayi hypothetical protein 0.0039 0.0397 0.0763
Echinococcus multilocularis dnaJ subfamily B 0.0481 0.5817 0.5809
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0358 0.2441
Brugia malayi Calcitonin receptor-like protein seb-1 0.0059 0.0643 0.1291
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.014
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0145 0.0128
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0301 0.0284
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.014
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0278 0.2282
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0051 0.0542 0.0525
Giardia lamblia Kinase, CMGC GSK 0.0106 0.1219 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.143 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.014
Brugia malayi RNA, U transporter 1 0.009 0.1014 0.2087
Schistosoma mansoni lamin 0.0032 0.0308 0.0292
Schistosoma mansoni intermediate filament proteins 0.0032 0.0308 0.0292
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0015 0.0096 0.0785
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0228 0.1815
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0108 0.014
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.1278 0.8837
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0121 0.5
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0079 0.0083
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0121 0.0537
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0108 0.0091
Echinococcus multilocularis tar DNA binding protein 0.0141 0.1641 0.1626
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0051 0.0542 0.1071
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0108 0.0143
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0106 0.1219 0.1203
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0125 0.0178
Plasmodium vivax glutathione reductase, putative 0.0049 0.0512 0.3707
Loa Loa (eye worm) hypothetical protein 0.0015 0.0097 0.0118
Schistosoma mansoni DNA helicase recq5 0.0012 0.0059 0.0042
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0059 0.0042
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0105 0.0087
Entamoeba histolytica hypothetical protein 0.0026 0.0228 0.1304
Plasmodium falciparum glutathione reductase 0.0049 0.0512 0.3905
Schistosoma mansoni importin beta-1 0.0032 0.0301 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0051 0.0542 0.1074
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0108 0.0143
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.1191 0.1175
Trypanosoma brucei trypanothione reductase 0.0049 0.0512 0.4201
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0308 0.0574
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0015 0.0096 0.0117
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0358 0.0341
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0008 0.0000000004934
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0051 0.0542 0.0525
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0793 0.0777
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0542 0.0525
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0121 0.5
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0199 0.092
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0051 0.0542 0.0525
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0348 0.0659
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.014
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0141 0.1641 0.3429
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0542 0.1074
Schistosoma mansoni alpha-glucosidase 0.014 0.1633 0.1619
Echinococcus multilocularis lamin 0.0032 0.0308 0.0292
Loa Loa (eye worm) DR-78 0.0016 0.0108 0.014
Echinococcus multilocularis ecdysone induced protein 78C 0.0051 0.0542 0.0525
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.1278 0.8837
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0199 0.1206
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0051 0.0542 0.1074
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0121 0.0369
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0358 0.2441
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0102 0.0196
Loa Loa (eye worm) hypothetical protein 0.0391 0.4704 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0059 0.0042
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.1911 0.1897
Brugia malayi ecdysone receptor 0.0016 0.0108 0.0143
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0278 0.1888
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0036
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0008 0.0000000004934
Echinococcus granulosus protein kinase shaggy 0.0106 0.1219 0.1203
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0102 0.0835
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0265 0.0248
Onchocerca volvulus 0.0057 0.0619 0.1167
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0108 0.014
Leishmania major trypanothione reductase 0.0049 0.0512 0.3797
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0358 0.0679
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0108 0.0143
Entamoeba histolytica hypothetical protein 0.0039 0.0397 0.2787
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0077 0.006
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0051 0.0542 0.1074
Loa Loa (eye worm) hypothetical protein 0.0282 0.337 0.7139
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0051 0.0542 0.1074
Loa Loa (eye worm) hypothetical protein 0.0051 0.0542 0.1071
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0043 0.0025
Schistosoma mansoni nuclear receptor 0.0016 0.0108 0.0091
Plasmodium falciparum importin beta, putative 0.0032 0.0301 0.2086
Schistosoma mansoni nuclear receptor 0.0016 0.0108 0.0091
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.1278 0.8837
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0051 0.0542 0.0525
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0308 0.057
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0121 0.0229
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0077 0.006
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0358 0.2573
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0035 0.0348 0.0332
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0106 0.1219 0.2523
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0121 0.0369
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0121 0.0997
Loa Loa (eye worm) hypothetical protein 0.0144 0.168 0.3514
Echinococcus granulosus bloom syndrome protein 0.0029 0.0265 0.0248
Treponema pallidum NADH oxidase 0.0017 0.0121 0.5
Plasmodium falciparum thioredoxin reductase 0.0049 0.0512 0.3905
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0397 0.038
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0337 0.4043 0.8582
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.1191 0.1175
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0108 0.0091
Entamoeba histolytica protein kinase domain containing protein 0.0106 0.1219 1
Trypanosoma brucei glucosidase, putative 0.0036 0.0358 0.2934
Schistosoma mansoni zinc finger protein 0.0016 0.0108 0.0091
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0108 0.0091
