Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ADAM metallopeptidase domain 17 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus multilocularis | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma japonicum | ko:K06059 a disintegrin and metalloproteinase domain 17, putative | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Disintegrin family protein | ADAM metallopeptidase domain 17 | 824 aa | 724 aa | 27.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0039 | 0.0106 | 0.0209 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0248 | 0.4929 | 1 |
Onchocerca volvulus | 0.0035 | 0.0029 | 1 | |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0105 | 0.1637 | 0.3302 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0248 | 0.4929 | 0.4929 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0248 | 0.4929 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0248 | 0.4929 | 1 |
Echinococcus multilocularis | adam 17 protease | 0.0223 | 0.4347 | 0.8602 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0248 | 0.4929 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0248 | 0.4929 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0254 | 0.5053 | 1 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0106 | 0.0213 |
Leishmania major | fk506-binding protein 1-like protein | 0.0248 | 0.4929 | 1 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.014 | 0.2434 | 0.4818 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0034 | 0 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0219 | 0.4266 | 0.8443 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.014 | 0.2434 | 0.4818 |
Echinococcus multilocularis | fk506 binding protein | 0.0248 | 0.4929 | 0.9755 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0248 | 0.4929 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0034 | 0 | 0.5 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0248 | 0.4929 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0034 | 0 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0219 | 0.4266 | 0.8443 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0248 | 0.4929 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0248 | 0.4929 | 0.4929 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0034 | 0 | 0.5 |
Echinococcus multilocularis | adam | 0.0039 | 0.0106 | 0.0209 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0248 | 0.4929 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0248 | 0.4929 | 1 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0248 | 0.4929 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0248 | 0.4929 | 0.9941 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0254 | 0.5053 | 1 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0105 | 0.1637 | 0.324 |
Trichomonas vaginalis | immunophilin, putative | 0.0248 | 0.4929 | 1 |
Echinococcus granulosus | adam | 0.0039 | 0.0106 | 0.0209 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0105 | 0.1637 | 0.324 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0223 | 0.4347 | 0.8602 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0034 | 0 | 0.5 |
Echinococcus granulosus | adam 17 protease | 0.0245 | 0.4858 | 0.9615 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0248 | 0.4929 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0248 | 0.4929 | 0.9755 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0248 | 0.4929 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0248 | 0.4929 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0248 | 0.4929 | 0.9755 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0249 | 0.4959 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0254 | 0.5053 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0254 | 0.5053 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.4172 | 0.4172 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0034 | 0 | 0.5 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0248 | 0.4929 | 1 |
Schistosoma mansoni | immunophilin | 0.0254 | 0.5053 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0034 | 0 | 0.5 |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.004 | 0.0124 | 0.0245 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0034 | 0 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0254 | 0.5053 | 1 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0034 | 0 | 0.5 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0248 | 0.4929 | 1 |
Schistosoma mansoni | immunophilin | 0.0219 | 0.4266 | 0.8443 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0105 | 0.1637 | 0.324 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 12 nM | Inhibition of TACE | ChEMBL. | 20638281 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.