Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0403 | 0.5 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0619 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0694 | 0.0351 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.4964 | 0.6868 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0091 | 0.3417 | 0.3929 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0619 | 0.0078 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.4964 | 0.6868 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.6945 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.4964 | 0.6868 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.6945 | 1 |
Echinococcus granulosus | geminin | 0.0169 | 0.6945 | 1 |
Brugia malayi | RNA binding protein | 0.0125 | 0.4964 | 0.5707 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.2351 | 0.2738 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0099 | 0.3778 | 0.4344 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.3417 | 0.4466 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.3417 | 0.4423 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.4649 | 0.5119 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.2351 | 0.2349 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0694 | 0.0118 |
Trichomonas vaginalis | set domain proteins, putative | 0.0236 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.4964 | 0.6868 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0403 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.4649 | 0.5119 |
Brugia malayi | TAR-binding protein | 0.0125 | 0.4964 | 0.5707 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0403 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0694 | 0.0118 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0403 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0091 | 0.3417 | 0.3634 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0694 | 0.0351 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.3417 | 0.4466 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0207 | 0.8697 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 0.4964 | 0.5499 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.3778 | 0.407 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.4964 | 0.6868 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 0.4964 | 0.6868 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 0.4964 | 0.5499 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0694 | 0.0196 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0403 | 0.0463 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0694 | 0.0118 |
Brugia malayi | Pre-SET motif family protein | 0.0207 | 0.8697 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0619 | 0.0712 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.2351 | 0.2703 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0694 | 0.0118 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0694 | 0.0196 |
Echinococcus multilocularis | geminin | 0.0169 | 0.6945 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0694 | 0.0118 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.4649 | 0.5345 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 0.4964 | 0.6893 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.3417 | 0.4423 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.3417 | 0.4423 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0694 | 0.0798 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0694 | 0.0118 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0403 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0694 | 0.0798 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.3778 | 0.407 |
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 0.4964 | 0.5499 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0403 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.3778 | 0.4344 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0694 | 0.0118 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0694 | 0.0196 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0619 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 0.4964 | 0.5707 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.3417 | 0.4423 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.3417 | 0.4423 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0619 | 0.0261 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.13 uM kg-1 | Inhibition of quipazine-induced head twitches in rats after 2 hrs of pretreatment | ChEMBL. | 8410990 |
IC50 (binding) | = 3.7 nM | Displacement of [3H]-ketanserin from 5-hydroxytryptamine 2 receptor in rat cortical membranes | ChEMBL. | 8410990 |
IC50 (binding) | = 370 nM | Displacement of [3H]-prazosin from alpha-1 adrenoceptors in whole rat brain membranes | ChEMBL. | 8410990 |
IC50 (binding) | = 510 nM | Displacement of [3H]-spiperone from dopamine D2 receptors in rat striatal membranes | ChEMBL. | 8410990 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.