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0051 0.0542 0.0999
Onchocerca volvulus 0.0094 0.1069 0.2141
Loa Loa (eye worm) hypothetical protein 0.0032 0.0301 0.0555
Plasmodium falciparum glutathione reductase 0.0017 0.0121 0.0537
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0199 0.0339
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0121 0.0104
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0079 0.0588
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0121 0.0369
Brugia malayi CXXC zinc finger family protein 0.0034 0.0329 0.0617
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0542 0.1074
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0199 0.105
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0125 0.0181
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0059 0.0643 0.1291
Plasmodium falciparum glycogen synthase kinase 3 0.0106 0.1219 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0145 0.0128
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0358 0.2441
Plasmodium vivax glycogen synthase kinase 3, putative 0.0106 0.1219 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0051 0.0542 0.1071
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0308 0.057
Leishmania major hypothetical protein, conserved 0.0015 0.0096 0.0143
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0108 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0051 0.0542 0.1071
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0079 0.0588
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0358 0.2886
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0051 0.0542 0.0525
Echinococcus granulosus ecdysone induced protein 78C 0.0051 0.0542 0.0525
Brugia malayi hypothetical protein 0.0019 0.0149 0.0232
Brugia malayi nuclear receptor NHR-88 0.0016 0.0108 0.0143
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0329 0.0614
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0121 0.0997
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0059 0.0042
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0278 0.1624
Loa Loa (eye worm) hypothetical protein 0.0019 0.0145 0.0219
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0019 0.0152 0.0498
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0035 0.0348 0.0332
Schistosoma mansoni tar DNA-binding protein 0.0141 0.1641 0.1626
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0412 0.0797
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0051 0.0542 0.1074
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0121 0.0369
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0121 0.0369
Onchocerca volvulus 0.0034 0.0329 0.0539
Schistosoma mansoni tar DNA-binding protein 0.0141 0.1641 0.1626
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0051 0.0542 0.0525
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0145 0.0219
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0121 0.0369
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0105 0.0087
Loa Loa (eye worm) hypothetical protein 0.0051 0.0542 0.1071
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0108 0.0091
Brugia malayi hypothetical protein 0.0035 0.0348 0.0659
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.1278 0.8837
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0051 0.0542 0.1071
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.014
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0699 0.5523
Echinococcus multilocularis musashi 0.0032 0.0308 0.0292
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0121 0.0997
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0106 0.1219 0.1203
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0656
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0121 0.0369
Onchocerca volvulus Protein ultraspiracle homolog 0.0051 0.0542 0.0999
Schistosoma mansoni hypothetical protein 0.0019 0.0145 0.0128
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0121 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0542 0.0525
Echinococcus multilocularis lamin dm0 0.0032 0.0308 0.0292
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0121 0.0997
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0096 0.0723
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.1911 0.1897
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0358 0.2886
Schistosoma mansoni tar DNA-binding protein 0.0141 0.1641 0.1626
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0121 0.0935
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0358 0.2886
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0358 0.2886
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0512 0.3797
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0079 0.0588
Brugia malayi hypothetical protein 0.003 0.0278 0.0509
Loa Loa (eye worm) hypothetical protein 0.003 0.0278 0.0505
Echinococcus granulosus importin subunit beta 1 0.0032 0.0301 0.0284
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0121 0.0537
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0096 0.0079
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0008 0.0000000004934
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0542 0.1074
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0051 0.0542 0.1074
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0278 0.1744
Brugia malayi intracellular kinase 0.0106 0.1219 0.2526
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0121 0.0369
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0145 0.0128
Trichomonas vaginalis dullard protein, putative 0.0015 0.0096 0.0723
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0035 0.0348 0.0656
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0108 0.0061
Echinococcus multilocularis snurportin 1 0.0337 0.4043 0.4032
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0358 0.2886
Onchocerca volvulus 0.0051 0.0542 0.0999
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.143 1
Echinococcus granulosus geminin 0.0202 0.2391 0.2378
Echinococcus granulosus dnaJ subfamily B 0.0481 0.5817 0.5809
Echinococcus multilocularis cpg binding protein 0.0036 0.0352 0.0336
Onchocerca volvulus 0.0032 0.0308 0.0495
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0199 0.0182
Loa Loa (eye worm) hypothetical protein 0.0051 0.0542 0.1071
Trypanosoma brucei protein kinase, putative 0.0106 0.1219 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0121 0.0369
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0108 0.0091
Entamoeba histolytica protein kinase, putative 0.0106 0.1219 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0542 0.1071
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0228 0.1815
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0265 0.2123
Loa Loa (eye worm) glutathione reductase 0.0049 0.0512 0.1007
Brugia malayi hypothetical protein 0.0282 0.337 0.714
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0108 0.0091
Schistosoma mansoni alpha-glucosidase 0.014 0.1633 0.1619
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.143 1
Echinococcus granulosus snurportin 1 0.0337 0.4043 0.4032
Leishmania major hypothetical protein, conserved 0.003 0.0278 0.1744
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0108 0.0091
