Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0038 | 0.1472 | 0.3513 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.1472 | 0.4426 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0038 | 0.1472 | 0.4426 |
Echinococcus granulosus | cathepsin l1 | 0.0026 | 0.0468 | 0.1408 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0038 | 0.1472 | 0.4426 |
Onchocerca volvulus | Cathepsin L homolog | 0.0038 | 0.1472 | 0.3513 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0062 | 0.3325 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.1472 | 0.4426 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0062 | 0.3325 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0038 | 0.1472 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0026 | 0.0468 | 0.1408 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0038 | 0.1472 | 0.3513 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0468 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Onchocerca volvulus | 0.0038 | 0.1472 | 0.3513 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0026 | 0.0468 | 0.3182 |
Echinococcus multilocularis | cysteine protease | 0.0038 | 0.1472 | 0.4426 |
Brugia malayi | intermediate filament protein | 0.0062 | 0.3325 | 1 |
Plasmodium vivax | vivapain-2 | 0.0038 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0062 | 0.3325 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Leishmania major | cathepsin L-like protease | 0.0147 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0134 | 0.8997 | 0.8997 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0038 | 0.1472 | 0.4426 |
Echinococcus multilocularis | cysteine protease | 0.0038 | 0.1472 | 0.4426 |
Plasmodium vivax | vivapain-2 | 0.0038 | 0.1472 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0038 | 0.1472 | 0.4426 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0038 | 0.1472 | 0.4426 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0038 | 0.1472 | 0.4426 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.003 | 0.0796 | 0.2393 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0038 | 0.1472 | 1 |
Echinococcus multilocularis | musashi | 0.0062 | 0.3325 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0038 | 0.1472 | 0.4426 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.0468 | 0.1408 |
Schistosoma mansoni | lamin | 0.0062 | 0.3325 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.1472 | 0.4426 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Onchocerca volvulus | 0.0062 | 0.3325 | 1 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0038 | 0.1472 | 0.3513 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0706 | 0.0833 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3235 | 0.9687 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0038 | 0.1472 | 0.3513 |
Onchocerca volvulus | 0.0038 | 0.1472 | 0.3513 | |
Loa Loa (eye worm) | ctsf protein | 0.0038 | 0.1472 | 0.3513 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Onchocerca volvulus | 0.0038 | 0.1472 | 0.3513 | |
Onchocerca volvulus | 0.0038 | 0.1472 | 0.3513 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0147 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0038 | 0.1472 | 0.3513 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0115 | 0.7525 | 0.7525 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0038 | 0.1472 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0038 | 0.1472 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1472 | 0.3513 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0033 | 0.1055 | 0.2055 |
Onchocerca volvulus | Cathepsin F homolog | 0.0038 | 0.1472 | 0.3513 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0026 | 0.0468 | 0.1408 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.3325 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0062 | 0.3325 | 1 |
Onchocerca volvulus | 0.0062 | 0.3325 | 1 | |
Echinococcus multilocularis | lamin | 0.0062 | 0.3325 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0033 | 0.1055 | 0.3174 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0038 | 0.1472 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0062 | 0.3325 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Onchocerca volvulus | 0.0038 | 0.1472 | 0.3513 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0038 | 0.1472 | 0.3513 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0038 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0062 | 0.3325 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.1472 | 0.4426 |
Echinococcus granulosus | lamin | 0.0062 | 0.3325 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0062 | 0.3325 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0038 | 0.1472 | 0.4426 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0468 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0147 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Onchocerca volvulus | 0.0038 | 0.1472 | 0.3513 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0147 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0026 | 0.0468 | 0.1408 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.1472 | 0.4426 |
Entamoeba histolytica | cysteine protease, putative | 0.0038 | 0.1472 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0038 | 0.1472 | 0.1472 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0706 | 0.0833 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.1472 | 0.4426 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0038 | 0.1472 | 0.4426 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0796 | 0.1146 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0038 | 0.1472 | 0.4426 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.0468 | 0.1408 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.1472 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0062 | 0.3325 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.003 | 0.0796 | 0.2393 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 45 % | Inhibition of human ICMT at 10 uM incubated with N-Acetyl-S-farnesyl-L-cysteine substrate for 5 mins followed by addition of [14C]-SAM measured after 30 mins by liquid scintillation counting | ChEMBL. | 21334890 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.