Loa Loa (eye worm) RecQ helicase 0.0029 0.0265 0.0478
Onchocerca volvulus 0.0032 0.0308 0.0495
Onchocerca volvulus 0.0016 0.0108 0.0061
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0656
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.1191 0.1175
Schistosoma mansoni nuclear hormone receptor 0.0051 0.0542 0.0525
Brugia malayi tailless protein 0.0016 0.0108 0.0143
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0108 0.0091
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0035 0.0348 0.0332
Onchocerca volvulus 0.0106 0.1219 0.2463
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.143 1
Entamoeba histolytica hypothetical protein 0.0039 0.0397 0.2787
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0228 0.1304
Loa Loa (eye worm) hypothetical protein 0.0051 0.0542 0.1071
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0108 0.0091
Trichomonas vaginalis dullard protein, putative 0.0015 0.0096 0.0723
Schistosoma mansoni hypothetical protein 0.0039 0.0397 0.038
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0145 0.0223
Schistosoma mansoni ran 0.0023 0.0199 0.0182
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0358 0.2886
Echinococcus granulosus CTD small phosphatase protein like 0.0015 0.0096 0.0079
Schistosoma mansoni DNA helicase recq1 0.0012 0.0059 0.0042
Echinococcus multilocularis GPCR, family 2 0.0019 0.0145 0.0128
Brugia malayi ecdysteroid receptor 0.0391 0.4704 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0121 0.0229
Schistosoma mansoni survival motor neuron protein 0.0057 0.0619 0.0603
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0121 0.0537
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0542 0.0525
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0051 0.0542 0.1071
Leishmania major importin beta-1 subunit, putative 0.0026 0.0228 0.1304
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0102 0.0196
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0121 0.0369
Loa Loa (eye worm) hypothetical protein 0.0059 0.0643 0.1288
Loa Loa (eye worm) hypothetical protein 0.0051 0.0542 0.1071
Loa Loa (eye worm) hypothetical protein 0.0015 0.0096 0.0114
Loa Loa (eye worm) hypothetical protein 0.0032 0.0301 0.0555
Echinococcus multilocularis thyroid hormone receptor alpha 0.0051 0.0542 0.0525
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0035 0.0348 0.0332
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0051 0.0542 0.0525
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0121 0.5
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0542 0.0525
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0542 0.1074
Brugia malayi nuclear receptor NHR-67 0.0016 0.0108 0.0143
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0358 0.0341
Giardia lamblia Kinase, CMGC GSK 0.0106 0.1219 1
Brugia malayi Thioredoxin reductase 0.0049 0.0512 0.101
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0015 0.0096 0.0315
Entamoeba histolytica protein kinase domain containing protein 0.0106 0.1219 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0059 0.00000000056889
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0051 0.0542 0.1071
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0096 0.0143
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0096 0.0723
Schistosoma mansoni ran 0.0023 0.0199 0.0182
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0104 0.1191 0.2466
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0059 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0358 0.2441
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0059 0.0643 0.1288
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0656
Echinococcus multilocularis microtubule associated protein 2 0.0823 1 1
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0106 0.1219 1
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0096 0.0723
Trichomonas vaginalis dullard protein, putative 0.0015 0.0096 0.0723
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0079 0.0652
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0108 0.0091
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0079 0.0588
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0108 0.0143
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0108 0.0143
Schistosoma mansoni hypothetical protein 0.0019 0.0145 0.0128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.1191 0.1175
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0121 0.0369
Brugia malayi Importin beta-1 subunit 0.0032 0.0301 0.0558
Schistosoma mansoni hypothetical protein 0.0202 0.2391 0.2378
Brugia malayi hypothetical protein 0.0016 0.0108 0.0143
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0106 0.1219 0.2523
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0108 0.014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.014
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.1278 0.8837
Schistosoma mansoni alpha glucosidase 0.0036 0.0358 0.0341
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0008 0.0000000004934
Loa Loa (eye worm) hypothetical protein 0.0051 0.0542 0.1071
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0397 0.038
Schistosoma mansoni cpg binding protein 0.0036 0.0352 0.0336
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0149 0.0773
Loa Loa (eye worm) hypothetical protein 0.0035 0.0348 0.0656
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0121 0.5
Schistosoma mansoni lamin 0.0032 0.0308 0.0292
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0542 0.1074
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0278 0.1888
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.014
Schistosoma mansoni cpg binding protein 0.0034 0.0329 0.0312
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0121 0.0537
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.1911 0.1897
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0108 0.0143
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0108 0.0091
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0121 0.0104
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.014
Leishmania major GTP-binding protein, putative 0.0023 0.0199 0.105
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0199 0.0182
Brugia malayi TAR-binding protein 0.0141 0.1641 0.3431
Loa Loa (eye worm) hypothetical protein 0.0013 0.0079 0.0079
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0121 0.0104
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0106 0.1219 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0105 0.0133
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0542 0.0525
Echinococcus multilocularis survival motor neuron protein 1 0.0282 0.337 0.3359
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0358 0.0676
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0199 0.0336
Schistosoma mansoni coup transcription factor 0.0051 0.0542 0.0525
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.1911 0.4009
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0059 0.0039
Schistosoma mansoni hypothetical protein 0.0015 0.0093 0.0076
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0051 0.0542 0.0525

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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